Clinical trials: Clinical Deterioration
Surgery, Deterioration, Clinical
vHDU Phase 5: Impact of an Ambulatory Monitoring System on Deterioration Detection and Clinical Outcomes
Sometimes in hospital, it is not noticed that patients are becoming unwell quickly enough. This may mean that they are less likely to survive than if the worsening of their illness had been picked up sooner.
- Trial name
- vHDU phase 5 (NCT05118477)
- Testing
- Ambulatory monitoring system, Active alerting system
- Where
- United Kingdom
- Volunteers
- 240 people
- Sponsor
- University of Oxford
Escalation of Care, Cardiopulmonary Arrest
Early Warning System for Clinical Deterioration on General Hospital Wards
The goal is to develop a two-tiered monitoring system to improve the care of patients at risk for clinical deterioration on general hospital wards (GHWs) at Barnes-Jewish Hospital (BJH).
- Conditions
- Escalation of Care, Cardiopulmonary Arrest, Respiratory Arrest, Severe Sepsis
- Trial name
- NCT01280942
- Testing
- EWS Nursing Alerts, Wireless Remote Sensor
- Where
- United States
- Volunteers
- 20,031 people
- Sponsor
- Washington University School of Medicine
Clinical Deterioration, Hemodynamic Instability
Early Identification of Clinical Deterioration Using a Wearable Monitoring Device
This study aims to provide myriad of physiological parameters in patients admitted in an internal medicine department, and which are defined as being in an increased risk of clinical deterioration within the first 72-hours after…
- Trial name
- NCT04220359
- Testing
- non-invasive monitoring
- Where
- Israel
- Volunteers
- 410 people
- Sponsor
- Biobeat Technologies Ltd.
Clinical Reasoning in Nursing Education, Virtual Simulation
MAGICS - Multi-Agent Generative AI in Clinical Simulation for Clinical Deterioration Training
This study compares the effectiveness of a Generative AI-integrated blended simulation programme and high-fidelity simulation alone on nursing students' clinical reasoning and learning experience during deterioration training
- Conditions
- Clinical Reasoning in Nursing Education, Virtual Simulation, Artificial Intelligence in Education, Deterioration, Clinical
- Trial name
- MAGICS (NCT07872735)
- Testing
- Generative AI-integrated Blended Simulation, High Fidelity Simulation
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Mortality, Clinical Deterioration
EWSs and 28-Day Mortality in Geriatric ED Patients
This prospective observational cohort study evaluated the prognostic performance of commonly used early warning scores for predicting 28-day all-cause mortality among geriatric patients presenting to the emergency department with…
- Conditions
- Mortality, Clinical Deterioration, Geriatric Patients, Frailty
- Trial name
- EWSsGer (NCT07577349)
- Testing
- Demographic Characteristics, Comorbidities, Vital Signs
- Where
- Turkey (Türkiye)
- Volunteers
- 2,744 people
- Sponsor
- Haseki Training and Research Hospital
Clinical Deterioration
Predicting ICU Transfers and Other Unforeseen Events (PICTURE)-Pediatric
The purpose of this study is to evaluate the effectiveness and user satisfaction of the study teams early warning system, called PICTURE, which utilizes artificial intelligence (AI) techniques and algorithms to identify patient…
- Trial name
- NCT07304050
- Testing
- PICTURE-Pediatric scores and alerts, Control Arm - Scores and alerts hidden
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- University of Michigan
Simulation
Serious Game Versus Traditional Teaching to Improve Clinical Reasoning Skills
Detection of patient deterioration is a major healthcare problem. Indeed, acute clinical deterioration of the patient is often preceded by changes of several physiological parameters within 6 to 24h before the event occurs.
- Trial name
- NCT03428269
- Testing
- simulation by gaming (LabForGames Warning), traditional education
- Where
- 4 sites in France
- Volunteers
- 146 people
- Sponsor
- Université Paris-Sud
Physician Judgment
Understanding Physician Signout Risk Perception
The purpose of the study is to compare the ability of physicians and a statistical index (the Rothman score) to predict clinical deterioration over the next 24 hours.
- Trial name
- UPS (NCT02648828)
- Testing
- Clinical deterioration
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
In-hospital Deterioration, Intra Hospital Cardiac Arrest
Correlation Between Monitoring Frequency and Clinical Deterioration in Hospitalized Patients
Acute deterioration among hospitalised patient can result in serious adverse events like cardiac arrest, unexpected death or unanticipated intensive care unit (ICU) admission.
- Conditions
- In-hospital Deterioration, Intra Hospital Cardiac Arrest, Sudden Death
- Trial name
- NCT02180854
- Testing
- Control group, Increased monitoring frequency
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Bispebjerg Hospital
Clinical Deterioration
Clinical Deterioration Early Warning System Score
At present, there is no universal early warning system implemented in all Basque hospitals, but there are previous experiences, sometimes based on models generated in other health systems.
- Trial name
- CDEWS (NCT06499376)
- Where
- Spain
- Volunteers
- 20,000 people
- Sponsor
- Hospital Galdakao-Usansolo
Alert Fatigue, Health Personnel, Deterioration, Clinical
Automated Alerts of Patient Deterioration vs. Routine Monitoring of High-risk Patients Admitted to Medical Wards
The primary aim of the current study is to assess the effect of continuous wireless vital signs monitoring with generation of real-time alerts compared to blinded monitoring without alerts on the cumulative duration of any…
- Trial name
- WARD (NCT04661748)
- Testing
- real time alarm of deviating vital signs
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Cirrhosis
To Study and Compare the Clinical Course and Development of Organ Failure in Severe Acute Hepatitis Without Ascites, Non-cirrhotic and Cirrhotic Patients With Ascites [Acute on Chronic Liver Failure] and Acute Deterioration of Previously Decompensated Cirrhosis.
The study will be conducted on patients admitted to Department of Hepatology from MARCH 2015 to DECEMBER 2016 at ILBS, New Delhi.All patients presenting to ILBS fulfilling the inclusion criteria will be included in the study and…
- Trial name
- NCT02465619
- Where
- India
- Sponsor
- Institute of Liver and Biliary Sciences, India
Vital Sign Monitoring, Clinical Deterioration
Continuous and Wireless Vital Sign Monitoring in Patients at Home After Acute Medical Admission
The current study aims to investigate the feasibility of transmitting continuous and wireless vital sign data in real time from patients home to the hospital in patients discharged after an acute medical hospitalization
- Conditions
- Vital Sign Monitoring, Clinical Deterioration, Disease Progression, Disease Attributes
- Trial name
- WARD-HOME (NCT05536206)
- Testing
- Wireless and continuously monitoring
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Bispebjerg Hospital
Non-small Cell Lung Cancer, Remote Monitoring
ETERNALS: Remote Monitoring in Lung Cancer Patients
The primary objective of this project is to determine the feasibility of an integrated remote monitoring system in the routine care of lung cancer patients receiving cytotoxic chemotherapy.
- Conditions
- Non-small Cell Lung Cancer, Remote Monitoring, Mobile Health, Chemotherapy Effect
- Trial name
- ETERNALS (NCT06479005)
- Testing
- Oura Ring
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Ziekenhuis Oost-Limburg
Emergency Medicine
Development and Evaluation of a Patient Safety Model
Despite systems for early detection of critical illness, 12% of patients in the emergency department develop clinical deterioration with an increased risk of death as a result.
- Trial name
- NCT03457272
- Testing
- New risk assessment
- Where
- 4 sites in Denmark
- Volunteers
- 34,556 people
- Sponsor
- University of Aarhus
Early Warning Score, Risk Stratification
Individual Early Warning Score (I-EWS)
Early Warning Score (EWS) is a clinical scoring system used in hospitals in Denmark and internationally to systematically observe admitted patients using a standardised response algorithm.
- Trial name
- NCT03690128
- Testing
- I-EWS with incorporated clinical assessment (Trigger Tool), Standard EWS - Control (Trigger Tool)
- Where
- 8 sites in Denmark
- Volunteers
- 150,000 people
- Sponsor
- Herlev Hospital
Multiple Trauma, Polytrauma
Development and Internal Validation of a Multimodal Prediction Score for Early Hemodynamic Deterioration in Adult Polytrauma Patients
Severe traumatic injury involving multiple body regions (polytrauma) carries a high risk of rapid bleeding, tissue hypoperfusion, and circulatory collapse.
- Conditions
- Multiple Trauma, Polytrauma, Hemodynamic Instability, Traumatic Shock
- Trial name
- NCT07850427
- Volunteers
- 300 people
- Sponsor
- Assiut University
Clinical Deterioration
Clinical Outcomes After Implementation of COntinuous Vital Sign Monitoring On the General Ward.
In 2018, continuous monitoring (CM) of 5 vital signs with a wearable device, including automated MEWS calculation within the EMR were introduced on the surgical and internal medicine ward of our hospital.
- Trial name
- COCOMO (NCT04189653)
- Testing
- Continuous Monitoring
- Where
- Netherlands
- Volunteers
- 3,896 people
- Sponsor
- Radboud University Medical Center
SARS-CoV-2 Infection
Microvascular Injury and Distal Thrombosis in COVID-19
Investigators aimed to better understand the pathophysiology of SARS-CoV-2 pneumonia in non-critically ill hospitalized patients secondarily presenting with clinical deterioration and increase in oxygen requirement
- Trial name
- MIND (NCT04990505)
- Testing
- lung ventilation/perfusion scintigraphy
- Where
- Monaco
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Princesse Grace
COPD, COPD Exacerbation Acute
ProAir Digihaler in COPD Disease Management: A Real World Study
A pilot study to explore the utilization of the TEVA ProAir Digihaler rescue medication use and inhalation parameters to identify disease deterioration to help in the management of COPD patients in clinical practice.
- Trial name
- NCT04821869
- Testing
- ProAir Digihaler, Digihaler
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Pulmonary Research Institute of Southeast Michigan