Clinical trials: Clinical Efficacy
UTI - Lower Urinary Tract Infection, Antibiotic Resistant Infection
Efficacy of Ciprofloxacin for the Treatment of Uncomplicated Urinary Tract Infection (uUTI)
This is a prospective, Phase 4, open label, multi-center study of the clinical and microbiologic efficacy of ciprofloxacin for the treatment of uncomplicated urinary tract infections in adult women.
- Trial name
- NCT03366207
- Testing
- Ciprofloxacin
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Iterum Therapeutics, International Limited
Back Pain
Safety and Efficacy of the TransDiscal System Versus Medical Management in Treating Chronic Discogenic Low Back Pain
The primary objective of this randomized controlled trial is to evaluate the safety and efficacy of the TransDiscal System (TDS) in treating discogenic pain of the lumbar spine using a modified disc biacuplasty procedure.
- Trial name
- COLD (NCT01263054)
- Testing
- TransDiscal System, Medical Management
- Where
- 9 sites in United States
- Volunteers
- 67 people
- Sponsor
- Halyard Health
Acute Spinal Cord Injury (SCI)
Phase 1b/2a Clinical Trial to Determine the Safety, Tolerability and Efficacy of TZ-161 in Spinal Cord Injury
Technophage identified a promising compound, Eletriptan hydrobromide, that intends to use as a repurposed drug, for the treatment of acute spinal cord injury (SCI) in human subjects.
- Trial name
- eSpine (NCT06677229)
- Testing
- Eletriptan HBr 40 mg
- Where
- 2 sites in Spain
- Volunteers
- 28 people
- Sponsor
- Technophage, SA
Antibiotic-associated Diarrhea
Efficacy and Safety of Sinquanon for Prevention of Antibiotic-associated Diarrhea in Adults
The purpose of this study is to evaluate the efficacy of a probiotic, SINQUANON, on the reduction of the occurrence of diarrhea associated with antibiotic use in adults.
- Trial name
- SPAADA (NCT05607056)
- Testing
- Sinquanon
- Where
- 3 sites in Bulgaria
- Volunteers
- 565 people
- Sponsor
- Neopharm Bulgaria Ltd.
Advanced Malignancies
A Study of SHR-1501 Combined With SHR-1316 in Patients With Advanced Tumors
The purpose of this study is to evaluate the safety and tolerability of SHR-1501 in combination with SHR-1316 in patients with advanced malignancies and to provide a recommended dose (RP2D) for subsequent clinical studies.
- Trial name
- NCT03995472
- Testing
- SHR-1501, SHR-1316
- Where
- 5 sites in Australia, China
- Volunteers
- 14 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Hypertension, Resistant to Conventional Therapy, Atrioventricular Block
Moderato System in Patients With Hypertension
The purpose of this double blind randomized study is the evaluation of the safety and efficacy of the Moderato System. The Moderato implantable pulse generator is indicated for patients who have hypertension and also require a…
- Trial name
- NCT03757377
- Testing
- BackBeat Moderato System, BackBeat Moderato Sytsem
- Where
- 4 sites in Belgium, Lithuania and 1 more
- Volunteers
- 203 people
- Sponsor
- BackBeat Medical Inc
Alzheimer's Disease, Dementia
A Study Of Oral PF-01913539 In Patients With Mild To Moderate Alzheimer's Disease
The purpose of this study is to demonstrate the safety and efficacy of PF-01913539 in the treatment of patients with mild-to-moderate Alzheimer's Disease.
- Conditions
- Alzheimer's Disease, Dementia, Dimebon, Investigational Drug
- Trial name
- NCT01066481
- Testing
- PF-01913539 5 mg
- Sponsor
- Pfizer
Excess Abdominal Fat
UltraShape Power for Abdominal Fat and Circumference Reduction
Prospective, one arm, baseline-controlled, clinical study for the evaluation of the UltraShape Power treatment using the U-Sculpt Power Transducer for non-invasive abdominal fat and circumference reduction.
- Trial name
- NCT02748928
- Testing
- UltraShape Power
- Where
- 8 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Syneron Medical
Dry Eye Syndromes, Dry Eye Disease
Efficacy and Safety Evaluation of Tavilermide Ophthalmic Solution for the Treatment of Dry Eye
The purpose of the study is to compare the efficacy and safety of 5% tavilermide ophthalmic solution to placebo for the treatment of the signs and symptoms of dry eye disease.
- Conditions
- Dry Eye Syndromes, Dry Eye Disease, Kerato Conjunctivitis Sicca
- Trial name
- NCT05848128
- Testing
- 5% Tavilermide ophthalmic solution, Vehicle ophthalmic solution
- Where
- 29 sites in United States
- Volunteers
- 642 people
- Sponsor
- Mimetogen Pharmaceuticals USA, Inc.
Benign Prostatic Hyperplasia, Benign Prostatic Hyperplasia With Lower Urinary Tract Symptoms
A Phase III Clinical Study of H077 Sustained-Release Tablets Compared With Silodosin Capsules in the Treatment of Benign Prostatic Hyperplasia
This is a randomized, double-blind, controlled, non-inferiority multicenter Phase III clinical study to evaluate the efficacy and safety of H077 sustained-release tablets versus silodosin capsules in treating benign prostatic…
- Trial name
- NCT07146386
- Testing
- H077 sustained-release tablet, Silodosin capsules Control Group
- Where
- 66 sites in China
- Volunteers
- 728 people
- Sponsor
- Shanghai Huilun Pharmaceutical Co., Ltd.
Atopic Dermatitis
A Phase I Clinical Study to Evaluate SM17 in Chinese Healthy Subjects and Patients With Moderate to Severe Atopic Dermatitis
This trial is a phase 1, randomized, double-blind, placebo-controlled trial conducted in Chinese Healthy Volunteers and Patients with moderate-to-severe Atopic Dermatitis It aims to evaluate the safety, tolerability…
- Trial name
- NCT07103369
- Testing
- SM17 for injection
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- SinoMab BioScience Ltd
Psoriasis
A Study of Guselkumab Given After Ustekinumab in Participants With Moderate to Severe Psoriasis in Routine Clinical Practice
The main purpose of this study is to describe how well Guselkumab works after switching from Ustekinumab in participants with moderate to severe psoriasis in a routine clinical setting.
- Trial name
- G-START (NCT07746583)
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Janssen-Cilag Kft.
Influenza
Study to Assess the Tolerability, Safety and Efficacy of GP681 Powder for Oral Suspension
This study aims to evaluate the tolerability, safety, pharmacokinetic characteristics and efficacy of a single oral dose of GP681 powder for oral suspension in pediatric and adolescent patients with uncomplicated influenza.
- Trial name
- NCT06643156
- Testing
- GP681 10mg/20mg/40mg
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Jiangxi Qingfeng Pharmaceutical Co. Ltd.
Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
Study to Evaluate the Pharmacokinetic Characteristics, Safety, Tolerability, and Preliminary Efficacy of 9MW1911 in Patients With Chronic Obstructive Pulmonary Disease (COPD).
The study will evaluate the pharmacokinetic characteristics, safety, tolerability, and preliminary efficacy of 9MW1911 in combination with standard of care COPD maintenance therapy in patients with moderate to severe COPD.
- Trial name
- NCT06175351
- Testing
- 9MW1911
- Where
- 22 sites in China
- Volunteers
- 80 people
- Sponsor
- Mabwell (Shanghai) Bioscience Co., Ltd.
Work Related Stress, Sense of Coherence
An Evaluation Study to Identify the Effectiveness of Clinical Supervision With Regards to Work-related Strain, Sense of Coherence, Increased Cultural Sensitivity and the Impact on Patient's Care: A Prospective Longitudinal Study in Mental Health Services in Qatar
Clinical supervision (CS) is a pragmatic approach, which enables nurses to work together; it can create a positive nursing environment, reduce stress, and increase clinical skills through peer support.
- Conditions
- Work Related Stress, Sense of Coherence, Cultural Sensitivity, Clinical Supervision
- Trial name
- NCT04196751
- Testing
- Clinical Supervision
- Where
- Qatar
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Dermal Filler, Hyaluronic Acid
Evaluate the Safety and Effectiveness of Sodium Hyaluronate When Used for the Correction of Nasolabial Folds
The aim of this study is to evaluate the safety and effectiveness of pain relief of modified sodium hyaluronate gel for injection when used for the correction of moderate or severe nasolabial folds.
- Conditions
- Dermal Filler, Hyaluronic Acid, Lidocaine, Nasolabial Fold
- Trial name
- NCT04569045
- Testing
- HA+Lidocaine, HA
- Where
- 2 sites in China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- SciVision Biotech Inc.
Hot Flashes
Phase 2 Study of SJX-653 in Postmenopausal Women With Moderate to Severe Vasomotor Symptoms
This study evaluates the efficacy, safety, tolerability, and pharmacokinetics of once daily SJX-653 in postmenopausal women with moderate to severe VMS.
- Trial name
- NCT04278872
- Testing
- SJX-653
- Where
- 22 sites in Belgium, Germany and 2 more
- Volunteers
- 13 people
- Sponsor
- Sojournix, Inc.
Partial Epilepsy
Efficacy and Safety of Eslicarbazepine Acetate as Adjunctive Therapy for Refractory Partial Epilepsy
The primary objective was to evaluate the efficacy of eslicarbazepine acetate (ESL) administered once daily at 1200 mg or 800 mg, compared with placebo as adjunctive therapy in patients with refractory partial epilepsy over a…
- Trial name
- NCT00957372
- Testing
- eslicarbazepine acetate, ESL - Open-label Extension (Part II)
- Where
- Portugal
- Volunteers
- 253 people
- Sponsor
- Bial - Portela C S.A.
Postprandial Heartburn
Safety and Efficacy of IQP-LH-101 in Postprandial Heartburn
This study is a randomized, placebo-controlled, single-blind, three-way crossover clinical trial to evaluate safety and efficacy of IQP-LH-101 (tablet form and liquid form) in postprandial heartburn.
- Trial name
- NCT01718639
- Testing
- IQP-LH-101 tablet, IQP-LH-101 liquid
- Where
- Germany
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- InQpharm Group
Osteopenia
Food Trial Evaluating the Efficacy of SBD111 Versus Placebo for the Clinical Dietary Management of the Metabolic Processes of Osteopenia
The aim of the trial is to determine if the SYNBIOTIC (prebiotic and probiotic), provided twice daily (capsule) will help support skeletal health in otherwise healthy postmenopausal women in the early years postmenopause (1-6…
- Trial name
- NCT05009875
- Testing
- Medical Food SBD111
- Where
- Australia
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- Solarea Bio, Inc
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