Clinical trials: Clinical Efficacy
Muscle Function
A Pilot Clinical Trial on the Efficacy of Two Carnitine-Based Products on Muscle Function in Healthy Older Adults
This study evaluates two L-Carnitine-based products on muscle function in healthy older adults (55 to 70 years old). These products are suspected to improve muscle function and possibly promote building of muscle mass.
- Trial name
- 15CAHL (NCT02317536)
- Testing
- Carnipure Product 1, Carnipure Product 2
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- KGK Science Inc.
Tumor
XS005 Injection Combined With Stupp Regimen for Adjuvant Chemotherapy in Subjects With Primary Glioblastoma(GBM)
The main objective of this clinical study is to evaluate the safety of XS005 injection; to determine the maximum tolerated dose . Furthermore, initial efficacy will be examined.
- Trial name
- NCT06147505
- Testing
- XS005 Injection
- Where
- China
- Volunteers
- 13 people
- Sponsor
- Dushu Lake Hospital Affiliated to Soochow University
Acute Ischemic Stroke
BXOS110 Injection in the Treatment of Acute Ischaemic Stroke
The purpose of this study was to evaluate the effectiveness of early administration of BXOS110 for injection in reducing overall disability in patients with acute ischaemic stroke.
- Trial name
- NCT06322394
- Testing
- high-dose BXOS110, low-dose BXOS110
- Where
- 24 sites in China
- Volunteers
- 300 people
- Sponsor
- Biocells (Beijing) Biotech Co.,Ltd
Overt Hepatic Encephalopathy
A Trial for Comparing Rifaximin, Probiotic and L-ornithine- L Aspartate With Lactulose in Overt Hepatic Encephalopathy.
The goal of this trial is to learn if drugs in group A, B, C and D works to treat reversal of grades in people with overt hepatic encephalopathy. It will also provide information regarding safety of drugs in group A, B, C and D.
- Trial name
- ARGO-HEC (NCT07037394)
- Testing
- Probiotic plus lactulose, Rifaximin plus lactulose, L-ornithine-L-aspartate plus latulose
- Where
- Pakistan
- Volunteers
- 252 people
- Sponsor
- Qurratul Ain Jamil
Osteoarthritis of the Knee
Apitox, Honeybee Toxin for Pain and Inflammation of Osteoarthritis
The study will identify the efficacy of Apitox, purified honeybee toxin, in 330 patients with diagnosed osteoarthritis of the knee.
- Trial name
- NCT01112722
- Testing
- Apitox, purified honeybee toxin, lyophilized in saline, histamine
- Where
- 15 sites in United States
- Volunteers
- 363 people
- Sponsor
- Apimeds, Inc.
Dentin Hypersensitivity
Clinical Effectiveness of Episodic Use of Bioactive Silica Based Versus in Management of Dentin Hypersensitivity (A 6m Randomized Clinical Trial)
The aim of the study to compare the clinical effectiveness of Episodic use of Bioactive Silica Based versus continuous use of fluoride based desensitizing toothpastes in management of dentin hypersensitivity (DH) of adult…
- Trial name
- NCT07120139
- Testing
- episodic use of the desensitizing toothpaste, continuous use of the conventional desensitizing toothpaste
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rawda Hesham Abd ElAziz
Advanced Malignant Cancer
A Clinical Trial on the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of TQB3019 Capsule in Subjects With Advanced Malignant Tumors
The trial was divided into two phases: dose escalation and dose expansion. The dosing regimens were single-dose study and continuous dosing study.
- Trial name
- NCT06943677
- Testing
- TQB3019 capsules
- Where
- 15 sites in China
- Volunteers
- 80 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
SARS-CoV-2, COVID-19
The Efficacy of Pre-procedural Mouth Rinses on COVID-19 Saliva Viral Load
Preoperative antiseptic mouth rinses have been widely used as a standard protocol before routine dental treatment reduces oral microorganism counts.
- Conditions
- SARS-CoV-2, COVID-19, Mouthwashes, Viral Load
- Trial name
- NCT04721457
- Testing
- Distilled Water, 1% Povidone Iodine (PVP-I), 1.5% Hydrogen Peroxide (H2O2)
- Where
- Saudi Arabia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Ankylosing Spondylitis
Comparative Clinical Trial to Evaluate Efficacy and Safety of BCD-055 and Remicade® in Patients With Ankylosing Spondylitis
BCD-055-2 is international multi-center comparative double-blind randomized clinical trial to evaluate efficacy and safety of BCD-055 (JSC "BIOCAD", Russia) and Remicade® in patients with ankylosing spondylitis.
- Trial name
- NCT02762812
- Testing
- BCD-055, Remicade®
- Where
- Russia
- Volunteers
- 199 people
- Sponsor
- Biocad
Gastritis, Acute Gastritis
Phase 4 Study of Sto M Tab. in Acute or Chronic Gastritis
This Phase 4, multicenter, randomized, double-blind, active-controlled, non-inferiority study aims to evaluate the non-inferiority of Stoem Tab. compared to Stillen Tab.
- Conditions
- Gastritis, Acute Gastritis, Chronic Gastritis
- Trial name
- NCT07631065
- Testing
- Stillen Tab., Sto M Tab.
- Volunteers
- 470 people
- Sponsor
- Mather's Pharm. Co., Ltd.
Postmenopausal Osteoporosis, Compliance
Clinical Study of Raloxifene and Strontium Ranelate in Postmenopausal Osteoporosis
The purpose of this study was to compare compliance and efficacy of raloxifene and strontium ranelate in a group of women with postmenopausal osteoporosis.
- Trial name
- NCT01544894
- Testing
- Raloxifene, Strontium ranelate
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Cerebral Palsy
Effectiveness of Routine Physical Therapy With Intensive Bimanual Training in Cerebral Palsy Children
Effectiveness of Routine Physical Therapy With or Without Home Based Intensive Bimanual Training on Clinical Outcomes in Cerebral Palsy Children
- Trial name
- NCT04755556
- Testing
- home based intensive bimanual training, Routine Physical Therapy
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Cardiovascular Disease, Coronary Artery Bypass
Safety and Efficacy Study of AVI-5126 When Used on Vein Grafts Before Use in Heart by-Pass Graft Surgery (CABG)
For some people who have heart by-pass surgery, the vein that is used to by-pass a blockage will, after some time, become narrowed and possibly blocked.
- Trial name
- NCT00451256
- Testing
- AVI-5126
- Where
- Ukraine
- Volunteers
- 600 people
- Sponsor
- Sarepta Therapeutics, Inc.
SARS-CoV Infection
Efficacy of L. Plantarum and P. Acidilactici in Adults With SARS-CoV-2 and COVID-19
Clinical research focused to evaluate the effect as coadyuvant of a combination of L. plantarum and P. acidilactici in adults positive for SARS-CoV-2 with mild clinical COVID-19 symptoms.
- Trial name
- NCT04517422
- Testing
- Probiotics
- Where
- Mexico
- Volunteers
- 300 people
- Sponsor
- AB Biotics, SA
Evidence-Based Practice, Nurse's Role
Feasibility and Effectiveness of the Advancing Research and Clinical Practice Through Close Collaboration (ARCC)
The Institute of Medicine's (IOM) ambitious goal for at least 90% of clinical decisions to be evidence-based includes nursing interventions and practice.
- Trial name
- ARCC (NCT03269331)
- Testing
- CTEP EBP Immersion
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- David Grant U.S. Air Force Medical Center
Parkinson Disease
A Clinical Study of NLY01 in Patient's With Early Parkinson's Disease
This is a phase 2 study designed to assess the safety, tolerability and efficacy of NLY01 in subjects with early untreated Parkinson's disease (PD).
- Trial name
- NCT04154072
- Testing
- NLY01, Vehicle
- Where
- 61 sites in United States, Canada
- Volunteers
- 255 people
- Sponsor
- Neuraly, Inc.
Type2 Diabetes Mellitus
Clinical Study to Assess the Safety, Efficacy and In-Use Tolerability of Herbal-Based Sugar Support Effervescent Tablets in Type-2 Diabetes Mellitus Patients
This is a Proof-of-Science, exploratory, prospective, single-treatment, two-group, clinical safety, efficacy and tolerability study of herbal based Sugar support effervescent tablets on the patients with Type 2 Diabetes Mellitus.
- Trial name
- NCT06961019
- Testing
- Sugar support effervescent Tablets
- Where
- India
- Volunteers
- 14 people
- Sponsor
- NovoBliss Research Pvt Ltd
Angiogenic Breast Cancer
Safety and Efficacy of Ga68-IAC PET/CT for Diagnosis and Clinical Management in Metastatic Breast Cancer Patients
This is a phase I/IIa, open label, multicenter interventional study of Gallium-68 radiolabeled Integrin Adhesion Complex antagonist conjugate (Ga-68-IAC) Positron Emission Tomography (PET/CT) imaging, intended for diagnosis, and…
- Trial name
- Shiva (NCT04480619)
- Testing
- Ga-68-IAC
- Where
- 3 sites in India, South Africa
- Volunteers
- 25 people
- Sponsor
- Advanced Imaging Projects, LLC
Herpes Zoster
A Study to Evaluate the Safety and Efficacy of Inactivated Varicella-zoster Vaccine (VZV) as a Preventative Treatment for Herpes Zoster (HZ) and HZ-related Complications in Participants Undergoing Hematopoietic Cell Transplants (HCTs) (V212-001)
This is a randomized, double-blind, placebo-controlled study to assess the safety and efficacy of inactivated VZV vaccine for the prevention of HZ and HZ-related complications in adult recipients of autologous hematopoietic cell…
- Trial name
- NCT01229267
- Testing
- V212
- Volunteers
- 1,257 people
- Sponsor
- Merck Sharp & Dohme LLC
COVID19
Efficacy of Nafamostat in Covid-19 Patients (RACONA Study)
RACONA is a prospective trial that will test the hypothesis that nafamostat can lower lung function deterioration and need for intensive care admission in COVID-19 patients.
- Trial name
- RACONA (NCT04352400)
- Testing
- Nafamostat Mesilate
- Where
- Italy
- Volunteers
- 256 people
- Sponsor
- University Hospital Padova
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