Clinical trials: Clinical High-risk
Caries
Antibacterial Effect of Miswak Toothpaste Compared to Fluoride Toothpaste
Meswak is scientifically formulated herbal toothpaste with pure extract of the Miswak plant 'Salvadore Persica', the famous 'Toothbrush Tree' used for centuries.
- Trial name
- NCT05109299
- Testing
- Miswak toothpaste, Fluoride toothpaste
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Cairo University
Hereditary Neoplasms, Cancer
Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Cancer
This is a clinical, epidemiologic, genetic, and laboratory study of individuals and families at high risk of cancer and selected tumors to investigate the genetic susceptibility and environmental exposures which may alter cancer…
- Conditions
- Hereditary Neoplasms, Cancer, Genetic Predisposition to Cancer, Environment
- Trial name
- NCT00001163
- Where
- United States
- Volunteers
- 5,201 people
- Sponsor
- National Cancer Institute (NCI)
Perioperative/Postoperative Complications
LUS and Consequences of High FiO2 in Children
The purpose of this study is 1. to evaluate effect of high FiO2 on the development of intraoperative atelectasis in mechanically ventilated children using LUS. 2.
- Trial name
- NCT04581226
- Testing
- Lung ultrasound
- Where
- 2 sites in Egypt
- Volunteers
- 33 people
- Sponsor
- Assiut University
Renal Stones
Ureteroscopic Lithotripsy for Renal Stones Using a Sheathless Approach or Using a Flexible and Navigable Ureteral Access Sheath (FANS)
The primary aim of the study is to compare stone free rates following ureteroscopic (URS) lithotripsy for renal stones with Thulium Fiber Laser (TFL) using a sheathless approach (low power laser settings) or using a flexible and…
- Trial name
- NCT07741084
- Testing
- Sheathless URS, FANS, low power, FANS, high power
- Where
- Norway
- Volunteers
- 225 people
- Sponsor
- Haukeland University Hospital
Human Papillomavirus Infection
Efficacy of Probiotic Lactobacillus Crispatus M247 in Promoting High-risk Human Papillomavirus (HR-HPV) Infection Clearance and Modifying Vaginal Microbiota
This clinical trial evaluates the efficacy of the probiotic strain Lactobacillus crispatus M247 in promoting the clearance of genital high-risk human papillomavirus (HR-HPV) infection and restoring the balance of the vaginal…
- Trial name
- NCT06802809
- Testing
- Lactobacillus crispatus M247 (Crispact®)
- Where
- 3 sites in Italy
- Volunteers
- 66 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Cardiovascular Diseases, Dyslipidemias
Efficacy, Safety and Cost-efficacy of a Pre-emptive Genotyping Strategy in Patients Receiving Statins
This is a Phase IV multicentre adaptive single-blinded randomized clinical trial if preemptively genotyping populations at risk of cardiovascular disease susceptible of receiving high or moderate doses of statin therapy is…
- Conditions
- Cardiovascular Diseases, Dyslipidemias, Statin Adverse Reaction, Pharmacogenic Myopathy
- Trial name
- PREVESTATGx (NCT06262685)
- Testing
- Preemptive pharmacogenetic atorvastatin dose based on CPIC guidelines, Preemptive pharmacogenetic simvastatin dose based on CPIC guidelines, Preemptive pharmacogenetic pitavastatin dose based on CPIC guidelines
- Where
- Spain
- Volunteers
- 216 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
High - Risk NMIBC
Observational Clinical Study on High - Risk NMIBC Patients Choosing Trimodality Bladder - Sparing Therapy
The goal of this observational study is to assess the safety and efficacy of trimodality bladder - sparing therapy in high - risk NMIBC patients.
- Trial name
- NCT07053748
- Testing
- Trimodality Bladder-preserving Therapy
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Oral Cavity Squamous Cell Carcinoma
Postoperative CCRT With Docetaxel vs Cisplatin in High Risk Oral Cavity Cancer
This is a randomized,controled, phase II, open label study of postoperative concurrent chemoradiotherapy with Docetaxel versus Cisplatin for high-risk squamous cell carcinoma of the oral cavity cancer.The primary purpose of this…
- Trial name
- NCT02923258
- Testing
- Docetaxel, Cisplatin, IMRT
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Colon Cancer
Compare Outcomes After High and Low Ligation of Inferior Mesenteric Artery in Colorectal Cancer
We aim comparing different outcomes between high and low tie ligation of inferior mesenteric artery in left colorectal cancer operable and elective surgeries.
- Trial name
- NCT06253949
- Testing
- ligation of inferior mesenteric artery in colorectal cancer
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Prostate Cancer, Lymph Node Cancer Metastatic
Study of Predicting Lymph Node Metastasis of High-risk Prostate Cancer by Artificial Intelligence Multi-omics Analysis
The pathological-omics and imaging-omics in this study are combined to construct an artificial intelligence (AI) model that can predict whether high-risk prostate cancer patients may have lymph node metastasis.
- Conditions
- Prostate Cancer, Lymph Node Cancer Metastatic, Artificial Intelligence (AI)
- Trial name
- NCT07112599
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Anhui Medical University
Nasopharyngeal Cancinoma (NPC), Nasopharyngeal Cancer
QL1706 (PD-1/CTLA-4 Bi-specific Antibody) and Chemoradiotherapy in Locoregionally-advanced Nasopharyngeal Carcinoma.
The trial aimed to compare QL1706 combined with induction chemotherapy plus concurrent chemoradiotherapy (IC+CCRT) versus IC+CCRT alone in High-risk Locoregionally-Advanced Nasopharyngeal Carcinoma (LANPC).
- Trial name
- NCT06749899
- Testing
- QL1706, Gemcitabine, Cisplatin
- Where
- 19 sites in China
- Volunteers
- 580 people
- Sponsor
- Sun Yat-Sen University Cancer Center
Chronic Lymphocytic Leukemia
Obinutuzumab With High-dose Ibrutinib for the Treatment of Patients With Chronic Lymphocytic Leukemia With Progressive Disease on Single Agent Ibrutinib.
The purpose of the study is to investigate whether the combination of obinutuzumab and ibrutinib (administered up to 840 mg per day) might be useful for the treatment of CLL or SLL that is not responding or no longer responding…
- Trial name
- NCT02611908
- Testing
- ibrutinib, obinutuzumab
- Sponsor
- Michael Choi
Keratinized Tissue Gain
Comparison of the Keratinized Tissue Gain in Frenal Relocation Alone to Frenal Relocation Combined With the Application of Free Gingival Graft in High Frenum Attachment in Adults
The goal of this randomized clinical study is to compare in Adults Clinical Effect of Frenal Relocation without Free Gingival Graft Application on Keratinized Tissue Gain When Compared to Frenal Relocation with Free Gingival…
- Trial name
- Frenotomy/FGG (NCT07854132)
- Testing
- Frenotomy, Frenotomy with Free Gingival Graft
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- October University for Modern Sciences and Arts
Postoperative Cognitive Complications, Delirium
Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery
This is a prospective observational cohort study of adult patients undergoing high-risk surgery at UT Southwestern Medical Center.
- Conditions
- Postoperative Cognitive Complications, Delirium, Perioperative/Postoperative Complications, Brain Injuries
- Trial name
- NCT07577726
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Gastric / Gastroesophageal Junction Adenocarcinoma
A Phase II Study of Ipilimumab N01 Plus Sintilimab for MSI-H or dMMR Gastric and Gastroesophageal Junction Cancer
This is a prospective, multicenter phase II clinical study designed to evaluate the efficacy and safety of ipilimumab N01 in combination with sintilimab in patients with MSI-H/dMMR gastric or gastroesophageal junction…
- Trial name
- NCT07878221
- Testing
- Ipilimumab N01, Sintilimab
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Fudan University
Opioid Consumption, Postoperative
Precision Pain Management - A Randomized Clinical Trial Assessing the Efficacy of Suzetrigine on Postoperative Analgesia Among Surgical Patients at Higher Risk for Persistent Postoperative Opioid Use (POU)
The purpose of the study is to investigate the efficacy of suzetrigine for treatment of acute postoperative pain among surgical patients identified as high risk for persistent postoperative opioid use (POU).
- Trial name
- NCT07672015
- Testing
- Suzetrigine, Standard Care (in control arm)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
High Caries Risk Patients
Clinical Evaluation of Bioactive Resin Composites Versus Caries Control Technique in Management of Class I Carious Cavities in High Caries Risk Patients: a Randomized Clinical Trial
The aim of the study is to clinically evaluate the performance of S-PRG based \& Alkasite based resin composite restorations versus conventional resin composite restorations after caries control in Class I carious cavities in…
- Trial name
- NCT06797843
- Testing
- "SPRG-based" Resin Composite : (BEAUTIFIL II, Shofu Inc. Kyoto, Japan)., Alkasite based restoration : Cention N, provisional Resin modified glass ionomer followed by Nanohybrid composite
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cairo University
Vitiligo
The Investigation on the Expression of High Mobility Group Protein Box-1 (HMGB1) in Peripheral Blood of Vitiligo Patients and Healthy Controls According to Clinical Features, Treatment and Disease Activity
Vitiligo is an acquired depigmented disorder that causes white spots on the skin due to the loss of melanocytes. It is a common disease which accounts for 0.5-1% of the whole population.
- Trial name
- NCT03741738
- Where
- South Korea
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Bladder Cancer
Study of Mycobacterium w in Superficial Transitional Cell Carcinoma of Bladder
The purpose of this study is to determine and compare the effect of this treatment on recurrence rate and to assess the toxicity in both arms of patients with STCC.
- Trial name
- STCC (NCT00694915)
- Testing
- Mycobacterium w, BCG (Bacillus Calmette-Guerin)
- Where
- 15 sites in India
- Volunteers
- 122 people
- Sponsor
- Cadila Pharnmaceuticals
ST-segment Elevation Myocardial Infarction (STEMI)
Intracoronary rhTNK-tPA Versus Tirofiban in Patients With STEMI and High Thrombus Burden
The goal of this clinical trial is to compare the efficacy and safety of intracoronary rhTNK-tPA or Tirofiban in patients with ST-segment elevation myocardial infarction and high thrombus burden.
- Trial name
- H2-THROMBUS (NCT06769256)
- Testing
- rhTNK-tPA, 4-8 mg, Tirofiban
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
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