Clinical trials: Clinical High-risk
Acute Graft-versus-host Disease
Clinical Implications of HMGB1 in Patients Treated With Chemotherapy or Hematopoietic Stem Cell Transplantation
Acute Graft-versus-host disease(aGVDH) after allogeneic hematopoietic stem cell transplantation is one of the meaningful issues in aspect of patient's recovery and survival.
- Trial name
- CHIP-SCT (NCT02044185)
- Testing
- salvage chemotherapy, total body irradiation
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul St. Mary's Hospital
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Study on the Efficacy and Safety of the TmBU Conditioning Regimen in High-risk or Relapsed/Refractory Acute Leukemia
This project is a prospective, single-center, randomized controlled clinical study. The subjects were high-risk or relapsed/refractory AML or ALL patients aged ≤ 65 years diagnosed by bone marrow cell morphology, immunology…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Transplantation, Stem Cell, Conditioning Therapy
- Trial name
- NCT06816134
- Testing
- TmBU conditioning Regimen, mBUCY conditioning regimen
- Where
- China
- Volunteers
- 48 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Chronic Obstructive Pulmonary Disease
The Role of HNHF to Improve Clinical Outcomes Following Severe AECOPD
Chronic Obstructive Pulmonary Disease (COPD) is a common lung disease, affecting 1.2 million people in the United Kingdom (UK). COPD patients suffer with episodes of worsening breathing symptoms called acute exacerbations…
- Trial name
- NCT03899558
- Testing
- Humidified nasal high-flow device
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Acute Exacerbation Chronic Obstructive Pulmonary Disease
Effect of Low-Dose Versus High-Dose Alpha-Lipoic Acid on Oxidative Stress, Inflammation, and Clinical Outcomes in Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is a progressive inflammatory lung disease characterized by persistent airflow limitation and enhanced oxidative stress.
- Trial name
- NCT07456176
- Testing
- Alpha Lipoic Acid 600 MG Oral Tablets, Alpha Lipoic Acid
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Vorolanib, Clear Cell Renal Cell Carcinoma (ccRCC)
Pucotenlimab Combination With Vorolanib as Neoadjuvant Therapy for ccRCC
Through the neoadjuvant treatment with a combination of Pucotenlimab and Vorolanib, it enabled the successful and safe implementation of partial nephrectomy in patients with localized renal cancer, who had indications for…
- Conditions
- Vorolanib, Clear Cell Renal Cell Carcinoma (ccRCC), Neoadjuvant Therapy
- Trial name
- NCT07386158
- Testing
- Pucotenlimab combination with Vorolanib
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Sun Yat-sen University
COVID, Sars-CoV2
Preventing COVID-19 Complications With Low- and High-dose Anticoagulation
The ongoing COVID-19 pandemic affects millions of humans worldwide and has led to thousands of acute medical hospitalizations. There is evidence that hospitalized cases often suffer from an important infection-related…
- Trial name
- COVID-HEP (NCT04345848)
- Testing
- Enoxaparin
- Where
- 4 sites in Switzerland
- Volunteers
- 160 people
- Sponsor
- University Hospital, Geneva
Stroke, Pain
HD-tDCS for Pain Reduction in Post-Stroke Pain: a Randomized Crossover Trial
This study aims to assess the effectiveness of multichannel transcranial direct current stimulation (tDCS) in alleviating pain and to evaluate its safety in patients with central post-stroke pain (CPSP)
- Conditions
- Stroke, Pain, CPSP, TDCS
- Trial name
- NCT06740591
- Testing
- HD-tDCS
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Pusan National University Yangsan Hospital
Mild Cognitive Impairment, Mild Dementia
Effect of High Frequency/Low Intensity Transcranial Magnetic Stimulation in Cognitive Traits of an Elderly Population of Subjects With Mild Cognitive Impairment and Mild Dementia.
There are no pharmacological interventions that delay or prevent the transition of mild cognitive impairment to dementia. Several studies have shown that transcranial magnetic stimulation (TMS) could be useful in increasing…
- Trial name
- NCT03983655
- Testing
- High Frequency Low Intensity TMS
- Where
- Mexico
- Volunteers
- 37 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Clinical High Risk for Psychosis
tDCS Coupled With Virtual Rehabilitation for Negative Symptoms in At-Risk Youth
Negative symptoms, which include the loss of motivation, social withdrawal and reduced emotional expression are prominent in youth at clinical high risk (CHR) for psychosis.
- Trial name
- NCT02951208
- Testing
- Active tDCS, Active VR Motivation Training
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Centre for Addiction and Mental Health
Multiple Sclerosis, Clinically Isolated Syndrome
Long-term Follow-Up of Patients Who Participated in Study 27025 (REFLEX)
REFLEXION is a double blind extension of the study 27025 (NCT00404352) (REFLEX). The purpose of the study is to obtain long-term follow-up data in subjects with clinically definite multiple sclerosis (MS) and subjects with a…
- Trial name
- REFLEXION (NCT00813709)
- Testing
- RNF
- Where
- 57 sites in Argentina, Austria and 22 more
- Volunteers
- 402 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Keratolysis
Vision Restoration With a Collagen Crosslinked Boston Keratoprosthesis Unit
This is a phase I/II prospective, randomized, multi-center, double-masked, vehicle-controlled clinical trial evaluating the safety and efficacy of corneal collagen cross-linking the keratoprosthesis carrier tissue in subjects who…
- Trial name
- NCT02863809
- Testing
- Riboflavin, Dextran, UVA Light Source
- Where
- 13 sites in United States
- Volunteers
- 76 people
- Sponsor
- Joseph B. Ciolino, MD
Dysphagia, Swallowing Disorders
Novel Pharyngeal Metrics to Predict Dysphagia Outcomes
This multi-site trial will follow a cohort of Veterans with dysphagia for 8 weeks as they undergo clinically guided oropharyngeal exercises with oropharyngeal strengthening as the primary goal.
- Trial name
- NCT04569097
- Testing
- standard of care lingual strengthening
- Where
- 3 sites in United States
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Human Papilloma Virus, Human Papilloma Virus Infection
Clinical Trial to Explore Papilocare Gel Efficacy to Repair of the Cervico-vaginal Mucosa With HPV High Risk Lesions.
Phase II, exploratory, randomized, open, controlled and parallel groups clinical trial to evaluate the effectiveness of exploratory gel Papilocare in the repair of the cervico-vaginal mucosa with lesions caused by HPV-HR.
- Conditions
- Human Papilloma Virus, Human Papilloma Virus Infection, Cervix Lesion
- Trial name
- PALOMA2 (NCT04199078)
- Testing
- Papilocare vaginal gel
- Where
- 19 sites in Spain
- Volunteers
- 164 people
- Sponsor
- Procare Health Iberia S.L.
Postoperative Delirium
Clinical Trial With Quetiapine Prophylaxis Postoperative Delirium in High Risk Surgical Patients
Double blinded Clinical trial to test efficacy of Quetiapine versus placebo in reducing postoperative delirium in high risk surgical patients after three days of treatment.
- Trial name
- NCT03739476
- Testing
- Quetiapine 25 milligrams capsule
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Gliomas
Cilengitide and Metronomic Temozolomide for Relapsed or Refractory High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas in Children and Adolescents
The primary objective of this study is to evaluate the efficacy of a combined treatment with cilengitide and metronomic oral temozolomide as measured by 6 months overall survival (OS) after diagnosis of relapse or tumour…
- Trial name
- HGG-CilMetro (NCT01517776)
- Testing
- Cilengitide, Temozolomide
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Severe Insufficient Nutrition
Clinical Evaluation of a Normoproteic Diet
The main objective of this trial is the clinical evaluation of a normoproteic diet, when this diet is used for total enteral nutrition in geriatric people.
- Trial name
- STDUGR (NCT01303289)
- Testing
- T-Diet plus Standard, Jevity
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Vegenat, S.A.
Postpartum Anxiety
Prevention of Postpartum Anxiety in High-Risk Women
The primary aim of this study is to evaluate whether a CBT group designed to target IU (CBT-IU) in pregnant women with heightened levels of IU, prevents postpartum anxiety.
- Trial name
- NCT05691140
- Testing
- Cognitive Behavioural Therapy
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Glioblastoma (GBM), Astrocytoma, Grade IV
UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-4
This study builds on the results of prior studies (UNITED and UNITED-3). The goal of UNITED-4 is to test whether an adaptive radiation therapy (RT) therapy approach ('dose painting'), with reduced margins, impacts approach in…
- Trial name
- UNITED-4 (NCT07459101)
- Testing
- Dose painting + Reduced Margins
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Sunnybrook Health Sciences Centre
Skin Laxity (Submental and Neck), Facial Skin Laxity
Safety and Effectiveness Evaluation of the High-intensity Focused Ultrasound Device for Lifting Lax Submental and Neck Tissue
This is a prospective, multicenter, randomized, evaluator-blinded, parallel-controlled, non-inferiority clinical study designed to evaluate the safety and effectiveness of the ULTRAFORMER MPT PLUS, a high-intensity focused…
- Conditions
- Skin Laxity (Submental and Neck), Facial Skin Laxity, Submental Tissue Laxity
- Trial name
- NCT07229430
- Testing
- ULTRAFORMER MPT PLUS, Ulthera System
- Where
- 5 sites in United States
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- CLASSYS Inc.
Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell
ChiCGB vs BEAM in High-risk or R/R Lymphomas
High-dose chemotherapy (HDT) with autologous stem cell transplantation (ASCT) plays a vital role in treating high-risked or relapsed/refractory lymphoma.
- Trial name
- NCT05466318
- Testing
- Chidamide, Cladribine, Gemcitabine
- Where
- 11 sites in China
- Volunteers
- 306 people
- Sponsor
- Sichuan University
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