Clinical trials: Clinical Course
Functional Dyspepsia
Clinical Course of Functional Dyspepsia and Factors Predicting Outcome in Patients Receiving Medication-based Treatment
Functional dyspepsia (FD) is one of most common chronic gastrointestinal disorders. Several types of drugs were demonstrated to be effective in reduction or remission of symptoms and severity of FD, including proton pump…
- Trial name
- NCT05513040
- Where
- 4 sites in China
- Volunteers
- 300 people
- Sponsor
- Air Force Military Medical University, China
Coronary Artery Disease
Using WHOOP Fitness Band to Measure Heart Health Variability Before and After Surgery
The goal of this observational study is to use the WHOOP device to measure heart rate variability (HRV) in patients with coronary artery disease (CAD) before and after they have CABG (coronary artery bypass graft) surgery.
- Trial name
- NCT07097168
- Where
- United States
- Sponsor
- Tufts Medical Center
Tricuspid Regurgitation
Prospective Registry of Patients With Isolated Severe Tricuspid Regurgitation
Prospective registry for patients with severe isolated tricuspid regurgitation (TR) without significant left-sided valvular or myocardial diseases.
- Trial name
- NCT01502462
- Where
- South Korea
- Volunteers
- 131 people
- Sponsor
- Asan Medical Center
Nonalcoholic Fatty Liver Disease (NAFLD)
Clinical Course and Biomarkers Associated With Nonalcoholic Fatty Liver Disease (NAFLD) in Chinese Patients With Obesity
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in many parts of the world. NAFLD can progress to nonalcoholic steatohepatitis (NASH) and result in cirrhosis and liver cancer.
- Trial name
- NCT07662356
- Testing
- Case Group
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Bipolar Disorder, Schizoaffective Disorder
Probiotics to Prevent Relapse After Hospitalization for Mania
The purpose of this study is to determine if taking a probiotic supplement versus a placebo will lower rates of relapse and improve the clinical course among participants who have been hospitalized for mania.
- Trial name
- NCT01731171
- Testing
- Probiotic Supplement, Inert Compound
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Sheppard Pratt Health System
Locally Advanced Resectable Rectal Cancer
Exploratory Study of Short-Course Radiotherapy Followed by Adebrelimab Combined With Chemotherapy for Organ Preservation in Locally Advanced Rectal Cancer
This prospective, single-arm, exploratory clinical study aims to evaluate the efficacy and safety of short-course radiotherapy (SCRT) sequentially followed by adebrelimab combined with chemotherapy as an organ-preservation…
- Trial name
- NCT07905950
- Testing
- Adebrelimab
- Where
- China
- Volunteers
- 155 people
- Sponsor
- Henan Cancer Hospital
Tuberculosis, Human Immunodeficiency Virus Infections
Short Course Intermittent Regimens for the Treatment of HIV-Associated Tuberculosis
Title: Randomized clinical trial to assess the efficacy of short course intermittent regimens for the treatment of HIV-associated tuberculosis Phase: Phase III trial Population: 300 HIV positive patients with tuberculosis.
- Trial name
- NCT00376012
- Testing
- Anti-TB drugs (Ethambutol, Isoniazid, Rifampicin and Pyrazinamide)
- Where
- India
- Volunteers
- 300 people
- Sponsor
- Tuberculosis Research Centre, India
Chronic Obstructive Pulmonary Disease
Clinical And Social Characteristics and Demographics in COPD
Chronic Obstructive Pulmonary Disease (COPD) is a condition resulting from environmentally induced lung damage e.g. cigarette smoking and air pollution which, over time, causes individuals to suffer from symptoms including…
- Trial name
- CASCADE (NCT02882165)
- Testing
- Medical review
- Where
- United Kingdom
- Volunteers
- 116 people
- Sponsor
- University of Southampton
Advanced Rectal Cancer
Short-course RT Followed by NALIRIFOX Plus Pucotenlimab as Neoadjuvant Therapy for High-risk Locally Advanced Rectal Cancer With MSS/pMMR
The goal of this clinical trial is conducted to evaluate the neoadjuvant regimen of short-course radiotherapy (SCRT) followed by NALIRIFOX chemotherapy plus Pucotenlimab immunotherapy for high-risk locally advanced rectal cancer.
- Trial name
- NCT07651007
- Testing
- iTNT-HX02
- Volunteers
- 29 people
- Sponsor
- Wang Xin
Soft Tissue Sarcomas
Short Course Of Preoperative Radiotherapy in Head and Neck-, Trunk- and Extremity Soft Tissue Sarcomas
Currently, soft tissue sarcomas (STS) are preoperatively irradiated in a conventionally fractionated regimen of 25 x 2 Gy in five weeks.
- Trial name
- SCOPES (NCT04425967)
- Testing
- pre-operative radiotherapy
- Where
- 4 sites in Netherlands
- Volunteers
- 168 people
- Sponsor
- The Netherlands Cancer Institute
Disorder in Complete Remission in Response to Treatment
Short-course Radiotherapy Combined With Neoadjuvant Chemotherapy and PD-1 Inhibitor in the Treatment of Locally Advanced Gastric Adenocarcinoma
This is a Prospective, Single-center, Single-arm, phase II clinical trial to explore the efficacy and safety of sintilimab (PD1 inhibitor) combined with XELOX chemotherapy, evaluate the pathological complete response rate of…
- Trial name
- NCT05563012
- Testing
- Sintilimal Injection
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Renmin Hospital of Wuhan University
Simulation Training
Effect of the Use of a Visual Feedback Device in RCP Trainings
To verify the efficacy of manikins with feedback in the training of physicians and nurses in the courses of Advanced Cardiac Life Support (ACLS) authorized by the American Heart Association (AHA) when compared to the traditional…
- Trial name
- NCT04338490
- Testing
- Feedback mannequim
- Where
- Brazil
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Patients With Initially Unresectable MSS-type Advanced Colorectal Cancer With Liver and/or Lung and Peritoneal Metastasis
Modified Short-Course Radiotherapy Combined With Immunochemotherapy and Targeted Therapy as First-Line Treatment for MSS Metastatic Colorectal Cancer
This is a single-arm interventional study targeting patients with initially unresectable MSS-type advanced colorectal cancer with liver and/or lung and peritoneal metastasis.
- Trial name
- NCT07512674
- Testing
- Receiving lymph node-sparing modified short-course radiotherapy combined with tislelizumab, CAPOX chemotherapy and bevacizumab targeted therapy
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Sir Run Run Shaw Hospital
Low Rectal Cancer
Nodes-sparing Short-course Radiation Combined With CAPOX and Tislelizumab for MSS Middle and Low Rectal Cancer
This is an open-label, prospective, multicenter phase II clinical trial to evaluate modified short-course radiation (Radiation targeting the tumor bed without irradiating surrounding tumor-draining lymph nodes) combined with…
- Trial name
- mRCAT (NCT05972655)
- Testing
- Modified short-course radiotherapy, PD-1 antibody, Capecitabine
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Sir Run Run Shaw Hospital
Rectal Cancer
SIB-RT Combined With CAPOX and PD-1 for High-Risk Rectal Cancer
The biological effective dose of short-course radiotherapy is relatively lower compared to long-course radiotherapy, which may lead to an increased local recurrence rate in patients with mid to low rectal cancer who are at high…
- Trial name
- NCT07297030
- Testing
- SIB-SCRT, CAPOX, Immunotherapy
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Sun Yat-sen University
SARS-CoV-2, Covid19
COVID-19 Child Health Investigation of Latent Disease in Hamburg
The study measures infection rates and the presence of antibodies for SARS-CoV-2 (COVID-19) among in- and outpatients of all pediatric hospitals, as well as volunteers aged 0 to 18 years in Hamburg, Germany.
- Trial name
- C19CHILD (NCT04534608)
- Where
- Germany
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Rectal Cancer
Node-sparing Short-Course Radiation Combined With CAPOX and Tislelizumab for MSS Rectal Cancer
This is a randomized, prospective, multicenter, open-label, Phase III clinical trial to evaluate node-sparing modified short-course radiation (Radiation targeting the tumor bed without irradiating surrounding tumor-draining lymph…
- Trial name
- mRCAT-III (NCT06507371)
- Testing
- node-sparing modified short-course radiotherapy, PD-1 antibody, Capecitabine
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Sir Run Run Shaw Hospital
Advanced Rectal Cancer, Distal Metastasis
A Combination Therapy Including Anti-PD-1 Immunotherapy in Rectal Cancer With Refractory Distal Metastasis
Though surgical resection remains the primary choice for advanced rectal cancer, about 80% are considered unresectable due to the number, size, or location of metastases.
- Trial name
- Miracle-2 (NCT05359406)
- Testing
- a combination therapy including tislelizumab
- Where
- China
- Volunteers
- 51 people
- Sponsor
- LI XIN-XIANG
Esophageal Squamous Cell Carcinoma (ESCC)
Short-course Radiotherapy Combined With Serplulimab and Chemotherapy as Neoadjuvant Treatment for Resectable ESCC
This study includes patients with resectable esophageal squamous cell carcinoma who will undergo local radiotherapy (PTV: 1.5Gy Bid, for 5 days), followed by neoadjuvant treatment with Serplulimab combined with cisplatin and…
- Trial name
- NCT07403435
- Testing
- Serplulimab
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Pressure Injury
Digital Multimedia in Clinical Nurse Education for Pressure Injury Prevention Via LINE@
The goal of this clinical trial is to integrate past indicators affecting the effectiveness of pressure injury care education among nurses and to explore the learning outcomes of nurses through different educational…
- Trial name
- NCT06527716
- Testing
- Teaching Strategy
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Asia University