Clinical trials: Clinical Course
Anemia, Sickle Cell, Blood Disease
Cooperative Study of The Clinical Course of Sickle Cell Disease
To determine the natural history of sickle cell disease from birth to death in order to identify those factors contributing to the morbidity and mortality of the disease.
- Trial name
- NCT00005277
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Crohn's Disease
Clinical Course of Korean Crohn's Disease Cohort
In the past decade, the incidence and prevalence of CD (Crohn's disease) has continued to increase in Korea. Previous studies have indicated that Asian IBD (inflammatory bowel disease) patients differ from those of Western…
- Trial name
- NCT01554007
- Testing
- Observation study
- Where
- 9 sites in South Korea
- Volunteers
- 2,000 people
- Sponsor
- Kyunghee University Medical Center
ESCC
Adebrelimab Plus Full-course Neoadjuvant Therapy for Resectable Locally Advanced ESCC (Phase 2)
This is a prospective, single-center, randomized phase 2 study of adebrelimab plus full-course neoadjuvant therapy in resectable locally advanced esophageal squamous cell carcinoma.
- Trial name
- NAT-ESCC-01 (NCT07584031)
- Testing
- Combination therapy with chemotherapy and immunotherapy, Surgery
- Volunteers
- 200 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Nasopharyngeal Carcinoma
Patients With Stage III-IVa Nasopharyngeal Carcinoma With or Without a Mobile Medical Platform Full-course Nutritional Intervention
To study the difference in the proportion of patients with nasopharyngeal carcinoma who lost more than 10% of their body weight within 1 month after radiotherapy and chemotherapy using the mobile platform for whole-process…
- Trial name
- NCT05834712
- Testing
- mobile platform or not mobile platform
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Sun Yat-sen University
Hepatitis A, Acute Hepatitis
Risk Factors and Outcomes of Hepatitis A in Children
This prospective observational study aims to evaluate the risk factors, clinical course, and outcomes among children with acute hepatitis A infection admitted to Assiut University Children Hospital.
- Trial name
- NCT07848321
- Volunteers
- 190 people
- Sponsor
- Assiut University
Pressure Injury
Digital Multimedia in Clinical Nurse Education for Pressure Injury Prevention Via LINE@
The goal of this clinical trial is to integrate past indicators affecting the effectiveness of pressure injury care education among nurses and to explore the learning outcomes of nurses through different educational…
- Trial name
- NCT06527716
- Testing
- Teaching Strategy
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Asia University
Periprosthetic Joint Infection, Anti-Bacterial Agents
Prospective Cohort Study on Antibiotic Course and Efficacy After Two-stage Revision in PJI.
This is a multicenter prospective cohort study in which patients were evaluated by inclusion and exclusion criteria before phase II revision surgery.
- Trial name
- PACER-PJI (NCT05284318)
- Testing
- Antibiotics treatment
- Where
- China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Neonatal Opioid Withdrawal Syndrome
Use of SVS Device to Improve Outcomes for Neonatal Opioid Withdrawal Syndrome.
Maternal use and addiction to opioids has resulted in an unprecedented rise in drug withdrawal complications in newborns known as neonatal opioid withdrawal syndrome (NOWS), also referred to as neonatal abstinence syndrome (NAS).
- Trial name
- NCT04834297
- Testing
- Prapela SVS mattress
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Tufts Medical Center
Parkinson Disease
Relationship Between Immunosuppressive Treatment Status and Clinical Course of Parkinson's Disease
The goal of this observational study is to learn if immunosuppressive drug treatment influences the clinical course of Parkinson's disease. Recent research suggests that Parkinson's disease may have an inflammatory background.
- Trial name
- NCT06834191
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Medical University of Warsaw
Covid19, Liver Diseases
Silymarin in COVID-19 Patients Admitted to Hospital With Elevated Liver Enzymes
Of patients admitted to an internal medicine ward with internistic diagnosis/es together with COVID-19, substantial proportion has elevated liver enzymes.
- Trial name
- SILCOVINT-21 (NCT04816682)
- Testing
- Silymarin
- Where
- 2 sites in Slovakia
- Volunteers
- 30 people
- Sponsor
- F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica
Tumor
Neurologic and Neurophysiologic Assessment of Clinical Course in Patients With Intraspinal Processes
Patients included in the study are treated at the Klinik für Neurochirurgie USZ. The clinical course is documented at Paraplegikerzentrum Balgrist using validated diagnostic procedures (e.g. SCIM, ASIA, neurophysiology).
- Trial name
- NCT01105520
- Testing
- Diagnostic
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
PANS, PANDAS
Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): Clinical Characterization and Prospective Course
This study is a brief (3 month) longitudinal study following children between the ages of 4-16 years old who have been diagnosed with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS).
- Trial name
- NCT04382716
- Testing
- No intervention
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Minnesota
COVID-19 Respiratory Infection
Xanthohumol as an Adjuvant Therapy in Critically Ill COVID-19 Patients
It has been well documented that coronavirus COVID-19 disease is associated with massive inflammatory response and cytokine storm. Several medications have been used to ameliorate COVID-19-related inflammation.
- Trial name
- NCT05463393
- Testing
- Xanthohumol - prenylated chalcone extracted from female inflorescences of hop cones (Humulus lupus). Hop-RXn™, BioActive-Tech Ltd, Lublin, Poland; http://xanthohumol.com.pl/
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Lublin
Back Pain
Health Effects of Mindfulness Based Stress Reduction Course in Treatment of Back Pain
Health effects of mindfulness based stress reduction course versus usual care in treatment of back pain: a randomized clinical trial Mindfulness based stress reduction (MBSR) course intervention for half of the research patients…
- Trial name
- NCT07528833
- Testing
- Mindfulness based stress reduction (MBSR) course
- Where
- 4 sites in Finland
- Volunteers
- 120 people
- Sponsor
- Tampere University Hospital
Acute Heart Failure, Dyspnea
Assessment of The Clinical Course of Dyspnea in Acute Heart Failure Patients
Acute heart failure (AHF) is defined as a gradual or rapid change in heart failure (HF) signs and symptoms, such as shortness of breath (also called dyspnea or breathlessness), leg swelling, fatigue, breathlessness with exertion…
- Trial name
- NCT01615926
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Northwestern University
Melanoma, Non Small Cell Lung Cancer
Exploratory Interventional Study of Prognostic Serum Biomarkers of Cancer Progression
Exploratory interventional study of prognostic serum biomarkers of cancer progression. Study of the relationship between the blood levels of soluble PDL1 and β2-microglobulin, and the clinical course of a metastatic solid tumor…
- Conditions
- Melanoma, Non Small Cell Lung Cancer, Renal Cancer
- Trial name
- Onco-PDL1s/B2M (NCT05426317)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
AML
The Role of Allo-HSCT in MRD-negative Patients With AML Under the Age of 60 Years in the First Complete Remission
Depending on the variant of the disease, patients are divided into 3 groups: A, B and C. Group A include patients with acute myeloid leukemia (AML) inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11, group B - AML with…
- Trial name
- NCT05339204
- Testing
- allo-HSCT
- Where
- Russia
- Volunteers
- 75 people
- Sponsor
- National Research Center for Hematology, Russia
Idiopathic Pulmonary Fibrosis, Idiopathic Interstitial Pneumonia
Clinical Course of Interstitial Lung Diseases: European IPF Registry and Biobank
Born out of the European Union 7th Framework Programme funded project European IPF Network (eurIPFnet), the European IPF Registry (eurIPFreg) has become Europe's leading database of longitudinal data from IPF patients, including…
- Conditions
- Idiopathic Pulmonary Fibrosis, Idiopathic Interstitial Pneumonia, Interstitial Lung Diseases, Diffuse Parenchymal Lung Diseases
- Trial name
- eurIPFreg (NCT02951416)
- Testing
- patient registry (observation and biomaterial sampling)
- Where
- 7 sites in Austria, France and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Andreas Guenther
Stress, Professional, Stress, Psychological
Brief Mindfulness Meditation Course to Reduce Stress in Healthcare Professionals
Stress among healthcare professionals is well documented. Untreated stress can lead to anxiety, depression, substance use, and suicide.
- Trial name
- NCT03781336
- Testing
- Mindfulness-based self care
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Ulcerative Colitis
Long-term Outcome of Patients With Acute Ulcerative Colitis After First Course of Intravenous Corticosteroids
All episodes of patients with acute UC admitted to Tampere University Hospital and treated with intravenous corticosteroids between January 2007 and January 2016 were identified from patient records and reviewed.
- Trial name
- NCT04564638
- Testing
- Corticosteroid
- Volunteers
- 217 people
- Sponsor
- Tampere University Hospital