Clinical trials: Clinical Efficacy
Pain, Hispanics
Efficacy of NSAID and Acetaminophen in the Control of Post-Operative Pain in Patients Undergoing Total Knee Replacement
An alternate perioperative pain control protocol composed of intravenous ketorolac and oral acetaminophen for patients who underwent total knee replacement was designed with the aim to determine its efficacy when compared to pain…
- Conditions
- Pain, Hispanics, Opioid Use, Multimodal Analgesia
- Trial name
- NCT05393414
- Testing
- Opioid based protocol, Opioid sparing protocol
- Where
- Puerto Rico
- Volunteers
- 81 people
- Sponsor
- University of Puerto Rico
Efficacy and Safety of Chiglitazar Sodium in the Treatment of T2DM Patients, Metformin Combined With Insulin Glargine in the Treatment of Type 2 Diabetes Patients Who Still Have Poor Hypoglycemic Effect
Efficacy and Safety of Chiglitazar Added to Glargine in Patients With Type 2 Diabetes
The goal of this clinical trial is to evaluate the Efficacy and Safety of Chiglitazar Added to Patients with type 2 diabetes who do not respond well to metformin combined with insulin glargine.
- Conditions
- Efficacy and Safety of Chiglitazar Sodium in the Treatment of T2DM Patients, Metformin Combined With Insulin Glargine in the Treatment of Type 2 Diabetes Patients Who Still Have Poor Hypoglycemic Effect, 128 Patients Were Randomly Assigned 1:1, Metformin and Insulin Glargine Combined With Chiglitazar Sodium Tablets 48mg/ Day Group
- Trial name
- NCT06007014
- Testing
- Chiglitazar sodium
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Yanbing Li
Carious Teeth
Laser Versus Silver Diamine Fluoride in Hall Technique in Primary Teeth
The hall technique for primary teeth depends on the idea of isolation of the carious non exposed primary tooth from all bacteria present in the oral cavity by using a stainless-steel crown which result in arresting of the caries…
- Trial name
- SDF (NCT05265104)
- Testing
- SDF with stainless steel crown, Diode laser application with stainless steel crown, stainless steel crown only
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Alzheimer Disease
Efficacy and Safety of MMFS in Early AD
This study is designed to evaluate the safety and efficacy of MMFS for improving cognition and global function in patients with probable Early Alzheimer's disease.
- Trial name
- NCT03531684
- Testing
- MMFS-205-SR
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Neurocentria, Inc.
Rectal Cancer
Efficacy and Safety Study of Neoadjuvant in Treating Patients With Resectable Local Recurrent Rectal Cancer
RATIONALE: Surgical resection and adjuvant therapy has become the main treatment for resectable local recurrent rectal cancer. However the efficacy and safety of adjuvant therapy is still unknown.
- Trial name
- NARC (NCT01271192)
- Testing
- surgical resection and adjuvant therapy, Neoadjuvant followed by operation
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Sun Yat-sen University
Pain
Is the Efficacy of Epidural Steroid Injections Related to the Different Volume Injections?
This study was aimed to investigate the impact of using different epidural volumes. Patients with acute discogenic pain were included in the study.
- Trial name
- NCT02343432
- Testing
- Triamcinolone, Epidural Volume, Bupivacaine
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Neslihan Uztüre
Thyroid Cancer
Safety and Efficacy of Sorafenib in Patients With Advanced Thyroid Cancer: a Phase II Clinical Study
Differentiated thyroid cancer includes papillary, follicular, Hurthle cell, and C-cell/medullary carcinoma. Even though incidence is relatively low (1% of all neoplasms), a rise in this disease has been recorded in the country…
- Trial name
- NCT02084732
- Testing
- Sorafenib
- Where
- Colombia
- Volunteers
- 35 people
- Sponsor
- Instituto Nacional de Cancerologia, Columbia
Periodontal Diseases, Periodontal Bone Loss
Clinical and Radiographic Assessment of Efficacy of Modified Minimally Invasive SurgicalTechnique (M-MIST) Alone and Combined With Enamel Matrix Proteins and Ox-derived Bone Graft in the Treatment of Single Bone Defects Between Teeth.
This study was performed to investigate the adjunctive clinical benefit of the application of enamel matric derivatives and xenograft with the modified minimally invasive surgical technique in the treatment of isolated intrabony…
- Trial name
- NCT07310732
- Testing
- modified minimally invasive surgical technique, modified minimally invasive surgical technique plus emdogain, modified minimally invasive surgical technique plus emdogain and xenograft
- Where
- India
- Volunteers
- 45 people
- Sponsor
- Rungta College of Dental Sciences and Research
Molar Incisor Hypomineralization, Anesthesia, Local
Effect of Silver Diamine Fluoride on Local Anesthesia in Hypomineralized Molars
The purpose of this randomized, controlled clinical study is to evaluate if application of 38% SDF increases the efficacy of local anesthesia during operative dentistry on permanent molars affected by molar-incisor hypoplasia…
- Trial name
- NCT05964387
- Testing
- SDF
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Cognitive Functions
Phenolic Complex k110-42 Therapy on Cognitive Functions in Down Children
The goal of this study is to evaluate the efficacy of phenolic complex k110-42 on cognitive function of children with Down syndrome
- Trial name
- NCT07284693
- Testing
- Phenolic complex k110-42, Neumentix
- Volunteers
- 108 people
- Sponsor
- Mansoura University
Biliary Atresia
A Real World Study on Clinical Efficacy of Bicarbonate Ringer's Solution in Biliary Atresia Children
In most babies with biliary atresia (BA) bile ducts on the inside and outside of the liver are affected eventually leading to a complete blockage of bile flow from the liver. This in turn causes scarring (fibrosis) in the liver.
- Trial name
- NCT04506021
- Testing
- Bicarbonate Ringer's solution, Other Crystalloid
- Volunteers
- 110 people
- Sponsor
- Tongji Hospital
AML, Adult
Natural Killer(NK) Cell Therapy in r/r AML
This is an open-label, Phase I study of QN-030a (allogeneic NK cell therapy) in relapse/refractory Acute Myeloid Leukemia (AML).
- Trial name
- NCT05665114
- Testing
- QN-030a, Cyclophosphamid, Fludarabine
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Zhejiang University
Tricuspid Regurgitation, Tricuspid Valve Disease
Clinical Safety and Efficacy of the VDyne Transcatheter Tricuspid Valve Replacement System for the Treatment of Tricuspid Regurgitation ( VISTA-US)
The purpose of this clinical study is to evaluate the safety and clinical efficacy of the VDyne System in the treatment of symptomatic severe tricuspid regurgitation (TR).
- Conditions
- Tricuspid Regurgitation, Tricuspid Valve Disease, Tricuspid Valvular Disorders
- Trial name
- VISTA-US (NCT05848284)
- Testing
- VDyne Transcatheter Tricuspid Valve Replacement System
- Where
- 11 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- VDyne, Inc.
Dyslipidemia With Hypertension
Study to Evaluate the Efficacy and Safety of Telmisartan/Amlodipine/Rosuvastatin
To evaluate efficacy and safety of co-administrated temisartan/amlodipine and rosuvastatin in subjects with dyslipidemia with hypertension.
- Trial name
- NCT03088254
- Testing
- Group I (Telmisartan 80 mg, Amlodipine 10 mg, Rosuvastatin 20 mg)
- Where
- 12 sites in South Korea
- Volunteers
- 126 people
- Sponsor
- Jeil Pharmaceutical Co., Ltd.
Breast Cancer
A Study of SI-B003 or BL-B01D1+SI-B003 in Patients With Unresectable Locally Advanced or Recurrent Metastatic HER2 Negative Breast Cancer
This phase II study is a clinical study to explore the efficacy and safety of SI-B003 monotherapy and BL-B01D1+SI-B003 combination therapy in patients with unresectable locally advanced or recurrent metastatic HER-2 negative…
- Trial name
- NCT06042894
- Testing
- BL-B01D1, SI-B003
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Sichuan Baili Pharmaceutical Co., Ltd.
Dental Caries in Children
Effectiveness of Teleorientation in Oral Hygiene During the COVID-19 Pandemic
The present study aims to evaluate the effectiveness of Teleorientation in oral hygiene during Pandemic by COVID-19 in children aged 6 to 10 years, attended at the Pediatric Clinic of Forp.
- Trial name
- NCT04967794
- Testing
- Teleorientation and Tooth Brushing Orientation
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cognitive Dysfunction, Cognitive Decline
Broccoli Sprout Extract for Cognitive Function
This clinical trial aims to determine whether broccoli sprout extract improves cognitive function in adults with mild cognitive impairment and to assess its safety.
- Trial name
- NCT07334366
- Testing
- Broccoli sprout extract (BSE)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Pusan National University Yangsan Hospital
Cerebrospinal Fluid Leak
The Efficacy and Safety of a Latest Dural Substitute
This prospective, multi-center, randomized, parallel-controlled clinical trial was designed to evaluate the efficacy and safety of Lyoplant Onlay in repairing cerebral dura mater. DURAFORM was regarded as the control group.
- Trial name
- ESLO (NCT04490629)
- Testing
- Lyoplant Onlay, DURAFORM
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pulp Disease, Dental, Pulp Necrosis
Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized Trial
The treatment of pulpal diseases in primary teeth represents a significant challenge in public health, particularly in emergency dental care settings, where factors such as limited clinical time, low child cooperation, and…
- Conditions
- Pulp Disease, Dental, Pulp Necrosis, Pulp Therapy in Primary Molars, Primary Teeth
- Trial name
- CTZ- emergency (NCT07542639)
- Testing
- CTZ Paste, ZOE Pulpectomy
- Volunteers
- 110 people
- Sponsor
- University of Sao Paulo
Severe Congenital Neutropenia, GATA2 Deficiency
Total Lymphoid Irradiation Pre-HSCT in Severe Congenital Neutropenia
Severe congenital neutropenia (SCN) is a group of primary immunodeficiencies caused by distinct gene mutations and characterized by neutrophil maturation impairment, which leads to neutropenia, predisposition to severe bacterial…
- Trial name
- NCT04844177
- Testing
- conditioning with TLI
- Where
- Russia
- Volunteers
- 10 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
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