Clinical trials: Citrulline
Citrulline, Blood Flow
Effect of L-Citrulline on Vascular Function
The objective of this project is to determine the importance of peripheral vascular function on gait performance in older adults.
- Conditions
- Citrulline, Blood Flow, Aging
- Trial name
- NCT03127917
- Testing
- L-citrulline
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Sarcopenia, Obesity
Citrulline Supplementation Combined With Exercise: Effect on Muscle Function in Elderly People (CITEX Study)
The main objective of this study is to determine if oral supplementation of Citrulline, when combined with HIIT, can produce significant changes in body composition, muscle quality, muscle metabolism and functional capacity in…
- Trial name
- CITEX (NCT02417428)
- Testing
- Citrulline, Exercise, without exercise
- Where
- Canada
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Université du Québec a Montréal
Atrial Septal Defect, Ventricular Septal Defect
Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery : Revised Protocol
This clinical trial will determine the safety and effectiveness of intravenous L-citrulline in children undergoing cardiopulmonary bypass during heart surgery.
- Conditions
- Atrial Septal Defect, Ventricular Septal Defect, Atrioventricular Septal Defect
- Trial name
- NCT01120964
- Testing
- Intravenous L-Citrulline
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Asklepion Pharmaceuticals, LLC
Type 2 Diabetes
Nutraceutical Citrulline in Pregnancy
The purpose of this study is to determine if oral of L-citrulline (3 grams/day) for 3 weeks provided in mid-pregnancy to pregnant women with type 2 diabetes will increase the plasma L-arginine/ADMA ratio, lower maternal blood…
- Trial name
- NCT02772887
- Testing
- L-Citrulline
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pittsburgh
Healthy Young, Older People With Cardiovascular Disease Risk
Watermelon and Beetroot Products on Endothelial Function
Cardiovascular disease is the main cause of death worldwide. Endothelial dysfunction is the first step to development of cardiovascular diseases.
- Trial name
- NCT04781595
- Testing
- Watermelon, Beetroot, Watermelon + beetroot
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Healthy Subjects
"Effects of Oral Citrulline on Protein Metabolism in Healthy Humans: a Prospective, Randomized, Double-blind , Cross-over Study" (Citrugrêle)
The specific aim of this study is to determine whether oral citrulline administration enhances whole body protein synthesis in healthy humans in the postabsorptive state.
- Trial name
- NCT00756080
- Testing
- citrulline
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Severe Sepsis, Acute Lung Injury
Citrulline in Severe Sepsis
This is a randomized, double-blind, placebo-controlled, phase 2 study to evaluate biochemical, clinical, and safety effects of 2 doses of intravenous L-citrulline compared to placebo in patients with severe sepsis at risk for or…
- Trial name
- NCT01474863
- Testing
- High Dose Citrulline, Low Dose Citrulline
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Vanderbilt University
Asthma
L-Citrulline Supplementation Pilot Study for Overweight Late Onset Asthmatics
In people who develop asthma after the age of 12 and who are also overweigh, there can be an increased burden of asthma symptoms, more flare-ups, and poorly-controlled asthma when compared to normal weight asthmatics.
- Trial name
- SANDIA (NCT01715844)
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pittsburgh
Dietary Supplementation
Effects of Combined Grape Seed Extract and L-citrulline Supplementation on Hemodynamic Responses in Young Males
This study was to examine the additive benefits with combined grape seed extract (GSE) and L-citrulline supplementation on hemodynamic responses to dynamic exercise, 11 young, healthy males were recruited for this study.
- Trial name
- NCT05116150
- Testing
- Grape seed extract
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- California Baptist University
Hypertension
L-citrulline Supplementation & Cold Exposure
Cardiovascular disease (CVD) is considered the primary cause of death in the developed world. Large scale epidemiological studies indicate that prevalence of hypertension along with adverse cardiovascular events peak during the…
- Trial name
- NCT01462591
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Florida State University
Acute Vaso Occlusive Crisis (VOC)
L-citrulline Injection in Patients Aged 6-21 Years Old with Sickle Cell Disease Presenting with Vaso-Occlusive Crisis (VOC)
The purpose of this study is to determine if intravenous L-citrulline can abrogate an active vaso-occlusive crisis in sickle cell disease, resulting in decreased pain, reduction or elimination of opiate usage, and reduction or…
- Trial name
- NCT04852172
- Testing
- L-citrulline, D5 1/2NS
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Asklepion Pharmaceuticals, LLC
Hypertension, Menopause
8 Weeks of L-CIT Supplementation and LIRET on Vascular Function in Hypertensive Postmenopausal Women
The overall objective of this project is to bring forth evidence that L-Citrulline (L-CIT) supplementation and low intensity resistance exercise training (LIRET) alone and combined will improve vascular function and muscle…
- Trial name
- NCT05227781
- Testing
- L-Citrulline
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Blood Pressure
The Effect of Short-term L-citrulline Supplementation on Blood Pressure and Arterial Stiffness
The goal of this clinical trial is to examine the effect of short-term L-Citrulline on central and peripheral blood pressure in healthy older adults.
- Trial name
- NCT05974813
- Testing
- L-Citrulline
- Where
- Cyprus
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- European University Cyprus
Nitrate, Nitrate/Citrulline
Nitrate Formulations and Exercise Performance
this study compares the acute effects of Nitrate and Nitrate plus citrulline supplementation on physical performance in recreationally trained males and females.
- Conditions
- Nitrate, Nitrate/Citrulline, Placebo
- Trial name
- NCT06531070
- Testing
- Nitrate
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Greenwich
Sepsis, Multiple Organ Failure
L-citrulline Supplementation During Sepsis
The purpose of this study is to study the stimulating effects of prolonged (8h) enteral L-citrulline supplementation on the normalisation of the plasma citrulline concentrations and the Arginine-NO metabolism, the…
- Trial name
- NCT00628381
- Testing
- L-citrulline supplementation, L-alanine
- Where
- Netherlands
- Volunteers
- 48 people
- Sponsor
- Maastricht University Medical Center
Diarrhea, Anorexia
Plasma Citrulline: A Marker for Monitoring & Quantifying Radiation-Induced Small Bowel Toxicity
Small bowel irradiation results in epithelial cell loss and consequently impairs function and metabolism. A metabolic end product of small bowel enterocytes is plasma citrulline.
- Conditions
- Diarrhea, Anorexia, Dyspepsia
- Trial name
- NCT01849107
- Testing
- Plasma citrulline
- Where
- South Korea
- Volunteers
- 49 people
- Sponsor
- Asan Medical Center
Bioavailability and AUC
The Objective of This Study Was to Compare and Quantify the Bioavailability of Citrulline Byproducts in Blood Samples and in Urine Samples After a Single Dose of the Assigned Dietary Supplement. The Treatment Arms Containing the Following Molecules: Citrulline HCL and L-Citrulline,
Citrulline dietary supplements are of interest for improving cardiovascular and exercise performance. The health benefits of citrulline are attributable to its ability to increase arginine levels in the body through the…
- Trial name
- NCT06977854
- Testing
- Removal from study. In case of adverse event, subject treated for the AE., removal from study
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Vireo Systems, Inc.
Fetal Growth Retardation
Arginine + Citrulline as a Supplement for Weight Gain in Fetus With a Decrease in Their Growth Curve
Introduction: The high incidence of intrauterine growth restriction is a public health problem; in this pathology, newborns present weight below the 10th percentile, this implies an increase in morbidity in the short term…
- Trial name
- NCT05029778
- Testing
- L-arginine 3g + L-Citruline 2 g
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Hospital Civil de Guadalajara
Menopause, Hypertension
2 Weeks of Citrulline Supplementation on Arterial Function in Postmenopausal Women With Elevated Blood Pressure or Hypertension
The objective of this project is to elucidate the effect of L-Citrulline (L-CIT) supplementation on vascular function at rest and during rhythmic handgrip exercise and functional sympatholysis via lower-body negative pressure in…
- Trial name
- NCT06025383
- Testing
- L-Citrulline
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
MELAS Syndrome
L-Citrulline Dose Finding Safety Study in MELAS
The main purpose of this study is to determine the safest maximum dose of an amino acid, citrulline, which will be used as potential treatment for adult patients with a disorder of energy metabolism called Mitochondrial…
- Trial name
- NCT03952234
- Testing
- L-Citrulline
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baylor College of Medicine