Clinical trials: Clinical Efficacy
Dental Caries
Selective Caries Removal (SCR) Versus Pulpotomy in Preventing Pulp Necrosis and Apical Periodontitis
The study design is a randomized controlled trial and up to 120 teeth, 50 in each of the 2 groups, will be enrolled from the patients at the National University Centre for Oral Health Singapore (NUCOHS) Endodontic unit.
- Trial name
- NCT04672070
- Testing
- Selective Caries Removal, Pulpotomy
- Where
- Singapore
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Solid Tumor, Adult, Lung Adenocarcinoma
TP53 R248Q TCR-T Cell Therapy for Advanced Solid Tumor
To evaluate the safety and efficacy of T cell therapy with mutated TP53 R248Q specific TCR transduction in patients with advanced solid tumor expressing the TP53 R248Q mutation and the HLA-A*11:01 allele.
- Conditions
- Solid Tumor, Adult, Lung Adenocarcinoma, Pancreas Cancer, Colorectal Cancer
- Trial name
- NCT06619886
- Testing
- Autologous, engineered T Cells targeting TP53 R248Q
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Wound Infection
The Clinical Efficacy of Next Science Wound Gel (NXTSC) in the Healing of Chronic Wounds
Determine the effect on wound treatment outcomes using a novel antimicrobial wound gel (NXTSC) for the treatment of infected wounds as the sole topical treatment of microbial infection at the wound site.
- Trial name
- NCT02465073
- Testing
- NXTSC wound gel, NXTSC wound gel plus Standard of Care, Standard of Care Group
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Southwest Regional Wound Care Center
Variceal Hemorrhage
Efficacy of Continuous Terlipressin Therapy After Endoscopic Variceal Ligation
Upper gastrointestinal (UGI) bleed of variceal origin is a common medical emergency. Prompt endoscopic variceal ligation (EVL) is therapeutic as well as diagnostic.
- Trial name
- TERLEVL (NCT06027970)
- Testing
- Terlipressin, 0.9% normal saline (NS)
- Where
- India
- Volunteers
- 165 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Bladder Urothelial Carcinoma, Lymph Node Metastasis
Propranolol With Tislelizumab Plus GC in Neoadjuvant Bladder UC
This is a prospective, multicenter, Phase Ib clinical study designed to evaluate the safety and preliminary efficacy of propranolol combined with tislelizumab plus gemcitabine/cisplatin (GC) as neoadjuvant therapy for patients…
- Trial name
- NCT07353294
- Testing
- propranolol, Tislelizumab, gemcitabine
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Bladder Cancer
Efficacy and Safety of Pseudomonas Aeruginosa for Intermediate and High-risk Non-muscle Invasive Bladder Cancer
This is a multicenter, single-arm study to evaluate the efficacy and safety of Pseudomonas aeruginosa the treatment of patients with intermediate and high risk non-muscle invasive bladder cancer.
- Trial name
- NCT05975151
- Testing
- Pseudomonas aeruginosa
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Qilu Hospital of Shandong University
PTSD
Safety Study of Riluzole to Treat Post-traumatic Stress Disorder (PTSD)
The purpose of this study is to determine whether Riluzole is effective in the augmentation treatment of post-traumatic stress disorder (PTSD) that is experienced by Active Duty military service members and Operation Enduring…
- Trial name
- NCT02155829
- Testing
- Riluzole
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Uniformed Services University of the Health Sciences
Suicide Awareness, Suicidal Ideation
"Youth Aware of Mental Health" in Galicia
The goal of this interventional study is to assess the effectiveness of the universal suicide prevention program "Youth Aware of Mental Health" in 3rd-year secondary education students in Galicia.
- Conditions
- Suicide Awareness, Suicidal Ideation, Suicide, Attempted, Depressive Symptoms
- Trial name
- YAM (NCT06251037)
- Testing
- Youth Aware of Mental Health in Galicia
- Where
- 68 sites in Spain
- Volunteers
- 4,453 people, healthy volunteers welcome
- Sponsor
- Fundacin Biomedica Galicia Sur
Clinical Competence, Nursing Education
Deliberate Repetitive Practice and Nursing Student Confidence in Peripheral Intravenous Catheter (PIVC) Insertion
This study examined whether a structured deliberate repetitive practice (DRP) simulation scenario was associated with changes in prelicensure nursing students' self-reported confidence and preparedness for peripheral intravenous…
- Conditions
- Clinical Competence, Nursing Education, Self-Efficacy
- Trial name
- NCT07850024
- Testing
- Deliberate Repetitive Practice (DRP) Simulation Scenario
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin-Eau Claire
Irritable Bowel Syndrome
Efficacy and Safety of Chinese Medicine JCM-16021 for Diarrhea-predominant Irritable Bowel Syndrome
This is a multicenter, randomized, double-blind, placebo controlled clinical trial, in order to evaluate the efficacy and safety of Chinese Medicine JCM-16021 for diarrhea-predominant irritable bowel syndrome.
- Trial name
- NCT03457324
- Testing
- JCM-16021
- Where
- 2 sites in China
- Volunteers
- 392 people
- Sponsor
- ZhaoXiang Bian
Gastro Esophageal Reflux
Antireflux Mucosectomy (ARMS) for Treatment of Gastroesophageal Reflux
This is a phase II clinical study to investigate the safety and efficacy of endoscopic antireflux mucosectomy (ARMS) for treatment of GERD.
- Trial name
- ARMS (NCT04194723)
- Testing
- Antireflux Mucosectomy
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Autism Spectrum Disorder
Effectiveness of Aerobic Exercises on the Autistic Children
Autism spectrum disorder (ASD) is a neurodevelopmental disorder manifesting stereotypic behaviors and problem in communication and social interaction.
- Trial name
- NCT05067361
- Testing
- Aerobic Exercise, Ball Exercises
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- University of Faisalabad
Hair Thinning, Hair Loss
A Clinical Trial to Examine the Efficacy of a Supplement to Support Healthy Hair and Skin
This is a triple-blinded, randomized, placebo-controlled clinical trial designed to evaluate the efficacy of Scale Media's Live Conscious Beyond Collagen supplement on overall hair and skin health.
- Trial name
- NCT06579742
- Testing
- Live Conscious Beyond Collagen
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Scale Media Inc
Psoriasis
Safety and Efficacy of HPP737 in Adult Patients With Plaque Psoriasis
The goal of this clinical trial is to learn if drug HPP737 works to treat moderate-to-severe plaque psoriasis in adults. It will also learn about the safety of drug HPP737.
- Trial name
- NCT07707141
- Testing
- HPP737 20mg
- Where
- 8 sites in China
- Volunteers
- 123 people
- Sponsor
- Newsoara Biopharma Co., Ltd.
Moderate-to-severe Atopic Dermatitis
A Phase II Study of QLS12010 Capsules in Adults With Moderate to Severe Atopic Dermatitis
This trial was designed to evaluate the efficacy and safety of QLS12010 Capsules in adults with moderate-to-severe atopic dermatitis.
- Trial name
- NCT07344051
- Testing
- QLS12010
- Volunteers
- 160 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Decompensated Cirrhosis, Portal Hypertension
The Effectiveness of L-ornithine-L-aspartate (LOLA) on Plasma Ammonia in Cirrhotic Patients After TIPS
The aim of this study is to evaluate the effectiveness of L-ornithine-L-aspartate (LOLA) on plasma ammonia in cirrhotic patients after Transjugular Intrahepatic Portosystemic Shunt (TIPS) procedure.
- Conditions
- Decompensated Cirrhosis, Portal Hypertension, Bleeding Varices, Refractory Ascites
- Trial name
- NCT01440829
- Testing
- L-ornithine-L-aspartate
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Air Force Military Medical University, China
Non Invasive Body Contouring
Clinical Evaluation of Linear Z for Body Contouring
This clinical study will evaluate the safety and effectiveness of LinearZ, a non-invasive focused ultrasound device, for body contouring of the lower abdomen and flanks.
- Trial name
- NCT07802431
- Testing
- High Intensity Focused Ultrasound
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Jeisys Medical Inc
Urinary Tract Infections
Clinical Trial of L. Reuteri in Urinary Tract Infections in Non Pregnant Women
RCT to evaluate the safety and efficacy of Lactobacillus reuteri DSM 16666 \& Lactobacillus reuteri DSM 17938 to significantly modify the frequency of clinical or bacteriological cure in women with non complicated acute cystitis…
- Trial name
- UTIReuteri (NCT03019172)
- Testing
- Lactobacillus reuteri
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Innovacion y Desarrollo de Estrategias en Salud
Acute Leukemia, Myelodysplastic Syndromes
A Study of ONO-7475 in Patients With Acute Leukemias
[Updated]: To assess the safety and tolerability of ONO-7475 monotherapy in patients with relapsed or refractory acute myeloid leukemia or relapsed or refractory myelodysplastic syndromes and to assess: i) safety and tolerability…
- Trial name
- NCT03176277
- Testing
- ONO-7475 3mg once daily, ONO-7475 6mg once daily, ONO-7475 10mg once daily
- Where
- 16 sites in United States
- Volunteers
- 42 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Self-efficacy and Perceived Stress Among Physiotherapy Interns in Clinical Training
Comparative Study of Self-Efficacy and Perceived Stress Among Physiotherapy Interns in Turkey and Egypt
This cross-sectional comparative study aims to assess and compare the self-efficacy and perceived stress levels among physiotherapy interns in Turkey and Egypt.
- Trial name
- SEPS-PT (NCT07249580)
- Testing
- Online Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medipol University
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