Clinical trials: Clinical Efficacy
Lower Limb Spasticity After Stroke
Study of a New Generation Botulinum Toxin A2NTX to Treat Spasticity After Stroke
To test the safety and efficacy of a new generation botulinum toxin preparation A2NTX for treating stroke patients with lower limb spasticity.
- Trial name
- A2NTX (NCT01910363)
- Testing
- A2NTX, BOTOX
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- University of Tokushima
Glaucoma
A First-In-Human Clinical Trial to Evaluate the Safety, Effectiveness and Surgical Characteristics of CADENCE in Patients With Refractory Glaucoma
To evaluate safety, effectiveness, and the surgical performance of CADENCE in patients with refractory glaucoma.
- Trial name
- NCT05131087
- Testing
- Cadence implant
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- New World Medical, Inc.
Diabetes Mellitus, Type 1
32 Week, Open, Randomized, 2 Way Cross Over Multicentre Trial to Compare Safety & Efficacy of Combination of HOE901 Insulin Analogue Once Daily at Bedtime + Lispro Insulin Before Meals vs NPH Insulin (Twice a Day) + Regular in Type 1 Diabetes Mellitus
To compare the efficacy (in terms of metabolic control evaluated through HbA1c levels) of treatment with insulin glargine as basal insulin and insulin analogue (insulin lispro) as mealtime insulin with a regimen of insulin NPH as…
- Trial name
- NCT00537251
- Testing
- Insulin glargine
- Volunteers
- 80 people
- Sponsor
- Sanofi
Essential Hypertension
Study of Efficacy and Safety of CVAA489 in Hypertensive Patients
The population that will be included in this study, will be regular Turkish hypertensive patients who are expected to consume sodium in high amounts.
- Trial name
- NCT02062645
- Testing
- amlodipine/valsartan
- Where
- 8 sites in Turkey (Türkiye)
- Volunteers
- 115 people
- Sponsor
- Novartis Pharmaceuticals
Covid19
Dose-Finding, Safety, and Efficacy Study of XVR011 Added to Standard of Care in Patients Hospitalised for COVID-19
This is a 2 part study where the first part (Phase 1) evaluates the safety of XVR011 and aims to identify the recommended Phase 2 dose.
- Trial name
- NCT04884295
- Testing
- XVR011
- Where
- 6 sites in Belgium, Italy and 1 more
- Volunteers
- 27 people
- Sponsor
- ExeVir Bio BV
Acute Ischemic Stroke, Endovascular Thrombectomy
A Multicenter, Randomized Controlled Clinical Investigation to Evaluate the Safety and Effectiveness of the Super-Bore 8/7F Aspiration Catheters in the Treatment of Acute Intracranial Large Vessel Occlusion
To Evaluate the Safety and Efficacy of the Super-Bore 8/7F Thrombosis Aspiration Catheter in the Treatment of Acute Intracranial Large Vessel Occlusion.
- Trial name
- NCT06559475
- Testing
- Super-Bore Thrombosis Aspiration Catheter treatment group, Conventional thrombectomy device treatment group
- Where
- China
- Volunteers
- 360 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Extracorporeal Carbon Dioxide Removal Plus Noninvasive Ventilation in Patients With COPD Not Eligible for Intubation
This study will evaluate whether adding extracorporeal carbon dioxide removal (ECCO2R) to noninvasive ventilation can improve breathing in adults hospitalized with a severe worsening of chronic obstructive pulmonary disease…
- Trial name
- NCT07785375
- Testing
- Extracorporeal Carbon Dioxide Removal, Noninvasive Ventilation
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- Hospital del Mar Research Institute (IMIM)
Idiopathic Pulmonary Fibrosis (IPF)
A Adaptive Design Clinical Trial to Evaluate the Efficacy and Safety of TDI01 Suspension in the Treatment of Idiopathic Pulmonary Fibrosis (IPF)
This study is a multicentre, randomised, double-blind, placebo-controlled, adaptive design clinical trial to evaluate the efficacy and safety of TDI01 suspension in the treatment of idiopathic pulmonary fibrosis (IPF).
- Trial name
- NCT07464912
- Testing
- TDI01
- Where
- China
- Volunteers
- 508 people
- Sponsor
- Beijing Tide Pharmaceutical Co., Ltd
Multiple Myeloma
The Efficacy and Safety of Colchicine Combined With Conventional Therapy in Multiple Myeloma Patients
To evaluate the efficacy and safety of investigational drug Colchicine combined with conventional lenalidomide based therapy in multiple myeloma subjects who had received first-line therapy (including Chimeric antigen receptor…
- Trial name
- NCT05802992
- Testing
- Colchicine, Lenalidomide
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Affiliated Hospital of Nantong University
Systemic Lupus Erythematosus, Lupus Nephritis
CHT105 for the Treatment of Refractory Lupus Nephritis
Systemic lupus erythematosus (SLE) is the most common systemic autoimmune disease in China. The kidneys are the organ most frequently affected in SLE and a major cause of mortality among SLE patients.
- Trial name
- NCT07517536
- Testing
- anti-CD19/70 CAR T cells (CHT105)
- Where
- China
- Volunteers
- 14 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Plantar Warts
A Phase I/II Double-blind Safety and Efficacy Evaluation of Nowarta110 in Patients With Plantar Warts
To evaluate drug safety and efficacy in patients treated with Nowarta110 and to determine therapeutic activity against Plantar Warts Clinical Tolerance Clinical Recovery Evaluate Safety
- Trial name
- NCT02338336
- Testing
- Nowarta110
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Nowarta Biopharma Inc
Hypogonadism
A Preliminary Clinical Study to Evaluate Fispemifene in the Treatment of Hypogonadism
The purpose of this study is to determine whether one or more fispemifene dose regimens are more effective than placebo in the treatment of hypogonadism in older men.
- Trial name
- NCT00290134
- Testing
- Fispemifene once daily for 4 weeks
- Where
- 16 sites in United States
- Volunteers
- 100 people
- Sponsor
- QuatRx Pharmaceuticals Company
Severe Stroke, Acute Stroke
Efficacy of End-Effector Robot-Assisted Gait Training in Subacute Stroke Patients
To date, no studies seems to compare conventional gait rehabilitation program with end-effector RAGT in subacute stroke patients by analysing the variations of gait kinematics beyond clinical multi prospective outcomes.
- Conditions
- Severe Stroke, Acute Stroke, Mild Stroke, Central Nervous System Diseases
- Trial name
- NCT03805009
- Testing
- Robot-Assisted Gait Training (RAGT)
- Where
- 2 sites in Italy
- Volunteers
- 26 people
- Sponsor
- IRCCS San Raffaele Roma
Acute Bacterial Conjunctivitis
A Study to Determine if 0.6% ISV-403 is Safe and Effective in the Treatment of Bacterial Conjunctivitis.
Evaluation of the clinical and microbial efficacy of 0.6% ISV-403, compared to vehicle in the treatment of bacterial conjunctivitis.
- Trial name
- NCT00347932
- Testing
- ISV-403, Vehicle
- Volunteers
- 957 people
- Sponsor
- Bausch & Lomb Incorporated
Temporomandibular Joint Disorders
Miofascial Release and Exercises Therapy in the Treatment of Temporomandibular Disorders
Objectives: The aim of this research is to compare the effectiveness of myofascial release therapy and exercise therapy on pain, quality of sleep, anxiety, trigger points, and joint sounds in individuals with temporomandibular…
- Trial name
- NCT02540863
- Testing
- myofascial release protocol and Rocabado exercise therapy, exercise therapy
- Volunteers
- 64 people
- Sponsor
- Universidad de Almeria
Mild to Moderate Dementia Due to Alzheimer's Disease, With or Without Coexisting Cerebrovascular Disease
A Clinical Study Evaluating the Efficacy and Safety of RPh201 Treatment in Individuals With Alzheimer's Disease With or Without Coexisting Cerebrovascular Disease
This study is a randomized, double-blind, placebo-controlled, multicentre, Phase 2 study, with an optional open-label extension, to evaluate the safety, tolerability, and efficacy of RPh201 in subjects with mild to moderate AD…
- Trial name
- NCT03462121
- Testing
- RPh201
- Where
- 5 sites in Canada
- Volunteers
- 83 people
- Sponsor
- Regenera Pharma Ltd
Benign Prostatic Hyperplasia, Overactive Bladder
The Combined Effect of Intravesical Botox Injections and HoLEP Surgery in Treating Benign Prostatic Hyperplasia and Overactive Bladder
Benign prostatic hyperplasia (BPH) is the most common benign neoplasm in men. Almost 90% of men in their 70s report lower urinary tract symptoms related to BPH.
- Trial name
- NCT05393921
- Testing
- Intravesical Botox injection
- Where
- 3 sites in United States
- Sponsor
- University Hospitals Cleveland Medical Center
Gingivitis, Dental Plaque
Next Science Antimicrobial Mouth Rinse Study
To assess the effect of a test antimicrobial oral rinse from Next Science on the prevention of oral biofilm formation and thereby preventing gingivitis by monitoring the oral microbial flora and measuring gingival inflammation…
- Trial name
- NCT03154021
- Testing
- Next Science OTC Oral Rinse with Essential Oils, OTC Oral Rinse Control
- Where
- 2 sites in United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Florida
nAMD
Multicenter, Phase I/II Study to Evaluate the Safety, Tolerability, PK and Efficacy of SCT520FF in Patients With nAMD
Multicenter, open-label, multi-dose study to evaluate the safety and tolerability in patients with nAMD treated with SCT520FF.
- Trial name
- NCT06672536
- Testing
- SCT520FF, EYLEA 2 MG
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Sinocelltech Ltd.
Rheumatoid Arthrits
A Study to Evaluate the Efficacy and Safety of Proximod in Patients With Rheumatoid Arthritis
This study is to evaluate the efficacy and safety of different doses of proximod in moderate-to-severe active rheumatoid arthritis subjects with inadequate response or intolerance to bDMARDs and/or tsDMARDs
- Trial name
- NCT07856511
- Testing
- Proximod
- Volunteers
- 590 people
- Sponsor
- Jiankuan (Suzhou) Biotechnology Company Limited
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