Clinical trials: Clinical Course
Multiple Myeloma, Renal Injury
A Clinical Study on the Whole-course Management (BCD-KPD-AutoHSCT) Scheme for Patients With RIMM
Multiple myeloma (MM) is still an incurable hematological tumor, and renal involvement is the main factor of poor prognosis. The recovery of renal function can partially reverse its poor outcome.
- Trial name
- NCT06203145
- Testing
- Bortezomib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Obesity, Depression
Pharmacokinetics of SSRI/SNRI After Bariatric Surgery
Psychiatric disorders and treatment with antidepressants SSRI/SNRI (selective serotonin reuptake inhibitors/ serotonin-norepinephrine reuptake inhibitors) are common in people with morbid obesity who are candidates for bariatric…
- Trial name
- NCT04928937
- Testing
- Roux-en-Y gastric bypass, sleeve gastrectomy
- Where
- Switzerland
- Volunteers
- 63 people
- Sponsor
- Luzerner Kantonsspital
Rectal Cancer
Action of Synbiotics on Irradiated GI Mucosa in Rectal Cancer Treatment
The aim of this study is to investigate how bacteria and fibre interact with the epithelial cells of the gastrointestinal mucosa to reduce inflammation and to diminish tissue damage caused by radiation therapy to patients…
- Trial name
- FIPIREX (NCT03420443)
- Testing
- Oat bran, Oat bran and blueberry husks, No oral supplementation
- Volunteers
- 30 people
- Sponsor
- Region Skane
COVID-19
Assessment of Clinical Effects of Coenzyme Q10 Levels in COVID-19 Patients in Intensive Care Unit
The study will be done in Hacettepe University Anesthesiology and Reanimation Intensive Care Unit. The investigators will accept COVID-19 diagnosed or suspected patients to the ICU.
- Trial name
- NCT05058716
- Testing
- blood sample
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Hacettepe University
Cirrhosis
To Study and Compare the Clinical Course and Development of Organ Failure in Severe Acute Hepatitis Without Ascites, Non-cirrhotic and Cirrhotic Patients With Ascites [Acute on Chronic Liver Failure] and Acute Deterioration of Previously Decompensated Cirrhosis.
The study will be conducted on patients admitted to Department of Hepatology from MARCH 2015 to DECEMBER 2016 at ILBS, New Delhi.All patients presenting to ILBS fulfilling the inclusion criteria will be included in the study and…
- Trial name
- NCT02465619
- Where
- India
- Sponsor
- Institute of Liver and Biliary Sciences, India
Polymyalgia Rheumatica
Etanercept Treatment in the Early Course of Polymyalgia Rheumatica
The purpose of this study is to evaluate the effect of the tumor necrosis factor alpha (TNF) antagonist, etanercept, on the early clinical course of polymyalgia rheumatica (PMR).
- Trial name
- NCT00524381
- Testing
- Etanercept (Enbrel)
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
Comparing a 6-month vs Long-term Course of Rezvilutamide With ADT Plus Chemotherapy in mHSPC
Primary Objective: To explore whether a 6-month course of Rezvilutamide in the triple therapy regimen is non-inferior to long-term Rezvilutamide treatment in improving radiographic progression-free survival (rPFS) in patients…
- Trial name
- NCT05956639
- Testing
- 6-month course of antiandrogen drugs, Long-term course of antiandrogen drugs
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Non-Hodgkin Lymphoma by Clinical Course
Safety and Efficacy Study of Bendamustine to Treat Non-Hodgkin Lymphoma
The purpose of this study is to determine whether bendamustine HCl for injection is safe and effective in the treatment of Rituximab refractory or relapsed B-cell indolent lymphoma.
- Trial name
- NCT01570049
- Testing
- Bendamustine
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Shandong Lanjin Pharmaceuticals Co.,Ltd
Clinical Course
SUPPLEMENTATION WITH BETA GLUCAN AND ADAPTATIVE RESPONSE.
Abstract: Studies demonstrate that the use of nutritional supplements containing beta-glucans stimulates the immune system, modulates inflammatory activity, and promotes so-called immune training.
- Trial name
- NCT06545149
- Testing
- BioNutri AR-1,
- Volunteers
- 44 people
- Sponsor
- Federal University of São Paulo
Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma
Short-Course Definitive Chemoradiotherapy Combined With Adjuvant or Concurrent Plus Adjuvant Camrelizumab for Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma
This study aims to compare the efficacy and safety of short-course definitive concurrent chemoradiotherapy plus immunotherapy followed by immunotherapy maintenance versus short-course definitive chemoradiotherapy plus…
- Trial name
- STELLAR01 (NCT07530094)
- Testing
- Camrelizumab
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Ning Jiang, M.D./Ph.D.
Nasopharyngeal Carcinoma
Late-Course Accelerated Hyperfractionated IMRT for Locoregionally Advanced Nasopharyngeal Carcinoma
Based on the radiobiological findings that accelerated tumor repopulation in nasopharyngeal carcinoma occurs in the late-course of radiation therapy, the investigators hypothesize that intensity-modulated radiation therapy(IMRT)…
- Trial name
- NCT00778908
- Testing
- Late-course accelerated hyperfractionated IMRT, Concomitant cisplatin chemotherapy, Conventionally fractionated IMRT
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Guangxi Medical University
Nasopharyngeal Carcinoma (NPC)
Efficacy and Safety of TPC Induction Chemotherapy Combined With Nimotuzumab and Toripalimab "Immune Sandwich" Regimen Versus Full-Course Immunotherapy for Locally Advanced Nasopharyngeal Carcinoma
Immunotherapy combined with chemoradiotherapy has become standard care for locally advanced nasopharyngeal carcinoma, yet radiotherapy-induced lymphopenia may impair the efficacy of concurrent PD-1 blockade.
- Trial name
- NCT07706985
- Testing
- Toripalimab combined with Nimotuzumab, Nimotuzumab
- Where
- China
- Volunteers
- 566 people
- Sponsor
- Sun Yat-sen University
Colorectal Neoplasms
Neoadjuvant Chemoradiotherapy Plus Tislelizumab Followed by TME for LARC.
Long course radiotherapy plus neoadjuvant chemotherapy followed by resection total mesorecta excision has accepted widespread recognized in the treatment of locally advanced rectal cancer (LARC).
- Trial name
- NCT04911517
- Testing
- long course radiotherapy + capecitabine + PD-1 monoclonal antibody treatment combinations
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Beijing Friendship Hospital
COVID-19
Clinical Course and Treatment of COVID-19 Inpatients in Hospital
The study is an epidemiological observational study. It serves to collect data from patients with positive COVID-19 test results who are hospitalized.
- Trial name
- NCT04527497
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- Wissenschaftliches Institut Bethanien e.V
Acute and Long Term Effects of COVID-19 on Systemic Inflammation, Acute and Long Term Effects of COVID-19 on Lung Function
Cardiopulmonary Inflammation and Multi-System Imaging During the Clinical Course of COVID-19 Infection in Asymptomatic and Symptomatic Persons
Background: COVID-19 virus infection differs among people. Some people have no or mild symptoms. For others, COVID-19 is life threatening and causes damage to the body s organs.
- Conditions
- Acute and Long Term Effects of COVID-19 on Systemic Inflammation, Acute and Long Term Effects of COVID-19 on Lung Function, Acute and Long Term Effects of COVID-19 on Cardiac Function, Acute and Long Term Effects of COVID-19 on Kidney Function
- Trial name
- NCT04401449
- Where
- 2 sites in United States
- Volunteers
- 202 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Opioid Dependence, Overdose
Effects on Mortality and Clinical Course of a Patient's Choice Model for Opioid Maintenance Treatment for Opioid Dependence - Evaluation of a System Enabling a Large Expansion of Treatment Providers and Treatment Access
Opioid dependence, for example involving addiction to injected or inhaled heroin or similar compounds, is associated with high mortality, typically from opioid overdose, and causes major physical and mental health complications…
- Trial name
- NCT05678036
- Testing
- Opioid maintenance treatment
- Where
- Sweden
- Volunteers
- 2,500 people
- Sponsor
- Region Skane
Chronic Liver Disease
To Study the Clinical Course and Outcomes of Non-electively Hospitalised Patients of Chronic Liver Disease (CLD) With Hepatic or Extra-hepatic Predominant Organ Failure(s) at 6 Months.
Title - To study the clinical course and outcomes of non-electively hospitalised patients of chronic liver disease (CLD) with Hepatic or Extra-hepatic predominant organ failure(s) at 6 months.
- Trial name
- NCT07270809
- Testing
- No Intervention
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Oral Lichen Planus
A Clinical Study of Curcuminoids in the Treatment of Oral Lichen Planus
A phase 2 randomized, placebo-controlled, double-blind trial of a two week course of curcuminoids in oral lichen planus will be conducted.
- Trial name
- NCT00525421
- Testing
- Curcuminoids
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nita Chainani Wu
Multiple Sclerosis
Aggressive Onset Multiple Sclerosis: A Practical Definition and Study of Its Clinical Course
Chart review.
- Trial name
- NCT02301572
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Weill Medical College of Cornell University
ESCC
Adebrelimab Plus Full-course Neoadjuvant Therapy for Resectable Locally Advanced ESCC (Phase 2)
This is a prospective, single-center, randomized phase 2 study of adebrelimab plus full-course neoadjuvant therapy in resectable locally advanced esophageal squamous cell carcinoma.
- Trial name
- NAT-ESCC-01 (NCT07584031)
- Testing
- Combination therapy with chemotherapy and immunotherapy, Surgery
- Volunteers
- 200 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital