Clinical trials: Cisplatin Nephrotoxicity, open to volunteers
Cisplatin Nephrotoxicity, Nephrotoxicity
Alpha-Lipoic Acid in Mitigating Cisplatin-Induced Nephrotoxicity
To assess the nephroprotective efficacy of Alpha-Lipoic Acid in preventing cisplatin-induced nephrotoxicity in oncology patients by monitoring renal function changes
- Trial name
- NCT07564479
- Testing
- Alpha-Lipoic Acid (ALA)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Minia University
Acute Kidney Injury, Cancer
Cisplatin Induced Kidney Toxicity
Cisplatin (CisP) is a chemotherapeutic agent used to treat head and neck and lung cancer in adults and over 15 different pediatric cancers.
- Trial name
- ACCENT (NCT04442516)
- Testing
- Questionnaire, sampling of blood, urine and saliva
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- The Hospital for Sick Children
Oncology
Pantoprazole in Cisplatin Nephrotoxicity
Pantoprazole in Cisplatin Nephrotoxicity
- Trial name
- NCT04217512
- Testing
- Pantoprazole low dose, Pantoprazole high dose, Standard hydration
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sherief Abd-Elsalam
Acute Kidney Injury, Renal Tubulopathy
Prevention of Cisplatin-induced Nephrotoxicity
The research design is a prospective, randomized, controlled clinical trial in children to study effect of aminophylline in preserving renal function in oncologic patient received cisplatin either combined with other CMT or used…
- Trial name
- NCT06196853
- Testing
- Aminophylline
- Where
- Thailand
- Volunteers
- 24 people
- Sponsor
- Mahidol University
Nephrotoxicity
Renoprotective Role of Vitamin C and Coenzyme Q10 in Nephrotoxicity
Cisplatin is a widely used chemotherapy drug for many solid tumors (e.g., lung, bladder, ovarian, head and neck cancers). Despite its efficacy, its clinical use is limited by severe side effects, mainly nephrotoxicity, which…
- Trial name
- VitC-CoQ10 (NCT07476443)
- Testing
- Vitamin C, Coenzyme Q 10
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Nephrotoxicity
L-Carnitine Protective Effect in Nephrotoxicity
The goal of this clinical trial is to assess the possible reno-protective effect of L-carnitine against cisplatin-induced nephrotoxicity in patients receiving cisplatin-based chemotherapy.
- Trial name
- LC (NCT07108777)
- Testing
- L-Carnitine Tartrate
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Tanta University
Cisplatin Nephrotoxicity, Cisplatin Adverse Reaction
Safety Study of GMDTC Injection in Participants With Solid Tumors and Cisplatin-Induced Renal Dysfunction
This trial is a multicenter, combined hydration, multiple-dose, dose-escalation phase Ib clinical study, designed to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic characteristics of the injection product…
- Trial name
- NCT07824843
- Testing
- GMDTC 1 mg/ml, GMDTC 2mg/ml, GMDTC 3mg/ml
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangdong Jianersheng Pharmaceutical Technology Co., Ltd.
Mucositis, Nephrotoxicity
Treatment of Radiation and Cisplatin Induced Toxicities with Tempol
A 10 week trial to assess the ability of Tempol to prevent and/or reduce toxicities associated with cisplatin and radiation treatment in head and neck cancer patients.
- Conditions
- Mucositis, Nephrotoxicity, Ototoxicity
- Trial name
- NCT03480971
- Testing
- Tempol
- Where
- 9 sites in United States
- Volunteers
- 120 people
- Sponsor
- Matrix Biomed, Inc.
Solid Tumors, Cisplatin Nephrotoxicity
Protecting the Kidney's Proximal Tubules From Platinum-Based Chemotherapy Toxicity
Patients with cancer who receive platinum-based chemotherapy are at increased risk of kidney injury caused by these drugs. This form of toxicity can lead to treatment delays, dose reductions, or permanent discontinuation of…
- Trial name
- DAPA-ARMOR (NCT07018622)
- Testing
- Dapagliflozin 10 MG Oral Tablet
- Where
- Mexico
- Volunteers
- 46 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran