Clinical trials: Clinical Efficacy
Chronic Periodontitis
1% Alendronate Gel in Treatment of Chronic Periodontitis Among Smokers
Locally delivered Alendronate (ALN) have potent inhibitory effect on bone and increases new bone formation in chronic periodontitis patients Till date no study has reported the effect of local delivery of ALN in chronic…
- Trial name
- NCT02168543
- Testing
- Alendronate
- Volunteers
- 46 people
- Sponsor
- Government Dental College and Research Institute, Bangalore
Acne
Topical ASC-J9 Cream for Acne
To evaluate the safety and efficacy of topical 0.1% and 0.025% ASC-J9 creams applied twice daily for facial acne compared to vehicle control.
- Trial name
- NCT01289574
- Testing
- ASC-J9
- Where
- 7 sites in United States, Taiwan
- Volunteers
- 181 people
- Sponsor
- AndroScience Corp
Hepatocellular Carcinoma, Liver Transplantation
Safety and Efficacy of Camrelizumab (Anti-PD-1 Antibody) in Recurrent HCC After Liver Transplantation
This is a prospective clinical study to investigate the safety and efficacy of anti-PD-1 immunotherapy (Camrelizumab) in patients with recurrent hepatocellular carcinoma (HCC) after liver transplantation.
- Trial name
- NCT04564313
- Testing
- Camrelizumab treatment
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Advanced Solid Tumor
A Clinical Study of SPH6516 Tablets in the Treatment of Advanced Solid Tumors.
To evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of SPH6516 tablets in the treatment of advanced solid tumors.
- Trial name
- NCT06266923
- Testing
- SPH6516 tablets
- Where
- 2 sites in China
- Volunteers
- 16 people
- Sponsor
- Shanghai Pharmaceuticals Holding Co., Ltd
Colorectal Carcinoma, Oligometastases
SCRT-CAPEOX-Serplulimab for MSS/pMMR Rectal Cancer With Oligometastases
Background and Significance: Colorectal cancer (CRC) ranks as the third most common cancer and the second leading cause of cancer-related deaths globally.
- Conditions
- Colorectal Carcinoma, Oligometastases, pMMR, MSS
- Trial name
- NCT06850103
- Testing
- short-course radiotherapy, CAPEOX/XELOX, Serplulimab
- Where
- China
- Volunteers
- 51 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Pain, Postoperative
Study of MK-0663/Etoricoxib in Postorthopedic Knee Replacement Surgery Pain (MK-0663-098)
The purpose of this study was to evaluate the efficacy and safety of Etoricoxib compared to placebo and ibuprofen in the treatment of postoperative pain associated with unilateral total knee replacement surgery.
- Trial name
- NCT00820027
- Testing
- Etoricoxib 90 mg, Etoricoxib 120 mg, Ibuprofen 600 mg
- Volunteers
- 776 people
- Sponsor
- Organon and Co
Hysteroscopy
Pericervical Analgesia Versus Analesia With Nitrous Oxide (N2O) in Outpatien Operative Hysteroscopy With Miniresector
This research will have the aim of evaluating and comparing the effectiveness of two methods (analgesia with nitrous oxide and pericervical analgesia, excluding the use of paracervical block due to the increased risk of…
- Trial name
- NCT06092541
- Testing
- Intervention Group: pericervical anesthesia, Nitroux Oxide anesthesia
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ospedale degli Infermi di Biella
Multiple Myeloma in Relapse, Multiple Myeloma Refractory
Phase I/II Study of SENL103 for Relapsed or Refractory Multiple Myeloma: A Multicenter, Open-Label, Single-Arm Trial.
To Evaluate Safety and Efficacy of S103 for Treating Relapsed or Refractory Multiple Myeloma
- Trial name
- NCT07421856
- Testing
- Autologous BCMA-targeting CAR T cells
- Volunteers
- 24 people
- Sponsor
- Hebei Senlang Biotechnology Inc., Ltd.
Gastroesophageal Reflux
Comparison of Treatment Outcome and Cost-effectiveness for GERD
This study was designed to evaluate the effectiveness of laparoscopic antireflux surgery for treatment of gastroesophageal reflux disease (GERD) comparing with that of non-surgical treatment.
- Trial name
- NCT03661151
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Sungsoo Park
Hepatic Encephalopathy
Efficacy and Safety of Nitazoxanide in Preventing Recurrence of Hepatic Encephalopathy
Efficacy and Safety of Nitazoxanide in preventing recurrence of Hepatic Encephalopathy.
- Trial name
- NCT04161053
- Testing
- Rifaximin, Nitazoxanide
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Leg Length Discrepancy
A Randomized Controlled Trial of Leg Length Discrepancy Techniques
This is a randomized clinical trial of epiphysiodesis techniques: percutaneous transphyseal screw epiphysiodesis versus percutaneous drill epiphysiodesis for the correction of leg length discrepancy.
- Trial name
- NCT02260856
- Testing
- Tantalum Beads & Injector, Percutaneous Drill Epiphysiodesis, Percutaneous Screw Epiphysiodesis
- Where
- 3 sites in United States, Canada
- Volunteers
- 170 people
- Sponsor
- Hospital for Special Surgery, New York
Arteriovenous Graft
LineMatrix® Biological Vascular Graft for the Creation of Arteriovenous Graft
The study is planned to be conducted at multiple centers, with an intended enrollment of 326 subjects. Protocol-eligible subjects will be randomized in a 1:1 ratio to either the investigational group or the control group.
- Trial name
- NCT07773051
- Testing
- LineMatrix® Biological Vascular Graft, GORE-INTERING®
- Where
- 12 sites in China
- Volunteers
- 326 people
- Sponsor
- Longhua Hospital
Missing Teeth
Efficacy of a Dental Implant System for Immediate Restoration
The primary objective of this study is to observe the performance of an implant system with a new surface (EK III NH dental implants) over a period of two years.
- Trial name
- NCT06651502
- Testing
- dental implant placement and immediate provisionalization
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
Atopic Dermatitis
CLINICAL EFFICACY OF EMOLLIENTS IN ATOPIC DERMATITIS PATIENTS
his was a monocentric, intra-individual study, that was performed in at least 45 valid cases (50% children ≥3 YO; 50% adults). Study duration was 168 days with five (5) visits (D0, D14, D28, D84 and D168) to the research center.
- Trial name
- NCT05783453
- Testing
- Cosmetic study
- Where
- Brazil
- Volunteers
- 63 people
- Sponsor
- Cosmetique Active International
Diffuse Large B Cell Lymphoma
An Exploratory Clinical Trial of Autologous Humanized Anti-cluster of Differentiation Antigen 19/20(CD19/CD20) Dual Specific CAR-T Cells Injection
This is a single-arm, open-label, dose escalation, phase I study, aiming to evaluate the safety and efficacy of Autologous Humanized Anti-CD19 and Anti-CD20 Dual Specific Chimeric Antigen Receptor (CAR) T-cells in patient with…
- Trial name
- NCT04486872
- Testing
- Autologous humanized anti-CD19 and anti-CD20 dual specific CAR-T Cells
- Where
- China
- Volunteers
- 18 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Peripheral Artery Disease
AcoArt Ⅱ/ BTK China: Drug-eluting Balloon for Below-The-Knee Angioplasty Evaluation in China
The purpose of this study is to determine whether DEB is more effective than common PTA balloon using under in long-term vessel patency and inhibiting restenosis in the infrapopliteal artery.
- Trial name
- NCT02137577
- Testing
- DEB catheter, common PTA balloon catheter
- Where
- 11 sites in China
- Volunteers
- 120 people
- Sponsor
- Acotec Scientific Co., Ltd
Glioma, Astrocytoma, Grade IV
SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)
This is a 3-part study. The purpose of Part 1 of the study is to evaluate the efficacy, safety, and pharmacokinetic (PK) characteristics of safusidenib in participants with recurrent/progressive IDH1-mutant World Health…
- Conditions
- Glioma, Astrocytoma, Grade IV, IDH1-mutant Glioma, Astrocytoma, IDH-Mutant, Grade 3
- Trial name
- SIGMA (NCT05303519)
- Testing
- safusidenib
- Where
- 61 sites in United States, Australia and 1 more
- Volunteers
- 365 people
- Sponsor
- Nuvation Bio Inc.
Chemotherapy-induced Nausea and Vomiting
Acupuncture for Chemical Therapy Induced Nausea and Vomiting
This is an expertise-based randomized controlled trial. The hypothesis of this study is that the differences in expertise of acupuncturist may impact clinical effect.
- Trial name
- NCT02842307
- Testing
- Manual acupuncture implemented by senior acupuncturists, Manual acupuncture implemented by junior acupuncturists, Manual acupuncture on P6 point
- Where
- 3 sites in China
- Volunteers
- 102 people
- Sponsor
- Beijing University of Chinese Medicine
Breast Neoplasms, Insomnia
Efficacy of Acupuncture Treatment for Breast Cancer-associated Insomnia
Through a scientific and standardized multicenter, randomized, and controlled study method, the investigators evaluated the clinical efficacy and safety of acupuncture in the treatment of breast cancer-related insomnia, with a…
- Trial name
- NCT05510700
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Yin Ping
Extensive Stage Small Cell Lung Cancer (ES-SCLC)
Phase 1 Study of HS-20093 Combinations in Patients With Extensive Stage Small Cell Lung Cancer
This is a Phase I clinical study of HS-20093. The purpose of this study is to evaluate the safety, tolerability, PK and efficacy of HS-20093 in combination with Adebrelimab in patients with Extensive Stage Small Cell Lung Cancer…
- Trial name
- NCT07063407
- Testing
- HS-20093 in combination with Adebrelimab
- Volunteers
- 50 people
- Sponsor
- Shanghai Hansoh Biomedical Co., Ltd
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