Clinical trials: Clinical High-risk
Primary Central Nervous System Lymphoma
Rituximab, Lenalidomide Combined With Methotrexate and Temozolomide For Primary Central Nervous System Lymphoma
This is a prospective single arm, multi-center, phase II clinical trial to observe the efficacy and safety of Rituximab, Lenalidomide combined with high-dose Methotrexate and Temozolomide (RL-MT) in the first-line treatment for…
- Trial name
- NCT04737889
- Testing
- Rituximab, Lenalidomide, Methotrexate
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Henan Cancer Hospital
High-risk PCI
Evaluate the Effectiveness and Safety of the OmniHeart 4.0 Percutaneous Ventricular Assist Device in Providing Hemodynamic Support for Patients Undergoing High-risk Percutaneous Coronary Intervention (PCI).
The objective of this clinical trial is to understand the effectiveness and safety of the OmniHeart 4.0 percutaneous ventricular assist device produced by ShanghaiDynaheart Medical Technology Co., Ltd.
- Trial name
- NCT07622446
- Testing
- OmniHeart 4.0 Percutaneous Ventricular Assist Device, ECMO
- Where
- 2 sites in China
- Volunteers
- 254 people
- Sponsor
- Shanghai Dynaheart Medtech Co., Ltd.
Benign Paroxysmal Positional Vertigo (BPPV)
Vertistop® D and Vertistop® L in Preventing Recurrence of High-recurrence BPPV
Randomized, 3-arm controlled clinical study, to evaluate the effectiveness of supplementation with Vertistop® D (food supplement containing alpha-lipoic acid at modified release, Carnosine and Zinc, Vitamin D and Vitamins B) and…
- Trial name
- NCT04849182
- Testing
- Vertistop D, Vertistop L
- Where
- Italy
- Volunteers
- 128 people
- Sponsor
- Azienda Sanitaria Locale di Matera
Breast Cancer
EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)
The EXActDNA-003 study will prospectively enroll participants who are planning to undergo chemotherapy for high-risk, early breast cancer, who are willing to provide tissue and blood specimens for circulating tumor DNA (ctDNA)…
- Trial name
- NCT06401421
- Testing
- ctDNA MRD test
- Where
- 61 sites in United States, Canada
- Volunteers
- 1,800 people
- Sponsor
- Exact Sciences Corporation
Colorectal Cancer
MRD-guided Deferred Adjuvant Therapy in Resectable Early-stage Colon Cancer
The aim of this clinical trial is to test whether minimal residual disease (MRD) status detected by circulating tumor DNA (ctDNA) could be used to guide precision therapy of post-surgery in colon cancer.
- Trial name
- MIRROR (NCT06204484)
- Testing
- CAPEOX adjuvant therapy, deferred CAPEOX adjuvant therapy, mFOLFOXIRI intensive adjuvant therapy
- Where
- China
- Volunteers
- 349 people
- Sponsor
- Sun Yat-sen University
End Stage Kidney Disease
Investigation of Performance and Compatibility of the Baxter Dialyzer Xenium XPH 210 During On-line Hemodiafiltration
The proposed study seeks to determine the appropriate balance between the removal of undesirable small molecular substances (urea, creatinine, phosphate) and large molecular substances (ß2-m) and the retention of important…
- Trial name
- NCT00976846
- Testing
- Dialyzer Baxter Xenium XPH 210
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- Praxisverbund Dialyse und Apherese
Congenital Heart Disease
Effect of a High Density Formula on Growth and Safety in Congenital Heart Disease Infants
The purpose of this study is to explore the effects of high density formula in early postoperative infants with congenital heart disease and to assess its safety.
- Trial name
- CHD (NCT02389491)
- Testing
- normal density formula (Necocate), high density formula(Infatrini)
- Volunteers
- 64 people
- Sponsor
- Children's Hospital of Fudan University
Stenoses, Aortic Valve
REPRISE China - Clinical Evaluation in China
To evaluate the safety and effectiveness of the Lotus Edge™ Valve System for transcatheter aortic valve replacement (TAVR) in symptomatic Chinese patients with calcific, severe native aortic stenosis who are considered at high…
- Trial name
- NCT03084510
- Testing
- Lotus Edge™ Valve System
- Where
- China
- Sponsor
- Boston Scientific Corporation
Severe Ulcerative Colitis
Multi-centre Acute Severe Ulcerative Colitis Prospective Cohort Study (Elevate ASUC)
Up to one third of patients with Ulcerative Colitis (UC) will require hospitalisation for severe disease (ASUC - Acute Severe Ulcerative Colitis), often within the first 12 months of diagnosis.
- Trial name
- ELEVATE-ASUC (NCT03907631)
- Testing
- Standard of care
- Where
- United Kingdom
- Volunteers
- 189 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Lymphoma, Large B-Cell, Diffuse
A Phase III Clinical Trial of High-dose Rituximab (500mg/m²) Combined With CHOP Regimen in the Treatment of Male Patient With Newly Diagnosed Advanced DLBCL
Comparison of MODIFIED progression-free survival (Modified-PFS) in high-dose rituximab (500mg/m²) plus CHOP versus standard-dose rituximab plus CHOP in previously untreated (TN) stage III-IV male DLBCL patients
- Trial name
- NCT06573645
- Testing
- Rituximab
- Volunteers
- 428 people
- Sponsor
- Xia Yi
Radiculopathy, Musculoskeletal Diseases
Clinical Effectiveness of High-Intensity Laser Therapy in Patients With Cervical Radiculopathy:
This investigation aims to investigate the effect of high intensity laser therapy on radicular symptoms, neuropathic pain, cervical range of motion and quality of life in patients with cervical radiculopathy compared to cervical…
- Conditions
- Radiculopathy, Musculoskeletal Diseases, Cervical Pain, Cervical Radicular Pain
- Trial name
- NCT04734977
- Testing
- High-intensity laser therapy (HILT), Therapeutic Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Afyonkarahisar Health Sciences University
SARS-CoV Infection, SARS (Severe Acute Respiratory Syndrome)
High Flow Nasal Cannula HFNC In Covid-19 Patients
Many non-invasive ventilatory choices are available for COVID-19 patient who are having mild to moderate respiratory distress and their use will decrease the chance of ICU admission, intubation and mechanical ventilation in…
- Trial name
- HFNC19LGH (NCT04560257)
- Testing
- High flow nasal cannula HFNC
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Lahore General Hospital
Cataract
Comparing Monofocal IOLs in Highly Myopic Cataract Patients
Comparison of Postoperative Outcomes in Patients with High Myopia Undergoing Cataract Surgery Implanted with Extended Depth of Focus Intraocular Lens (ICB00) and Monofocal Intraocular Lens (ZCB00)
- Trial name
- NCT06905938
- Testing
- no intervention
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wenzhou Medical University
Oligospermia, DNA Damage
Comparison of ICSI Outcomes in Cycles Using Testicular and Ejaculate Sperm From Couples With High SDF
In patients with oligospermia in the ejaculate or previous ICSI failures if it concurs with high DNA fragmentation, it has been hypothesized that the use of sperm obtained from the testicle would improve the clinical results…
- Conditions
- Oligospermia, DNA Damage, IVF, ICSI
- Trial name
- NCT04795440
- Testing
- Testicular biopsy
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Fundación IVI
Patients With High-risk Prostate Cancer
Circulating Tumor Cells in High-Risk Prostate Cancer Treated With High-dose Radiotherapy and Hormone Therapy
The detection and quantification of Circulating tumor cells CTCs in peripheral blood of patients with prostate adenocarcinoma may be useful at least for: Getting a correct stratification of patients with high-risk prostate cancer…
- Trial name
- NCT01800058
- Where
- 3 sites in Spain
- Volunteers
- 68 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Learning Process in Nursing Graduation, Compliant Behavior
Effectiveness of High Fidelity Simulation for Safety in the Medication Process in Intensive Care
Nursing plays an important role in the medication process in intensive care units. The application of active methodologies guided by the simulation strategy can help in the formation of qualified professionals and in the safer…
- Trial name
- NCT03828526
- Testing
- High Fidelity Simulation, Traditional teaching strategy
- Where
- Brazil
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Presence of High Intracranial Pressure
An Evaluation of Non-invasive ICP Monitoring in Patients Undergoing Invasive ICP Monitoring Via an External Ventricular Drainage (EVD) Device
Invasive intracranial pressure (ICP) monitoring is highly effective, but involves risks. HS-1000 measures ICP non-invasively by assessing the acoustic properties of the patient's head.
- Trial name
- NCT02284217
- Testing
- EVD
- Where
- 7 sites in United States, Germany
- Volunteers
- 100 people
- Sponsor
- HeadSense Medical
Acute Myeloid Leukaemia, High-risk Myelodysplastic Syndrome
A Trial of Treatments to Assess the Effects on Outcome of Adults With AML and MDS Undergoing Allogeneic SCT
Treatment options for older adults with Acute Myeloid Leukaemia (AML) and Myelodysplasia (MDS) are limited. Although stem cell transplantation remains one of the most effective treatments it is associated with severe side effects…
- Trial name
- COSI (NCT04217278)
- Testing
- Vyxeos, Fludarabine, Busulphan
- Where
- 14 sites in United Kingdom
- Volunteers
- 333 people
- Sponsor
- University of Birmingham
B Cell Lymphoma, B-cell Acute Lymphoblastic Leukemia
Anti-CD19 CAR in PiggyBac Transposon-Engineered T Cells for Relapsed/Refractory B-cell Lymphoma or B-cell Acute Lymphoblastic Leukemia
Our previous study demonstrated that anti-CD19 chimeric antigen receptor in piggyBac transposon-engineered T cells have strong tumor-killing activity in vitro and therapeutic effects in cell line-derived xenograft models, and no…
- Trial name
- NCT04289220
- Testing
- Anti-CD19 CAR-T Cells Injection
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Yan'an Affiliated Hospital of Kunming Medical University
Pressure Ulcer
Low-level Laser Therapy Versus High Frequency on Pressure Ulcers Treatment
Patients admitted in the Emergency Service that have pressure ulcers will be selected by eligibility criteria and randomized into three groups according to the adopted therapy: wound dressing (CG); wound dressing + high-frequency…
- Trial name
- NCT02296697
- Testing
- Low-level laser therapy AlGaInP, High-frequency therapy with O3 formation, Wound dressing with saline solution
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
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