Clinical trials: Cleft Palate Children
Cleft Lip, Cleft Palate
Oral Cleft Prevention Trial in Brazil
Cleft lip and palate are a significant component of morbid human birth defects in the developing world. By supplementing a high-risk group of women with folic acid (4.0 mg versus 0.4 mg) from preconception and continuing…
- Trial name
- NCT00098319
- Testing
- Folic acid (0.4mg vs. 4.0mg)
- Where
- 3 sites in Brazil
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Velopharyngeal Insufficiency in Children With Isolated or Combined Cleft Palate
Prospective Evaluation of Speech Function Through Patient- and Parent-response Outcome Measurements in Velopharyngeal Insufficiency
Cleft lip and/or palate (CL/P) is the most common congenital malformation, with about one in 500 children born with CL/P in Sweden, corresponding to approximately 175 births annually.
- Trial name
- NCT05838261
- Testing
- Pharyngeal flap
- Where
- 6 sites in Sweden
- Volunteers
- 50 people
- Sponsor
- Umeå University
Delayed Language in Cleft Palate
Delayed Language Development in Children With Cleft Palate at Sohag University Hospital
This is a retrospective study on children with cleft palate who came to the multidisciplinary cleft clinic at Sohag University Hospital from September 2017 to September 2023
- Trial name
- NCT06151340
- Testing
- Data collection
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Sohag University
Cleft Palate Children
Length of Hospital Stay and Postoperative Analgesic Requirements After Introduction of a Specific Maxillary Nerve Block in Children Undergoing Cleft Palate Surgery
Cleft lip and palate (CLP) is one of the most common congenital malformations and requires repeated surgical correction during childhood.
- Trial name
- NCT07279883
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Cleft Palate Children, Speech Therapy
Effect and Cost-utility of of High Intensity vs. Low Intensity Speech Intervention in Children With Cleft Palate
Achieving speech that is understandable and acceptable to others is the key outcome in cleft treatment. Therefore, speech therapy provided by a speech-language pathologist is necessary.
- Conditions
- Cleft Palate Children, Speech Therapy, Speech Disorders in Children, Cleft Lip and Palate
- Trial name
- NCT06381713
- Testing
- High intensive combined phonetic-phonological intervention, Low intensive combined phonetic-phonological intervention
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- University Ghent
Cleft Palate Children
A Comparison of Speech Outcome in Pediatric Cleft Patients, After Modified Furlow-Sommerlad Palatoplasty in Comparison to Modified Furlow Palatoplasty Alone
Nowadays, surgical success of cleft palate patients is ascribed to the sufficiency of velopharyngeal closure, and the associated speech results such as voice nasality, resonance and articulation.
- Trial name
- SPEAC (NCT03995199)
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- AZ Sint-Jan AV
Otitis Media in Children, Cleft Palate Children
Respiratory Tract Microbiome and Probiotics in Children With Cleft Palate
Otitis media with effusion (OME) involves fluid accumulation in the middle ear without infection, sometimes causing discomfort and hearing loss in children.
- Trial name
- NCT06505330
- Testing
- Probactiol Baby
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Antwerp
Velopharyngeal Insufficiency, Real Time MRI
Etiological Study of Persistent Velopharyngeal Insufficiency in Children With Operated Velopalatine Cleft by Analysis of Velopharyngeal Motor Skills in Static and Dynamic MRI
Velopharyngeal insufficiency is defined as the inability of the soft palate to isolate the nasopharynx from the oropharynx. It is a frequent sequela in patients with a velopalatine cleft despite anatomical restoration of the soft…
- Conditions
- Velopharyngeal Insufficiency, Real Time MRI, Cleft Palate
- Trial name
- FENTIRM (NCT06072495)
- Testing
- real time MRI
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cleft Lip and Palate
Methods of Providing Information Prior to an Alveolar Bone Graft
Patients born with a cleft of the lip and/or palate may have a gap in the bone in the roof of their mouth and in the area of bone where the teeth develop.
- Trial name
- NCT04381078
- Testing
- ACE - AudioVisual Guide
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Cleft Lip Palate
Quadratus Lumborum Block for Iliac Bone Harvest in Pediatric Cleft Alveolus Repair
This prospective, randomized, double-blinded controlled trial will investigate the effectiveness of a lateral quadratus lumborum (QL) block in 50 children aged 6-14 years undergoing iliac crest bone grafting for cleft alveolus…
- Trial name
- NCT07846761
- Testing
- Lateral quadratus lumborum block
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Oslo University Hospital
Cleft Palate Children
Feasibility and Performance of Virtual Software for Virtual Bone Graft Planning in Cleft Patients
Objective: The investigators aim to compare the licensed Brainlab Iplan® software, considered the gold standard, to the 3D slicers and Blender freeware for the segmentation of the unilateral cleft defect, as well as the creation…
- Trial name
- VIR-CLEFT (NCT03994679)
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- AZ Sint-Jan AV
Cleft Lip Palate, Orofacial Cleft
Effect of Opioid-Free vs Opioid-Based Anesthesia on Postoperative Pain and Emergence Agitation in Children Undergoing Cleft Surgery
Orofacial clefts are among the most common congenital malformations, affecting approximately 1 in 700-1500 live births worldwide.
- Conditions
- Cleft Lip Palate, Orofacial Cleft, Agitation, Emergence, Analgesia Assessment
- Trial name
- NCT07557576
- Testing
- Ketamine (1 mg/kg), Dexmedetomidine (1-0,8-0,6-0,4 mcg/kg/h), Fentanyl 5 mcg/kg
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- Iva Smiljanić
Dental Age Estimation, Cleft Lip and Palate
Dental Age Estimation by Different Methods in Patients With Cleft Lip and Palate
The aim of this study is to investigate whether there is a significant difference in dental age between children with CLP and healthy controls using the Willems method, Cameriere European formula and London Atlas.
- Trial name
- NCT05573295
- Testing
- Diagnostic Test: Willems method, Diagnostic Test: Cameriere method, Diagnostic Test: London Atlas method
- Where
- Turkey (Türkiye)
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Cleft Palate Children, Speech Disorders in Children
Effect of Performance-specific Cleft Speech Intervention and Long-term Learning in Children With a Cleft Palate
Speech therapy in children with a palate deals with two scientific challenges that will be addressed in this project. The first challenge is selecting the best speech approach for a child with a specific cleft speech…
- Conditions
- Cleft Palate Children, Speech Disorders in Children, Cleft Lip and Palate, Speech Therapy
- Trial name
- NCT06105099
- Testing
- Motor-phonetic intervention, Phonological intervention, Combined phonetic-phonological intervention
- Where
- Belgium
- Volunteers
- 135 people
- Sponsor
- University Ghent
Cleft Lip, Cleft Palate
Cleft Palate Surgery and Speech Development
Compare the outcome of two primary surgeries techniques (von Langenbeck and Furlow double z-plasty) performed on children with cleft lip/palate to determine if one results in significantly better velopharyngeal competency for…
- Trial name
- NCT00004639
- Testing
- Furlow double z-plasty palatoplasty palate repair, Von Langenbeck palatoplasty palate repair
- Where
- 2 sites in United States, Brazil
- Volunteers
- 475 people
- Sponsor
- University of Florida
Cleft Palate, Growth
Cleft Palate Technique and Maxillary Growth
comparison of the maxillary growth between cleft palate patients that underwent to repair by 2 flap palatoplasty versus Furlow with buccinator technique
- Trial name
- NCT05405738
- Testing
- 2 flap palatoplasty technique, normal group, Furlow with buccinator technique
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Fayoum University
Cleft Palate
Sleep and Behavior in Children With Cleft Palate
The purpose of this study is to determine whether cleft palate repair increases the risk for obstructive sleep apnea in children and whether sleep apnea could explain learning and behavior difficulties that are often observed.
- Trial name
- NCT01046591
- Testing
- Polysomnography
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Cleft Lip, Cleft Palate
Systematic Pediatric Care for Oral Clefts - South America
Cleft lip and palate are a significant component of morbid human birth defects in the developing world. This study measures the impact of having a child born with a cleft lip on subsequent maternal/infant family health, and…
- Conditions
- Cleft Lip, Cleft Palate, Congenital Defects
- Trial name
- NCT00097149
- Testing
- Systematic pediatric care
- Where
- Brazil
- Volunteers
- 696 people
- Sponsor
- NICHD Global Network for Women's and Children's Health
Sedation, Emergence Delirium
Nebulized Dexmedetomidine Combined With Ketamine Versus Nebulized Dexmedetomidine for Cleft Palate
To compare the efficacy of the pre-operative nebulization of a combination of dexmedetomidine and ketamine versus nebulization of dexmedetomidine alone for sedation and prevention of emergence delirium in children undergoing…
- Trial name
- NCT05821972
- Testing
- Nebulization of dexmedetomidine and ketamine, Nebulization of dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Cleft Lip and Palate, Social Isolation
Perception of Appearance and Social Acceptance Between Cleft and Non-Cleft Children in Early Adolescence
Background: Using three-dimensional (3D) surface imaging, this study aims to understand the differences in perception between schoolchildren with and without cleft lip and palate (CLP), as well as to explore peer awareness and…
- Trial name
- Cleft social (NCT06539572)
- Testing
- Cleft lip repair; palatoplasty; alveolar bone grafting
- Where
- Taiwan
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital