Clinical trials: Clinical Pharmacology
Breast Feeding, Human Milk
UmbrelLACT Study: Clinical Lactation Study on the Exposure to Medicines Via Human Milk
The goal of this observational study is to determine the concentration of medicines in human milk during maternal medicine intake.
- Trial name
- UmbrelLACT (NCT06042803)
- Testing
- Human milk collection, Optionally: maternal blood sample, Optionally: child blood sample
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Asthmatic
Lung Bioavailability and Total Systemic Exposure to Beclomethasone17MonoPropionate and Formoterol Across Two Strengths of NEXThaler Inhalation Powder
The study is aimed to assess the dose proportional total systemic exposure (when the administration is without the activated charcoal) to B17MP (active metabolite of BDP) and its lung bioavailability (when the administration is…
- Trial name
- NCT01738087
- Testing
- NEXThaler 100/6 mcg DPI, Flixotide Accuhaler 500 mcg, NEXThaler 200/6 mcg DPI
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Fibromyalgia
CBD (Cannabidiol)/THC (Tetrahydrocannabinol) Solution as a Pharmacological Strategy for Patients With Fibromyalgia (FibroCann)
Fibromyalgia is considered a chronic pain syndrome, non-inflammatory, of unknown etiology, which manifests itself in the musculoskeletal system in up to 2.5% of the general population, predominantly in females, mainly between 35…
- Trial name
- NCT05283161
- Testing
- cannabidiol and tetrahydrocannabinol
- Volunteers
- 40 people
- Sponsor
- FG Brasil LTDA
Scientific Collaboration in Clinical Pharmacology
Where Did the Authors Work When They Conducted Their Clinical Pharmacology Studies?
It is unknown in which countries the clinical pharmacology studies published in leading specialized journals were conducted. The hypothesis is that studies in this specialty tend to be conducted and published by authors from a…
- Trial name
- NCT07115680
- Testing
- human participants, data or material
- Where
- Spain
- Volunteers
- 503 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Leukemia, Lymphoma
Suberoylanilide Hydroxamic Acid in Treating Patients With Advanced Solid Tumors That Have Not Responded to Previous Therapy
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of suberoylanilide hydroxamic acid in treating patients who…
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Prostate Cancer
- Trial name
- NCT00005634
- Testing
- vorinostat
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Continuous Methamphetamine Dependence, Methamphetamine Dependence in Remission
Safety Study to Assess Atomoxetine With MA Abusers and Healthy Controls
Methamphetamine (MA) abuse is a national public health concern. People who are dependent on MA have problems with mental functions (e.g., learning, remembering, focusing attention, solving problems).
- Trial name
- NCT02014064
- Testing
- Atomoxetine
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Healthy
A Study of ABT-384 Levels and Pharmacodynamic Activity Measured in Cerebrospinal Fluid
The objectives of this study are to assess the cerebral spinal fluid (CSF) pharmacokinetics and the plasma/CSF pharmacokinetic/pharmacodynamic relationship of ABT-384 in healthy male volunteers.
- Trial name
- NCT01009216
- Testing
- ABT-384
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Abbott
Respiratory Distress Syndrome of Newborn
A Clinical Pharmacological Study of Dose Halving of Dexamethasone in Pregnant Women With Preterm Labour With Preterm Birth at Greater Than or Equal to 34 Gestational Weeks (34GW+)
This study plans to conduct a DEX dose halving study and a normal dose study in 34+0-35+6 GW women with preterm preterm labour. In addition, this study plans to conduct a DEX dose halving study and a normal dose study in 34-38+6…
- Trial name
- NCT06350565
- Testing
- Dexamethasone
- Volunteers
- 48 people
- Sponsor
- Peking University Third Hospital
Cognitive Impairment
Characterizing Clinical and Pharmacological Neuroimaging Biomarkers
This study is part of a larger overall study that seeks to characterize clinical and pharmacological neuroimaging biomarkers. The purpose of this registered protocol is understand the effect of emotion on cognitions by…
- Trial name
- NCT03842800
- Testing
- MRI, Ketamine
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Yale University
Hepatic Impairment
Pharmacokinetic Study of Alpelisib in Subjects With Hepatic Impairment.
To characterize the pharmacokinetics and safety of alpelisib in subjects with hepatic impairment compared to matched healthy control subjects.
- Trial name
- NCT02624557
- Testing
- Alpelisib
- Where
- 4 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Urological Surgery, Photobiomodulation (PBM)
PBM Patch for Postoperative Pain Relief After Urological Surgery
This study is a prospective, randomized, double-blind, placebo-controlled clinical study designed to evaluate the efficacy and safety of a photobiomodulation (PBM) patch (Super Vi PBM Patch - Soothing) and an enhanced PBM patch…
- Conditions
- Urological Surgery, Photobiomodulation (PBM), Non-pharmacological Intervention, Double-blind Randomized Controlled Study
- Trial name
- NCT07671612
- Testing
- Super Vi PBM Patch - Soothing, Super Vi PBM Patch - Soothing EX
- Where
- 2 sites in Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
In Vitro Fertilization
A Study to Investigate the Efficacy and Safety of a Single Injection of Corifollitropin Alfa (Organon 36286) for Ovarian Stimulation Using Daily Recombinant Follicle Stimulating Hormone (FSH) as Reference (P05787)
To investigate the efficacy and safety of a single injection of 150 μg Corifollitropin Alfa (Organon 36286) to induce multifollicular development for controlled ovarian stimulation using daily recombinant FSH (recFSH) as a…
- Trial name
- NCT00696800
- Testing
- Corifollitropin alfa, RecFSH / Follitropin beta (Days 1 to 7), RecFSH / Follitropin beta (Days 8 to hCG)
- Volunteers
- 1,509 people
- Sponsor
- Organon and Co
Healthy Adult Participants
Understanding Oral Nicotine Pouch Use in Healthy Volunteers
The goal of this clinical trial is to understand how using oral nicotine pouches effects the body in healthy volunteers. The main questions it aims to answer are: 1.
- Trial name
- NCT07829939
- Testing
- 0 mg oral nicotine pouches, 3 mg oral nicotine pouches, 6 mg oral nicotine pouches
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HTLV-1-Associated Myelopathy (HAM)
A Clinical Pharmacological Study of MT-3921 in Subjects With HTLV-1 Associated Myelopathy (HAM)
The purposes of this study is to assess the safety, tolerability, and pharmacokinetics of MT-3921 in subjects with Human T-cell Leukemia Virus Type 1 (HTLV-1)-Associated Myelopathy(HAM).
- Trial name
- NCT05240612
- Testing
- MT-3921
- Where
- Japan
- Volunteers
- 15 people
- Sponsor
- Tanabe Pharma Corporation
Clinical Pharmacology
Study on the Safety of BAY 63-2521, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given as a Single Oral Dose of 1 mg Tablet in Participants With Impaired Liver Function and Healthy Participants Matched for Age-, Gender-, and Weight
BAY 63-2521 is intended to be used for a disease that affects the blood flow through the lungs. Renal impairment is a common condition in patients with this disease.
- Trial name
- NCT04366622
- Testing
- Riociguat (Adempas, BAY 63-2521)
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
Major Depressive Disorder (MDD
Multimodal Pharmacological Study of Clinical Cohorts for Major Depressive Disorder
This study focuses on the neurobiological changes in MDD patients with high suicidal risk during rapid antidepressant treatments, such as Esketamine and Electroconvulsive Therapy (ECT).
- Trial name
- NCT07602153
- Testing
- Therapeutic intervention
- Volunteers
- 130 people
- Sponsor
- Shanghai Mental Health Center
Randomized Controlled Trial
Cost-utility and Physiological Effects of LDN in Patients With Fibromyalgia
Background: Low-dose naltrexone (LDN) may be useful in managing the pathologies that alter inflammatory markers, such as Crohn's disease or fibromyalgia (FM).
- Trial name
- INNOVA (NCT04739995)
- Testing
- Low-dose naltrexone
- Where
- Spain
- Volunteers
- 99 people
- Sponsor
- Fundació Sant Joan de Déu
Healthy
Tepotinib Drug-Drug Interaction Study With Carbamazepine in Healthy Participants
The purpose of this study was to assess the effect of multiple doses of carbamazepine on single- dose tepotinib pharmacokinetics in healthy participants.
- Trial name
- NCT05213481
- Testing
- Tepotinib, Carbamazepine
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Cardiovascular Disease
Effectiveness of Non-pharmacological Interventions in Patients With Cardiovascular Risk Factors in Primary Care
The principal objective is analyzed whether a selective intervention no pharmacological (use of ABPM +/- prescription of physical exercise) for cardiovascular risk factors in patients with high cardiovascular risk in primary…
- Trial name
- NCT03452709
- Testing
- therapeutic exercise, ABPM ambulatory blood pressure monitoring
- Where
- Spain
- Volunteers
- 3,656 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Pancreatic Neoplasms, Pancreatic Cancer
Clinical Trial of High-dose Vitamin C for Advanced Pancreatic Cancer
This is a phase II study. It is designed to provide information about if high-dose ascorbate (vitamin C) increases survival for pancreatic cancer patients.
- Trial name
- PACMAN-II (NCT01515046)
- Testing
- Gemcitabine with escalating ascorbic acid
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Joseph J. Cullen