Clinical trials: Cleft Palate
Cleft Lip and Palate
The Effect of Bone Marrow Stem Cells Harvested from the Iliac Crest Versus Mandibular Ramus in Alveolar Cleft Regeneration
This comparative and prospective study was conducted on 10 patients with alveolar cleft defects. Patients with alveolar cleft defects were randomly selected and randomly divided into two equal groups: Group A: received Autologous…
- Trial name
- NCT06636643
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Velopharyngeal Insufficiency, Real Time MRI
Etiological Study of Persistent Velopharyngeal Insufficiency in Children With Operated Velopalatine Cleft by Analysis of Velopharyngeal Motor Skills in Static and Dynamic MRI
Velopharyngeal insufficiency is defined as the inability of the soft palate to isolate the nasopharynx from the oropharynx. It is a frequent sequela in patients with a velopalatine cleft despite anatomical restoration of the soft…
- Conditions
- Velopharyngeal Insufficiency, Real Time MRI, Cleft Palate
- Trial name
- FENTIRM (NCT06072495)
- Testing
- real time MRI
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Fetal Anomaly, Ultrasound
Trial Observationnal
The aim of this retrospective longitudinal study was to describe a key factor in the prenatal diagnosis of isolated cleft palate on the axial transverse view, in order to provide better understanding, detection and diagnosis of…
- Trial name
- CLEFTPALATDIAG (NCT05785338)
- Testing
- Posterior angle of the hard palate
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Poitiers University Hospital
Cleft Lip and Palate, Temporomandibular Disorder
Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Temporomandibular Disorders
The aim of this study was to assess the electrical activity of the temporal and masseter muscles in cleft lip and palate (CLP) children with pain-related temporomandibular disorders (TMD) and in CLP individuals with no TMD by…
- Trial name
- NCT03308266
- Testing
- electromyography
- Where
- Poland
- Volunteers
- 87 people
- Sponsor
- Pomeranian Medical University Szczecin
Cleft Palate
Using of Acellular Dermal Matrix in Cleft Palatal Fistula and Compare With Use of Conchal Cartolage
The fact that still exist is which method for repairing of secondary cleft palatal fistula is the best. This study will have shown whether using of Acellular dermal Matrix decreased the fistula formation versus using Conchal…
- Trial name
- NCT03170505
- Testing
- repairing fistula
- Volunteers
- 60 people
- Sponsor
- Isfahan University of Medical Sciences
Cleft Palate
Middle Ear Pressure Disregulation in Cleft Palate Patients
The investigators know that middle-ear disease is very common in infants with cleft palate and causes hearing loss that can last into childhood.
- Trial name
- NCT00423072
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Pittsburgh
Cleft Palate
Retrospective Study on the Outcome of Cleft Palate Repair: Comparing US Surgical and Ethicon Suture Materials
Investigator initiated retrospective chart review to study the effects of changing suture material on the healing and outcome of cleft palate surgery were.
- Trial name
- NCT00584272
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of California, Davis
Cleft Lip and Palate
Cleft Lip and Palate Treatment Outcomes Study
Infants with cleft lip and palate often benefit from presurgical infant orthopedic treatment before surgical repair. Multiple standard of care approaches are selected based on each infant's clinical presentation and family…
- Trial name
- NCT07687537
- Volunteers
- 100 people
- Sponsor
- University of Florida
Cleft Lip and Cleft Palate
Aesthetic and Functional Self-Assessment Following Rhinoseptoplasty in Patients With Unilateral Cleft Lip and Palate
Secondary rhino-septoplasty in unilateral cleft lip and palate is the treatment of choice for the correction of aesthetic deformities and the functional impact on ventilation nasal. It remains a difficult treatment.
- Trial name
- RHINOFENTE (NCT07048418)
- Testing
- Mailing and completing CLEFT-Q and NOSE questionnaires
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Montpellier
Cleft Lip and Palate
Effectiveness of Nasal-alar Elevator Combined With Taping Vs. Taping Alone on Improving the Nose Esthetics and Maxillary Arch Dimensions in Infants With Unilateral Complete Cleft Lip and Palate
This randomized trial is designed to assess the effectiveness of nasal elevator as a presurgical infant orthopedics on improvement of nose esthetics vs taping alone.
- Trial name
- NCT04331379
- Testing
- Nasal Elevator, Taping Alone
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Recovery After Cleft Palate Surgery
Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery
A cleft deformity of the lip and/or palate is one of the commonest major birth defects. Primary surgery of cleft palates (CP) varies according to the different surgical teams.
- Trial name
- NCT02923869
- Testing
- Levobupivacaine, Bupivacaine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Cleft Palate
Comparison of Different Feeding Appliances for Cleft Palate Babies
This study will compare flexible , rigid feeding plates and a special feeding bottle for children with cleft palate.
- Trial name
- NCT06103162
- Testing
- flexible feeding plate
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tanta University
Breast Cancer
Platinum for Triple-Negative Metastatic Breast Cancer and Evaluation of p63/p73 as a Biomarker of Response
The purpose of this research study is to : Determine how effective cisplatin or carboplatin is in slowing the time it takes for ER negative (estrogen-receptor-negative), PR negative (progesterone receptor-negative), HER2 negative…
- Trial name
- NCT00483223
- Testing
- Cisplatin, carboplatin
- Where
- 10 sites in United States
- Volunteers
- 86 people
- Sponsor
- Massachusetts General Hospital
Cleft Palate
Efficacy of Oral Versus Intravenous Acetaminophen for Primary Pediatric Cleft Palate Repair
The purpose of this investigator-initiated study is to determine whether acetaminophen is an effective pain reliever for primary cleft palate repair in children and possesses opioid sparing effects.
- Trial name
- NCT01500109
- Testing
- Oral acetaminophen, Ofirmev®, Opioid only
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Loma Linda University
Cleft Lip and Palate
The Effectiveness of Adhesive Versus Conventional Nasoalveolar Molding on Children With Unilateral Cleft Lip and Palate
The present study will compare the effectiveness of adhesive nasoalveolar molding (GS-NAM) and conventional nasoalveolar molding on the alveolar ridge, nasal, and labial growth in children with unilateral cleft lip and palate.
- Trial name
- NCT06451276
- Testing
- Nasoalveolar molding in unilateral cleft lip and palate
- Where
- 2 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Rare Diseases, Aniridia
Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies
The cross-sectional observational clinical study related to rare eye diseases is a multi-center study in which the hypothesis is that neurokinin 1 receptor and/or substance P expression is increased in REDs associated with…
- Conditions
- Rare Diseases, Aniridia, Neurotrophic Keratopathy, Limbal Stem Cell Deficiency
- Trial name
- NCT06412718
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- IRCCS Ospedale San Raffaele
Anesthesia Emergence Delirium
Effect Of Combination of Morphine+Fentanyl on Emergence Delirium in Patients of Cleft Lip and Palate Repair
Emergence Delirium And Recovery Profile In Patients Undergoing Cleft Lip And Cleft Palate Repair With Either Combination Of Morphine Plus Fentanyl Or Fentanyl Alone
- Trial name
- NCT03010540
- Testing
- MORPHINE PLUS FENTANYL, Fentanyl
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Unilateral Complete Cleft Lip and Palate
Printed Aligners for Nasoalveolar Molding Treatment
study will provide nasoalveolar molding (NAM) treatment, special care for infants born with cleft lip and palate. This novel appliance will help to provide the care in accurate and easy form by help of both digital work flow and…
- Trial name
- NAM (NCT06683560)
- Testing
- : photopolymer resin material "graphy" Tera Harz 85 will be used to print 3D printed aligners for NAM treatment
- Where
- 2 sites in Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Renal Cell Carcinoma, Hepatocellular Carcinoma
Effect of Sorafenib or Regorafenib on P63 Expression and Keratinocyte Differentiation in Human Skin
Skin toxicity is a frequently observed side effect in the era of "molecularly targeted therapies". Skin toxicity following administration of protein kinase inhibitors such as sorafenib, regorafenib, lapatinib, sunitinib, and…
- Conditions
- Renal Cell Carcinoma, Hepatocellular Carcinoma, Colorectal Carcinoma
- Trial name
- NCT01466504
- Testing
- skin punch biopsy
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Otitis Media, Cleft Palate
Furlow Palatoplasty With Tensor Tenopexy
This study compares a standard method for palate repair (the Furlow palatoplasty) with a modification of that method to determine which, if either, is more effective in reducing the duration of middle-ear disease (fluid in the…
- Trial name
- NCT01535131
- Testing
- palatoplasty
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Pittsburgh