Clinical trials: Clinical High-risk
Acute Pulmonary Embolism
HOME-PE2 : Home Treatment Versus Hospitalization in Patients With Acute Pulmonary Embolism, no Clinical Severity Criteria, and Either Right Ventricular Dysfunction or Elevated Troponin: a Randomized Controlled Trial
This study (HOME-PE2) is a multicenter, randomized controlled trial comparing home treatment versus hospitalization in patients with acute pulmonary embolism (PE) who have no clinical severity criteria according to the Hestia…
- Trial name
- HOME-PE2 (NCT07506291)
- Testing
- Home treatment, Hospitalization
- Where
- 18 sites in France
- Volunteers
- 568 people
- Sponsor
- University Hospital, Angers
Schizophrenia, Cognitive Impairment
Eye-Movement Intervention for Cognitive Impairment Across Schizophrenia Spectrum
The goal of this clinical trial is to determine whether a gamified eye-movement intervention can improve cognitive function in individuals across the schizophrenia spectrum, including clinical high-risk individuals, first-episode…
- Conditions
- Schizophrenia, Cognitive Impairment, Clinical High Risk for Psychosis
- Trial name
- NCT07702526
- Testing
- Eye-Movement Training, Finger-Controlled Game Training
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Leukemia, Acute
Clinical Application of Novel Panels for Early Precision Diagnosis and Relapse Prediction in High-risk Leukemia
Based on the investigator's previous data on risk classification for acute leukemia,the investigators will design a set of panels to detect the gene expression and genomic variants (SNPs, mutation, insertion, deletion and fusion…
- Trial name
- NCT03297476
- Testing
- High-risk subtype detection panels
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhongda Hospital
Dental Caries, Glass-Ionomer Cement
Heated Glass Ionomer Cement in Primary Molars
Objective: The aim of this study was to assess the influence of heated in the clinical success of proximal high viscosity glass ionomer cement (GIC) restorations in primary molars.
- Conditions
- Dental Caries, Glass-Ionomer Cement, Primary Teeth
- Trial name
- NCT04291872
- Testing
- Glass -Ionomer Cement with /without Led Light Cure
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Marmara University
B-Cell Non-Hodgkin's Lymphoma (NHL), Lymphoma, Non-Hodgkins
T-Cell Therapy (EB103) in Adults With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (NHL)
This is an open-label, multi-center, Phase 1/2 clinical trial evaluating the safety and effectiveness of EB103 in R/R B-cell NHL patients with the highest unmet medical needs, such as Human Immunodeficiency Virus (HIV)-associated…
- Conditions
- B-Cell Non-Hodgkin's Lymphoma (NHL), Lymphoma, Non-Hodgkins, Lymphomas Non-Hodgkin's B-Cell, Non-Hodgkin Lymphoma
- Trial name
- STARLIGHT-1 (NCT06343311)
- Testing
- EB103
- Where
- 5 sites in United States
- Volunteers
- 27 people
- Sponsor
- Estrella Immunopharma, Inc.
Psychosis
Developing Clinical Tools to Communicate Genetic Risk for Individuals Who Are Clinical High Risk for Psychosis
While great strides are being made in identifying early signs that place people at a 'high risk state' for different illness conditions, at the same time, advances are being made in the identification of genes associated with…
- Trial name
- NCT04325568
- Testing
- PsyGist and Clinician Manual
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- New York University
Recurrent Stage IV High Risk Neuroblastoma
Study on Sintilimab in Stage IV High Risk Neuroblastoma
A phase I observational study on the safety and efficacy of treatment of recurrent stage IV high risk neuroblastoma with Nivolumab
- Trial name
- SCMC-S-2020 (NCT04412408)
- Testing
- Sintilimab
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai Children's Medical Center
Multiple Sclerosis
Evaluation of the Clinical Contribution of Quantitative MRI in Neuro-imaging
This study aims to develop the use of a quantitative MRI (qMRI) approach in neuroimaging for MS patients. To achieve this task the main goals of this study will be: to standardize and optimize qMRI protocols (acquisition time…
- Trial name
- NormaBRAIN (NCT07245589)
- Testing
- 3T MRI, 7T MRI, Clinical examination of MS patients
- Where
- France
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Blood Pressure, Complication,Postoperative
HIgh Versus STAndard Blood Pressure Target in Hypertensive High-risk Patients Undergoing Major Abdominal Surgery
This study is a multicenter randomized controlled trial comparing two strategies of mean arterial blood pressure management (MAP ≥ 80mmHg vs MAP ≥ 65 mmHg) in high-risk surgical patients undergoing elective…
- Conditions
- Blood Pressure, Complication,Postoperative, Intraoperative Hypotension
- Trial name
- HISTAP (NCT05637606)
- Testing
- Ephedrine, Norepinephrine, Etilefrine Hydrochloride bolus
- Where
- 18 sites in Italy
- Volunteers
- 636 people
- Sponsor
- Humanitas Clinical and Research Center
Gastrointestinal Endoscopy
Etomidate Combined With Propofol Versus Propofol for Sedation in High-Altitude Patients During Gastroscopy: a Randomized Multicenter Clinical Trial
One of the most common adverse events during sedated gastrointestinal endoscopy is hypoxemia, which can lead to serious consequences.
- Trial name
- NCT07079176
- Testing
- etomidate combined with propofol, propofol
- Volunteers
- 732 people
- Sponsor
- RenJi Hospital
Stroke
Effect of HIIT on Post-Stroke Fatigue
This study aims to investigate the effect of high-intensity interval training (HIIT) on fatigue severity among individuals with chronic stroke.
- Trial name
- NCT07273058
- Testing
- HIIT, MICT, stretching
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Metabolic Syndrome X
Effect of Exercise Training on the Function of the High Density Lipoprotein (HDL)-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Metabolic Syndrome(HERMET-Study)
The purpose of the present study is to characterize the quality of HDL-Cholesterol in patients with metabolic syndrome and reduced blood HDL-Cholesterol levels and to examine the effect of exercise training on the…
- Trial name
- HERMET (NCT00515476)
- Testing
- physical exercise
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Intubation;Difficult
Preoxygenation for Difficult Airway Management
Tracheal intubation in operating room for patients at risk of difficult intubation remains a critical event. The aim of this study is to determine whether Nasal High Flow Therapy by nasal cannula Optiflow® administered before and…
- Trial name
- PREOPTI-DAM (NCT03604120)
- Testing
- Preoxygenation with high flow therapy by nasal cannula, Preoxygenation by standard Facial mask
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Nantes University Hospital
Ovarian Epithelial Cancer
Timing of Surgery After Neoadjuvant Chemotherapy for Advanced Ovarian Cancer
Ovarian cancer is among the top five primary causes of cancer-related mortality in women. Most ovarian malignant tumours originate from epithelial cells The majority of patients typically have advanced-stage tumours at diagnosis.
- Trial name
- NCT06404671
- Testing
- Delayed interval cytoreductive surgery (DICS), Early interval cytoreductive surgery (EICS)
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Alexandria University
Severe Respiratory Disease
Study to Evaluate the Human Infection of the Lower Respiratory Tract in Children at High Risk
Estimate the incidence rate of hMPV infection detected by RT-PCR from frozen nasal wash aspirates in children at high risk for severe LRI disease (hospitalized at <2 years of age).
- Trial name
- NCT00192439
- Testing
- High Risk Respiratory Disease
- Where
- 24 sites in United States, Australia and 2 more
- Volunteers
- 1,500 people
- Sponsor
- MedImmune LLC
Rectal Cancer
SIB-RT Combined With CAPOX and PD-1 for High-Risk Rectal Cancer
The biological effective dose of short-course radiotherapy is relatively lower compared to long-course radiotherapy, which may lead to an increased local recurrence rate in patients with mid to low rectal cancer who are at high…
- Trial name
- NCT07297030
- Testing
- SIB-SCRT, CAPOX, Immunotherapy
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Sun Yat-sen University
Pressure Ulcers
A Pilot Study of the Envision® Surface
This study is to evaluate the clinical safety and effectiveness of the Envision® surface.
- Trial name
- NCT00405834
- Testing
- Envision® Patient Support System
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hill-Rom
High Frenum Attachment
Clinical Efficacy of Frenectomies Using Diode Laser Versus Conventional Techniques
The aim of present study was to compare the keratinized gingival tissue measurements, degree of subjective complaints, and functional complications of using an 980 nm diode laser versus a scalpel for frenectomies.
- Trial name
- NCT03156387
- Testing
- Diode laser, Scalpel
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- T.C. Dumlupınar Üniversitesi
Obesity, Insulin-resistant
HIT in Insulin-resistant and Insulin-sensitive Obese Adolescents
Evaluate the effects of HIT on the cardiorespiratory performance and substrate oxidation of insulin-resistant and insulin-sensitive obese adolescents.
- Conditions
- Obesity, Insulin-resistant, Adolescents
- Trial name
- NCT03042234
- Testing
- Group Insulin-Resistant, Group Insulin-Sensitive
- Where
- 3 sites in Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
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