Clinical trials: Clinical Outcomes
Osteoarthritis, Knee
A Biomechanical Exercise Program for Knee OA
Prescribing exercise for people with painful knee osteoarthritis (OA) is essential for pain management, improved function, and chronic disease prevention.
- Trial name
- NCT02370667
- Testing
- Biomechanical Exercise (BE), Traditional Exercise (TE), Meditation Control (M)
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- McMaster University
Respiratory Syncytial Viruses
A Two-Part Infant Study for Early Diagnosis of Respiratory Syncytial Virus (RSV) and Evaluation of JNJ-53718678 in RSV Acute Respiratory Tract Disease
The purpose of this two-part designed study is to assess in the setting of a planned early interception of pediatric RSV disease, early viral and disease kinetics (observational stage) and the antiviral effects of an Respiratory…
- Trial name
- NCT04068792
- Testing
- RSV Mobile Application, JNJ-53718678 2.5 mg/kg, JNJ-53718678 3 mg/kg
- Where
- 10 sites in Argentina, Belgium and 3 more
- Volunteers
- 22 people
- Sponsor
- Janssen Research & Development, LLC
Muscle Atrophy, ACL Reconstruction
Testosterone Administration and ACL Reconstruction in Men
This study is being done to test whether taking testosterone can prevent loss of muscle mass and strength due to anterior cruciate ligament (ACL) reconstructive surgery.
- Conditions
- Muscle Atrophy, ACL Reconstruction, Trauma, Osteoarthritis
- Trial name
- TACL (NCT01595581)
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Southern California
Major Depressive Disorder
Electroconvulsive Therapy Amplitude Titration
This study is focused on advancing ECT treatment for older adults with depressive disorders by refining neuromodulation stimulus parameters to improve efficacy and cognitive safety.
- Trial name
- NCT04621786
- Testing
- Mecta Spectrum 5000Q paired with Soterix Medical 4X1 HD - ECT Multi-Channel Stimulation Interface
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of New Mexico
Baker's Cyst
PRP vs Corticosteroid in Baker's Cyst
This is a Prospective study with Randomized patients into either Ultrasound-guided Platelets-Rich-Plasma injection and Ultrasound guided Corticosteroid Injection, with 3 months and 6 months follow ups after aspiration at our…
- Trial name
- NCT02249377
- Testing
- Platelets-Rich-Plasma, Corticosteroid
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
Chronic Pancreatitis, Insulin Dependent Diabetes
Hydroxychloroquine and Metabolic Outcomes in Patients Undergoing TPAIT
This will be a pilot, 12-month phase II, open label, randomized, two-arm, single-blinded, placebo-controlled, parallel clinical trial of individuals undergoing TPAIT (Total Pancreatectomy and Autologous Islet Transplantation) for…
- Trial name
- NCT03283566
- Testing
- Hydroxychloroquine
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The Cleveland Clinic
Hunter Syndrome, Mucopolysaccharidosis II
Safety and Clinical Outcomes in Hunter Syndrome Patients 5 Years of Age and Younger Receiving Idursulfase Therapy
The objective of this study is to determine the safety of once weekly dosing of idursulfase 0.5 mg/kg administered by intravenous (IV) infusion for male Hunter syndrome patients ≤ 5 years old.
- Conditions
- Hunter Syndrome, Mucopolysaccharidosis II, MPS II
- Trial name
- NCT00607386
- Testing
- Idursulfase
- Where
- 3 sites in Brazil, Poland and 1 more
- Volunteers
- 28 people
- Sponsor
- Shire
Type 2 Diabetes Mellitus
Sitagliptin Cardiovascular Outcomes Study (MK-0431-082)
This is a clinical trial designed to assess the cardiovascular outcome of long-term treatment with sitagliptin used as part of usual care compared to usual care without sitagliptin in participants with type 2 diabetes mellitus…
- Trial name
- TECOS (NCT00790205)
- Testing
- Sitagliptin
- Volunteers
- 14,671 people
- Sponsor
- Merck Sharp & Dohme LLC
Vitreoretinal Disease
Clinical Comparison of 27+® and 23-gauge ULTRAVIT® 7500 Cpm Vitrectomy Outcomes
The purpose of this study is to compare the treatment day change between immediate postoperative and immediate preoperative intraocular pressure (IOP) between 27-gauge and 23-gauge vitrectomy instruments.
- Trial name
- NCT02477605
- Testing
- CONSTELLATION® 27-gauge Combined Surgical Pak, CONSTELLATION® 23-gauge Combined Surgical Pak, Vitrectomy surgery
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Alcon Research
Myopia
LASIK Flap Thickness and Visual Outcomes Using the WaveLight FS200 Femtosecond Laser
The objective of this study is to evaluate the visual outcome, accuracy, predictability and complications of LASIK flap creation using the Alcon Wavelight FS200 Femtosecond laser and compare these results to those obtained using…
- Trial name
- FS200 (NCT02060461)
- Testing
- FS200 femtosecond laser LASIK, IntraLase femtosecond laser LASIK
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- The Cleveland Clinic
Chronic Migraine
Duration of Benefit for OnabotulinumtoxinA in Treatment of Chronic Migraine
To obtain a patient specific understanding of response to treatment with onabotulinumtoxinA by collecting and correlating pre and post treatment subject specific history, clinical outcomes, and histological changes.
- Trial name
- NCT02037425
- Testing
- onabotulinumtoxinA
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Cady, Roger, M.D.
Surgery
Evaluating Outcomes in Cardiac Surgery Patients Who Receive Sugammadex vs. Placebo
This is a prospective randomized blinded controlled trial that will enroll 175 subjects undergoing cardiopulmonary bypass at NorthShore University HealthSystem.
- Trial name
- NCT05801679
- Testing
- Sugammadex
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Endeavor Health
Severe, Symptomatic Aortic Stenosis
The SOLACE-AU Clinical Trial
The objective of the study is to observe the safety, efficacy and cost effectiveness of the Edwards SAPIEN XT valve for the treatment of severe calcific degenerative aortic stenosis.
- Trial name
- SOLACE-AU (NCT01675596)
- Testing
- TAVR Implantation of the Transcatheter Aortic Valve Prosthesis
- Where
- 11 sites in Australia
- Volunteers
- 199 people
- Sponsor
- Edwards Lifesciences