Clinical trials: Clinical Course
Diabetes, Diabetic Nephropathy
Association Between Rosiglitazone Use and Clinical Course of Diabetic Nephropathy: Population-Based Study
Recent data show that Rosiglitazone treatment can reduce proteinuria in diabetic patients. However, currently there are no trials that examine the effects of Rosiglitazone on kidney disease progression, that is, doubling of serum…
- Conditions
- Diabetes, Diabetic Nephropathy, Renal Protection
- Trial name
- NCT00497666
- Testing
- Rosiglitasone (retrospective observation)
- Where
- Israel
- Sponsor
- Assaf-Harofeh Medical Center
Scientific Writing Training Course
Evaluation of Competencies in Scientific Writing and Attendees' Satisfaction After Two Different Types of Training Courses: SCRIU-B Study
Scientific writing is one of the competencies required and requested by health professionals. There are several course formats designed for acquiring these competencies, although the improvement after taking part in these courses…
- Trial name
- SCRIU-B (NCT05798598)
- Testing
- Scientific writing training course
- Where
- Spain
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Dr. Antoni Esteve Foundation
Tuberculosis
Short-Course Isoniazid and Rifampin Compared With Isoniazid for Latent Tuberculosis Infection
The objective of the study was to compare the compliance and the side effects of a short course to treatment of latent tuberculosis infection during 3 months(isoniazid plus rifampin)group I, with the standard course for 6…
- Trial name
- NCT00397709
- Testing
- I ( isoniazid), II (isoniazid + rifampin )
- Where
- Spain
- Volunteers
- 228 people
- Sponsor
- Hospital Virgen de la Luz
Respiratory Tract Infections
Observation of Initial Procalcitonin and the Clinical Course of Patients With Acute Respiratory Tract Infections
Observation of the initial Procalcitonin values and the clinical course of consecutively included patients with Acute Respiratory Tract Infections at general medical practices in greater Hannover.
- Trial name
- NCT00827060
- Where
- Germany
- Volunteers
- 702 people
- Sponsor
- Hannover Medical School
Mild Spinal Tuberculosis
Short-Course Anti-tuberculosis Regimens for Mild Spinal Tuberculosis
To evaluate the non-inferiority in efficacy between the rifapentine- and moxifloxacin-containing short-course regimens (with rifampicin replaced by rifapentine and ethambutol replaced by moxifloxacin, while isoniazid and…
- Trial name
- NCT06917495
- Testing
- Rifampin, Isoniazid, Rifapentine (RPT)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shandong University
Monitoring of Depth of Anesthesia, AAI Index
Monitoring of Adequate Course of General Anesthesia
Clinical monitoring is the most common method of adjustment of the appropriate level of general anesthesia. However, the episodes of intraoperative awareness are still reported, suggesting that clinical observations may not be…
- Trial name
- MoDA (NCT03331692)
- Testing
- monitoring of the proper level of general anesthesia
- Where
- Poland
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Military Institute od Medicine National Research Institute
Dyspepsia
The Clinical Course and Factors for the Progression of Uninvestigated Dyspepsia to Functional Dyspepsia
Dyspepsia is one of the most common gastrointestinal diseases. This disease was defined as predominant epigastric pain lasting for at least 1 month, which can be accompanied with other symptoms, such as epigastric fullness, and…
- Trial name
- NCT05823636
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Air Force Military Medical University, China
Schizophrenia
The Management of Schizophrenia in Clinical Practice (MOSAIC)
This study is a disease-based registry designed to follow patients with a DSM-IV-TR (Diagnostic and Statistic Manual of Mental Disorders, Text Revision) diagnosis of schizophrenia, schizoaffective disorder, or schizophreniform…
- Trial name
- NCT01746134
- Where
- 44 sites in United States
- Volunteers
- 557 people
- Sponsor
- Genentech, Inc.
Nasopharyngeal Carcinoma, Leucogen
A Multi-center, Randomized, Double-blind, Phase III Clinical Trial of Leucogen Versus Placebo on Leukocyte and Platelet Whole-course Management Assisted by PFLL Chemotherapy in the Treatment of Stage IV, Recurrent or Metastatic NPC
Toxic and side effects during and after chemoradiotherapy for nasopharyngeal carcinoma seriously affect patients' treatment compliance and long-term quality of life.
- Conditions
- Nasopharyngeal Carcinoma, Leucogen, Chemotherapy, Myelosuppression
- Trial name
- NCT05780294
- Testing
- 5-fu, Lobaplatin, leucogen
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Sun Yat-sen University
Adenocarcinoma of the Esophagus or Esophagogastric Junction
Palliative Short-course Hypofractionated Radiotherapy Followed by Chemotherapy in Adenocarcinoma of the Esophagus or Esophagogastric Junction Trial - a Phase II Clinical Trial Protocol.
In this trial, patients with histologically proven adenocarcinoma of the esophagus or esophagogastric junction noneligible for surgery or chemoradiation with curative intent will be included.
- Trial name
- PALAESTRA (NCT02241499)
- Testing
- Radiation therapy, Oxaliplatin and fluorouracil.
- Where
- Sweden
- Volunteers
- 29 people
- Sponsor
- Lund University Hospital
Idiopathic Pulmonary Fibrosis, Idiopathic Interstitial Pneumonia
Clinical Course of Interstitial Lung Diseases: European IPF Registry and Biobank
Born out of the European Union 7th Framework Programme funded project European IPF Network (eurIPFnet), the European IPF Registry (eurIPFreg) has become Europe's leading database of longitudinal data from IPF patients, including…
- Conditions
- Idiopathic Pulmonary Fibrosis, Idiopathic Interstitial Pneumonia, Interstitial Lung Diseases, Diffuse Parenchymal Lung Diseases
- Trial name
- eurIPFreg (NCT02951416)
- Testing
- patient registry (observation and biomaterial sampling)
- Where
- 7 sites in Austria, France and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Andreas Guenther
Hepatic and Hepatobiliary Disorders
Essentiale® Paste in Patients With Gastrointestinal Symptoms in Acute or Chronic Liver Diseases
Primary Objective: To assess safety of Phosphatidylcholine paste 600 mg (ESSENTIALE® paste) oral 3 times a day for 12 weeks in patients with gastrointestinal symptoms in acute and chronic liver diseases.
- Trial name
- EPLID (NCT02517385)
- Testing
- Phosphatidylcholine
- Where
- Russia
- Volunteers
- 147 people
- Sponsor
- Sanofi
Inflammatory Bowel Disease (IBD), Ulcerative Colitis
Healthy Approach to Physical and Psychological Problems in Youngsters With IBD (HAPPY-IBD).
The presented study aims to reduce symptoms of depression and anxiety in adolescents with inflammatory bowel disease and increased symptoms of anxiety and depression by using the disease specific CBT program (PASCET-PI)in order…
- Conditions
- Inflammatory Bowel Disease (IBD), Ulcerative Colitis, Crohn's Disease, Anxiety
- Trial name
- HAPPY-IBD (NCT02265588)
- Testing
- Cognitive behavioral therapy
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- Erasmus Medical Center
Pancreatic Neoplasms
Trial of Neoadjuvant Short Course IMRT Followed by Surgery and IORT for Resectable Pancreatic Cancer
The current standard treatment for patients with primarily resectable pancreatic tumors consists of surgery followed by adjuvant chemotherapy.
- Trial name
- NEOPANC (NCT01372735)
- Testing
- neoadjuvant short course IMRT, IORT
- Where
- 3 sites in Germany
- Volunteers
- 46 people
- Sponsor
- University Hospital Heidelberg
Quality of Life
A Real-world Clinical Study of Kapok Initiative
This study is a prospective and effective research study. The aim is to assess the difference in the quality of life of the family members of patients with colorectal cancer after application of follow-up disease management using…
- Trial name
- NCT04735991
- Testing
- Kapok Initiative
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese Academy of Medical Sciences
ESCC
Adebrelimab Plus Full-course Neoadjuvant Therapy for Resectable Locally Advanced ESCC (Phase 2)
This is a prospective, single-center, randomized phase 2 study of adebrelimab plus full-course neoadjuvant therapy in resectable locally advanced esophageal squamous cell carcinoma.
- Trial name
- NAT-ESCC-01 (NCT07584031)
- Testing
- Combination therapy with chemotherapy and immunotherapy, Surgery
- Volunteers
- 200 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Latent Tuberculosis, Kidney Failure
Short-course Rifamycin-based Regimens for Latent Tuberculosis in Patients With End-stage Kidney Disease
Objective To determine if treatment completion with a 4-month rifampin (4R) or 3-month rifapentine (P) + isoniazid (H) weekly for 12 weeks (3HP) regimens is better than with a 3-month (3HR) regimen for treatment of latent…
- Trial name
- NCT05021731
- Testing
- Rifampicin plus Isoniazid, Rifapentine plus Isoniazid, Rifampicin alone
- Volunteers
- 225 people
- Sponsor
- Miguel Santín
Polymyalgia Rheumatica
Etanercept Treatment in the Early Course of Polymyalgia Rheumatica
The purpose of this study is to evaluate the effect of the tumor necrosis factor alpha (TNF) antagonist, etanercept, on the early clinical course of polymyalgia rheumatica (PMR).
- Trial name
- NCT00524381
- Testing
- Etanercept (Enbrel)
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Hepatitis C Virus Infection, Response to Therapy of
Clinical Trial to eLiminate HCV-infection in Treatment-naïve, Renally Impaired EgyptiAn Patients on Renal Dialysis, With Chronic Hepatitis C Genotype 4
Primary Efficacy Objective -To assess whether a 12-week treatment course with oral 50 mg elbasvir plus 100 mg grazoprevir given in a single daily dose to treatment-naïve patients with end-stage renal disease (ESRD) and infected…
- Trial name
- CLEAR-C4 (NCT03381859)
- Testing
- Elbasvir/Grazoprevir 50 MG-100 MG Oral Tablet [ZEPATIER]
- Where
- Egypt
- Sponsor
- University of Maryland, Baltimore
Fibromyalgia Syndrome, Fibromyalgia
Effects of 2-Aticyto Complex and D-Ribose on Pain and Clinical Course in Patients With Fibromyalgia
This multicenter, randomized, double-blind, placebo-controlled study will evaluate whether an oral supplement containing 2-Aticyto Complex and D-ribose (FibroThol), added to ongoing standard medical treatment, improves pain…
- Trial name
- NCT07495943
- Testing
- 2-Aticyto Complex and D-ribose Oral Supplement
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital