Clinical trials: Clinical Course
Rectal Cancer, Neoadjuvant Therapies
Modified Long-Course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for MSS/pMMR High-risk Mid/Low LARC (MODIFI-RC-I)
The goal of this clinical trial is to evaluate whether a total neoadjuvant therapy (TNT) regimen combining long-course chemoradiotherapy, sequential chemotherapy, and PD-1 inhibitor can improve response rates, enhance…
- Conditions
- Rectal Cancer, Neoadjuvant Therapies, Immune Checkpoint Therapy, Radiotherapy
- Trial name
- NCT06923345
- Testing
- Reduced CTV, Conventional CTV
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Allergic Asthma
Efficacy Of Bacterial Lysate In Asthmatic Children
This study evaluate the efficacy of Mechanical Bacterial Lysate (PMBL - Ismigen®) to improve the asthma control level (ACT score) as add-on treatment to routine asthma treatment in children aged 6 to 16 with uncontrolled or…
- Trial name
- EOLIA (NCT02541331)
- Testing
- ISMIGEN
- Where
- 4 sites in Poland
- Volunteers
- 150 people
- Sponsor
- Lallemand Pharma AG
Attention Deficit Disorder With Hyperactivity
Genetic, Brain Structure, and Environmental Effects on ADHD
Background: Attention deficit hyperactivity disorder (ADHD) is one of the most common and inheritable of all neuropsychiatric disorders. It causes problems with attention and impulse control.
- Trial name
- NCT01721720
- Where
- United States
- Volunteers
- 1,091 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Soft Tissue Atrophy
Comparative Analysis Using the Collagen Matrix and Autogenous Graft: Clinical Course, Aesthetic Results
This was an interventional prospective randomized clinical trial (RCT) in parallel groups. The sample size is 32 patients who were randomly divided into two groups depending on the surgical intervention used.
- Trial name
- NCT05870774
- Testing
- Soft tissue augmentation with CTG, Soft tissue augmentation with CM
- Where
- Russia
- Volunteers
- 52 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Common Cold, Influenza
Efficacy and Safety Study of Ingavirin® to Treat Influenza and Other Acute Respiratory Viral Infections in Patients 3-6 y.o.
The purpose of this study is to determine whether Ingavirin ® dosed 30 mg daily is effective and safe in the treatment of influenza and other acute respiratory viral infections in the course of standard therapy in 3-6 years old…
- Trial name
- ACCORD (NCT02644018)
- Testing
- Imidazolyl ethanamide pentandioic acid
- Where
- 13 sites in Russia
- Volunteers
- 190 people
- Sponsor
- Valenta Pharm JSC
Friedreich Ataxia, Cardiomyopathy
Clinical Course Of Disease In Participants With FA-CM
Characteristics and clinical course of disease In participants with cardiomyopathy associated with Friedreich Ataxia (CLARITY-FA)
- Trial name
- NCT06865482
- Where
- 19 sites in United States, Brazil and 6 more
- Volunteers
- 65 people
- Sponsor
- Lexeo Therapeutics
HIV Infections
Safety and Effectiveness of Short-Term Anti-HIV Drug Therapy for Recent HIV-1 Infection
The purpose of this study is to determine the safety and effectiveness of an anti-HIV drug regimen followed by treatment interruption in people recently infected with HIV.
- Trial name
- NCT00414518
- Testing
- Tenofovir disoproxil fumarate/Emtricitabine, Lopinavir/Ritonavir
- Where
- 3 sites in United States, Zimbabwe
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Primary Headache Disorder
Gender Differences and Features of the Clinical Course of Primary Headaches
The pathophysiological mechanisms that underlie primary headache disorders, such as migraine and cluster headache (CH), are complex and not yet fully clarified.
- Trial name
- NCT05760625
- Testing
- analysis BDNF
- Where
- Uzbekistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Tashkent Medical Academy
Infectious Diarrhea, Acute Gastroenteritis
Lactobacillus Acidophilus and Limosilactobacillus Reuteri for Acute Diarrhea in Children
This randomized controlled trial evaluated the effect of a combination of Lactobacillus acidophilus DSMZ 26280 and Limosilactobacillus reuteri DSMZ 25441 on the duration of diarrhea and gut microbiota composition in children aged…
- Trial name
- NCT07342088
- Testing
- Probiotic, Standard therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 145 people
- Sponsor
- Eskisehir Osmangazi University
Covid19
COVID-19 Infection in Cancer Pantients
It's an obsevational retrospective/prospective study. Analyzing the evolution of COVID 19 infection in cancer patients can provide interesting information in the management of these patients.
- Trial name
- COICA (NCT04569292)
- Testing
- No intervention on patients
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Ospedale Andrea Tortora di Pagani
Chronic Rhinosinusitis (CRS), Exacerbations
Effect of Pleuran on the Clinical Course of Patients With Chronic Rhinosinusitis
The goal of this clinical research is to learn if Imunoglukan P4H® as an add-on therapy to the standard of care treatment according to the EPOS guidelines (intranasal corticosteroids and saline irrigation) can help to prevent CRS…
- Conditions
- Chronic Rhinosinusitis (CRS), Exacerbations, Respiratory Tract Infections (RTI), Antibiotic Prophylaxis
- Trial name
- EPCCOR (NCT07460934)
- Testing
- Imunoglukan P4H® capsules
- Where
- 5 sites in Czechia, Slovakia
- Volunteers
- 85 people
- Sponsor
- Pleuran, s.r.o.
Drug Toxicity
GHB Poisoning and Poisoning Induced by Others
Patients with suspected GHB poisoning presenting to Oslo Accident and Emergency Outpatient Clinic (Oslo Legevakt) or a hospital in Oslo (Oslo University Hospital Ullevål, Diakonhjemmet, Lovisenberg) will be included.
- Trial name
- NCT03651778
- Where
- Norway
- Volunteers
- 250 people
- Sponsor
- Odd Martin Vallersnes
Cubital Tunnel Syndrome, Peroneal Nerve Entrapment
Mechanomyography for Predictor of Prognosis in CuTS and PND Patients
The study will be a non-blinded two cohort design consisting only of symptomatic patients with CuTS or compressive peroneal neuropathy or in need of peroneal nerve decompression. The first cohort will be - patients with CuTS.
- Trial name
- NCT04322448
- Testing
- Mechanomyography (MMG)
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Washington University School of Medicine
Chronic Heart Failure, Coronary Artery Disease
The Influence of Metformin on Chronic Heart Failure Clinical Course in Patients With Prediabetes
It is well known fact, that prediabetes is a predictor of high cardiovascular mortality, increasing the risk of developing such adverse cardiovascular events as myocardial infarction, stroke and sudden cardiac death.
- Conditions
- Chronic Heart Failure, Coronary Artery Disease, PreDiabetes
- Trial name
- NCT04549415
- Testing
- Metformin Hydrochloride, lifestyle modification
- Where
- Kyrgyzstan
- Volunteers
- 97 people
- Sponsor
- National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
Cardiovascular Diseases, Venous Thromboembolism
Study on the Clinical Course Of Pulmonary Embolism
The course of both pulmonary embolism (PE) and one of its more relevant late complications, i.e. chronic thromboembolic pulmonary hypertension (CTEPH) is still substantially unknown.
- Conditions
- Cardiovascular Diseases, Venous Thromboembolism, Pulmonary Hypertension
- Trial name
- SCOPE (NCT01781858)
- Volunteers
- 700 people
- Sponsor
- University of Padova
Rectal Cancer
Short-Course Radiotherapy Followed by Immunotherapy Combined With Chemotherapy for Microsatellite Stable Locally Advanced Rectal Cancer: A Prospective, Randomized, Controlled Phase II Clinical Trial
Microsatellite stable (MSS) locally advanced rectal cancer (LARC) remains a major therapeutic challenge despite advances in multimodal treatment.
- Trial name
- NCT07594925
- Testing
- Sintilimab, Chemotherapy Drugs, radiotherapy
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Delirium
Comparison of Dexmedetomidine and Propofol on the Delirium and Neuroinflammation in Patients With SIRS.
Assessment of sedative effects of dexmedetomidine and propofol on the clinical course of delirium and neuroinflammation in patients with SIRS using CAM-ICU scale and protein S100b in serum.
- Trial name
- NCT02366299
- Testing
- Dexmedetomidine, Propofol
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
CMV
Clinical and Immunological Features of the CMV Infection Atypical Course in Immunocompetent Individuals
Current study evaluates possible correlations between the content of various cell populations, the genetic material of the virus and antibodies to it in the blood of patients and the risk of thrombosis development in patients…
- Trial name
- NCT04392297
- Testing
- Bood leukocyte subsets, CMV specific T-cells, serum CMV IgM / IgG antibodies
- Where
- Belarus
- Volunteers
- 45 people
- Sponsor
- The Republican Research and Practical Center for Epidemiology and Microbiology
Functional Dyspepsia, Irritable Bowel Syndrome
Psychoemotional Status and Functional Gastrointestinal Disorders
This prospective cohort study will evaluate the influence of psychoemotional status on the clinical course and quality of life of adult patients with functional dyspepsia and/or irritable bowel syndrome diagnosed according to…
- Trial name
- NCT07539051
- Testing
- Questionnaire and Symptom Assessment, Helicobacter pylori Status Assessment
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Center of New Medical Technologies
Pulmonary Disease, Chronic Obstructive
Inert Dusts and Pathology of Chronic Obstructive Pulmonary Disease
The main objective of the study is the exploration of the natural course of COPD and its biological background. To this end, active workers without COPD and workers in functional classes GOLD 0-III are investigated by a combined…
- Trial name
- NCT00618137
- Where
- Austria
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna