Clinical trials: Clinical Malaria
Malaria, RDT
Abbott NxTekTM Malaria RDT WHO Prequalification Study
Since their introduction in the late 90's, rapid diagnostic tests (RDTs) have dramatically improved our ability to control malaria but proved insufficient to support elimination efforts because of their limited sensitivity…
- Conditions
- Malaria, RDT, Diagnoses Disease
- Trial name
- NCT05444790
- Testing
- Rapid Diagnostic Test
- Where
- 3 sites in Indonesia, Peru and 1 more
- Volunteers
- 4,563 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Malaria
Phase 1 Clinical Trial With Controlled Human Malaria Infection (CHMI) to Evaluate the Safety and Efficacy of the Plasmodium Falciparum Vaccine Candidate FMP012 Administered Intramuscularly With AS01B Adjuvant System in Healthy Malaria-Naïve Adults
The proposed study is a Phase 1 study with controlled human malaria infection (CHMI) designed primarily to evaluate the safety of the FMP012 combined with AS01B adjuvant system.
- Trial name
- NCT02174978
- Testing
- FMP012 with AS01B adjuvant system, P falciparum Controlled Human Malaria Infection (CHMI)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Plasmodium Vivax Malaria
Clinical Trial for the Development of a Safe Malaria Challenge Model That Can be Reproduced in Humans
The purpose of this study is to demonstrate that volunteers can be safely and reproducibly infected with Plasmodium vivax (P. vivax) by the bites of experimentally infected Anopheles dirus (An. dirus) mosquitoes carrying P.
- Trial name
- Pvivax (NCT00935623)
- Testing
- Malaria Challenge
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Plasmodium Vivax Infection, Plasmodium Vivax Clinical Episode
Effect of Liver and Blood-stage Treatment on Subsequent Plasmodium Reinfection and Morbidity
This study specifically seeks to quantify the contribution of relapes to the burden of P. vivax infections and disease by determining on the effect of radical pre-erythrocytic and erythrocytic clearance on subsequent rates of…
- Conditions
- Plasmodium Vivax Infection, Plasmodium Vivax Clinical Episode, Plasmodium Falciparum Infection, Plasmodium Falciparum Clinical Episode
- Trial name
- NCT02143934
- Testing
- Primaquine, Chloroquine, Artemether Lumefantrine
- Where
- Papua New Guinea
- Volunteers
- 524 people, healthy volunteers welcome
- Sponsor
- Papua New Guinea Institute of Medical Research
Malaria
Diagnostic Utility of Volatile Organic Compounds in Human Breath for Acute Clinical Malaria in Ethiopia
This is a diagnostic efficacy study to evaluate a set of biomarkers in human breath indicative of an acute malaria infection. The investigators plan to enroll 75 malaria patients and 175 febrile non-malaria patients in Ethiopia.
- Trial name
- NCT02793414
- Sponsor
- Menzies School of Health Research
Malaria, Diagnoses Disease
RapiGEN BIOCREDIT Malaria Ag RDTs WHO Prequalification Study
Since their introduction in the late 90's, rapid diagnostic tests (RDTs) have markedly improved our ability to control malaria; yet they have inherent limitations which include low sensitivity in Plasmodium vivax detection and…
- Conditions
- Malaria, Diagnoses Disease, RDT
- Trial name
- NCT05085301
- Testing
- Rapid diagnostic test
- Where
- 2 sites in Indonesia, Sudan
- Volunteers
- 674 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Falciparum Malaria
Clinical Investigation of In-vivo Susceptibility of P.Falciparum to Artesunate in Western Cambodia
There are worrying signs that parasitological responses to the artemisinin drugs for uncomplicated falciparum malaria are slower than elsewhere in the world.If responses to artesunate are poor it is essential to have…
- Trial name
- NCT00493363
- Testing
- Artesunate, Artesunate + Mefloquine
- Where
- Cambodia
- Volunteers
- 40 people
- Sponsor
- University of Oxford
Cerebral Malaria
Efficacy of Intrarectal Versus Intravenous Quinine for the Treatment of Childhood Cerebral Malaria
Cerebral malaria is the most lethal complication of P.falciparum infection with a mortality rate between 5 and 40%. Intravenous quinine remains the recommended treatment for cerebral malaria.
- Trial name
- NCT00124267
- Testing
- Intrarectal quinine
- Where
- Uganda
- Volunteers
- 108 people
- Sponsor
- Makerere University
Malaria
Innovation Platform
In this study, a prospective evaluation of novel malaria diagnostic tools under development will be performed in malaria-endemic countries to assess their clinical performance for detection of malaria at point-of-care (POC).
- Trial name
- NCT04558528
- Testing
- Novel in vitro diagnostics and medical applications
- Where
- 2 sites in Indonesia, Rwanda
- Volunteers
- 640 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Fever Malaria
Clinical Evaluation of the STANDARD™ Q Malaria/CRP Duo Test
The aim of this study is to assess the clinical performance (sensitivity, specificity, positive and negative predictive values) of the STANDARD™ Q Malaria/CRP Duo Test when used by health care workers (HW) in a point of care…
- Trial name
- NCT04791800
- Testing
- Malaria/CRP combination test
- Where
- India
- Volunteers
- 1,808 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Malaria
A Clinical Trial to Assess the Safety and Immunogenicity of New Malaria Vaccine Candidates ChAd63 Pfs25-IMX313 and MVA Pfs25-IMX313
This is a clinical trial in which healthy volunteers will be administered one or two experimental malaria vaccines. ChAd Pfs-IMX313 will either be administered alone or with MVA Pfs25-IMX313 in a prime-boost regime.
- Trial name
- NCT02532049
- Testing
- ChAd63 Pfs25-IMX313, MVA Pfs25-IMX313
- Where
- 2 sites in United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria,Falciparum, Anemia in Children
Comparing Chemoprevention Drugs for School-based Malaria Control
This is an individually randomized, controlled, single blind three arm clinical trial of malaria chemoprevention strategies Arm 1: Intermittent preventive treatment with dihydroartemisinin-piperaquine (IPT-DP).
- Trial name
- NCT05980156
- Testing
- Dihydroartemisinin-Piperaquine, Chloroquine, Sulfadoxine pyrimethamine
- Where
- Malawi
- Volunteers
- 646 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Advanced Breast Cancer, Advanced Liver Cancer
Plasmodium Immunotherapy for Breast and Liver Cancers
The purpose of this study is to evaluate the safety and preliminarily evaluate the effectiveness of Plasmodium immunotherapy for advanced breast cancers and advanced liver cancers.The treatment will last 4-6 weeks from the day of…
- Trial name
- NCT03474822
- Testing
- Blood-stage infection of P.vivax
- Where
- China
- Volunteers
- 60 people
- Sponsor
- CAS Lamvac Biotech Co., Ltd.
Malaria
Study of Malaria Treatment at Phuoc Long Hospital, Binh Phuoc Province, Vietnam
Background: There are worrying signs from Western Cambodia that parasitological responses to artesunate containing treatment regimens for uncomplicated falciparum malaria are slower than elsewhere in the world.
- Trial name
- NCT01165372
- Testing
- Artesunate or dihydroartemisinin-piperaquine
- Where
- Vietnam
- Volunteers
- 166 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Malaria
Safety and Immunogenicity in Age De-Escalation of PfSPZ Vaccine in Tanzanian Adults, Children, and Infants
The present trial will evaluate safety and tolerability as well as the vaccine-induced humoral and cellular immune responses in healthy Tanzanian adults, adolescents, children, and infants who receive doses of 1.8x10^6, 9.0x10^5…
- Trial name
- NCT02613520
- Testing
- PfSPZ Vaccine, Normal Saline, PfSPZ Challenge (for CHMI)
- Where
- Tanzania
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Plasmodium Falciparum, Plasmodium Vivax Malaria
PpPfs25/ISA51 and ScPvs25/ISA51 Vaccines for Malaria
This study, conducted at Johns Hopkins University Center for Immunization Research in Washington DC, will test the safety and immune response of healthy volunteers to two experimental malaria vaccines.
- Trial name
- NCT00295581
- Testing
- PpPfs25/ISA51 & ScPvs25/ISA51
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
R21/Matrix-M in African Children Against Clinical Malaria
A Phase III randomized controlled multi-centre trial to evaluate the efficacy of the R21/Matrix-M vaccine in African children against clinical malaria
- Trial name
- NCT04704830
- Testing
- R21/Matrix-M, Rabies vaccine, Hepatitis A vaccine or Meningococcal vaccine
- Where
- United Kingdom
- Volunteers
- 4,800 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
Malaria in Strasbourg University Hospital
The primary purpose is to describe the anamnestic, clinical, biological, and therapeutic characteristics of imported malaria in people originated from endemic areas.
- Trial name
- ACMUS (NCT03594084)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Strasbourg, France
Malaria
Effect of Paracetamol on Renal Function in Plasmodium Knowlesi Malaria
Acute kidney injury is a common complication of severe Plasmodium knowlesi malaria, and an important contributor to mortality. The exact pathogenic mechanisms of AKI in knowlesi malaria are not known, however it is hypothesised…
- Trial name
- PACKNOW (NCT03056391)
- Testing
- Paracetamol
- Where
- 4 sites in Malaysia
- Volunteers
- 360 people
- Sponsor
- Menzies School of Health Research
Malaria
A Clinical Study of Piperaquine, Pyronaridine, and Artesunate Administered in Combination in Healthy Adults
This is an open-label pharmacokinetic study in 24 healthy Thai participants. Participants will be admitted in the inpatient ward and each participant will attend a total of 4 visits, including one screening visit and three…
- Trial name
- APP (NCT07470424)
- Testing
- Piperaquine, Artesunate-pyronaridine (Pyramax), Piperaquine and artesunate-pyronaridine (Pyramax)
- Where
- Thailand
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Oxford