Clinical trials: Clinical High-risk
End-stage Renal Disease
Clearum High Flux Hemodialyzer Used in Hemodialysis for Subjects With End-Stage Renal Disease
The study will be a prospective, interventional, non-randomized, single-center study in 20 ESRD patients on hemodialysis. The study will compare performance of the Clearum HS dialyzer to typical values obtained with other…
- Trial name
- NCT04395131
- Testing
- Clearum HF Hemodialyzer
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Mozarc Medical US LLC
Breast Cancer
Pilot Study to Evaluate High Resolution PET Image-Guidance for Sampling of Breast Abnormalities
The purpose of this pilot clinical study is to test a methodology for using high-resolution Positron Emission Tomography (PET) imaging to guide vacuum-assisted core biopsy of breast abnormalities identified on PET.
- Trial name
- PEM-BX (NCT00606931)
- Testing
- Stereo Navigator Accessory to PEM Flex PET Scanner
- Where
- 5 sites in United States
- Volunteers
- 22 people
- Sponsor
- Naviscan PET Systems
Influenza A Virus Infection
Blood and Plasma Collection For Use in Future Clinical Trials
Treatment options are limited for the treatment of influenza. This study will collect blood from people who have been exposed to the influenza virus or who have received a seasonal influenza vaccine.
- Trial name
- NCT01136057
- Testing
- Collection of Anti-Influenza A Immune Plasma
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Uremia
A Comparative Study of Two Kinds of Hemodialysis Filters
This study exploring the expression characteristics of different cells of peripheral blood after exposure to two kinds of hemodialysis filter membrane materials will help to elucidate the key mechanisms of hemodialysis filter…
- Trial name
- NCT05899283
- Testing
- OCI-HF160, FX800HDF
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Chinese PLA General Hospital
Hypertension
Dietary Counseling to Reduce Salt Intake in Patients With High Blood Pressure
High salt diet increases risk of development of hypertension. In hypertensive patients, low salt diet decreases blood pressure. Not surprisingly public health authorities endorse low salt diet in hypertensive patients.
- Trial name
- NCT02283697
- Testing
- Dietary Counseling, Control: Standard Care
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- Ottawa Hospital Research Institute
Clinical High-Risk, Psychological
Skills Group for Youth at Clinical High-Risk for Psychosis
This study is intended to test the feasibility of an integrated cognitive behavioral therapy (CBT) and dialectical behavioral therapy (DBT) skills group for adolescents and young adults at clinical high-risk (CHR) for psychosis.
- Trial name
- NCT05398120
- Testing
- Skills Group
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Chronic Pain, Elbow Tenderness
Clinical Trial for High Intensity Laser Therapy (HILT) for Elbow Epicondylosis
This study will determine the efficacy of High Intensity Laser Therapy (HILT) for the treatment of elbow epicondylosis
- Conditions
- Chronic Pain, Elbow Tenderness, Elbow Pain Upon Active Resistive Motion
- Trial name
- HILT (NCT01992627)
- Testing
- HILTERAPIA HIRO 3.0
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- CM Chungmu Hospital
Obesity, Overweight
Effect of High Caloric Intake at Lunch Against Dinner on Weight Loss
The purpose of the present study is to evaluate the effect of consuming higher caloric intake at lunch in contrast to dinner on weight loss of obese and overweight female adults when they are in a multidisciplinary weight loss…
- Trial name
- NCT02399280
- Testing
- Lunch as main meal(LM)+ Diet, Dinner as main meal(DM)+ Diet
- Where
- Iran
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Novindiet Clinic
Non-Small Cell Lung Cancer
A Study of Chidamide Combined With Ivonescimab in the Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) With Acquired Resistance to Immunotherapy and High Yes-associated Protein (YAP) Expression
This is a prospective, single-arm, multi-center, phase II clinical trial to evaluate the efficacy and safety of Chidamide in combination with Ivonescimab in the treatment of advanced non-small cell lung cancer with secondary…
- Trial name
- NSCLC， YAP (NCT07412262)
- Testing
- Chidamide in combination with Ivonescimab
- Where
- 2 sites in China
- Volunteers
- 32 people
- Sponsor
- Guangdong Association of Clinical Trials
Recurrent Acute Lymphoblastic Leukemia, Recurrent B Acute Lymphoblastic Leukemia
Genetically Engineered Cells (Anti-CD19/CD20/CD22 CAR T-cells) for the Treatment of Relapsed or Refractory Lymphoid Malignancies
This phase I trial tests the safety, side effects and best infusion dose of genetically engineered cells called anti-CD19/CD20/CD22 chimeric antigen receptor (CAR) T-cells following a short course of chemotherapy with…
- Conditions
- Recurrent Acute Lymphoblastic Leukemia, Recurrent B Acute Lymphoblastic Leukemia, Recurrent B-Cell Prolymphocytic Leukemia, Recurrent Chronic Lymphocytic Leukemia
- Trial name
- NCT05418088
- Testing
- Anti-CD19/CD20/CD22 CAR T-Cells, Cyclophosphamide, Fludarabine Phosphate
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- Sumithira Vasu
Prostate Cancer, Prostate Cancer Patients
177Lu-PSMA-617 Combined With Darolutamide in Neoadjuvant Treatment of High-risk Localized Prostate Cancer: a Prospective, Single-arm, Multi-center Clinical Trial
The goal of this clinical trial is to explore the efficacy and safety of darolutamide combined with 177Lu-PSMA-617 in treating high-risk localized prostate cancer patients who are scheduled to undergo radical prostatectomy.
- Trial name
- IUNU-PC-123 (NCT07677566)
- Testing
- Darolutamide combined with 177Lu-PSMA-617
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Advanced Systemic Mastocytosis (AdvSM), SM With an Associated Hematologic Neoplasm (SM-AHN)
(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis
This is an open-label, two-part Phase 2 study investigating CGT9486 for the treatment of patients with Advanced Systemic Mastocytosis (AdvSM), including patients with Aggressive SM (ASM), SM with Associated Hematologic Neoplasm…
- Conditions
- Advanced Systemic Mastocytosis (AdvSM), SM With an Associated Hematologic Neoplasm (SM-AHN), Mast Cell Leukemia (MCL), Aggressive Systemic Mastocytosis (ASM)
- Trial name
- NCT04996875
- Testing
- bezuclastinib
- Where
- 42 sites in United States, Australia and 12 more
- Volunteers
- 140 people
- Sponsor
- Cogent Biosciences, Inc.
Glioma, Brain Neoplasm
Safety and Tolerability Study of 131I-TM-601 to Treat Adult Patients With Recurrent Glioma.
This drug is being developed to treat a type of brain cancer, glioma. This study was designed to determine a safe and well tolerated dose.
- Trial name
- NCT00040573
- Testing
- 131I-TM-601
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- TransMolecular
Leukoaraiosis
the Effects of Cerebral Collateral Circulation on the Outcome of Leukoaraiosis in High-risk Population
This study observed the relationship between cerebral collateral circulation and the prognosis of leukoaraiosis in high-risk population.
- Trial name
- NCT03246373
- Where
- China
- Volunteers
- 1,037 people
- Sponsor
- Shanghai Zhongshan Hospital
High-risk Prostate Cancer
Immunotherapy With N 803, ETBX-071, and M-CENK in Combination With Radiation for Participants With High-Risk Prostate Cancer.
This study tests a new treatment for men with high-risk prostate cancer who can't have surgery. The treatment combines three experimental drugs and radiation therapy.
- Trial name
- NCT06765954
- Testing
- N-803 (IL-15 Superagonist), ETBX-071 (PSA-based Oncolytic Virus), M-CENK (Activated NK Cells)
- Sponsor
- ImmunityBio, Inc.
Dental Caries, Dental Caries in Children
Restoration Repairs Using Composite Resin Versus Glass Ionomer in Primary Molars: a Randomized Clinical Trial
The objective of this randomized clinical study is to evaluate the survival of repairs in restorations using composite resin (CR) or high viscosity glass ionomer cement (GIC) in primary molars.
- Trial name
- NCT04491981
- Testing
- Encapsulated Glass Ionomer Cement, Composite resin
- Where
- Brazil
- Volunteers
- 312 people
- Sponsor
- University of Sao Paulo
Cholesterol, HDL
Prospective Randomized Clinical Trial Evaluating the Impact of Vinegar on High Density Lipoprotein
This is a double-blinded randomized placebo controlled prospective clinical trial evaluating the impact of apple cider vinegar on serum HDL.
- Trial name
- NCT00755924
- Testing
- Vinegar
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Secondary Dental Caries
Assessment of Bioactive Bulk Fill Composite Versus High Viscosity Glass Ionomer Restorations for Carious Lesions
This trial will be conducted to compare the clinical performance between a new bioactive resin composite material and high viscosity glass ionomer for restoring occlusal carious lesions of posterior teeth in patients scheduled…
- Trial name
- NCT05332041
- Testing
- Predicta Bioactive bulk fil composite restoration
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Caries,Dental, Dental Caries
The Impact of Sage Extract on GTS B and D Gene Expression in S. Mutans
Glucosyltransferases (Gtfs) play a crucial role in the pathogenesis of dental caries caused by Streptococcus mutans. Gtfs is recognized as an attractive target for effective therapeutic interventions aimed at inhibiting…
- Conditions
- Caries,Dental, Dental Caries, Dental Diseases
- Trial name
- NCT06703554
- Testing
- Sage Oil Mouthwash, Chlorohexidine Mouthwash
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Prevention of Dental Caries
The Influence of Preventive Regimens Containing Different Toothpastes on Caries Risk of High Risk Patients: A Randomized Clinical Trial
66 Participants will be divided into three groups according to the tested regimen (A), where (A1) represents participants will be exposed to regimen including dual zinc plus arginine based toothpaste (Colgate total), (A2)…
- Trial name
- NCT04032210
- Testing
- dual Zinc plus Arginine based toothpaste (Colgate total), Zinc based toothpaste (Crest complete), Fluoride based toothpaste (Signal)
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cairo University
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