Clinical trials: Clear Aligner Therapy
Malocclusion, Class I/II, Crowding, Tooth
Treatment Outcome of Clear Aligner and Traditional Fixed Appliances in Four Premolar Extraction Cases
Patients with severe crowding requiring the extraction of four premolars will be enrolled in this study. The degree of apical root resorption associated with using the clear aligner technique compared with vestibular fixed…
- Trial name
- NCT07236775
- Testing
- Clear Aligners, Traditional fixed appliances
- Where
- Syria
- Volunteers
- 40 people
- Sponsor
- Damascus University
Masseter Muscle Activity, Anterior Temporalis Muscle Activity
Orthodontic Clear Aligners Vs Conventional Fixed Appliance's Impact on Muscular Activities Among Adults Using SEMG (Surface Electromyography)
This clinical trial goal is to evaluate the difference in masticatory activities in adult patients treated with clear aligners compared to conventional fixed appliances treatment.
- Trial name
- NCT06699290
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Riyadh Elm University
Malocclusion
Effect of VPro5 Therapy on Clear Aligner Therapy
The investigators hypothesize that brief, daily application of HFA will increase the efficiency of clear aligner treatment by altering PDL metabolism without increasing pain or discomfort.
- Trial name
- NCT03240770
- Testing
- VPro5 device, Deviation from Standard Tray Wear Time (14 Days)
- Where
- 4 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mani Alikhani
White Spot Lesion
The Role of Fluoride Varnish Application in Preventing White Spot Lesions During Clear Aligner Treatment: A Controlled Split-Mouth Study
aim of study: is to compare the effect of the fluoride varnish application on the prevention of white spot lesions (WSLs) during clear aligner therapy Design Details: Each participant will have one side of the mouth assigned to…
- Trial name
- NCT07319884
- Testing
- White spot lesion with fluoride varnish application, White spot lesion without fluoride varnish application
- Where
- Egypt
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Patient Comfort, Malocclusion
Comparison of Patient-Reported Comfort Between Two Clear Aligner Trimming-Line Designs: A Split-Mouth Study
The trimming-line design of clear aligners (supragingival versus juxtagingival) is a routine clinical decision whose influence on patient-reported comfort has not been established; available evidence on aligner comfort derives…
- Conditions
- Patient Comfort, Malocclusion, Oral Health
- Trial name
- COMFORT-ALIGN (NCT07660809)
- Testing
- Supragingival trimming-line design, Juxtagingival festooned trimming-line design
- Where
- Romania
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Rotation of Tooth
A Novel Attachment Design for Tooth Rotation With Clear Aligner Therapy
Clear aligners are thin, transparent plastic trays that straighten teeth gradually and are a popular, more discreet alternative to traditional braces.
- Trial name
- NCT07881146
- Testing
- novel attachment configuration
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Boston University
Angle Class I Maloclussion, Dental Crowding
Orthodontic Treatment Outcomes of Self Ligating System Compared to Clear Aligner System
This study is a multi-center, prospective, parallel-group randomized controlled trial designed to compare the orthodontic treatment outcomes of a passive self-ligating bracket system (Damon Ultima) versus a clear aligner system.
- Trial name
- NCT07638397
- Testing
- self ligating bracket, Clear aligner
- Where
- Iraq
- Volunteers
- 42 people
- Sponsor
- University of Baghdad
Distalization, Class II Malocclusion
Comparison of Distalization of Maxillary First and Second Molars Between a Miniscrew Implant Supported Device and Clear Aligners.
The goal of this randomized clinical trial is to compare distalization of maxillary first and second molars achieved with a device supported with mini screw implants in the palate (Advanced Molar Distalization Appliance, AMDA®)…
- Conditions
- Distalization, Class II Malocclusion, Aligner Therapy, Distalization by Miniscrews
- Trial name
- NCT07040176
- Testing
- Upper molar distalization
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Aristotle University Of Thessaloniki
Malocclusion
A Prospective Multicenter Clinical Investigation Evaluating the Accuracy of the Trimline Design When Treated With SureSmile® Aligners.
This is a three-armed, multicenter clinical study evaluating the SureSmile clear aligner medical device. The primary objective is to confirm the safety and assess the accuracy of different tooth movements.
- Trial name
- NCT07290790
- Testing
- SureSmile® Clear Aligners
- Where
- 6 sites in United States, Spain and 1 more
- Volunteers
- 90 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Malocclusion
Accuracy of Dental Movements Using Clear Aligners Treatment: a Single-center Prospective Observational Study
The aim of the present prospective observational study is to evaluate the accuracy of dental movements in the three planes of space, assessing the correspondence between the virtual planned movements and the clinical outcomes…
- Trial name
- NCT06561945
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS Ospedale San Raffaele
Endocrine Disruptors
A Comparison of Direct 3D Printed Clear Aligner System and Indirect Clear Aligner Systems With Fixed Orthodontic Treatment in Terms of Endocrine Disrupting Monomer Release, Treatment Effectiveness and Efficiency
The aim of this study is to evaluate the release of endocrine disrupting monomers from clear aligners as a result of exposure to intraoral factors by measuring their concentration in saliva and to evaluate their reliability of…
- Trial name
- NCT06685029
- Testing
- Clear aligner treatment, Fixed Orthodontic Appliance Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Ahmet Yağcı
Orthodontic Treatment, Saliva
Salivary Flow, pH, and Buffering Capacity in Fixed and Clear Aligner Orthodontic Treatment
Study Design: A randomized controlled trial with two parallel arms and an allocation ratio of 1:1. Setting: The study will be conducted in the orthodontic department of Riyadh Elm University hospitals in Riyadh City, Saudi…
- Trial name
- NCT07397871
- Testing
- Fixed orthodontic appliances, Clear Aligner Treatment
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- Riyadh Elm University
Eating Behaviors
Eating Attitudes in Orthodontic Patients
This study was conducted on 70 individuals who presented to the Orthodontics Department of the Faculty of Dentistry at Necmettin Erbakan University.
- Trial name
- NCT07038772
- Testing
- Orthodontic treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Konya Necmettin Erbakan Üniversitesi
Open Bite
Investigate the Effectiveness of 3D-printed Shape Memory Aligners in the Treatment of Anterior Open Bite
The goal of this randomised clinical trial study is to investigate 3D-printed shape memory aligners in the treatment of anterior dental open bite adult patients. The main questions it aims to answer are: 1.
- Trial name
- NCT07420777
- Testing
- SMA with attachment, SMA without attachments, CA with attachment
- Where
- Iraq
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Kufa University
Dental Plaque Accumulation, Oral Hygiene in Orthodontic Patients
Comparison of Plaque Removal Efficacy of Different Toothbrushes in Clear Aligner Patients
This study aims to compare the effectiveness of manual and powered toothbrushes in removing dental plaque in patients undergoing clear aligner orthodontic treatment.
- Conditions
- Dental Plaque Accumulation, Oral Hygiene in Orthodontic Patients, Clear Aligner Therapy
- Trial name
- NCT07383636
- Testing
- Manual Toothbrush, Powered Toothbrush
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Mersin University
Root Resorption, Pain Perception
AI-Designed Clear Aligners: A Randomized Clinical Trial
The goal of this clinical trial is to evaluate the clinical performance and validity of applying AI-based TruRoot-designed clear aligners in adult orthodontic patients.
- Conditions
- Root Resorption, Pain Perception, Treatment Duration
- Trial name
- NCT06968325
- Testing
- AI-based TruRoot group:, Conventional clear aligner group
- Where
- Iraq
- Volunteers
- 40 people
- Sponsor
- University of Baghdad
Crowding, Tooth
The Effectiveness of Clear Aligner and Traditional Fixed Appliances in Achieving Good Occlusion in Complex Orthodontic Cases
Patients who have severe crowding that requires four premolars extraction will be treated in this study. The efficacy and effectiveness of in-house clear aligners therapy compared with vestibular fixed appliances in the treatment…
- Trial name
- NCT05500456
- Testing
- Clear aligners, Fixed appliances
- Where
- Syria
- Volunteers
- 36 people
- Sponsor
- Damascus University
Class III Malocclusion
Mandibular Sequential Distalization Versus Class III Elastics With Clear Aligners in Class III Patients
Distalizing mandibular molars may be indicated for patients with minor skeletal Class III discrepancies or in Class III subjects with mild crowding.
- Trial name
- NCT06859606
- Testing
- Lower molar distalization, Class III elastics
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Saint Camillus International University of Health Sciences
Composite Resins, Clear Aligner Therapy
Color Stability and Fluorescence Properties of Two Aligner Attachment Composites
This split mouth study aims to evaluate whether 2 different composite materials used for making clear aligner attachments change color over time and do they have different fluorescent characteristics when illuminated with…
- Trial name
- NCT07806214
- Testing
- GC Aligner Connect, VOCO AlignerFlow LC
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Marmara University