Clinical trials: Clinical High-risk
Desaturation of Blood, Obesity
High-Flow Nasal Cannula and Desaturation Episodes in the Morbidly Obese Patients
It is standard practice in the United States and many parts of world to perform Gastrointestinal (GI) endoscopy with the patient under deep sedation.
- Conditions
- Desaturation of Blood, Obesity, Colonoscopy, Sleep Apnea
- Trial name
- NCT03148262
- Testing
- The Comfort Flo system, The Salter nasal cannula
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- University of Texas Southwestern Medical Center
Renal Failure, Acute Renal Failure
Premarket Clinical Safety Assessment of the ELISIO™-HX
The primary safety objective of this study is to evaluate the safety of the use of the high-permeability hemodialyzer series ELISIO™-HX, by showing that the pre-dialysis albumin levels are not affected using the investigational…
- Conditions
- Renal Failure, Acute Renal Failure, Chronic Renal Failure, Chronic Kidney Diseases
- Trial name
- NCT07058909
- Testing
- ELISIO™-HX Dialyzer
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Nipro Medical Corporation
Subclinical Atrial Fibrillation, Cardiac Arrhythmias
The Clinical Outcomes and Therapeutic Effects in Patients With Cardiac Implantable Electronic Device-detected Subclinical and Clinical Atrial Fibrillation.
Atrial high-rate episodes (AHREs) detected by cardiac implantable electronic devices (CIEDs) are associated with an increased risk of progression to clinical atrial fibrillation (AF), stroke, heart failure, and mortality.
- Trial name
- AHRE (NCT07649109)
- Testing
- Early Rhythm Control Strategy, Usual Care
- Where
- Taiwan
- Volunteers
- 450 people
- Sponsor
- National Taiwan University Hospital
Class I Cavities in High Caries Risk, Class I Composite Restorations
The Clinical Performance of Two Dentine Replacement Materials in Deep Occlusal Cavities (Randomized)
Higher mechanical properties are needed to restore structurally compromised posterior teeth, short fiber reinforced resin composite and injectable bioactive resin composites provide superior properties to flowable composites that…
- Conditions
- Class I Cavities in High Caries Risk, Class I Composite Restorations, Randomized Clinical Trial, Occlusal Caries
- Trial name
- NCT06924047
- Testing
- Beautifil Flow Plus X, EverX Flow
- Volunteers
- 50 people
- Sponsor
- Dalia Sameh Fawzi
Hyperlipidemia
Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Hyperlipidemia or Mixed Dyslipidemia at Risk of Cardiovascular Events
This study is a multicenter, randomized study in subjects with high cholesterol receiving highly effective statins to assess the efficacy, safety and tolerability of Bococizumab (PF-04950615;RN316) to lower LDL-C.
- Trial name
- SPIRE-LDL (NCT01968967)
- Testing
- Bococizumab (PF-04950615; RN316)
- Where
- 249 sites in United States, Canada and 10 more
- Volunteers
- 2,139 people
- Sponsor
- Pfizer
Helicobacter Pylori
Helicobacter Pylori and Vonoprazan Dual Therapy
Our previous study included 119 Helicobacter pylori(H. pylori)-infected Chinese patients without previous eradication history who were randomized to low-or high-dose amoxicillin-vonoprazan regimens consisting of amoxicillin 1…
- Trial name
- NCT05649709
- Testing
- L-VA dual therapy, H-VA dual therapy
- Where
- China
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Nanchang University
Breast-Conserving Surgery
Regenerative Collagen Scaffold for Breast Volume Restoration After Breast Cancer Excision
This clinical trial evaluates the safety and efficacy of High Purity Type I Collagen scaffold for breast volume restoration following breast-conserving surgery (BCS).
- Trial name
- NCT07219316
- Testing
- High Purity Type I Collagen Scaffold (Regenerative Matrix)
- Where
- 2 sites in India
- Volunteers
- 40 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Vitamin D Deficiency, Thoracic Surgery
Prevention of Vitamin D Deficiency Following Pediatric CHD Surgery: a Phase II Dose Evaluation Randomized Controlled Trial Comparing Usual Care With a High Dose Pre-operative Supplementation Regimen Based on the Institute of Medicine Daily Upper Tolerable Intake Level
Our research group has shown that almost all children with congenital heart disease (CHD) are vitamin D deficient following heart surgery.
- Conditions
- Vitamin D Deficiency, Thoracic Surgery, Pediatric Disorders, Heart Defects, Congenital
- Trial name
- HICCUPS 2 (NCT01838447)
- Testing
- Cholecalciferol
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Children's Hospital of Eastern Ontario
Prodromal Schizophrenia
Neurofeedback Training for High Risk Psychosis
Young people who are at great risk for developing psychosis have cognitive deficits which are strongly related to functioning in the community.
- Trial name
- NCT03447548
- Testing
- Neurofeedback processing speed training, Active control
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- Hartford Hospital
Sinusitis
Clinical Trial of the Treatment of Acute Sinusitis With Standard-dose Versus High-dose Amoxicillin/Clavulanate
The aim is to determine if high-dose amoxicillin/clavulanate is more effective than standard-dose amoxicillin/clavulanate in treating acute bacterial sinusitis in adults seen at a primary care office.
- Trial name
- NCT02340000
- Testing
- standard dose amoxicillin/clavulanate, high dose amoxicillin/clavulanate
- Where
- United States
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Analgesia, Postoperative Pain
Volume vs Concentration: Quadratus Lumborum Blocks With High Volume/Low Concentration or Low Volume/ High Concentration in Nephrectomies
The quadratus lumborum has since 2016 become standard of care for abdominal and retroperitoneal surgeries at UPMC-Shadyside Hospital, replacing paravertebral blocks, and as part of a broader multimodal analgesia institutional…
- Conditions
- Analgesia, Postoperative Pain, Block
- Trial name
- NCT04077398
- Testing
- Ropivacaine 0.5% Injectable Solution
- Where
- United States
- Sponsor
- Bruce Ben-David
Non-muscle Invasive Bladder Cancer
Safety and Efficacy of APL-1202 in Combination With Epirubicin Hydrochloride Versus Epirubicin Hydrochloride Alone in Intermediate and High-risk Chemo-refractory Non-muscle Invasive Bladder Cancer (NMIBC) Patients
To evaluate the clinical efficacy (median event-free survival) of APL-1202 in combination with Epirubicin hydrochloride versus Epirubicin hydrochloride alone in intermediate and high-risk chemo-refractory non-muscle invasive…
- Trial name
- ACCRUE (NCT04490993)
- Testing
- APL-1202 in combination with Epirubicin
- Where
- China
- Volunteers
- 359 people
- Sponsor
- Jiangsu Yahong Meditech Co., Ltd aka Asieris
Pediatric Obesity, COVID-19
Exercise and Diet for Pediatric Obesity
The coronavirus disease (COVID-19), is a communicable pandemic disease as stated by the world health organization (WHO), which has been affecting the world since December 2019.
- Trial name
- NCT05336006
- Testing
- High-intensity aerobic training with high protein diet, Control group
- Where
- Saudi Arabia
- Volunteers
- 76 people
- Sponsor
- Prince Sattam Bin Abdulaziz University
Multiple Sclerosis
Open, Multicentric, Prospective, Quality of Life Study in Multiple Sclerosis Patients
To evaluate the evolution of the impact on daily life activities over the first 12 months following the introduction of interferon beta-1b treatment in patients presenting RRMS or patients at high risk of developing Multiple…
- Trial name
- NCT00928967
- Testing
- Interferon beta-1b, (Betaseron BAY86-5046)
- Where
- France
- Volunteers
- 67 people
- Sponsor
- Bayer
Class V Dental Caries, High Caries Risk Patients
Clinical Evaluation of Different Bioactive Restorative Materials for Cervical Carious in High Caries Risk Patients
The aim of the study is to clinically evaluate three different bioactive restorative material in cervical carious lesion in high caries risk patients. Reducing the incidence of recurrent caries is the primary outcome
- Trial name
- NCT06736964
- Testing
- Giomer
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Sensorineural Hearing Loss (Disorder)
Clinical Applications of Round Window Imaging Anatomy in Cochlear Implant Surgery
The purpose of this study is to measure the size of the round window niche and its relation to the mastoid segment of the facial nerve and the mastoid cortex, using high resolution computerized tomography of the temporal bone, in…
- Trial name
- NCT02093806
- Testing
- measurment
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Bnai Zion Medical Center
Healthy
High-fidelity Simulation in Health Care Education
The purpose of this study is to determine whether the use of high-fidelity simulation in health care education is an effective training and evaluation model.
- Trial name
- NCT00690144
- Testing
- High-fidelity high-fidelity mannequin simulator (SimMan, Laerdal, Stavanger, Norway).
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Neoplasms, Prostate, Benign Prostatic Hyperplasia
Economic Analyses of the REDUCE Trial
The objective of this project is to conduct a retrospective economic analysis of the use of dutasteride for the prevention of prostate cancer based on data from the REDUCE clinical trial.
- Conditions
- Neoplasms, Prostate, Benign Prostatic Hyperplasia, Cancer
- Trial name
- NCT01337258
- Testing
- Dutasteride
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Psychotic Disorders, Prodromal Symptoms
Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy Trial
The present study is a confirmatory efficacy trial of Family Focused Therapy for youth at clinical high risk for psychosis (FFT-CHR).
- Conditions
- Psychotic Disorders, Prodromal Symptoms, Prodromal Schizophrenia, Psychosis
- Trial name
- NCT04338152
- Testing
- Family Focused Therapy for Clinical High Risk Youth (FFT-CHR), Enhanced Care (EC)
- Where
- 7 sites in United States, Canada
- Volunteers
- 220 people
- Sponsor
- University of California, Los Angeles
B-ALL
Blinatumomab as Maintenance Therapy in Patients With High-risk B-lineage Acute Lymphoblastic Leukemia Post Allogeneic Hematopoietic Cell Transplantation
Patients ≥ 14 years of age after B-ALL allogeneic transplantation received 4 cycles of maintenance therapy with blinatumomab +/- TKI and were followed for more than 1 year to assess overall survival (OS), relapse-free survival…
- Trial name
- NCT06658938
- Testing
- Blinatumomab
- Volunteers
- 30 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
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