Clinical trials: Cirrhosis Liver
Liver Cirrhosis
Liver Cirrhosis Patients' Digital Health Literacy and Perspective on Digital Healthcare, a Multicenter Questionnaire Study
The goal of this study is to investigate digital health literacy in liver cirrhosis patients. Participants will fill in two questionnaires by email or mail.
- Trial name
- NCT06745843
- Testing
- Questionnaire
- Where
- Netherlands
- Volunteers
- 86 people
- Sponsor
- Maastricht University Medical Center
Acquired Bleeding Disorder, Cirrhosis
Safety and Efficacy of Activated Recombinant Human Factor VII in Cirrhotic Patients Undergoing Partial Hepatectomy
This trial is conducted in Asia. The aim of this trial is to evaluate the haemostatic efficacy of activated recombinant human factor VII in cirrhotic patients scheduled to undergo partial hepatectomy due to liver cancer or benign…
- Trial name
- NCT01562821
- Testing
- activated recombinant human factor VII
- Where
- 7 sites in China, Taiwan and 1 more
- Volunteers
- 235 people
- Sponsor
- Novo Nordisk A/S
Cirrhosis, Liver, Fibrosis, Liver
Safety and Effectiveness of Sulfasalazine in the Treatment of Liver Fibrosis/Cirrhosis.
This is a controlled, observational clinical study initiated by investigators to investigate the efficacy and safety of sulfasalazine in the treatment of cirrhosis in patients with cirrhosis.
- Trial name
- NCT06293378
- Testing
- Sulfasalazine enteric-coated tablets
- Where
- 2 sites in China
- Volunteers
- 330 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Cirrhosis
"Anticipant"-TIPS After a First Portal-hypertension-related Complication in Cirrhosis
Further decompensation (FD) in cirrhosis represents a prognostic stage associated with an even higher mortality than that associated with the first decompensation.
- Trial name
- Ant-TIPS (NCT07889726)
- Testing
- TIPS, Standard of Care (SOC)
- Where
- 8 sites in France
- Volunteers
- 266 people
- Sponsor
- University Hospital, Toulouse
Liver Cirrhosis
Using Autologous Bone Marrow Cells With Wharton Gel Exosomes to Stimulate Hepatic Cell Repair in Liver Cirrhosis
the study includes patients with liver cirrhosis irrespective of the stage excluding people with active tumor or other major health issue endangering life, the protocol includes the use of autologous bone marrow derived…
- Trial name
- bone marrow (NCT07374185)
- Testing
- Autologous Bone Marrow Aspirate Concentrate
- Where
- Iraq
- Volunteers
- 10 people
- Sponsor
- Global Stem Cell Center, Baghdad
Liver Fibroses, Liver Cirrhoses
Prevalence of Liver Fibrosis and Cirrhosis in Patients With Squamous Cell Carcinoma of the Head and Neck
Tobacco and alcohol are the two major risk factors for upper respiratory tract cancer (VADS).
- Conditions
- Liver Fibroses, Liver Cirrhoses, Squamous Cell Carcinoma of the Head and Neck
- Trial name
- fibr'HOM (NCT03139058)
- Testing
- Evaluation of the hepatic fibrosis
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Primary Sclerosing Cholangitis, Primary Biliary Cirrhosis
Biobank for Cholestatic Liver Diseases.
This study is a biobank of specimens and clinical data for use in current and future research to better understand the cholestatic liver diseases primary biliary cirrhosis/cholangitis (PBC) and primary sclerosing cholangitis…
- Conditions
- Primary Sclerosing Cholangitis, Primary Biliary Cirrhosis, Cholangiocarcinoma, Liver Cancer
- Trial name
- NCT03445585
- Where
- United States
- Volunteers
- 9,150 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hepatic Insufficiency
Pharmacokinetics of Everolimus in Subjects With Hepatic Insufficiency
This clinical pharmacology research study will assess the safety and pharmacokinetics of the drug everolimus in patients with impaired hepatic function as compared to healthy volunteers.
- Trial name
- NCT00968591
- Testing
- Everolimus
- Where
- 3 sites in Germany, Russia and 1 more
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Hepatitis C
Impact of Sofosbuvir and Daclatasvir Concentration on HCV RNA
Sofosbuvir plus daclatasvir with or without ribavirin is one of the currently recommended treatment option for chronic hepatitis C.
- Trial name
- NCT03318887
- Testing
- Sofosbuvir/daclatasvir with or without ribavirin
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Hospices Civils de Lyon
Liver Cirrhosis Due to Virus C Chronic Hepatitis
Autologous Bone Marrow Mononuclear Cells in Liver Cirrhosis
This is a phase I clinical study to evaluate feasibility, safety and kinetics of cellular therapy with autologous bone marrow-derived mononuclear cells (BMMC) in patients with liver cirrhosis due to virus C hepatitis.
- Trial name
- CELTHEP-02 (NCT00832247)
- Testing
- Autologous bone marrow mononuclear cells infusion
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Cirrhosis
Restrictive Versus Liberal Red Blood Cell Transfusion in Patients of Cirrhosis With Septic Shock
Consecutive cirrhotics who present to emergency department of ILBS with documented or suspected sepsis induced hypotension with Hb <8 gm/dl will be randomly assigned to restrictive (Target Hb 7-8 gm/dl) to liberal (Target Hb…
- Trial name
- NCT03433508
- Testing
- Liberal, Restrictive
- Where
- India
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhosis
The Use of Fibroscan to Assess Liver Fibrosis in Patients With Cardiac Pacemakers
This study is designed to determine if the Fibroscan (Echosens, Paris), a non-invasive, ultrasound-based device used to estimate fibrosis in patients with chronic liver disease, interferes with implanted cardiac pacemaker and/or…
- Trial name
- NCT02415348
- Testing
- Fibroscan
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Saskatchewan
Cirrhosis, Ascites Hepatic
Albumin Assisted Diuresis in Patients with Cirrhosis and Ascites
A small, pilot proof-of-concept placebo-controlled trial to explore the effects of albumin on diuresis in patients with cirrhosis, ascites and lower extremity edema.
- Trial name
- NCT06812390
- Testing
- Albumin infusion (25% albumin), Normal Saline (0.9% NaCl)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Anahita Rabiee MD MHS
Re-stenosis, Cirrhosis of the Liver
The Influence Cirrhosis of the Liver on the Coronary Re-stenosis (LTX- Stent Study)
The aim of the study is to choose an optimal stent and to get further knowledge about the mechanisms of the engraftment of a stent.
- Trial name
- NCT02809248
- Testing
- ZES, BMS
- Sponsor
- RWTH Aachen University
Ascites
Comparison of Crystalloid and Colloid I.V Fluid Therapy in Prevention of Paracentesis Induced Circulatory Dysfunction (PICD) and Renal Dysfunction in Patients With Decompensated Liver Cirrhosis in Egypt: a Randomized Piolet Study
2.2 Aim(s) of the Research (50 words max): To Compare between crystalloid and colloid I.V fluid therapy in the prevention of paracentesis induced circulatory dysfunction (PICD) and renal dysfunction in patients with decompensated…
- Trial name
- NCT05220891
- Testing
- Paracentesis
- Volunteers
- 60 people
- Sponsor
- Shady Ashraf Kassem
Cirrhosis of the Liver
Trial of Faecal Microbiota Transplantation in Cirrhosis
Patients with advanced cirrhosis have enteric dysbiosis with small bowel bacterial overgrowth and translocation of bacteria and their products across the gut epithelial barrier.
- Trial name
- PROFIT (NCT02862249)
- Testing
- Faecal microbiota transplantation
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- King's College London
Cirrhosis, Liver, Gastroesophageal Varices
Development of 4D Flow MRI for Risk Stratification of Variceal Bleeding in Cirrhosis
The goal of this research is to validate novel non-invasive Magnetic resonance imaging (MRI) biomarkers to detect Gastroesophageal varices (GEV) in patients with cirrhosis, including fractional flow change in the portal vein and…
- Conditions
- Cirrhosis, Liver, Gastroesophageal Varices, Fontan Procedure
- Trial name
- NCT04867954
- Testing
- Ensure Plus®, Pre-clinical validation contrast enhanced MRI, Clinical validation MRI
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Hepatocellular Carcinoma
Utility of Abbreviated Magnetic Resonance Imaging as a Screening Tool for Hepatocellular Carcinoma in Cirrhotic Patients
The goal of this study is Utility of abbrevational magnetic resonance imaging as a screening tool for hepatocellular carcinoma in cirrhotic patients.
- Trial name
- NCT05716620
- Testing
- MRI
- Where
- India
- Volunteers
- 380 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Portal Vein Thrombosis, Liver Cirrhosis
Compare the Efficacy and Safety of Dabigatran and Enoxaparin in Patients With Portal Vein Thrombosis With Cirrhosis
Portal vein thrombosis (PVT) is prevalent among patients with cirrhosis, and its prevalence rises with the severity of liver disease.
- Trial name
- NCT06818279
- Testing
- Dabigatran, Enoxaparin
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cirrhosis, Portal Hypertension
Evaluation of Minimal Hepatic Encephalopathy in Patients With Cirrhosis and Portal Hypertension
Minimal hepatic encephalopathy (MHE) is a subclinical cognitive impairment and represents the mildest type of hepatic encephalopathy (HE).
- Trial name
- Evencipor (NCT04807803)
- Testing
- Assessment of Minimal hepatic encephalopathy (MHE)
- Where
- 2 sites in France
- Volunteers
- 82 people
- Sponsor
- IHU Strasbourg
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