Clinical trials: Clinical Efficacy
ASD
Evaluate the Efficacy and Safety of DHA in the Adjuvant Treatment of Children With ASD.
In the etiopathogenesis of autistic spectrum disorder (ASD) several hypotheses have been described that include inflammation, metabolic alterations, activation of oxidative stress, changes in the intestinal microbiota and in the…
- Trial name
- NCT03620097
- Testing
- EuPoly-3 DHA Infant
- Volunteers
- 60 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Schizophrenia
A Clinical Trial to Evaluate the Efficacy and Safety of SEP-363856 in Acutely Psychotic People With Schizophrenia, Followed by an Open-label Extension Phase
A clinical study to investigate the effect of 2 doses of an investigational drug in acutely psychotic adult patients with schizophrenia. The study will consist of a double-blind phase followed by an open-label extension phase.
- Trial name
- NCT04825860
- Testing
- SEP-363856 50 mg, SEP-363856 75 mg
- Where
- 54 sites in China, Japan and 2 more
- Volunteers
- 83 people
- Sponsor
- Sumitomo Pharma Co., Ltd.
Vulvovaginal Atrophy
Clinical Investigation to Assess the Safety and Efficacy of the Laser for the Treatment of Vulvovaginal Atrophy
The purpose of this study is to assess the safety and the efficacy of a laser in the treatment of vulvovaginal atrophy (VVA), that is to assess the change in the severity of the vaginal dryness symptom, by means of a visual…
- Trial name
- NCT02085980
- Testing
- Laser treatment
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- El. En. SpA
Pancreatic Adenocarcinoma
Albumin-Bound Paclitaxel and Gemcitabine With or Without S-1 as First-Line Treatment for Advanced Pancreatic Cancer
This study is a prospective, open-label, randomized controlled trial that enrolled previously untreated patients with locally advanced or metastatic pancreatic cancer.
- Trial name
- NCT06789679
- Testing
- Gemcitabine, albumin-bound paclitaxel, S-1, Gemcitabine, albumin-bound paclitaxel
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Myelodysplastic Syndrome
Study of Clinical Efficacy and Safety of Tosedostat in MDS
Study WCMC IST-CTI-MDS evaluates the safety and tolerability of tosedostat in adult patients with pathologically confirmed MDS (< 20% blasts in bone marrow, peripheral blood, or both) by World Health Organization (WHO)…
- Trial name
- IST-CTI-MDS (NCT02452346)
- Testing
- Tosedostat
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Weill Medical College of Cornell University
Foot Ulcer, Diabetic Foot
A Study on the Efficacy and Safety of Long-Term Treatment and Re-Treatment of Lower Extremity Diabetic Ulcers With REGRANEX
The purpose of this study is to evaluate the efficacy and safety of REGRANEX® Gel compared with placebo when applied for up to 52 consecutive weeks to recurring or non-healing ulcers of the ankle or foot related to diabetes.
- Conditions
- Foot Ulcer, Diabetic Foot, Skin Ulcer, Diabetic Neuropathies
- Trial name
- NCT00034788
- Testing
- Becaplermin
- Volunteers
- 84 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Depressive Disorder
An Eight-week Study Evaluating the Efficacy of a 100mg Dose of Saredutant Once Daily, in Elderly Patients With Major Depressive Disorder
The purpose of the study is to evaluate the efficacy of saredutant in the treatment of Major Depressive Disorder in elderly patients.To evaluate the tolerability, safety and efficacy on disability and quality of life in patients…
- Trial name
- NCT00415142
- Testing
- saredutant (SR48968), escitalopram
- Where
- 8 sites in United States, Croatia and 6 more
- Volunteers
- 393 people
- Sponsor
- Sanofi
Type 1 Diabetes, Type 2 Diabetes
Efficacy, Safety and Satisfaction of the New Pen Needle 33 Gauge x 4 mm.
During the last years, even more little needles are used for the injection of sub cutaneous insulin, for the diabetes therapy. The aim of this study is to evaluate the non inferiority of a new needle, smaller than another needle…
- Trial name
- AGO01 (NCT01745549)
- Testing
- Needle for insulin pen, 4 mm long and with a diameter of 33 gauge, Needle for insulin pen, 4 mm long and with a diameter of 32 gauge
- Where
- 4 sites in Italy
- Volunteers
- 87 people
- Sponsor
- Consorzio Mario Negri Sud
Blepharospasm
Safety and Efficacy of NABOTA in Treatment of Essential Blepharospasm
The purpose of this study is to evaluate the Efficacy and Safety of NABOTA in treatment of essential blepharospasm
- Trial name
- NCT02947815
- Testing
- Clostridium Botulinum Toxin Type A
- Where
- South Korea
- Volunteers
- 234 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Hormone Regulation
A Clinical Trial to Examine the Efficacy of a Supplement to Support Hormone Regulation in Women
This randomized, triple-blind, placebo-controlled trial will evaluate the efficacy of Live Conscious's Beyond Hormone supplement in regulating hormone production in women.
- Trial name
- NCT06531668
- Testing
- Beyond Hormone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Scale Media Inc
Soft Tissue Sarcoma, Melanoma
TQB2916 Injection Combined With Chemotherapy or Penpulimab Injection in the Treatment of Solid Tumors
This project is a clinical trial on the efficacy and safety of TQB2916 injection combined with chemotherapy or penpulimab injection in solid tumors. This project is divided into two cohorts.
- Trial name
- NCT06500091
- Testing
- TQB2916 injection + doxorubicin hydrochloride for injection, TQB2916 injection+penpulimab injection
- Where
- 11 sites in China
- Volunteers
- 54 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Atrial Septal Defect (ASD), Patent Foramen Ovale (PFO)
FIH Study With CBSO
The objective of this study is to evaluate the effectiveness and the safety of the intracardiac septal closure device (CBO), as well as the practicability of implantation of this device using the accessories (DS for CBO).
- Trial name
- NCT01960491
- Testing
- Device Closure of Atrial Septal Defect
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Carag AG
Alzheimer's Disease
Post-marketing Surveillance of Donepezil Hydrochloride -Investigation of the Clinical Safety and Effectiveness in Patients With Alzheimer's Disease
To investigate the clinical safety and effectiveness of donepezil hydrochloride administration in patients with mild or moderate Alzheimer's Disease
- Trial name
- NCT01251718
- Testing
- donepezil hydrochloride
- Where
- 106 sites in Japan
- Volunteers
- 894 people
- Sponsor
- Eisai Co., Ltd.
Type 1 Diabetes
Randomized Study of Real-Time Continuous Glucose Monitors (RT-CGM) in the Management of Type 1 Diabetes
Subjects with intensively-treated type 1 diabetes and glycated hemoglobin (HbA1c) 7.0%-10.0% in 3 age groups (>25, 15-24, 8-14) will be randomized to a continuous glucose monitoring (CGM) group or control group.
- Trial name
- NCT00406133
- Testing
- Continuous glucose monitor
- Where
- 11 sites in United States
- Volunteers
- 451 people
- Sponsor
- Jaeb Center for Health Research
Osteoarthritis, Knee
Study to Evaluate the Efficacy and Safety of Intra-articular DA-5202 in Patients With Osteoarthritis of the Knee
This Phase II clinical study is to evaluate the efficacy and safety of DA-5202 in patients with osteoarthritis of the knee.
- Trial name
- NCT02554240
- Testing
- DA-5202 20mg, DA-5202 10mg, Na Hyaluronate 20mg
- Where
- South Korea
- Volunteers
- 115 people
- Sponsor
- Dong-A ST Co., Ltd.
Tricuspid Valve Regurgitation, Heart Valve Diseases
TRISCEND JAPAN Study
A prospective, open, non-randomized, multicenter, clinical trial to evaluate the safety and effectiveness of the Edwards EWJ-202 transcatheter tricuspid valve replacement system in the treatment of patients with at least severe…
- Conditions
- Tricuspid Valve Regurgitation, Heart Valve Diseases, Cardiovascular Diseases
- Trial name
- TRISCEND JAPAN (NCT05760989)
- Testing
- Edwards EWJ-202 Transcatheter Tricuspid Valve Replacement System
- Where
- 8 sites in Japan
- Volunteers
- 53 people
- Sponsor
- Edwards Lifesciences
Prosthesis User, Digitalism
"Clinical Evaluation of Retraction Cord Effectiveness Using Intraoral Scanner
Dental-supported fixed partial dentures (FPDs) have long been a commonly preferred treatment method for the rehabilitation of teeth with excessive substance loss and for addressing existing tooth deficiencies.
- Trial name
- NCT06447389
- Testing
- retraction cordu (SURE-CORD®PLUS)
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Urinary Tract Infection in Pregnancy
Lactobacillus Reuteri for Treatment of Uncomplicated UTI in Pregnant Women
Prevalence of uro-genital infections during pregnancy move between 7% to 12% in developed countries, meanwhile in developing countries this figure moved between 14% and until 55%, such is the case of Mexico.
- Trial name
- UTIPregnant (NCT03362697)
- Testing
- Probiotics, Antibiotics
- Where
- Mexico
- Volunteers
- 150 people
- Sponsor
- Innovacion y Desarrollo de Estrategias en Salud
Type 2 Diabetes
Clinical Trial to Assess the Efficacy and Safety of YYC405 in Type 2 Diabetes Patients
Phase 3 study to assess the Efficacy and Safety of YYC405 in Type 2 Diabetes Patients
- Trial name
- NCT05226897
- Testing
- YYC405-T, Metformin≥1000mg, Dapagliflozin 10mg
- Where
- South Korea
- Volunteers
- 256 people
- Sponsor
- Yooyoung Pharmaceutical Co., Ltd.
Diffuse Large B-cell Lymphoma, HIV
Rituximab Plus CHOP Chemotherapy for Diffuse Large B-cell Lymphoma
The purpose of this study is to establish the safety of rituximab plus cyclophosphamide, doxorubicin, vincristine,prednisone (R-CHOP) in HIV-infected and HIV-uninfected diffuse large B-cell lymphoma (DLBCL) patients in Malawi.
- Trial name
- NCT02660710
- Testing
- R-CHOP
- Where
- Malawi
- Volunteers
- 39 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
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