Clinical trials: Clinical Disease and/or Syndrome
Acute Lymphoblastic Leukemia, in Relapse, Chemotherapeutic Toxicity
Efficacy of the Use of Bortezomib for the Treatment of Relapsed Leukemia or Positive MRD
Various drugs have been added to different treatment regimens in order to improve the response rate in patients with Acute Lymphoblastic Leukemia, however, it has been shown that adding Bortezomib to the relapsing regimen…
- Conditions
- Acute Lymphoblastic Leukemia, in Relapse, Chemotherapeutic Toxicity, Minimal Residual Disease
- Trial name
- NCT05137860
- Testing
- Bortezomib
- Where
- Mexico
- Volunteers
- 56 people
- Sponsor
- Hospital General de Mexico
Parkinson's Disease
Tango for Treatment of Motor and Non-motor Manifestations in Parkinson's Disease.
Parkinson's disease involves many motor difficulties as well as non-motor ones. Recent research has strongly suggested that exercise is very important for Parkinson's disease.
- Trial name
- NCT01573260
- Testing
- Argentinean Tango classes, Simple pamphlet about the exercise in PD
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Bladder Cancer
Xpert Bladder Cancer Monitor; Prospective, Single, Tertiary-care Center Implementation Study
The primary objective of this prospective, single-centre study is to establish the clinical performance characteristics of Xpert Bladder Cancer Monitor on the GeneXpert Instrument Systems in comparison to the methods currently…
- Trial name
- NCT03715660
- Testing
- Xpert bladder cancer monitor
- Where
- Egypt
- Volunteers
- 198 people
- Sponsor
- Mansoura University
Leukemia, Leukemia, B-Cell, Chronic
Treatment of B-CLL With Human IL-2 and CD40 Ligand and Plasmid Gene Modified Autologous Tumor Cells
This study is for patients that have chronic lymphocytic leukemia (CLL). This research study aims to determine the safety and dosage of special cells that may make the patients own immune system fight the cancer.
- Trial name
- CLIPA (NCT00078520)
- Testing
- Dose Level 1, Dose Level 2, Dose Level 2- Fixed Dose
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Baylor College of Medicine
Mild Cognitive Impairment (MCI), Mild Alzheimer Disease
iTBS in MCI and Mild AD
This study aims to examine the effects of iTBS on cognitive function in individuals with MCI or mild AD, with a secondary objective of exploring prefrontal TBS mechanisms for cognitive function and the effect of iTBS on BDNF.
- Trial name
- NCT06670820
- Testing
- Active rTMS
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Defense Medical Center, Taiwan
Inflammatory Bowel Diseases, Crohns Disease
A Study on Administration Choices of Vedolizumab and Outcomes for Adults With Inflammatory Bowel Disease (IBD) (VARIETY - CROATIA AND SLOVENIA)
Inflammatory bowel disease consists of either ulcerative colitis (UC) or Crohn's disease (CD). The main aim of this study is to describe real-world treatment patterns in adults with moderate to severe ulcerative colitis or…
- Conditions
- Inflammatory Bowel Diseases, Crohns Disease, Colitis, Ulcerative
- Trial name
- NCT04885920
- Where
- 8 sites in Croatia, Slovenia
- Volunteers
- 120 people
- Sponsor
- Takeda
Parkinson Disease(PD)
Effects of Dance on the Turning Characteristics of Patients With Parkinson's Disease
The proposed control intervention trial, aims to analyse the effects of Dance in the turning characteristics in patients with Parkinson Disease (PD) using three- dimensional (3D) analysis during the timed up and go (TUG) test.
- Trial name
- NCT05113524
- Testing
- Dance, No intervention
- Where
- 2 sites in Brazil, United Kingdom
- Volunteers
- 15 people
- Sponsor
- Federal University of Rio Grande do Sul
Advanced Breast Cancer
A Study to Learn About a New Medicine Called Vepdegestrant (ARV-471, PF-07850327) in People Who Have Advanced Metastatic Breast Cancer
A study to learn about a new medicine called ARV-471 (PF-07850327) in people who have advanced metastatic breast cancer.
- Trial name
- VERITAC-2 (NCT05654623)
- Testing
- ARV-471, Fulvestrant
- Where
- 312 sites in United States, Argentina and 29 more
- Volunteers
- 624 people
- Sponsor
- Pfizer
Multiple Sclerosis (MS) - Relapsing-remitting
Monthly Monitoring of Plasma NfL in Treated Relapsing-remitting Multiple Sclerosis to Detect Persistent Infraclinical Disease Activity
Reference MRI scan is recommended 6 months after treatment onset in patients with multiple sclerosis (MS), and follow-up scans at 12 months later to monitor subclinical activity.
- Trial name
- MoMo-NfL (NCT07292480)
- Testing
- Monthly pNfL monitoring
- Where
- 6 sites in France
- Volunteers
- 84 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Gall Bladder Cancer, Intrahepatic Cholangiocarcinoma (Icc)
A Cell-free DNA Methylation Blood-Based Test for Biliary Tract Cancers Screening
Biliary tract carcinoma (BTC), including gallbladder cancer, intrahepatic cholangiocarcinoma, and extrahepatic cholangiocarcinoma, ranks sixth in incidence among gastrointestinal malignancies and tenth in cancer-related mortality…
- Conditions
- Gall Bladder Cancer, Intrahepatic Cholangiocarcinoma (Icc), Extrahepatic Cholangiocarcinoma, Hilar Cholangiocarcinoma
- Trial name
- NCT07176962
- Where
- China
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Yingbin Liu, MD, PhD, FACS
ARTERIAL OCCLUSIVE DISEASE
Experimental Study of the Vascular Prosthesis Manufactured by Electrospinning
The purpose of this study is to determine whether the Vascular prosthesis manufactured by Electrospinning is safe with respect to the development of thrombosis.
- Trial name
- NCT02255188
- Testing
- blood sampling procedure
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Pulmonary Fibrosis, Interstitial Lung Disease (ILD)
This is a Trial Designed to Evaluate the Combination of Nerandomilast With Mycophenolate Across a Wide Variety of Pulmonary Fibrosis Subtypes, With the Aim of Providing Clinicians With Assurance That This is an Appropriate Therapeutic Combination.
This is a trial designed to evaluate the combination of nerandomilast with mycophenolate across a wide variety of pulmonary fibrosis subtypes, with the aim of providing clinicians with assurance that this is an appropriate…
- Trial name
- NERAM-PF (NCT07570888)
- Testing
- Nerandomilast 18 mg - adult formulation
- Volunteers
- 120 people
- Sponsor
- University of British Columbia
Thoracic Outlet Syndrome
Electromyography in Thoracic Outlet Syndrome
Record the ENMG data carried out systematically in patients treated by rehabilitation for thoracic outlet syndrome in order to assess their characteristics and judge the relevance of these data in the context of the diagnosis and…
- Trial name
- ENMG-AFC (NCT05360303)
- Where
- France
- Volunteers
- 67 people
- Sponsor
- Nantes University Hospital
Parkinson Disease, Balance
Effects of Exer Gaming on Balance and Gait in Parkinson's Patients
To compare the effects of exer-gaming with conventional physiotherapy on balance and gait in Parkinson's patients
- Trial name
- NCT05043727
- Testing
- Exer gaming, conventional treatment plan
- Where
- Pakistan
- Volunteers
- 16 people
- Sponsor
- Riphah International University
Early Stage Non-small Cell Lung Cancer
Camrelizumab With Chemotherapy in Adults With Medically Inoperable Early Stage NSCLC
The purpose of this study is to assess the efficacy and safety of Camrelizumab plus chemotherapy in the treatment of adult participants with medically inoperable Stage I or IIA non-small cell lung cancer (NSCLC).
- Trial name
- NCT04530227
- Testing
- Biological: Camrelizumab, Pemetrexed, Nab-paclitaxel
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Chronic Kidney Disease
Effect of Growth Hormone on Leptin, Cytokines and Body Composition of Children With Growth Failure Due to Chronic Kidney Disease
Circulating concentrations of cytokines, such as leptin, tumor necrosis factor-alpha and interleukins 1 and 6 are increased in patients with chronic kidney disease (CKD).
- Trial name
- NCT00194961
- Testing
- Recombinant Human Growth Hormone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Weill Medical College of Cornell University
Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
Rotating Frame Relaxation Imaging in Patients With Multiple Sclerosis
The aim of this study is to develop novel magnetic resonance imaging (MRI) protocols suitable for patients with multiple sclerosis using advanced MRI such as rotating frame relaxation imaging.
- Conditions
- Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Chronic Progressive
- Trial name
- ROMUS (NCT02403570)
- Testing
- Brain MRI
- Where
- Finland
- Volunteers
- 21 people
- Sponsor
- Turku University Hospital
Pulmonary Disease, Postoperative Complications
Hyperinflation Respiratory Therapies in Cardiac Surgery Patients
The purpose of this prospective randomized clinical trial is to evaluate three different types of hyperinflation respiratory therapies, Intermittent Positive Pressure Breathing (IPPB), Intermittent positive end expiratory…
- Trial name
- NCT04164173
- Testing
- EzPAP, Metaneb, Intermittent Positive Pressure Breathing (IPPB)
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Kidney Disease Requiring Chronic Dialysis, Sarcopenic Obesity
Oral Nutritional Supplement Intervention Among Hemodialysis Patients With Sarcopenic Obesity
Chronic kidney disease patients with sarcopenic obesity are noted to have impairment in physical performance and reducing their quality of life, and the investigators also founded these patients are at higher risk of mortality.
- Conditions
- Chronic Kidney Disease Requiring Chronic Dialysis, Sarcopenic Obesity, Body Composition
- Trial name
- NCT03347773
- Testing
- ReGen 18%
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Knee Osteoarthritis
Effect of an Information- and Self-management App for People With Knee Osteoarthritis
The primary aim of the trial is to assess if an information- and self-management app provided in the period between referral and consultation in specialist healthcare can improve knowledge about osteoarthritis and decision…
- Trial name
- OA-AID (NCT07603973)
- Testing
- Information- and self-management app, Control
- Where
- Norway
- Volunteers
- 204 people
- Sponsor
- Diakonhjemmet Hospital
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