Clinical trials: Clinical Disease and/or Syndrome
Chronic Obstructive Airway Disease
Pulmonary Disease in a Psychiatric Inpatient Population
Purpose: Patients with mental health disorders have a reduced life expectancy, compared to the general population. The shorter life expectancy is caused by natural and unnatural death.
- Trial name
- NCT01823627
- Testing
- Spirometry with reversibility test
- Where
- Denmark
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Psykiatrien Syd
Aortic Valve Insufficiency, Aortic Valve Stenosis
ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
The objective of this study is to establish the safety and effectiveness of the Edwards SAPIEN X4/X4S Transcatheter Heart Valve (THV) in subjects who are at high or greater risk with a failing aortic bioprosthetic valve.
- Trial name
- NCT05172973
- Testing
- SAPIEN X4/X4S THV
- Where
- 37 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- Edwards Lifesciences
Coronary Stenosis, Coronary Artery Disease
Diastolic Hyperemia-Free Ratio in Patients With CAD
The investigators aimed to identify the value of concordance between the diastolic hyperemia-free ratio (DFR) and fractional flow reserve (FFR) during pre-interventional and post-interventional period using a 0.014" COMET II…
- Trial name
- ICE-HEAT (NCT05421169)
- Testing
- diastolic hyperemia-free ratio (DFR)
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Venous Thromboembolism, Venous Thromboses
Risk Stratification for Venous Thromboembolism in Hospitalized Medical Patients
Hospital-acquired venous thromboembolism (HA-VTE) is one of the leading preventable causes of in-hospital mortality, but prevention of VTE in hospitalized medical patients remains challenging, as preventive measures such as…
- Conditions
- Venous Thromboembolism, Venous Thromboses, Pulmonary Embolism, Deep Vein Thrombosis
- Trial name
- RISE (NCT04439383)
- Where
- 3 sites in Switzerland
- Volunteers
- 1,353 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Parkinson Disease
Effect of Rasagiline on BIA 9-1067 Pharmacokinetics
The purpose of this study is to investigate the effect of rasagiline on BIA 9-1067 pharmacokinetics in healthy subjects.
- Trial name
- NCT01532141
- Testing
- BIA 9-1067, Rasagiline
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Essential Fatty Acid Deficiency (EFAD)
Pediatric Study to Evaluate Risk of Developing Essential Fatty Acid Deficiency When Receiving Clinolipid or Standard-of-Care Lipid Emulsion
This will be a descriptive study designed to evaluate the propensity for hospitalized pediatric patients treated adequately with Clinolipid or standard of care for up to 90 days to develop Essential Fatty Acid Deficiency (EFAD).
- Trial name
- NCT02476994
- Testing
- Clinolipid, Intralipid
- Where
- 4 sites in United States
- Volunteers
- 1 people
- Sponsor
- Baxter Healthcare Corporation
Cognitive Impairment, Long COVID
Addressing Cognitive Fog in Long-COVID-19 Patients
This study will assess two options to help patients better manage the cognitive fog and emotional distress that may be associated with having Long-COVID.
- Trial name
- NCT05597722
- Testing
- Digital cognitive behavioral intervention-RxWell, Amphetamine-Dextroamphetamine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Eva Szigethy
Critically Ill
Optimization of Nutritional Therapy in Mechanically Ventilated, Critically Ill Patients.
The aim of this study is to investigate whether an individualized determination of energy requirements using indirect calorimetry instead of a formula-based approach leads to an optimized nutritional support and as a consequence…
- Trial name
- ONCA (NCT03249051)
- Testing
- Indirect Calorimetry
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Hohenheim
Chronic Rhinosinusitis Without Nasal Polyps, Asthma
Adherence in Global Airways
There is a strong case for treating diseases of both the upper and lower airways (global airways) simultaneously because they share the same inflammatory mechanisms.
- Conditions
- Chronic Rhinosinusitis Without Nasal Polyps, Asthma, Chronic Rhinosinusitis With Nasal Polyps, Chronic Rhinosinusitis (Diagnosis)
- Trial name
- AIR2022 (NCT05553951)
- Testing
- Controlgroup, Intervention
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Christiane Haase
Rheumatoid Arthritis
A Study of the Safety of Rituximab in Combination With Other Anti-Rheumatic Drugs in Subjects With Active Rheumatoid Arthritis
This is a Phase III, open-label study of a total of approximately 560 subjects with active rheumatoid arthritis (RA) who have had an inadequate response to one or more disease-modifying anti-rheumatic drugs (DMARDs).
- Trial name
- SUNDIAL (NCT00443651)
- Testing
- Rituximab, Anti-inflammatory drugs
- Volunteers
- 578 people
- Sponsor
- Genentech, Inc.
Chronic Lymphocytic Leukemia
Ofatumumab as Part of Reduced Intensity Conditioning (RIC) Regimen for Patients With High Risk Chronic Lymphocytic Leukemia (CLL) Undergoing Allogeneic Hematopoietic Cell Transplantation
A good proportion of patients with chronic lymphocytic leukemia (CLL) can be managed effectively with palliative chemotherapy. However, there is a group of younger patients with poor risk disease whose life expectancy is…
- Trial name
- NCT01455051
- Testing
- Ofatumumab
- Where
- 9 sites in Spain
- Volunteers
- 25 people
- Sponsor
- Grupo Espanol de trasplantes hematopoyeticos y terapia celular
Aortic Valve Stenosis
Targeting Pulsatile Load to Increase Exercise Capacity and Quality of Life After Aortic Valve Replacement for Severe Aortic Stenosis (PULSE AS)
The current trial is designed to assess the safety and efficacy of sustained oral administration of inorganic nitrate in patients with severe aortic stenosis and to assess the mechanisms by which inorganic nitrate enhances oxygen…
- Trial name
- PULSE-AS (NCT03483051)
- Testing
- Potassium Nitrate, Potassium Chloride
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pennsylvania
Spinocerebellar Ataxia
Measuring Neurological Impairment and Functional Visual Assessment In Spinocerebellar Ataxias
Measuring the various difficulties patients with spinocerebellar ataxias (SCA) report in an accurate manner is important to be able to test any therapy that may be developed.
- Trial name
- NCT00654251
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Mississippi Medical Center
Bypass Complication, Cardioplegia Solution Adverse Reaction
Investigation of Myocardial Protection Level With Specific Cardioplegia Methods in Cardiac Surgery
Investigating the myocardial effects of cold blood cardioplegia and del nido cardioplegia solution, which are routinely used in clinical practice, will contribute to the studies in the literature on the safety and efficacy of…
- Conditions
- Bypass Complication, Cardioplegia Solution Adverse Reaction, Endothelial Degeneration, Oxidative Stress
- Trial name
- NCT05603429
- Testing
- Endocan, E-Selectin, TNF-alpha, Total Oxidant and Antioxidant Status
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital
Osteoarthritis
R3® Acetabular System in Patients With Degenerative Hip Disease
This is a prospective, non-randomized, consecutive series, multicenter clinical study that will include patients who will have total hip replacement with the R3 Acetabular System.
- Trial name
- NCT01407029
- Where
- 8 sites in United States, Canada
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Smith & Nephew, Inc.
Left Ventricular Hypertrophy, Hypertension
Response of the Myocardium to Hypertrophic Conditions in the Adult Population
Hypertension and aortic stenosis are the two leading conditions that cause thickening of the heart muscles (left ventricular hypertrophy). Left ventricular hypertrophy is initially adaptive to maintain optimal heart function.
- Conditions
- Left Ventricular Hypertrophy, Hypertension, Myocardial Fibrosis
- Trial name
- NCT02670031
- Testing
- Cardiovascular Magnetic Resonance, Echocardiogram, Electrocardiogram
- Where
- Singapore
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Chronic Liver Disease
VIATORR Device Registry
The primary objective is to confirm the clinical performance and safety of the GORE® VIATORR® TIPS (Transjugular Intrahepatic Portosystemic Shunt) Endoprosthesis with Controlled Expansion throughout the device functional lifetime…
- Trial name
- NCT05661331
- Testing
- Transjugular intrahepatic portosystemic shunt
- Where
- 7 sites in Austria, France and 3 more
- Volunteers
- 196 people
- Sponsor
- W.L.Gore & Associates
Intermittent Claudication, Peripheral Arterial Disease
Effect of Exercise on Patients With Claudication Undergoing Surgery
Title: How does exercise improve the calf muscle in patients with poor blood supply to their leg? Purpose of the project: Patients with peripheral arterial disease have a poor blood supply to their lower leg.
- Trial name
- NCT01980602
- Testing
- Supervised Exercise program
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Hull
Respiratory Tract; Infection, Upper (Acute), Colonization, Asymptomatic
Studying Respiratory Infections and Colonisation in Children Using Daily Minimally-invasive Nasal Sampling
Rationale: Respiratory tract infections (RTI) are a major cause of morbidity in young children in high- income countries and the major cause of mortality in developing countries.
- Trial name
- SAMSAM (NCT06049537)
- Where
- Netherlands
- Volunteers
- 46 people
- Sponsor
- Leiden University Medical Center
Gastroesophageal Reflux Disease (GERD), Gastroesophageal Reflux (GER)
Development of Machine Learning Models to Predict Postoperative GERD Symptom Resolution After Laparoscopic Nissen Fundoplication
This study aims to develop machine learning models to predict postoperative gastroesophageal reflux symptom resolution after laparoscopic Nissen fundoplication using Elastic Net regression and synthetic minority oversampling…
- Trial name
- NCT06862037
- Testing
- Laparoscopic Nissen fundoplication
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Korea University Anam Hospital
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