Clinical trials: Clinical Efficacy
Contraception
The Safety and Effectiveness of the Essure (Model ESS505) Device to Prevent Pregnancy in Women
To evaluate the safety and long-term (approximately one year) effectiveness of the Essure System for Permanent Birth Control ESS505 device in preventing pregnancy.
- Trial name
- NCT01861886
- Testing
- ESS505 (BAY1454033)
- Where
- 5 sites in Netherlands, Spain
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Bayer
Vulvovaginal Candidiasis (VVC)
ProF-001_Phase IIa
This is a multi-center, randomized, prospective, active-controlled, double-blind, dose-escalation study comparing dose response of clinical efficacy, safety, local tolerability of three different doses of ProF-001/Candiplus®…
- Trial name
- NCT03115073
- Testing
- Candiplus, Clotrimazole
- Where
- 3 sites in Austria
- Volunteers
- 84 people
- Sponsor
- ProFem GmbH
Heart Failure
Efficacy and Safety of Jia Shen Tablets in Chronic Heart Failure
Evaluate the efficacy and safety of Jia Shen Tablets in patients with Chronic Heart Failure.
- Trial name
- NCT06669169
- Testing
- Low dose Jia Shen Tablet, High dose Jia Shen Tablet
- Where
- China
- Volunteers
- 288 people
- Sponsor
- Tasly Pharmaceutical Group Co., Ltd
Heart Failure, Heart Failure With Reduced Ejection Fraction
Effectiveness of CRD-740 in Heart Failure
This is a study evaluating the effectiveness of CRD-740 in patients with either Heart Failure with Reduced Ejection Fraction (HFrEF) or Heart Failure with Preserved Ejection Fraction (HFpEF) after 12 weeks of treatment.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction, Cardiovascular Diseases
- Trial name
- CARDINAL-HF (NCT05409183)
- Testing
- CRD-740
- Where
- 34 sites in United States, Canada and 2 more
- Volunteers
- 60 people
- Sponsor
- Cardurion Pharmaceuticals, Inc.
Gingivitis, Plaque
A Twelve Week Study of Experimental Mouth Rinses
The purpose of this study is to evaluate the safety and efficacy of experimental mouth rinse formulations compared to a hydroalcohol control mouth rinse and a positive control mouth rinse for the reduction of gingivitis and…
- Trial name
- NCT05120141
- Testing
- Colgate Cavity Protection Toothpaste, American Dental Association (ADA) Ref Toothbrush, Prototype 1 Mouth Rinse
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Rotator Cuff Tear
BioWick SureLock Clinical Outcomes Study
The purpose of this study is to collect postmarket data in subjects who receive surgical treatment of a full-thickness rotator cuff tear (of at least 1.5 cm) with the BioWick™ SureLock™ implant.
- Trial name
- NCT03199391
- Testing
- BioWick SureLock Implant
- Where
- 7 sites in United States
- Volunteers
- 71 people
- Sponsor
- Zimmer Biomet
Cervical Spine Disease, Pain, Postoperative
Clinical Study on the Safety and Efficacy of the Minimally Invasive Ennovate® Method for Pedicle Screw Placement
The study's main purpose is the collection of clinical data on the patients benefit and safety of pedicle screw placement through an innovative minimally invasive surgical approach compared to the state of the art open surgical…
- Trial name
- MISPEC (NCT06960018)
- Testing
- Ennovate® Cervical, open surgical technique, Ennovate® Cervical, minimal invasive surgical technique
- Where
- 3 sites in Germany
- Volunteers
- 76 people
- Sponsor
- Aesculap AG
Acute Respiratory Viral Infection
Clinical Trial of the Efficacy and Safety of Raphamin in the Treatment of ARVI in Children Aged 3-12 Years
Multicenter double-blind placebo-controlled randomized in parallel groups clinical trial.
- Trial name
- NCT06715891
- Testing
- Raphamin
- Where
- 35 sites in Russia
- Volunteers
- 374 people
- Sponsor
- Materia Medica Holding
Plaque
Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis.
To evaluate the efficacy of a stannous fluoride toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis.
- Trial name
- NCT07398846
- Testing
- 0.454%Stannous fluoride toothpaste, 0.075% Cetylpyridinium Chloride (CPC) and 0.28% zinc lactatmouthwashe, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Diabetic Neuropathies
Cytoflavin in the Treatment of Patients With Diabetic Polyneuropathy
One of the most common complications of diabetes mellitus is diabetic polyneuropathy, which leads to disability and reduces quality of life.
- Trial name
- CYLINDER (NCT04649203)
- Testing
- Cytoflavin (Inosine + Nicotinamide + Riboflavin + Succinic Acid)
- Where
- 16 sites in Russia
- Volunteers
- 216 people
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company
Type 1 Diabetes Mellitus
A Study of the Safety and Efficacy of MK-1293 Compared to Lantus™ in Participants With Type 1 Diabetes Mellitus (T1DM) (MK-1293-003)
The purpose of this study is to compare the safety and efficacy of MK-1293 to Lantus™ in participants with T1DM. The primary hypothesis is that after 24 weeks, the mean change in hemoglobin A1c (A1C) from baseline is non-inferior…
- Trial name
- NCT02059161
- Testing
- MK-1293, Lantus™, Prandial Insulin
- Volunteers
- 508 people
- Sponsor
- Merck Sharp & Dohme LLC
Primary Biliary Cholangitis (PBC)
A Long-Term Study of Elafibranor in Adult Participants With Primary Biliary Cholangitis
The participants of this study will have confirmed Primary Biliary Cholangitis (PBC) and cirrhosis (scarring of the liver). PBC is a slowly progressive disease, characterised by damage to the bile ducts in the liver, leading to a…
- Trial name
- ELFIDENCE (NCT06016842)
- Testing
- Elafibranor
- Where
- 198 sites in United States, Argentina and 26 more
- Volunteers
- 276 people
- Sponsor
- Ipsen
Neuroendocrine Tumors
Phase III Study of Surufatinib in Treating Advanced Extrapancreatic Neuroendocrine Tumors
A randomized, double-blind, placebo controlled, multi-center Phase III study to assess the efficacy of Surufatinib 300 mg once a day in treating advanced extrapancreatic neuroendocrine tumors.
- Trial name
- NCT02588170
- Testing
- Surufatinib
- Where
- 5 sites in China
- Volunteers
- 219 people
- Sponsor
- Hutchison Medipharma Limited
Primary Hypercholesterolemia or Mixed Hyperlipidemia
QLC7401 Monotherapy in Non-familial Hypercholesterolemia or Mixed Dyslipidemia
This Phase III clinical trial aims to assess the efficacy and safety of QLC7401 monotherapy in adults with non-familial primary hypercholesterolemia or mixed dyslipidemia who are not receiving lipid-lowering therapy.
- Trial name
- NCT07444086
- Testing
- QLC7401
- Volunteers
- 510 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Primary Open-angle Glaucoma, Ocular Hypertension
Levobetaxolol Hydrochloride Eye Drops for Treatment of Primary Open-angle Glaucoma or Ocular Hypertension
To evaluate the safety and efficacy of Levobetaxolol in Chinese patients with glaucoma.
- Trial name
- NCT02617459
- Testing
- Levobetaxolol eye drops, Betaxolol eye drops
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Hypercholesterolemia
Ezetimibe (EZ)/Atorvastatin (Ator) (MK-0653C) vs. Ator in Chinese Hypercholesterolemic Participants (MK-0653C-439)
This study will evaluate the EZ/Ator fixed-dose combination (FDC) tablet (MK-0653C) as second line Low-Density Lipoprotein - Cholesterol (LDL-C) treatment in Chinese participants.
- Trial name
- NCT03768427
- Testing
- EZ 10 mg/Ator 10 mg, EZ 10 mg/Ator 20 mg, Atorvastatin
- Where
- 30 sites in China
- Volunteers
- 454 people
- Sponsor
- Organon and Co
Knee Osteoarthritis
Assessment of Efficacy of a Single Intra-articular Injection of HYALUBRIX 60 in Knee Osteoarthritis
The purpose of this study is to evaluate the effect of one single intra-articular (IA) injection of HYALUBRIX 60® plus physical exercise program (PEP) in terms of pain reduction, compared to PEP alone, in patients with knee…
- Trial name
- NCT06113783
- Testing
- HYALUBRIX 60
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Asthma
Safety and Efficacy of YHD001 in Asthma
The main objective is to evaluate the safety/tolerability and efficacy of YHD001 compared to singulair or placebo in patients (n=96) with partially controlled asthma.
- Trial name
- NCT01424124
- Testing
- YHD001 dose level 1, YHD001 dose level 2, Singulair
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Yuhan Corporation
Acute Sinusitis
Safety and Efficacy of Cefecin Tab. in Patients With Acute Sinusitis
This is a multi-center, double-blind, randomized, active controlled, parallel group phase 4 clinical trial to re-confirm the efficacy and safety of cefetamet pivoxil formulation in sinusitis patients
- Trial name
- CASIS (NCT04664803)
- Testing
- Cefecin Tab., Omnicef Cap.
- Volunteers
- 284 people
- Sponsor
- Korea United Pharm. Inc.
Solid Tumors Harboring NTRK Fusion
A Study Called VICTORIA to Learn More About How Well Larotrectinib Works in Adults With TRK Fusion-positive Cancer by Comparing Larotrectinib Data From Clinical Studies With Data of Other Treatments From Actual Practice
This is an observational study in which patient data from the past of adult people with solid tumors harboring NTRK gene fusion are studied.
- Trial name
- NCT05192642
- Testing
- Larotrectinib(Vitrakvi, BAY2757556), Data on other treatments
- Where
- United States
- Volunteers
- 368 people
- Sponsor
- Bayer
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