Clinical trials: Clinical Efficacy
Dentin Sensitivity
A Clinical Study to Determine the Safety and Effectiveness of Dentinal Hypersensitivity Treatment With Two Different Toothbrushes
This study will determine the effects toothbrush type (power or manual) has on the safety and effectiveness of professional dentinal hypersensitivity treatment with a marketed oxalate-containing solution.
- Trial name
- NCT02513212
- Testing
- Potassium Oxalate, Stannous fluoride paste, Manual toothbrush
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Autism Spectrum Disorder
A Study on Probiotic Formula in Autistic Children
A Randomized controlled double-blind clinical study on the effectiveness and safety of probiotic formula in Autistic children with gastrointestinal symptoms.
- Trial name
- NCT06419530
- Testing
- Probiotic formula capsule, FMT capsule
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Third Military Medical University
Atrophy, Vaginal Diseases
A Clinical Study to Evaluate Ospemifene in the Treatment of Vulvar and Vaginal Atrophy in Postmenopausal Women
The purpose of this study is to determine whether ospemifene is more effective than placebo in the treatment of vulvar and vaginal atrophy (VVA) in postmenopausal women.
- Trial name
- NCT00276094
- Testing
- Ospemifene 30 mg, Ospemifene 60 mg, Nonhormonal vaginal lubricant
- Volunteers
- 826 people
- Sponsor
- Shionogi
ADPKD (Autosomal Dominant Polycystic Kidney Disease)
Trial of JMKX003142 in Participants With Rapidly Progressive Autosomal Dominant Polycystic Kidney Disease (ADPKD)
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JMKX003142 in Participants with Rapidly Progressive…
- Trial name
- NCT06800651
- Testing
- JMKX003142 will be administered orally, Plcacebo
- Where
- China
- Volunteers
- 135 people
- Sponsor
- Jemincare
Type2 Diabetes
Efficacy of Multigrain Supplementation in Type II Diabetes Mellitus
The objective of this study is to evaluate the efficacy of instant multigrain supplementation on the glycemic status, cardiometabolic implications, oxidative stress and nutritional status in Type II DM patients.
- Trial name
- NCT04597229
- Testing
- Instant multigrain supplement
- Where
- Malaysia
- Volunteers
- 50 people
- Sponsor
- Universiti Sains Malaysia
Angulated Screw-retained, Esthetics
Clinical Efficacy of Angulated Screw-retained and Cemented Single Implant Crowns in Esthetic Region
Objective: To compare the clinical efficacy of angulated screw-retained and cemented single implant crowns(SIC) in esthetic region. Methods/Design: The study was a prospective, single center, randomized controlled clinical trial.
- Trial name
- NCT04539912
- Testing
- angulated screw retained crown, cemented crown
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Junyu Shi
Systemic Lupus Erythematosus
A Treatment Effectiveness Study Among SLE Patients Receiving Anifrolumab in Routine Clinical Practice.
Anifrolumab Study of Treatment Effectiveness in the Real World (ASTER) study will collect real world data to obtain a good understanding of the (sustained) clinical effect and patient quality of life outcomes among diagnosed SLE…
- Trial name
- ASTER (NCT05637112)
- Testing
- None (Observational study)
- Where
- 74 sites in Austria, Belgium and 7 more
- Volunteers
- 551 people
- Sponsor
- AstraZeneca
Leg Ulcers
Efficacy and Safety of Light Compression System in the Local Treatment of Mixed Leg Ulcers (PROMETHEE Clinical Investigation)
Evaluation of the efficacy (wound epithelialization and time to closure) and safety (emergence and nature of adverse event) of a lite compression system versus a tubular bandage in the local treatment of mixed leg ulcers…
- Trial name
- PROMETHEE (NCT06899919)
- Testing
- Treatment with light compression systeme during 16-week treatment period (6 medical visits are planned: D0, W2, W4, W8, W12, W16), Light compression system of the mixed leg ulcer stage C6 / C6r of the CEAP classification
- Where
- 3 sites in France
- Volunteers
- 210 people
- Sponsor
- Laboratoires URGO
Recurrence (Disease Attribute)
Combination Therapy Prevents the Relapse of RA
This trial aims to compare the cost effective and effect of preventing recurrence by different treatment of TFP and HCQ combined SSZ for remittent RA.
- Trial name
- NCT02320630
- Testing
- Entanercept, HCQ, MTX
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Peking University First Hospital
Acute Graft Versus Host Disease, Malignant Hematologic Neoplasm
Effectiveness and Safety of a Single-Center Clinical Study on a CD25 Monoclonal Antibody-Containing GVHD Prophylaxis Scheme to Reduce the Incidence of Severe Acute GVHD After Umbilical Cord Blood Transplantation for Malignant Hematologic Diseases
Evaluating the safety and effectiveness of a CD25 monoclonal antibody-based prophylactic acute graft-versus-host-disease (aGVHD) regimen following unrelated umbilical cord blood transplantation (UCBT) for malignant hematologic…
- Trial name
- NCT06480630
- Testing
- Basiliximab
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Anhui Provincial Hospital
HCC
Cabozantinib in Hepatocellular Carcinoma
There have been lack of clinical studies on the role of drug treatment in patients who develop progressive disease with immune checkpoint inhibitors.
- Trial name
- NCT04588051
- Testing
- Cabozantinib
- Where
- 2 sites in Hong Kong, South Korea
- Volunteers
- 20 people
- Sponsor
- Stephen Chan Lam
Pancreatic Cancer, Pancreatic Carcinoma
A Study of Glipizide to Treat High Blood Sugar in People With Pancreatic Cancer
The purpose of this study is to find out how effective and safe glipizide is for lowering blood sugar in people with pancreatic cancer.
- Conditions
- Pancreatic Cancer, Pancreatic Carcinoma, Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer Metastatic
- Trial name
- NCT06168812
- Testing
- Glipizide
- Where
- 7 sites in United States
- Volunteers
- 29 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Coronary Artery Bypass Graft, Discharge Education
The Effect of Different Training Methods On Discharge
This study was conducted to examine the effects of different discharge training methods on readiness to discharge and self-efficacy in individuals undergoing coronary artery bypass graft surgery.
- Trial name
- NCT05737901
- Testing
- Education Booklet, Mobile application
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Aydin Adnan Menderes University
Myxoid Liposarcoma
Brostallicin Clinical Trial for Myxoid Liposarcoma
This is a Phase II, multicenter, open-label clinical trial designed to determine the efficacy and safety of Brostallicin when administered once every 3 weeks in patients with myxoid liposarcoma with (12;16) translocation.
- Trial name
- SMI-BRS-202 (NCT00633165)
- Testing
- Brostallicin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Systems Medicine LLC
Renal Anemia
A Study of PEG-EPO Injection (CHO Cells) for Maintenance Therapy of Patients With Renal Anemia .
The purpose of the study is to explore the optimal dose and administration of the experimental drug, and to evaluate the safety and efficacy of the drug in patients with renal anemia.
- Trial name
- NCT05629598
- Testing
- Recombinant human erythropoietin injection, Human erythropoietin injection
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Angde Biotech Pharmaceutical Co., Ltd.
Lymphoma, Large B-Cell, Diffuse
A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
Researchers are looking for ways to treat germinal center B-cell-like diffuse large B-cell lymphoma (GCB DLBCL). DLBCL is a fast-growing blood cancer that affects B-cells.
- Trial name
- NCT06890884
- Testing
- Zilovertamab vedotin, Rituximab, Cyclophosphamide
- Where
- 147 sites in United States, Belgium and 7 more
- Volunteers
- 594 people
- Sponsor
- Merck Sharp & Dohme LLC
Breast Cancer
Effect of a Natural Health Product on Urinary Estrogen Metabolites
The purpose of this study is to determine if a supplemental formula can beneficially alter the ratio of urinary estrogen metabolites.
- Trial name
- NCT01089049
- Testing
- FemMED Breast Health Formula
- Where
- Canada
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Nutrasource Pharmaceutical and Nutraceutical Services, Inc.
Disuse Atrophy
Leucine Supplementation and Skeletal Muscle Disuse
Leucine supplementation is widely known for promoting strong influence on skeletal muscle remodeling. This study aims to evaluate the effect of leucine supplementation on disuse-induced skeletal muscle atrophy.
- Trial name
- NCT01192009
- Testing
- Leucine
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Malignant Pleural Effusion, Malignant Peritoneal Effusion
Safety and Efficacy Study of Virus Activated Killer Immune Cells (VAK) for Malignant Pleural and Peritoneal Effusion
Theory of VAK： 1. Immune cells (T cells for example) of cancer subjects may be domesticated by the tumor microenvironment, and have low efficacy to kill cancer cells.
- Trial name
- NCT05565014
- Testing
- Virus Activated Killer immune Cells, Saline
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Sheng Hu
Carious Teeth
Laser Versus Silver Diamine Fluoride in Hall Technique in Primary Teeth
The hall technique for primary teeth depends on the idea of isolation of the carious non exposed primary tooth from all bacteria present in the oral cavity by using a stainless-steel crown which result in arresting of the caries…
- Trial name
- SDF (NCT05265104)
- Testing
- SDF with stainless steel crown, Diode laser application with stainless steel crown, stainless steel crown only
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
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