Clinical trials: Clinical Markers
Ventilator-Associated Pneumonia, Acute Respiratory Distress Syndrome
Clinical and Biological Markers in Acute Respiratory Failure
In a recent experimental study, the investigators showed that the growth factor Activin A is expressed in the lungs of rats with the acute respiratory distress syndrome (ARDS) at levels that are comparable with those determined…
- Trial name
- NCT02019095
- Testing
- Bronchoscopy for the sampling of bronchoalveolar lavage (BAL) fluid
- Where
- 2 sites in Greece
- Volunteers
- 55 people
- Sponsor
- University of Athens
Burning Mouth Syndrome
Inflammatory Markers in Saliva of Patients With Burning Mouth Syndrome
Burning Mouth Syndrome (BMS) is a chronic pain disorder that presents with inflammation and burning sensation in the oral cavity without visible lesions.
- Trial name
- burningmouth (NCT06217731)
- Testing
- Laser+clonazepam, Laser, Clonazepam
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Universidad de Murcia
Prediabetic State, Insulin Resistance
Effect of Linagliptin + Metformin vs Metformin Alone in Patients With Prediabetes
Type 2 diabetes is a worldwide epidemic disease, and preventive strategies are needed to face this health problem. The goal of this clinical trial is to evaluate the effect of linagliptin + metformin vs metformin alone on…
- Trial name
- PRELLIM (NCT03004612)
- Testing
- Linagliptin + metformin, Metformin
- Where
- Mexico
- Volunteers
- 144 people
- Sponsor
- Universidad de Guanajuato
Myasthenia Gravis, Generalized
Markers of Favorable Response to Complement Inhibitors Therapy
Myasthenia gravis is an autoimmune neurological disease caused by autoantibodies primarily directed against components of the postsynaptic membrane of the neuromuscular junction.
- Trial name
- OPTIMISE (NCT06455709)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Female Infertility, Reproductive Health
A Clinical Trial to Evaluate the Effects of a Supplement on Markers of Female Fertility
This study evaluates the effects of a daily dietary supplement (WeNatal For Her) on markers of female fertility, reproductive health, and sexual health over three menstrual cycles.
- Conditions
- Female Infertility, Reproductive Health, Fertility, Hormonal Imbalance
- Trial name
- NCT07740187
- Testing
- WeNatal For Her Supplement
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- WeNatal
Multiple Sclerosis
THE EFFECTS OF AEROBİC EXERCİSE ON NEUROVASCULAR UNİT AND CLİNİCAL PROGRESSİON MARKERS İN INDİVİDUALS WİTH MULTİPLE SCLEROSİS
This study is a randomised controlled trial designed to thoroughly investigate the effects of aerobic exercise on NVU biomarkers in individuals with MS.
- Trial name
- NCT07325019
- Testing
- aerobic exercise intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Lokman Hekim University
Osteoporosis, Postmenopausal
Generic Zoledronic Acid Versus Original Zoledronic Acid in Postmenopausal Osteoporotic Women
This study compares the efficacy and safety of generic zoledronic acid (Yigu®) and original zoledronic acid (Aclasta®) in the treatment of postmenopausal osteoporotic women in China.
- Trial name
- NCT03158246
- Testing
- Generic Zoledronic Acid, Original Zoledronic Acid, calcium
- Volunteers
- 466 people
- Sponsor
- Cttq
Ischemic Stroke
Cohort of Ischemic STROKE Patients
Ischemic stroke is the first cause of acquired disability of the adult, the second cause of dementia and the third cause of death in the industrialized countries, what constitutes à major public health issue.
- Trial name
- HIBISCUSSTROKE (NCT03149705)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Obesity
Effect of Self Regulation With Mindfulness Training on Body Mass Index and Cardiovascular Risk Markers in Obese Adults
This study is designed to assess the effect of a mindfulness training program with special focus on diet and nutrition vs. dietary counseling in 40 obese adults (BMI range 30-40) and their partner/spouses (irrespective of their…
- Trial name
- NCT01375504
- Testing
- Dietary Counseling, Mindfulness Training Program
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Mayo Clinic
Myalgic Encephalomyelitis
Effect of CoQ10 Plus Selenium Supplementation on Clinical Outcomes and Biochemical Markers in ME/CFS (CoSeME Study)
In recent years, it has been suggested that nutritional deficiencies may be of causal relevance in individuals with ME/CFS. These include deficiencies of vitamins and trace elements.
- Trial name
- CoSeME (NCT05128292)
- Testing
- CoQ10 plus Selenium
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Osteoarthritis, Hip Osteoarthritis
Wharton's Jelly-derived Mesenchymal Stem Cells in Osteoarthritis
This phase I/II study will enroll 100 subjects with mild to moderate osteoarthritis of the hip/knee/ glenohumeral joint will be enrolled according to strict inclusion and exclusion criteria.
- Conditions
- Osteoarthritis, Hip Osteoarthritis, Knee Osteoarthritis, Glenohumeral Osteoarthritis
- Trial name
- NCT03866330
- Testing
- Intraarticular injection of WJMSC
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Anxio Depressive Disorder
Heart Rate Variability as a Clinical Marker in a Population of Anxio-depressive Patients
The heart rate (HR) is regulated by the autonomic nervous system (ANS) and results from a balance between the sympathetic nervous system (SNS) that accelerates the heart rate and the parasympathetic nervous system that slows the…
- Trial name
- NCT04192669
- Testing
- Heart rate monitoring
- Where
- Belgium
- Volunteers
- 44 people
- Sponsor
- Tatiana Besse-Hammer
Prediabetes
Effects of Coffee Consumption on Metabolic Markers in Adults With Prediabetes and Obesity
Epidemiological studies have shown an inverse association between coffee consumption and risk of type 2 diabetes. However, the randomized controlled trials in prediabetes are limited to evaluate the effects of coffee.
- Trial name
- NCT06330727
- Testing
- Coffee capsule, Corn starch capsule
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Parkinson Disease
PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort
The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of…
- Trial name
- PPMI (NCT04477785)
- Where
- 50 sites in United States, Austria and 10 more
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Allergic Rhinitis
The Use of Hydrogen Ion Water (Shan Shang Water) in the Treatment of Allergic Rhinitis
The goal of this clinical trial is to evaluate whether Shan Shang Water (hydrogen ion water) can help treat allergic rhinitis in adults and affect immune markers.
- Trial name
- SSWAR (NCT06756243)
- Testing
- Hydrogen Ion Water（Shan Shang Water）, Budesonide Nasal Spray therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pregnancy Related, Maternal-Fetal Relations
Maternal and Fetal Metabolic Changes
The goal of this observational prospective project is to study the metabolic alterations during normal and complicated pregnancies, obtaining an early detection of metabolic changes, offering new insights into future prevention…
- Conditions
- Pregnancy Related, Maternal-Fetal Relations, Metabolism Disorder, Glucose
- Trial name
- MoMM-FET (NCT06288126)
- Where
- Italy
- Volunteers
- 457 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Autoimmune Encephalitis
Clinical Features and Prognostic Markers in Adult Patients With AE Requiring ICU Treatment
Autoimmune encephalitis (AE) is a potentially life-threatening inflammation of the central nervous system (CNS) and constitutes 20%-30% of encephalitis cases in adults AE often leads to subacute, severe, and debilitating…
- Trial name
- NCT06456736
- Testing
- None, non-interventional study
- Volunteers
- 200 people
- Sponsor
- Central South University
Pregnancy, Environmental Exposure
Evaluation of the Effectiveness of PREVENIR (PREVention ENvIronnement Reproduction) Platforms
Unblinded randomized clinical superiority trial in two parallel groups (intervention vs. no intervention) national multicentre to evaluate the effectiveness of the platforms on the evolution of phenoxyacetic acid levels measured…
- Conditions
- Pregnancy, Environmental Exposure, Prevention
- Trial name
- PREVENIR-G (NCT06642818)
- Testing
- protocolized interview and prevention messages
- Volunteers
- 300 people
- Sponsor
- University Hospital, Bordeaux
Juvenile Idiopathic Arthritis, Rheumatoid Arthritis
Medical Follow-up of New Cases of Polyarthritis in Children and Young Adults
Population: Juvenile idiopathic arthritis (JIA), rheumatoid arthritis (RA) and seronegative / psoriatic / undifferentiated arthritis (UA), systemic lupus erythematosus (SLE) or diffuse systemic sclerosis dSS).
- Conditions
- Juvenile Idiopathic Arthritis, Rheumatoid Arthritis, Psoriatic Arthritis, Systemic Lupus Erythematosus
- Trial name
- NCT07000916
- Where
- Belgium
- Volunteers
- 1,000 people
- Sponsor
- Université Catholique de Louvain
Breast Neoplasms, Female
Fluorocholine PET/MR in Breast Cancer
Objectives: Our study is conducted to use the pre-treatment Fluorocholine (FCH) Positron emission tomography/magnetic resonance (PET/MR) imaging in breast cancer patients, to investigate whether the conventional PET/MR imaging…
- Trial name
- NCT07587086
- Testing
- PET-MRI (PET/MR)
- Where
- Taiwan
- Volunteers
- 195 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan