Clinical trials: Clinical High-risk
Vitamin D Deficiency, Hyperparathyroidism
Abnormally High Parathyroid Hormone Levels Worsens Outcomes in Vitamin D Depleted Critical Care Patients
This study aims to investigate the impacts of abnormally elevated PTH levels on clinical outcomes among critically ill patients with vitamin D depletion.
- Conditions
- Vitamin D Deficiency, Hyperparathyroidism, Critically Ill Patients Admitted in ICU
- Trial name
- NCT06711874
- Where
- Taiwan
- Volunteers
- 320 people
- Sponsor
- National Taiwan University Hospital
Hypertension, Life Style
The Effect Of High Intensity Interval Training And Moderate Intensity Continuous Training In Patients With Hypertension
Comparison of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) in patients with hypertension patient in terms of aerobic capacity, blood pressure level, anxiety and depression scores…
- Trial name
- NCT06243224
- Testing
- High intensity interval training, Moderate intensity continuous training
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Ankara City Hospital Bilkent
Carotid Artery Disease, Carotid Stenosis
Adapt Monorail Carotid Stent System: A Postmarket Clinical Follow-up Study
The purpose of this study is to get outcomes data for the Adapt Monorail Carotid System used in conjunction with the FilterWire Embolic protection system for treatment of patients that suffer from carotid artery stenosis and that…
- Conditions
- Carotid Artery Disease, Carotid Stenosis, Stroke
- Trial name
- ASTI (NCT01133327)
- Testing
- Carotid Artery Stenting
- Where
- 11 sites in Belgium, Germany and 1 more
- Volunteers
- 100 people
- Sponsor
- Boston Scientific Corporation
Dental Veneers
A Clinical Trial of the Impact of Speed and Conventional Sintering on Ultra-thin, Highly Translucent, Multilayered Zirconia Laminate Restorations
A Minimally invasive esthetic restorative approach with the advancement of highly translucent multilayered monolithic zirconia ceramic can provide minimal thickness that affords high strength and esthetics without the need for…
- Trial name
- NCT05751616
- Testing
- Laminate veneers with speed sintering, Laminate veneers with conventional sintering
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Hams Hamed Abdelrahman
Clinical High-risk
Develop a Psychosis Risk Calculator for Chinese Mental Health Servises
This project will use the collected clinical and biological information of high-risk groups, use embedded computer chips, and use big data background analysis system to comprehensively evaluate the risk of high-risk groups, and…
- Trial name
- NCT04509778
- Testing
- routine clinical treatment
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Mental Health Center
Peripheral Arterial Occlusive Disease
The Effect of High Dose Arginine Infusion on Hemodynamic and Peripheral Microcirculation
The aim of this study was to investigate the effect of a 24- hrs L-arginine infusion on hemodynamic and on parameters of microcirculation in patients with peripheral arterial occlusive disease (PAOD).
- Trial name
- NCT01682889
- Testing
- Arginine
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical Scientific Fund of the Mayor of Vienna
Acute Respiratory Failure
CORALINE - Correlation Between Physiological and Clinical Variables and Failure of Non-Invasive Respiratory Support in Patients With Acute Respiratory Failure
This observational study aims to evaluate the relationship between clinical and physiological variables and the failure of non-invasive respiratory support (NIRS), including high-flow nasal oxygen (HFNO) and non-invasive…
- Trial name
- CORALINE (NCT06989385)
- Testing
- This is an observational study. Interventions are standard of care and include: High-flow nasal oxygen (HFNO) Non-invasive ventilation (NIV) Pnose monitoring
- Where
- Italy
- Volunteers
- 325 people
- Sponsor
- University of Modena and Reggio Emilia
Blood Loss, Surgical, Coagulation Disorder
Phase 3 Trial of Reltodecacog Alfa (VMX-C001) vs Usual Pharmacological Care in Patients Taking a FXa Direct Oral Anticoagulant Who Require Urgent Surgery With or Without Heparin.
The goal of this clinical trial is to learn if reltodecacog alfa (VMX-C001) works to to allow blood clotting control in participants who take FXa Direct Oral Anticoagulants (DOACs) during surgery or other invasive procedures that…
- Trial name
- EQUILIBRIX-S (NCT07288489)
- Testing
- Reltodecacog alfa, Usual Pharmacological Care
- Where
- 77 sites in United States, Australia and 16 more
- Volunteers
- 800 people
- Sponsor
- VarmX B.V.
Osteoarthritis, Genu Varum
Clinical Outcomes of Open Wedge High Tibial Osteotomy With Autologous Bone Marrow or Adipose-derived Stem Cell Therapy
The purpose of this research is to confirm the efficacy of cartilage regeneration (or stem cell transplant) simultaneously performed with high tibial osteotomy.
- Trial name
- HTOSC (NCT02642848)
- Testing
- HTO with microfracture, Transplantation of bone marrow stem cell, Transplantation of adipose derived stem cell
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Dongsik Chae
Neonatal Sepsis
Clinical Value of Metagenomic Sequencing in Neonatal Sepsis
This study aimed to enroll 2000 neonatal patients with suspected sepsis or clinical diagnosed sepsis. These patients will undergo both conventional methods and metagenomics sequencing to detect the pathogenic microorganisms of…
- Trial name
- NCT05416918
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Children's Hospital of Fudan University
Hernia, Ventral Hernia
Prospective Clinical Evaluation of High-Purity Type I Collagen in Select High-Risk Hernia Repair Scenarios
This prospective, single-arm clinical study evaluates the safety, feasibility, and early clinical outcomes of High-Purity Type I Collagen (HPTC; Surgicoll-Mesh®) when used as a biologic reinforcement in selected hernia repair…
- Conditions
- Hernia, Ventral Hernia, Incisional Hernia, İnguinal Hernia
- Trial name
- NCT07360691
- Testing
- High-Purity Type I Collagen Mesh
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
B-ALL
Blinatumomab as Maintenance Therapy in Patients With High-risk B-lineage Acute Lymphoblastic Leukemia Post Allogeneic Hematopoietic Cell Transplantation
Patients ≥ 14 years of age after B-ALL allogeneic transplantation received 4 cycles of maintenance therapy with blinatumomab +/- TKI and were followed for more than 1 year to assess overall survival (OS), relapse-free survival…
- Trial name
- NCT06658938
- Testing
- Blinatumomab
- Volunteers
- 30 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Parkinson Disease
Effects of Home-based High-speed Bodyweight Resistance Training in Individual With Parkinson's Disease
Exercises that involve increasing the speed of movements are beneficial for individuals with Parkinson's disease (PD) and have the potential to reduce bradykinesia and improve mobility.
- Trial name
- NCT06646523
- Testing
- High-speed bodyweight resistance training, Control group (Bodyweight intervention, usual speed)
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- Federal University of Minas Gerais
Function of Renal Transplant
Perioperative Aminophylline to Improve Early Kidney Function After a Kidney Transplant
The aim of this study is to evaluate whether peri-transplant administration of a drug named aminophylline to children undergoing a kidney transplant from deceased donors improves early graft function and also projects on long…
- Trial name
- RTphylline (NCT01759862)
- Testing
- Aminophylline, Theophylline drug levels
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Cardiac Surgery, Coronary Artery Bypass Grafting
Oscillating Positive Expiratory Pressure (OPEP) Therapy in High Risk Patients Following Cardiac Surgery
Respiratory dysfunction following cardiac surgery is well documented and due in part to the location of the incision and nature of the surgery.
- Conditions
- Cardiac Surgery, Coronary Artery Bypass Grafting, Chronic Obstructive Pulmonary Disease (COPD), Older Adults
- Trial name
- NCT02732574
- Testing
- Oscilatory Positive Expiratory Pressure (OPEP) device
- Where
- Canada
- Volunteers
- 162 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Peri-Implantitis and Peri-implant Mucositis
The Use of Adjunct Oxygen High-Level Laser Therapy on the Clinical and Microbiological Outcomes of Peri-implant Disease
The goal of this clinical trial is to learn whether using a special light-activated treatment called photodynamic therapy, or more specifically, its modified version called oxygen high-level laser therapy, using a high-powered…
- Trial name
- NCT07287956
- Testing
- Oxygen high-level laser therapy (Diode laser and hydrogen peroxide), Diode laser therapy
- Where
- Jordan
- Volunteers
- 16 people
- Sponsor
- King Abdullah University Hospital
Knee Osteoarthritis, Osteoarthritis
"Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy in Older Adults With Knee Osteoarthritis"
This randomized, double-blind clinical trial aims to evaluate the effect of high-intensity pulsed electromagnetic field therapy (HI-PEMF) applied either exclusively on the knee joint or bimodally on the knee and quadriceps, in…
- Conditions
- Knee Osteoarthritis, Osteoarthritis, Osteo Arthritis of the Knee, Gonarthrosis
- Trial name
- HIPEMF-OAK (NCT07198750)
- Testing
- HI-PEMF - Knee (Chronic Pain Protocol), HI-PEMF - Quadriceps (Muscle Strengthening Protocol), Home-Based Exercise Program
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Hospital Civil de Guadalajara
West Nile Fever
High-Titer Neutralizing Plasma for West Nile Fever in Hospitalized Patients
This study will test whether plasma containing high levels of neturalizing antibodies against West Nile virus (WNV) can help people hospitalized with severe West Nile fever recover faster and avoid serious complications.
- Trial name
- NCT07094724
- Testing
- Plasma
- Where
- Israel
- Volunteers
- 37 people
- Sponsor
- Gili Regev-Yochay MD
End Stage Renal Disease
Comparison of the Clinical Performance of 3 THERANOVA 400 Dialyzer Prototypes With a High-Flux Dialyzer in Hemodialysis Mode
The study investigates the performance of a new dialyzer (Theranova 400) containing a membrane with increased pore sizes. The performance will be determined by the removal of middle molecules (with different molecular size) from…
- Trial name
- NCT02377570
- Testing
- THERANOVA 400 dialyzer prototype AA, THERANOVA 400 dialyzer prototype BB, THERNOVA 400 dialyzer prototype CC
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Vantive Health LLC
Knee Deformity
Clinical Study to Evaluate Adaptos®Ortho Wedge Bone Graft Substitute in High Tibial Osteotomy
The aim of this study is to obtain performance and safety data of the new investigational device, dual-part Adaptos®Ortho Wedge, for its intended use in orthopaedic surgery.
- Trial name
- NCT05570760
- Testing
- Adaptos®Ortho Wedge (bone grafting surgery), OWHTO without bone grafting, chronOS® Wedge (bone grafting surgery)
- Where
- 6 sites in Finland, Hungary
- Volunteers
- 87 people
- Sponsor
- Biomendex Oy
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