Clinical trials: Claudin18.2 Positive Advanced Solid Tumors
Advanced Solid Tumors
A Study to Evaluate Claudin 18.2-Directed ADC LCB02A in Advanced Solid Tumors
This is a Phase 1/2 open label study consisting of dose escalation cohorts (Phase 1) followed by expansion cohorts (Phase 2). The Phase 1 dose escalation population includes subjects with advanced solid tumors that are refractory…
- Trial name
- NCT07460375
- Testing
- LCB02A
- Where
- 8 sites in United States, Canada and 1 more
- Volunteers
- 191 people
- Sponsor
- LigaChem Biosciences, Inc.
Advanced Solid Tumors
A Study of QLS31905 in Patients With Advanced Solid Tumors
This is a multi-center, open-label design to evaluate the safety and tolerance of QLS31905 in patients with advanced solid tumors, together with an assessment of pharmacokinetic characteristics and efficacy.
- Trial name
- NCT05278832
- Testing
- QLS31905
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Advanced Solid Tumors (Such as Gastric Cancer), Advanced Solid Tumors (Such as Adenocarcinoma at the Gastroesophageal Junction)
A IIT Study of 177Lu-DOTA-SNA040
This clinical trial is a single-center, open-label, non-randomized, first-in-human (FIH), dose-escalation study evaluating the safety, tolerability, and preliminary efficacy of 177Lu-DOTA-SNA040 in patients with advanced…
- Conditions
- Advanced Solid Tumors (Such as Gastric Cancer), Advanced Solid Tumors (Such as Adenocarcinoma at the Gastroesophageal Junction), Advanced Solid Tumors (Such as Pancreatic Cancer), Advanced Solid Tumors (Such as Cholangiocarcinoma)
- Trial name
- NCT07595237
- Testing
- 177Lu-DOTA-SNA040
- Where
- China
- Volunteers
- 12 people
- Sponsor
- SmartNuclide Biopharma
Claudin18.2 Positive Advanced Solid Tumors
CAR-T for Claudin18.2 Positive Solid Tumors
The purpose of this clinical trial is to learn if autologous claudin18.2-directed chimeric antigen receptor T-cell (CAR-T) therapy works to treat claudin18.2 positive solid tumors in adults.
- Trial name
- NCT07266311
- Testing
- claudin18.2 CAR-T
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Chengdu Ucello Biotechnology Co., Ltd.
Claudin18.2 Positive Advanced Solid Tumors
Treating Claudin18.2-positive Advanced Solid Tumors with XKDCT225(Targeting Claudin18.2-CAR-T)
A single-center, single-arm, dose-escalation exploratory clinical trial of the safety, efficacy, and pharmacokinetics of XKDCT225 cell injection in Claudin18.2-positive advanced solid tumors
- Trial name
- NCT06782425
- Testing
- XKDCT225
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shenzhen Celconta Life Science Co., Ltd.