Clinical trials: Clinical High-risk
Apnea, Hypoxia
High Flow Nasal Oxygen Therapy Undergoing Colonoscopy
Investigation of the Clinical Efficacy of High Flow Nasal Oxygen in Patients Over 60 Years of Age Undergoing Colonoscopy
- Trial name
- NCT05396274
- Testing
- High Flow Nasal Cannula
- Volunteers
- 70 people
- Sponsor
- Turkish Society of Anesthesiology and Reanimation
Cardiac Surgery, Coronary Artery Bypass Grafting
Oscillating Positive Expiratory Pressure (OPEP) Therapy in High Risk Patients Following Cardiac Surgery
Respiratory dysfunction following cardiac surgery is well documented and due in part to the location of the incision and nature of the surgery.
- Conditions
- Cardiac Surgery, Coronary Artery Bypass Grafting, Chronic Obstructive Pulmonary Disease (COPD), Older Adults
- Trial name
- NCT02732574
- Testing
- Oscilatory Positive Expiratory Pressure (OPEP) device
- Where
- Canada
- Volunteers
- 162 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Stroke
Clinical, Electrophysiological and E-field Modelling Evidence of High Density Transcranial Direct Current Stimulation in Motor Stroke
The present study aims to investigate the therapeutic potential of a high definition transcranial direct current stimulation protocol, stimulating frontal and cerebellar areas boosting the cognitive and motor recovery of stroke…
- Trial name
- E-brain (NCT05329818)
- Testing
- high definition transcranial direct current stimulation
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Xavier Corominas
Cardiac Pacing, Complications
Prevention of Venous Thrombosis After Permanent Transvenous Leads Implantation
The aim of this study was to compare the safety and efficacy of warfarin versus placebo, administered for 6 months, in the prevention of thromboembolic complications after transvenous cardiac devices implantation in high-risk…
- Conditions
- Cardiac Pacing, Complications, Venous Thrombosis
- Trial name
- NCT00621491
- Testing
- Warfarin
- Where
- Brazil
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
IDH1 wt Allele, Recurrent Anaplastic Astrocytoma
MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma
This phase I trial studies best dose and side effects of oncolytic adenovirus DNX-2401 in treating patients with high-grade glioma that has come back (recurrent).
- Conditions
- IDH1 wt Allele, Recurrent Anaplastic Astrocytoma, Recurrent Glioblastoma, Recurrent Gliosarcoma
- Trial name
- NCT03896568
- Testing
- Oncolytic Adenovirus Ad5-DNX-2401, Therapeutic Conventional Surgery
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- M.D. Anderson Cancer Center
Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia (B-ALL), Relapsed/Refractory Non-Hodgkin Lymphoma
NexCAR19 (Talikabtagene Autoleucel) in Relapsed/Refractory B-Cell Malignancies (NexCAR19)
The NexCAR19 study is a national, open-label, multicenter Phase 2-3 clinical trial designed to evaluate the efficacy and safety of the anti-CD19 chimeric antigen receptor (CAR) T-cell product, Talikabtagene Autoleucel, in…
- Conditions
- Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia (B-ALL), Relapsed/Refractory Non-Hodgkin Lymphoma, Diffuse Large B-Cell Lymphoma (DLBCL), High-grade B-cell Lymphoma (HGBCL)
- Trial name
- NexCAR19 (NCT07502118)
- Testing
- Talikabtagene Autoleucel
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Health Institutes of Turkey
DME, Dental
Clinical Performance of High Viscosity Bioactive Injectable Composite in Deep Marginal Elevation
Using a bioactive resin composite in subgingival Class II cavities can provide enhanced caries resistance by releasing multiple ions, including fluoride.
- Conditions
- DME, Dental, Deep Margin Elevation
- Trial name
- Randomized (NCT06875544)
- Testing
- Beautifil F00, G-aenial Universal Injectable Flowable Composite
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
B Cell Lymphoma, B-cell Acute Lymphoblastic Leukemia
CD19 CAR-T Cell Therapy for Relapsed/Refractory B-cell Lymphoma and B-cell Acute Lymphoblastic Leukemia
The primary objective of this study is to evaluate the safety and clinical activity of anti-CD19 Chimeric Antigen Receptor T cells (KD-019 CAR-T)infusion in the treatment of relapsed/refractory B-cell Lymphoma and B-cell acute…
- Trial name
- NCT03854994
- Testing
- Anti-CD19 CAR-T Cells Injection
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Yan'an Affiliated Hospital of Kunming Medical University
Hypertension, Cardiovascular Diseases
China Salt Substitute Study
Cardiovascular disease is a leading cause of death and disability worldwide, and blood pressure is a leading determinant of this risk.
- Trial name
- NCT00145756
- Testing
- low sodium high potassium salt substitute
- Where
- 6 sites in China
- Volunteers
- 600 people
- Sponsor
- The George Institute
Non-fluent Aphasia, Glioma
High-frequency nrTMS on the Contralateral Broca Mirror Area for Glioma Patients With Early Postoperative Aphasia
The goal of this randomized clinical controlled trial is to determine whether the application of high frequency neuronavigated repetitive transcranial magnetic stimulation (nrTMS) on the contralateral of Broca's area can…
- Trial name
- NCT05788445
- Testing
- nrTMS treatment
- Volunteers
- 48 people
- Sponsor
- Beijing Neurosurgical Institute
Platinum-resistant Ovarian Cancer
IN10018 in Combination With Standard Chemotherapy in High-grade Serous Epithelial Ovarian Cancer
This is a phase Ib/II, open label clinical study to evaluate the safety, tolerability and antitumor activities of IN10018 in combination with standard chemotherapy in subjects with high-grade serous ovarian cancer (including…
- Trial name
- NCT05551507
- Testing
- IN10018 in combination with PLD
- Where
- 7 sites in China
- Volunteers
- 150 people
- Sponsor
- InxMed (Shanghai) Co., Ltd.
Purpura, Thrombocytopenic, Idiopathic
High-dose Dexamethasone Versus Conventional Dose Prednisone for Initial Treatment of Primary Immune Thrombocytopenia (ITP)
The project was undertaking by Qilu Hospital of Shandong University and other 11 well-known hospitals in China. In order to report the efficacy and safety of high-dose dexamethasone compared to conventional dose prednisone for…
- Trial name
- NCT01356511
- Testing
- Prednisone, Dexamethasone
- Where
- China
- Volunteers
- 261 people
- Sponsor
- Shandong University
Chronic Myelogenous Leukemia, Ph1-Positive, Acute Myeloid Leukemia
Clinical Trial of BP1001 (Liposomal Grb2 Antisense Oligonucleotide) in Combination With Dasatinib in Patients With Ph + CML Who Have Failed TKI, Ph+ AML, Ph+ MDS
The primary objective of the Phase Ib study is to determine the dose-limiting toxicity (DLT) and maximal tolerated dose (MTD) of BP1001 in combination with dasatinib in patients with with Philadelphia Chromosome Positive (Ph+)…
- Conditions
- Chronic Myelogenous Leukemia, Ph1-Positive, Acute Myeloid Leukemia, Myelodysplastic Syndrome
- Trial name
- NCT02923986
- Testing
- BP1001 (varying dose), BP1001 (fixed dose), Dasatinib
- Where
- United States
- Sponsor
- Bio-Path Holdings, Inc.
Myelodysplastic Syndromes
PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS
The primary objective of the trial is to assess the activity of the combined use of Valproic Acid (VPA)in combination with 5-Azacytidine (5-Aza C) in the treatment of MDS.
- Trial name
- NCT00439673
- Testing
- 5-Azacytidine, Valproic Acid, ATRA
- Where
- 7 sites in Italy
- Volunteers
- 62 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Clinical High Risk for Psychosis
Gabapentin in Patients at Clinical Risk for Psychosis
The purpose of this study is to test the effects of the drug gabapentin on brain function thought to be important in the development of schizophrenia.
- Trial name
- NCT02557945
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- New York State Psychiatric Institute
Cervix Cancer
Development of Clinically High Efficient Platforms for Individualised Treatment of Cervix Cancer
Retrospective study utilizing patient data to develop and validate Machine Learning application. Available imaging data sets of patients who have completed treatment will be used to develop Normal tissue complication probability…
- Trial name
- NCT05102240
- Where
- India
- Volunteers
- 1,800 people
- Sponsor
- Tata Memorial Hospital
Nasopharyngeal Carcinoma
Phase II Trial of Neoadjuvant and Adjuvant Anti-PD-1 Antibody Toripalimab Combined With CCRT in NPC Patients
This is a randomized Phase II trial to study the effectiveness and toxicity of neoadjuvant and adjuvant PD-1 antibody Toripalimab combined with concurrent cisplatin chemoradiotherapy versus cisplatin concurrent chemoradiotherapy…
- Trial name
- NCT03925090
- Testing
- Cisplatin+Toripalimab
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sun Yat-sen University
Knee Osteoarthritis
A Study to Evaluate the Clinical Performance and Safety of an Intra-articular Hyaluronic Acid in Knee Osteoarthritis
This is a study to evaluate the Clinical Performance and Safety of a single intra-articular (i.a.) injection of hyaluronic acid product (as HL-01) in the treatment of pain due to osteoarthritis (OA) of the knee.
- Trial name
- NCT03200288
- Testing
- HL-01: high and low molecular weight hyaluronic acid
- Where
- 31 sites in Belgium, Germany and 3 more
- Volunteers
- 692 people
- Sponsor
- IBSA Institut Biochimique SA
Breast Cancer, Hot Flashes
Menopausal Symptoms in Women With Breast Cancer or At High Risk of Breast Cancer Treated on Another Clinical Trial
RATIONALE: Gathering information about the frequency and intensity of hot flashes in patients with breast cancer and in patients who have a high risk of developing breast cancer may help doctors learn more about menopausal…
- Trial name
- NCT00666913
- Testing
- informational intervention
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- Case Comprehensive Cancer Center
Intrahepatic Cholangiocarcinoma, PD1 Antibody
Phase II-III Clinical Trial of PD1 Antibody (Toripalimab), Lenvatinib and GEMOX Neoadjuvant Treatment for Resectable Intrahepatic Cholangiocarcinoma With High-risk Recurrence Factors
A randomized controlled, multicenter, open, seamless phase II-III clinical trial is designed to target patients with resectable intrahepatic cholangiocarcinoma with high-risk recurrence factors which has extremely low…
- Conditions
- Intrahepatic Cholangiocarcinoma, PD1 Antibody, Lenvatinib, Gemox Chemotherapy
- Trial name
- NCT04669496
- Testing
- Neoadjuvant treatment
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Shanghai Zhongshan Hospital
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