Clinical trials: Clinical Depression
Grief, Anxiety
Online Multi-component Psychological Intervention for Prevention of Grief Disorder Due to COVID-19
This study evaluates the effectiveness of an online Multi-component psychological intervention, that is focused on providing self-support to the Mexican population for the prevention of complicated grief disorder, by reducing…
- Conditions
- Grief, Anxiety, Depression, Sleep Disturbance
- Trial name
- NCT04638842
- Testing
- Online Intervention Grief COVID-19
- Where
- Mexico
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Universidad Internacional de Valencia
Treatment Resistant Depression, Major Depressive Disorder
Clinical Study of GH001 in Depression
The aim of the study is to investigate the safety of GH001 (containing 5-methoxy-dimethyltryptamine; 5-MeO-DMT), and to investigate its effects on severity of depressive symptoms, and its dose-related psychoactive effects in…
- Conditions
- Treatment Resistant Depression, Major Depressive Disorder, Depression
- Trial name
- NCT04698603
- Testing
- 5 Methoxy N,N Dimethyltryptamine
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- GH Research Ireland Limited
Major Depressive Disorder \(MDD, Depressive Disorder, Major
Electrical Vestibular Nerve Stimulation (VeNS) as a Treatment for Major Depressive Disorder (MDD)
Trial title: A Randomized, Double Blind Sham Controlled Clinical Trial to Evaluate the Efficacy of Electrical Vestibular Nerve Stimulation (VeNS), Compared to a Sham Control for Treatment of Major Depressive Disorder (MDD) …
- Trial name
- NCT06470035
- Testing
- Active VeNS Device
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 170 people
- Sponsor
- Neurovalens Ltd.
Advanced Cancer
Outcomes of Triaged Family Care in Advanced Cancer
The purpose of this study is to assess the quality of life of patients with advanced cancer and their family caregivers and to evaluate two doses of a family-based program of care versus control.
- Trial name
- FOCUS-Triage (NCT00709176)
- Testing
- Brief FOCUS Program, Extensive FOCUS Program
- Where
- 5 sites in United States
- Volunteers
- 484 people
- Sponsor
- University of Michigan
Insomnia, Suicidal Ideation
RCT of Brief CBT-I in Primary Care Veterans With Suicidal Thoughts
There is a strong association between insomnia and suicidal thoughts and behaviors. Insomnia also frequently co-occurs with other common conditions associated with suicide such as depression and posttraumatic stress disorder.
- Trial name
- NCT03603717
- Testing
- Cognitive Behavioral Therapy for Insomnia, Sleep Hygiene
- Where
- 3 sites in United States
- Volunteers
- 283 people
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder 1
Treatment of Major Depressive Disorder Post Stroke With Transcranial Direct Current Stimulation
Stroke is one of the main public health problems in America Latina. It can be associated with several neuropsychiatric complications, which include a broad spectrum of emotional distress and cognitive, results in important…
- Trial name
- NCT01525524
- Testing
- Transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- University of Sao Paulo
Chronic Pain
Mixed Reality-Based Rehabilitation Software for Chronic Secondary Musculoskeletal Pain
This study evaluated the efficacy and safety of a mixed reality-based chronic pain rehabilitation software (PK-MPT) for adults with chronic secondary musculoskeletal pain.
- Trial name
- NCT06936059
- Testing
- Mixed Reality based analgesic therapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Depression in Chronic Hepatitis C
Effects of Direct-acting Antiviral Agents on HCV Cognitive Function, and Depression in HCV Related Cirrhosis: A Prospective Clinical Trial
Minimal hepatic encephalopathy (MHE) is an important clinical variant of hepatic encephalopathy (HE), which occurs in up to 60-70% of patients with cirrhosis.
- Trial name
- NCT04330508
- Testing
- Depression and Cognitive Tests
- Where
- India
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Breast Cancer Female, Quality of Life
5-element Music Therapy on Patients With Breast Cancer
In this study, we observed the clinical effect of using music therapy of TCM to improve the status of liver depression in patients with postoperative breast cancer patients, Second we want to explore the efficacy and advantages…
- Conditions
- Breast Cancer Female, Quality of Life, Depression, Anxiety
- Trial name
- NCT04442035
- Testing
- 5-element music therapy
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Major Depressive Disorder With Excessive Daytime Sleepiness Symptoms
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
CLARITY (Clinical Assessment of Response in the Treatment of Depression with Daytime Sleepiness Using Solriamfetol) is a Phase 3, double-blind, placebo-controlled, multicenter randomized withdrawal trial in patients with major…
- Trial name
- CLARITY (NCT07484217)
- Testing
- Solriamfetol 150 MG
- Where
- 40 sites in United States
- Volunteers
- 508 people
- Sponsor
- Axsome Therapeutics, Inc.
Depressive Symptoms
Nurse-Led Interprofessional Mental Health Promotion Intervention for Older Home Care Clients
Objective: The objective of this study is to evaluate the feasibility, acceptability and effectiveness of a 6-month nurse-led, interprofessional mental health promotion intervention aimed at older home care clients with…
- Trial name
- NCT01407926
- Testing
- Nurse-Led Mental Health Promotion Intervention
- Where
- Canada
- Volunteers
- 142 people
- Sponsor
- McMaster University
Type 2 Diabetes Mellitus (T2DM), Health-related Quality of Life
Psychological Well-Being, Depression, and Health-Related Quality of Life in Adults With Type 2 Diabetes: A Cross-Sectional Study
This prospective cross-sectional observational study aims to explore the relationships among psychological well-being, depression, and quality of life in patients with type 2 diabetes attending the outpatient metabolic clinic at…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Health-related Quality of Life, Depressive Symptoms, Psychological Well-being
- Trial name
- PWDQ-T2D (NCT07241325)
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital
Major Depressive Disorder (MDD)
Predictors of Relapse in Major Depressive Disorder (PERFORM-D)
Major depressive disorder (MDD) is a common condition involving recurring periods of depression. One of the major challenges faced by people with MDD is that the episodes of depression tend to recur even after they are…
- Trial name
- PERFORM-D (NCT06746155)
- Where
- 9 sites in Canada
- Volunteers
- 252 people
- Sponsor
- Abraham Nunes
Depressive Disorder, Major Depression
A Study of SR58611A in the Prevention of Depression Relapse in Patients With Major Depressive Disorder
The purpose of the study is to assess whether treatment with SR58611A can prevent relapse of depressive symptoms in patients with major depressive disorder.
- Trial name
- CALYPSO (NCT00345098)
- Testing
- SR58611A
- Where
- 13 sites in Argentina, Bulgaria and 11 more
- Volunteers
- 704 people
- Sponsor
- Sanofi
Major Depressive Disorder
rTMS Study in Depression to Evaluate the Relationship Between Brain Plasticity and Clinical Outcome
Depression is a highly prevalent condition characterized by persistent low mood, energy, and activity that can affect one's thoughts, mood, behavior, and sense of well-being.
- Trial name
- NCT04032015
- Testing
- TMS
- Sponsor
- Stanford University
Seasonal Affective Disorder, Mood Disorders
Clinical Trials of Three Non-Drug Treatments for Winter Depression (SAD)
We are offering non-pharmacologic therapy for alleviation of symptoms associated with depressed mood that recurs annually in fall or winter.
- Conditions
- Seasonal Affective Disorder, Mood Disorders, Depression
- Trial name
- NCT00006517
- Testing
- bright light box, dawn simulator, high-output negative ion generator
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- New York State Psychiatric Institute
Depression - Major Depressive Disorder
A Megastudy of Single-Session Interventions for Depression
This project aims to learn if new kinds of digital single-session interventions (SSIs) for depression could be effective for American adults. Many existing SSIs are delivered in a simple text-based format.
- Trial name
- NCT06856668
- Testing
- Behavioral Activation (Action Brings Change Project 10-Minute Version), Mindful Acceptance, Moral Elevation
- Where
- United States
- Volunteers
- 7,505 people
- Sponsor
- Northwestern University
Major Depressive Disorder, Treatment Resistant Depression
Low-Intensity Focused Ultrasound for Treatment-Resistant Depression
The Investigators are proposing to demonstrate safety and efficacy of LIFUP for treatment resistant major depressive disorder in a ten-patient pilot study.
- Trial name
- NCT06013384
- Testing
- Low-Intensity Focused Ultrasound Pulsation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Medical University of South Carolina
Depressive Disorder
An Eight-Week Study Evaluating the Efficacy of Two Fixed Doses (250 mg Twice Daily and 100 mg Twice Daily) of SSR149415 in Patients With Major Depressive Disorder
The purpose of the study is to evaluate the efficacy of SSR149415 in the treatment of Major Depressive Disorder, defined as a change from baseline to visit 7 in the Hamilton Depression Rating Scale.
- Trial name
- LENA (NCT00361491)
- Testing
- SSR149415
- Where
- 7 sites in Argentina, Bulgaria and 5 more
- Volunteers
- 324 people
- Sponsor
- Sanofi
Psychological Well-being
Impact of Forest Baths on Emotional Well-being in People With Sub-clinical Symptomatology of Anxiety and Depression
The investigators intend to evaluate patients aged 18 to 99 years with symptoms of anxiety and/or mild depression. A randomized controlled clinical trial will be carried out to evaluate the impact of the guided practice of forest…
- Trial name
- NAT-UAB (NCT05827692)
- Testing
- Intervention group A
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Laura Comendador-Vazquez