Clinical trials: Clinical Course
Obesity, NAFLD
Bariatric Endoscopy and NAFLD
Find out how bariatric endocopy will influence clinical course of non alcoholic fatty liver disease.
- Conditions
- Obesity, NAFLD, Liver Steatosis, Liver Fibrosis
- Trial name
- NCT04669470
- Testing
- bariatric endoscopy, mainly intragastric baloons, plication of stomach too
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University of Ostrava
Stage II Rectal Cancer AJCC v8, Stage III Rectal Cancer AJCC v8
Testing the Addition of an Anti-Cancer Drug, Irinotecan, to the Standard Chemotherapy Treatment (FOLFOX) After Long-Course Radiation Therapy for Advanced-Stage Rectal Cancers to Improve the Rate of Complete Response and Long-Term Rates of Organ Preservation and Continuing Response
This phase II/III trial compares the effect of usual treatment approach alone (FOLFOX or CAPOX after chemoradiation) with using FOLFIRINOX after chemoradiation in patients with stage II-III rectal cancer.
- Conditions
- Stage II Rectal Cancer AJCC v8, Stage III Rectal Cancer AJCC v8, Locally Advanced Rectal Adenocarcinoma
- Trial name
- JANUS (NCT05610163)
- Testing
- Capecitabine, 5-fluorouracil, Leucovorin calcium
- Where
- 685 sites in United States, Puerto Rico
- Volunteers
- 760 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Chronic Obstructive Pulmonary Disease, Peripheral Artery Disease
Chronic Obstructive Pulmonary Disease in Combination With Atherosclerosis (Clinical and Biochemical Study)
one-centered, open, non-randomized, controlled clinical trial will focus on a comprehensive study of the clinical, functional and molecular biochemical characteristics of the natural course of COPD in combination with peripheral…
- Trial name
- NCT04474717
- Testing
- Breath Condensate Collection, clinical examination, spirometry, blood monocyte assay
- Where
- Russia
- Volunteers
- 476 people
- Sponsor
- Ryazan State Medical University
Cerebrovascular Accident, Stroke, Acute
Fabry and Cardiomyopathy (FaCard)
Primary objective and endpoint is the analysis of the long-term course of lyso-Gb3 and its clinical correlation to the progression of the cardiomyopathy in N215S-Fabry patients.
- Conditions
- Cerebrovascular Accident, Stroke, Acute, Cerebral Stroke
- Trial name
- FaCard (NCT01429597)
- Where
- Germany
- Sponsor
- CENTOGENE GmbH Rostock
Congenital CMV Infection
Evaluation of Long-term Efficacy of 4 to 6-month Course Antiviral Therapy for Neurodevelopmental Impairments Caused by Congenital Cytomegalovirus Infection
Title: Evaluation of Long-term Efficacy of 4-month versus 6-month Course Antiviral Therapy for Neurodevelopmental Impairment Caused by Congenital CMV Infection: A Multicenter, Randomized, Controlled, Non-inferiority Clinical…
- Trial name
- NCT07450365
- Testing
- Intravenous ganciclovir (6 mg/kg, twice daily) or oral valganciclovir (16 mg/kg, twice daily) was administered for a treatment course of 4 months., Patients received a 6-month course of anti-CMV therapy. The treatment regimen consisted of either intravenous ganciclovir (6 mg/kg, twice daily) or oral valganciclovir (16 mg/kg, twice daily).
- Volunteers
- 150 people
- Sponsor
- Hu Bofei
Posttraumatic Stress Disorder, PTSD
Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)
By doing this research project, the investigators hope to learn which strategies work best to help veterans who are not benefiting from their first PTSD treatment or not completing between-session homework assignments regularly…
- Trial name
- ADAPT-PTSD (NCT07176273)
- Testing
- Modular Cognitive Processing Therapy, Modular Prolonged Exposure Therapy, Step Down Treatment
- Where
- 4 sites in United States
- Volunteers
- 302 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Locally Advanced Rectal Cancer (LARC)
A Single-center, Phase II Study on Efficacy & Safety of SCRT+CAPOX+Serplulimab+Bevacizumab for MSS Rectal Cancer
In a single-center, prospective, phase II study (ClinicalTrials registration number: [to be filled in]) initiated by our center to evaluate the safety and preliminary efficacy of short-course radiotherapy followed by sequential…
- Trial name
- NCT07347951
- Testing
- Short-course radiotherapy, CAPOX chemotherapy, Targeted therapy with bevacizumab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Heart Failure
A Study on Disease Awareness and Treatment Compliance of Heart Failure Patients
The AWARENESS HF-PD is a cross-sectional, multicenter, survey-based study. Cases who were admitted to the outpatient clinic and hospitalized with the diagnosis of Heart Failure (Acute and Chronic) will be included in the study.
- Trial name
- AWARENESS-HF (NCT05180396)
- Testing
- Questionnaires
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- AstraZeneca Turkey
Diabetes Mellitus
The Influence of Advanced Age, Obesity and Diabetes Type on Course and Outcome of Pregnancy With Diabetes Mellitus.
Results of this project will enable investigators to get information and to compare maternal and pregnancy characteristics and perinatal outcomes of women with different types of Diabetes Mellitus and to identify the independent…
- Trial name
- NCT04833062
- Testing
- Ultrasound, Survey
- Volunteers
- 4,600 people
- Sponsor
- Nazarbayev University Medical Center
Stroke, Acute, Educational Problems
Off-script Diagnosis & Differential Diagnosis (D&D) Training and Residents' Stroke Knowledge
This study is a single-center, randomized, open-label, controlled, endpoint-blinded study to assess the effect of off-script diagnosis \& differential diagnosis (D\&D) training in improving the residents' knowledge of acute…
- Conditions
- Stroke, Acute, Educational Problems, Clinical Course
- Trial name
- CAST-AIS (NCT06941753)
- Testing
- Off-script diagnosis & differential diagnosis (D&D) training
- Where
- China
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Tuberculosis
Short-Course Isoniazid and Rifampin Compared With Isoniazid for Latent Tuberculosis Infection
The objective of the study was to compare the compliance and the side effects of a short course to treatment of latent tuberculosis infection during 3 months(isoniazid plus rifampin)group I, with the standard course for 6…
- Trial name
- NCT00397709
- Testing
- I ( isoniazid), II (isoniazid + rifampin )
- Where
- Spain
- Volunteers
- 228 people
- Sponsor
- Hospital Virgen de la Luz
Type 2 Diabetes Mellitus (T2DM), Hyperglycemia
Effects of Short and Long Courses of Intermittent Hypoxic-Hyperoxic Training in Patients With Type 2 Diabetes Including Elderly
This is a single-center randomized controlled trial evaluating the efficacy and safety of short (3 days) versus long (10 days) courses of intermittent hypoxic-hyperoxic training (IHHT) in patients with type 2 diabetes mellitus…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Hyperglycemia, Metabolic Syndrome, Older Adults (65 Years and Older)
- Trial name
- EFIR (NCT07574333)
- Testing
- Intermittent Hypoxic-Hyperoxic Training (3 days), Intermittent Hypoxic-Hyperoxic Training (10 days), Normoxic gas breathing
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Postoperative Complications, Deterioration, Clinical
Observational Study of Early Postoperative Deterioration and Complications
This prospective observational research project aims to investigate how vital sign deterioration and complications within the (PACU) relate to early deterioration and complications in the surgical wards 72 hours post-PACU…
- Conditions
- Postoperative Complications, Deterioration, Clinical, Postoperative Care, Anesthesiology
- Trial name
- NCT06013891
- Where
- Denmark
- Volunteers
- 240 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Myocarditis Viral
Presentation, Patterns of Myocardial Damage, and Clinical Course of Viral Myocarditis
Viral myocarditis has been recognized as a cause of congestive heart failure, however diagnosis and treatment represents a challenging process.
- Trial name
- NCT04312490
- Testing
- endomyocardial biopsy
- Where
- Egypt
- Volunteers
- 51 people
- Sponsor
- Assiut University
Chronic Liver Disease
Observational Clinical Study of the Natural Course and Long-term Prognosis of Patients With Chronic Liver Disease
Chronic liver disease is a global public health problem. Without timely diagnosis and treatment, chronic liver disease can progress to hepatitis, liver fibrosis, and cirrhosis, while causing a variety of complications such as…
- Trial name
- NCT05653830
- Where
- China
- Volunteers
- 50,000 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Chronic Respiratory Failure
Prognosis in Patients With Chronic Respiratory Failure Receiving Domiciliary Noninvasive Positive Pressure Ventilation (NPPV)
The purposes of the present study are (1) to analyze baseline patient characteristics cross-sectionally, (2) to analyze the prognosis and its predictive factors, and (3) to examine longitudinal clinical course in patients with…
- Trial name
- NCT00905476
- Where
- 11 sites in Japan
- Volunteers
- 56 people
- Sponsor
- Kyoto University, Graduate School of Medicine
Locally Advanced Rectal Cancer
Short-course Radiotherapy Followed by Tislelizumab + CapeOX in the Treatment for Locally Advanced Rectal Cancer
This study is a single-center, prospective, open-label, randomized controlled clinical study, and the purpose of this study was to compare the pathological complete response rate (PCR) of patients with locally advanced rectal…
- Trial name
- NCT05086627
- Testing
- Tislelizumab, Short-course radiotherapy, Capecitabine+Oxaliplatin
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Hebei Medical University Fourth Hospital
CMV
Clinical and Immunological Features of the CMV Infection Atypical Course in Immunocompetent Individuals
Current study evaluates possible correlations between the content of various cell populations, the genetic material of the virus and antibodies to it in the blood of patients and the risk of thrombosis development in patients…
- Trial name
- NCT04392297
- Testing
- Bood leukocyte subsets, CMV specific T-cells, serum CMV IgM / IgG antibodies
- Where
- Belarus
- Volunteers
- 45 people
- Sponsor
- The Republican Research and Practical Center for Epidemiology and Microbiology
MPS IIIB (Sanfilippo B Syndrome)
Natural History Study to Characterise the Course of Disease Progression in Participants With Mucopolysaccharidosis Type IIIB
The objectives of this study are to describe the clinical and biochemical characteristics and course of disease progression in participants with Mucopolysaccharidosis type IIIB (MPS IIIB)
- Trial name
- NCT02293408
- Where
- 7 sites in United States, Brazil and 4 more
- Volunteers
- 30 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Covid19, Corona Virus Infection
Clinical, Functional, Immunological and Genetic Factors on the Severity of the Course of Coronavirus Infection
The purpose of the program. To determine the clinical, functional, immunological, and genetic factors affecting the severity of the course of acute coronavirus infection COVID-19 and PostCovid syndrome, in order to develop…
- Trial name
- NCT04987853
- Testing
- Clinical and functional analysis, Neurological analysis, Immunological analysis:
- Where
- Kazakhstan
- Volunteers
- 300 people
- Sponsor
- National Research Center for Cardiac Surgery, Kazakhstan