Clinical trials: Clinical Decision Support Systems
Hypertension
Implementation of Machine Learning and Hemodynamic Profiles Based Clinical Decision Support Systems for Personalized Guideline Accordant Antihypertensive Regimens in Primary Care: a Pragmatic Cluster Randomized Controlled Trial
This trial is a prospective, multicenter, single-blind, three-arm parallel-group, cluster randomized controlled trial assessing the effectiveness and safety of two types of CDSS in primary care settings in China.
- Trial name
- NCT06828692
- Testing
- Group A (clinical guideline+machine learning), Group B (clinical guideline+impedance cardiograph+machine learning), Group C (usual care)
- Where
- China
- Volunteers
- 2,160 people
- Sponsor
- China National Center for Cardiovascular Diseases
Decision Support Systems, Clinical, Prostate Cancer
Pioneering Advances in Care and Education (PACE)
This clinical trial evaluates the use of novel decision support educational materials and services using health coaches. The study includes men newly diagnosed with low-risk prostate cancer. A 160 men will be recruited.
- Trial name
- PACE (NCT03397160)
- Testing
- Decision Support Intervention (DSI)
- Where
- 4 sites in United States
- Volunteers
- 119 people
- Sponsor
- University of California, San Francisco
Palliative Care
iLIVE Medication Study
The iLIVE medication study is a before-after study where medication optimisation of patients with an estimated life expectancy of six months is investigated. The investigators will include 400 patients in 3 countries.
- Trial name
- iLIVEmed (NCT04717882)
- Testing
- CDSS-OPTIMED
- Where
- 3 sites in Netherlands, Sweden and 1 more
- Volunteers
- 400 people
- Sponsor
- Prof. dr. Stefan Sleijfer
Sepsis, Acute Respiratory Distress Syndrome (ARDS)
Evaluating Artificial Intelligence-Based Clinical Decision Support for Sepsis and ARDS
Sepsis and acute respiratory distress syndrome (ARDS) are common in intensive care units. Managing sepsis and ARDS is inherently complex and requires making numerous decisions under uncertainty.
- Trial name
- NCT07025096
- Testing
- Artifical Intelligence-Generated Treatment Recommendations
- Where
- United States
- Volunteers
- 355 people
- Sponsor
- University of Pennsylvania
Lower Resp Tract Infection
TREATment of Lower Respiratory Tract Infection in Selected Hospitals in Southern Sri Lanka (TREAT-SL): a Stepped-Wedge Cluster Randomized Trial
This is a stepped-wedge, cluster-randomized, two-arm, open-label, clinical trial of an electronic clinical decision support tool (eCDST) for the diagnosis and treatment of lower respiratory tract infection (LRTI) among patients…
- Trial name
- TREAT-SL (NCT06331364)
- Testing
- electronic clinical decision support tool (eCDST) diagnostic plan
- Where
- 3 sites in Sri Lanka
- Volunteers
- 765 people
- Sponsor
- Duke University
Cardiopulmonary Arrest, Resuscitation
Augmented Reality to Support Cardiopulmonary Resuscitation
A prospective, multicenter, randomized clinical trial in two tertiary pediatric emergency department. It will assess, amongst pediatric healthcare teams, whether the use of augmented reality supportive devices improves adherence…
- Conditions
- Cardiopulmonary Arrest, Resuscitation, Pediatric
- Trial name
- NCT06376643
- Testing
- Augmented reality supportive tool, Conventional method (AHA pocket reference card)
- Where
- 2 sites in Canada, Switzerland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Johan Siebert, MD
Chronic Heart Failure (CHF)
Assessment of the Impact of Clinical Decision Support Systems Included in Electronic Health Records
A non--interventional study to assess the impact of clinical decision support systems included in electronic health records on compliance with guidelines, including routing of patients with CHF, follow-up care, prescription and…
- Trial name
- NCT06248658
- Where
- Russia
- Volunteers
- 66,166 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Ischemic Cerebrovascular Disease, Artificial Intelligence
Research on Early Prediction Model of Ischemic Cerebrovascular Disease Based on Artificial Intelligence Technology.
Establish an artificial intelligence clinical decision support system for patients with carotid/vertebral artery cerebrovascular stenosis, early identification of patients who may have cerebral infarction.
- Conditions
- Ischemic Cerebrovascular Disease, Artificial Intelligence, Prediction Model
- Trial name
- NCT06978348
- Where
- China
- Volunteers
- 244,296 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Organ Donation After Circulatory Death, Organ Donation
Improving Deceased Organ Donation and Transplantation Using the Donation Advisor Clinical Decision Support Tool
Every year, thousands of Canadians receive life-saving, cost-effective organ transplants, while thousands more still wait or die because not enough organs are available.
- Conditions
- Organ Donation After Circulatory Death, Organ Donation, Clinical Decision Support Tool
- Trial name
- DART (NCT07903428)
- Testing
- Donation Advisor clinical decision-support tool
- Volunteers
- 10 people
- Sponsor
- OBS Medical Ltd
Intraoperative Hypotension, Hemodynamic Instability
AI-Assisted Blood Pressure Control During Anesthesia
This proof-of-concept randomized controlled trial evaluates a reinforcement learning (RL)-based clinical decision support system for intraoperative hemodynamic management during non-cardiac surgery.
- Trial name
- RL-PRAIS PoC (NCT07123675)
- Testing
- Device: AI Clinical Decision Support System, Procedure: Standard of Care Anesthesia
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Critically Ill, Hyperglycemia
Improving Blood Glucose Control With a Computerized Decision Support Tool: Phase 2
The Purpose of this study is to: 1. Introduce the refined, validated, and safe computerized bedside decision support tool for blood glucose management in critically ill adult and pediatric ICU patients that was studied in Phase 1…
- Trial name
- NCT00654797
- Testing
- glucose control with computer generated recommendations
- Where
- 10 sites in United States
- Volunteers
- 200 people
- Sponsor
- Intermountain Health Care, Inc.
Hypertension
Practice Facilitation to Scale up a CDS for Hypertension Management
Hypertension (HTN) is the most prevalent modifiable risk factor for cardiovascular disease among U.S. adults. Despite a long history of established guidelines to support clinical management, only half of U.S.
- Trial name
- NCT05588466
- Testing
- CDS Alone, CDS plus practice facilitation
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- New York City Department of Health and Mental Hygiene
Patient Acceptance of Health Care, Acute Renal Failure
DETECT-IP: a Clinical Decision Support System and Intelligent Procedures to Counter Some Adverse Drug Events in Older Hospital Patients
Current evidence shows that computerized decision support systems (CDSS) have shown to be insufficiently effective to prevent adverse drug reactions (ADRs) at large scale (e.g. whole hospital).
- Trial name
- DETECT-IP: (NCT05923983)
- Testing
- Clinical decision support, Will not receive Clinical Decision Support
- Where
- France
- Volunteers
- 783 people
- Sponsor
- University Hospital, Lille
Stroke, Headache
A Diagnostic Test on DeepDoc-an AI-based Decision Support System
DeepDoc is an AI-based decision support system for the early etiology diagnosis of neurological diseases using clinical data points from patients admitted to hospital within 24 hours.This study aims to evaluate whether the…
- Conditions
- Stroke, Headache, Vertigo, Meningitis/Encephalitis
- Trial name
- NCT04055766
- Testing
- DeepDoc AI-based Decision Support System
- Volunteers
- 4,000 people
- Sponsor
- Xijing Hospital
Emergency Service, Hospital, Social Determinants of Health
Predictive Modeling for Social Needs in Emergency Department Settings
The overall objective of this study is to support emergency department management of patients' health-related social needs. This study will measure the impact of a decision support system that informs clinicians about which…
- Trial name
- NCT06655974
- Testing
- Health-related social needs decision support system
- Where
- United States
- Volunteers
- 518,512 people, healthy volunteers welcome
- Sponsor
- Indiana University
Critical Illness, Sepsis
Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial
This is a prospective, unmasked, randomized, multicenter clinical trial evaluating the impact of point-of-care large language model (LLM)-based decision support on diagnostic accuracy and clinical outcomes in adult medical…
- Conditions
- Critical Illness, Sepsis, Acute Respiratory Failure (ARF), Multi-organ Failure
- Trial name
- POC-AI-ICU (NCT07293078)
- Testing
- Point-of-care large language model decision support (ChatGPT-5)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- MetroWest Artificial Intelligence Research Workgroup
Healthcare
Clinical and Economic Impact of an Electronic Medical Record Interfaced Decision Support System Reinforced With Patient Specific Pharmacogenetic Data for Minimizing Severe Drug-Drug Interactions
Leumit Health Services, an health maintenance organization operating in Israel, will incorporate a web-based, decision support system for handling drug-drug interactions and drug information, termed DDI+ reinforced with patient…
- Trial name
- DDI+ (NCT01765621)
- Testing
- DDI+ System and Pharmacogenetic Data
- Where
- Israel
- Volunteers
- 973 people, healthy volunteers welcome
- Sponsor
- Leumit Health Services
Rare Disorders, Rare Diseases
Artificial Intelligence for General and Rare Disease Diagnosis
A multicentre, randomised diagnostic accuracy study to evaluate whether the GENESIS AI diagnostic support system can improve diagnostic accuracy and efficiency for physicians managing real-world clinical general and rare cases.
- Conditions
- Rare Disorders, Rare Diseases, Generalist AI
- Trial name
- NCT07625436
- Testing
- AI-Assisted Diagnosis
- Where
- 11 sites in China
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Differential Diagnosis, Diagnostic Accuracy
Evaluation of One-Shot Vision Differential Diagnosis (OSVDE) and Multi-Step Conversational Non-Inferiority (MSCNE) in AI Medical Interviewing
This study evaluates the diagnostic performance of a multimodal artificial intelligence (AI) system (AIMD.1) using de-identified medical images and semi-synthetic patient simulations.
- Trial name
- OSVDE-MSCNE (NCT07470463)
- Testing
- AI Diagnostic System (AIMD.1)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Magic Health Inc. (d.b.a. Nolla Health)
Clinical Decision Support
Optimizing the Influenza Clinical Decision Support Tool
The proposed study aims to examine several iterations of the Influenza Best Practice Alert at NYU Langone Health. The goal is to increase ordering of the influenza vaccine through the alert.
- Trial name
- NCT03415425
- Testing
- Current Version of the Influenza Alert, Alternate Modifications of the Influenza Alert
- Where
- United States
- Volunteers
- 25,881 people
- Sponsor
- NYU Langone Health