Clinical trials: Clinical High-risk
Acute Pancreatitis
Clinical Usefulness of Cortisol, Antinuclear Antibodies and High-sensitivity C-reactive Protein in Acute Pancreatitis
Acute pancreatitis (AP) is a potentially life-threatening disease with varying severity of presentation. Nearly 60%-80% of all cases of AP in developed countries are attributable to either gallstone disease or alcohol abuse.
- Trial name
- NCT03830060
- Testing
- Measurement of cortisol
- Volunteers
- 50 people
- Sponsor
- Assiut University
Mantle Cell Lymphoma (MCL)
Orelabrutinib and Rituximab With Optional Autologous Hematopoietic Stem Cell Transplantation in MCL Treatment
This multicenter, open-label, trial aims to evaluate the efficacy and safety of orelabrutinib in combination with rituximab with optional autologous hematopoietic stem cell transplantation in patients with non-high-risk mantle…
- Trial name
- NCT07199296
- Testing
- Orelabrutinib, Rituximab (R), BEAM (carmustine (BCNU), etoposide, cytarabine, melphalan)
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Ruijin Hospital
Cancer
High Intensity Functional Training in the Rehabilitation of Cancer Survivors
The primary aim of this study is to investigate changes in health related quality of life (HRQoL) and cancer-related fatigue (CRF) following a 16-weeks of HIFT as a part of the rehabilitation of cancer survivors.
- Trial name
- NCT04001127
- Testing
- High Intensity Functional Training
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- Andreas Lund Hessner
MSS Metastatic Colorectal Cancer
Fruquintinib Combined With Adebrelimab and High and Low Dose Radiotherapy in the Treatment of Second-line and Above Failure MSS Metastatic Colorectal Cancer.
The goal of this clinical trial is to learn about Fruquintinib combined with Adebrelimab and high and low dose radiotherapy in the treatment of second-line and above failure MSS(microsatellite stability) metastatic colorectal…
- Trial name
- NCT06613113
- Testing
- Fruquintinib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Ningbo Medical Center Lihuili Hospital
Aortic Stenosis
A Comparison of Advanced Imaging Techniques in Aortic Stenosis
In patients with aortic stenosis the valve through which blood is pumped out of the main heart chamber is narrowed. This results in heart muscle working harder to open the valve so blood can circulate around the body.
- Trial name
- AIm-AS (NCT01775215)
- Testing
- Cardiac I123-MIBG Scintigraphy, Cardiac MRI, Stress and rest Echocardiogram
- Where
- United Kingdom
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Neuroblastoma
Clinical Analysis of Naxitamab (hu3F8) in the Treatment of Pediatric High Risk or Refractory/ Relapsed Neuroblastoma
This is an prospective study to evaluate the safety and efficacy of naxitamab monotherapy or combined with chemotherapy or combined with chemotherapy and checkpoint inhibitor in the treatment of pediatric high-risk and…
- Trial name
- NCT06013618
- Testing
- Naxitamab monotherapy, GM-CSF, Irinotecan
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sun Yat-Sen University Cancer Center
Atonic Postpartum Hemorrhage, High Risk Pregnancy
Carbetocin Versus Oxytocin for Prophylaxis Against Atonic Primary Post-partum Hemorrhage
Comparison between Carbetocin and Oxytocin as prophylaxis against Primary Postpartum Hemorrhage.
- Trial name
- NCT05479357
- Testing
- Oxytocin, Carbetocin
- Volunteers
- 80 people
- Sponsor
- Sohag University
Coronary Artery Disease
Conventional Versus Intentional StraTegy in Lesions With High Risk PrEdiction of Side Branch OccLusion in InterVEntion
The purpose of the present study is to investigate if intentional strategy (a more aggressive side branch protection strategy: elective two-stent or jailed balloon technique) is associated with significant reduction of side…
- Trial name
- CIT-RESOLVE (NCT02644434)
- Testing
- Conventional Strategy, Intentional strategy
- Where
- China
- Volunteers
- 566 people
- Sponsor
- China National Center for Cardiovascular Diseases
Insulin Resistance
Effects of Novel Fiber on Glucose Homeostasis in Individuals at Risk for Diabetes
This study will critically evaluate the effects of a novel dietary fiber administered to subjects at high risk for developing diabetes to determine if this intervention will improve insulin sensitivity compared to control product…
- Trial name
- NCT00820807
- Testing
- Novel dietary fiber
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cargill
Diabetes Mellitus, Type 2, Metabolic Syndrome X
Meta-analyses of Impotrant Food Sources of Sugars and Incident Cardiometabolic Diseases
There is an urgent need for stronger evidence to support recommendations for the role of sugars in diabetes and related cardiometabolic diseases.
- Conditions
- Diabetes Mellitus, Type 2, Metabolic Syndrome X, Hypertension, Cardiovascular Diseases
- Trial name
- NCT02702375
- Testing
- Fructose-containing Sugars
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
TNBC, Adjuvant Therapy
A Prospective, Multicenter, Phase II Clinical Study of Postoperative Chemotherapy Combined With QL1706 for High-risk Triple-negative Breast Cancer.
This study is a prospective, multicenter, phase II clinical trial designed to evaluate the efficacy and safety of postoperative chemotherapy combined with QL1706 in patients with high-risk triple-negative breast cancer.
- Conditions
- TNBC, Adjuvant Therapy, Lymph Node Positive
- Trial name
- NCT07622836
- Testing
- Aipaluoli-tovorilimab plus AC-T chemotherapy as postoperative adjuvant therapy
- Where
- China
- Volunteers
- 59 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
High Myopia
The Effect and Safety of Different Doses of Atropine on Myopic Progression of Highly Myopic Children: Multi-centered Randomized Clinical Trial
Objective: to evaluate the efficacy of different concentrations of atropine eye drops in controlling the progression (diopter, axial length) of high myopia in young children, and to compare the compliance, adverse reaction and…
- Trial name
- NCT04699357
- Testing
- Atropine
- Where
- 3 sites in China
- Volunteers
- 219 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Hypertension, Hyperlipidemia
Amlodipine/Atorvastatin Combination to Reduce the Health Risk of High Blood Pressure and High Cholesterol Levels
The purpose of the study is to measure the effect of the amlodipine/atorvastatin combination pill in reducing both elevated blood pressure and cholesterol levels to levels suggested by guidelines
- Trial name
- GEMINI-AALA (NCT00143234)
- Testing
- Amlodipine/atorvastatin single pill
- Where
- 118 sites in Argentina, Australia and 25 more
- Volunteers
- 1,825 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Multiple Myeloma
Efficacy of Bortezomib Consolidation After High-dose Melphalan With Stem Cell Support in Myeloma Patients
Multiple myeloma is a malignant incurable hematological disease where survival has been significantly improved by high-dose melphalan with autologous stem cell support (ASCT) in younger patients.
- Trial name
- NCT00417911
- Testing
- bortezomib
- Where
- 20 sites in Denmark, Finland and 3 more
- Volunteers
- 400 people
- Sponsor
- Nordic Myeloma Study Group
Grade 1 Meningioma, Grade 2 Meningioma
Comparing Radiation After Surgery to Observation After Surgery in Patients With Clinical Low-Risk, Molecular High-Risk Meningioma, and Evaluating Observation After Surgery in Patients With Clinical and Molecular Low-Risk Meningioma
This phase III trial compares post-surgical surveillance to post-surgical radiation therapy for improving survival without disease progression in clinically low-risk patients with a grade 1 meningioma that is new or that has come…
- Conditions
- Grade 1 Meningioma, Grade 2 Meningioma, Recurrent Grade 1 Meningioma
- Trial name
- NCT07785687
- Testing
- Patient Observation, Magnetic Resonance Imaging, Biospecimen Collection
- Volunteers
- 464 people
- Sponsor
- NRG Oncology
Adult Patients With Platinum-sensitive, Relapsed, High Grade Serous Epithelial Ovarian Cancer
NIRAPK : Study of the Relationship(s) Between Clinical, Biological and Pharmacokinetic Metrics and Toxicities When Niraparib is Used as Maintenance Treatment for Ovarian Cancer Patients.
Ovarian cancer is the seventh most common cancer in women worldwide and is the leading cause of gynecologic cancer deaths in high-income countries.
- Trial name
- NIRAPK (NCT04861181)
- Testing
- Pharmacokinetics, Dosage of Niraparib
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Hospices Civils de Lyon
Placenta Accreta
Feasibility of HIFU for Management of Placenta Accreta (HIFU-ACCRETA)
Placental accretion during pregnancy refers to an abnormally deep insertion of the placenta into the uterus, leading to the impossibility of removing the placenta without inducting uterine or surrounding organs lesions.
- Trial name
- HIFU-ACCRETA (NCT04003428)
- Testing
- High Intensity Focused Ultrasound
- Sponsor
- Hospices Civils de Lyon
Chondrosarcoma
A Study of Anlotinib Combined With or Without PD-1 Antibody on Unresectable High-grade Chondrosarcoma
There is no standard treatment for chondrosarcoma. Some small sample of studies has shown that anti-angiogenic TKIs show certain activity in the treatment of chondrosarcoma.
- Trial name
- NCT05193188
- Testing
- Anlotinib hydrochloride, PD-1 inhibitor
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Fibromyalgia
High-Intensity vs. Preferred-Intensity Resistance Training in Fibromyalgia
This randomized crossover clinical trial aims to verify and compare the effects of high-intensity (HIG) and preferred-intensity (PIG) resistance training on the health of women with fibromyalgia (FM).
- Trial name
- NCT07734662
- Testing
- Preferred-Intensity Resistance Training Group (PIG), High-Intensity Resistance Training Group (HIG)
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of the State of Santa Catarina
Muscle-Invasive Bladder Cancer (MIBC)
EV + Toripalimab vs GC as Neoadjuvant Therapy in Locally Advanced/High-Risk MIBC
The purpose of this Phase II, open-label, multicenter, randomized controlled study is to evaluate the efficacy and safety of Enfortumab Vedotin in combination with Toripalimab compared to Gemcitabine plus Cisplatin.
- Trial name
- NCT07647289
- Testing
- enfortumab vedotin (EV), Toripalimab, Gemcitabine (Chemotherapy)
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Peking University Third Hospital
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