Clinical trials: Clinical Practice, open to volunteers
Acute Respiratory Failure With Hypoxia
PEEP in Patients With Acute Respiratory Failure
Positive end-expiratory pressure (PEEP) has become an essential component of the care of critically ill patients who require ventilatory support.
- Trial name
- NCT04912960
- Testing
- Mechanical ventilation
- Where
- 3 sites in Spain
- Volunteers
- 15 people
- Sponsor
- Jesus Villar
TCE-RRMM
ASPIRE: A Registry Study Of Chinese Patients With TCE-RRMM Treated By Elranatamab
This registry study will provide valuable evidence to assess and validate its effectiveness in the Chinese MM population, refine clinical application strategies, and support the optimization of BCMA BsAbs use in MM treatment in…
- Trial name
- ASPIRE (NCT07320326)
- Testing
- Elranatamab
- Where
- China
- Volunteers
- 159 people
- Sponsor
- Peking University People's Hospital
Hidradenitis Suppurativa (HS)
Short-term Treatment Satisfaction in Hidradenitis Suppurativa Patients Initiated on Cosentyx in Routine Clinical Practice in Saudi Arabia
This study aims to assess the treatment satisfaction of HS patients newly started on secukinumab in Saudi Arabia, in terms of patient reported convenience, perceived safety, perceived effectiveness and global treatment…
- Trial name
- ILLUMINATE-SA (NCT06785779)
- Testing
- Secukinmab
- Where
- 4 sites in Saudi Arabia
- Volunteers
- 77 people
- Sponsor
- Novartis Pharmaceuticals
Pain, Dementia
Testing the Pain Clinical Practice Guideline
There are evidence based processes for assessment and management of pain using pharmacologic and nonpharmacological approaches. These were reviewed and included within the Pain Management Clinical Practice Guideline (Pain…
- Trial name
- NCT05858996
- Testing
- Pain-CPG-EIT, Pain-CPG-Education Only
- Where
- 11 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Maryland, Baltimore
Metastatic Breast Cancer
HER2-positive Metastatic Breast Cancer in Kazakhstan
Planned study population consists of approximately 240 adult patients with HER2-positive mBC receiving anti-HER2 therapy in 12 oncological centers (in each center it is expected to recruit about 20 patients) in different regions…
- Trial name
- NCT07593196
- Where
- 12 sites in Kazakhstan
- Volunteers
- 240 people
- Sponsor
- AstraZeneca
Oncology
Clinical Nursing Practice Supported by Results of Research: Mixed-method Study
The purpose of the study is to assess the attitudes and the use of research by nurses at the IRCCS-CRO Aviano. Furthermore, it will make it possible to identify attitudes towards the use/non-use of research results, specific…
- Trial name
- PRACTICE (NCT06668818)
- Where
- Italy
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Arthritis, Rheumatoid
Persistence of Biological Treatment and Inhibitors of Jak Kinases in Patients With Rheumatoid Arthritis.
One-center observational study aimed at determining the survival of patients with rheumatoid arthritis treated with targeted synthetic disease-modifying drugs (FAMEsd) and biologic disease-modifying drugs (FAMEb).
- Trial name
- Arthritis (NCT05062421)
- Where
- Spain
- Volunteers
- 540 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Infertility
Implementing IVM for Fertility Treatment in Clinical Practice
The ovarian reserve consists of a finite pool of follicles that gradually declines throughout a woman's reproductive life. During conventional IVF, exogenous gonadotropins are administered for 10-14 days to support the growth and…
- Trial name
- IVM-DK 2-0 (NCT07894952)
- Testing
- In vitro maturation
- Where
- Denmark
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
HIV, HIV Antiretroviral Therapy (ART) Adherence
Selection of Resistant Mutations to Dolutegravir in PLWH Treated in Mozambique
The HIV infection not fully controlled, despite being under antiretroviral treatment, could make virus resistance against the antiretroviral treatments, making hardest the well control of HIV infection.
- Trial name
- REDOCH (NCT06607588)
- Testing
- Not applicable- observational study
- Where
- Mozambique
- Volunteers
- 200 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Eating Disorders in Adolescence, Transition of Care
Feasibility of the TransitionED Framework for Youth and Young Adults With Eating Disorders
Moving from pediatric (children's) health care to adult health care can be challenging for youth and young adults with eating disorders.
- Trial name
- TransitionED 3 (NCT07518641)
- Testing
- TransitionED Healthcare Transition Framework
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- McMaster University
Acute Decompensated Heart Failure (ADHF)
Levosimendan in Acute Decompensated Heart Failure
Acute decompensated heart failure (ADHF) is one of the major causes of hospitalization and mortality worldwide. Despite advances in medical treatments, managing ADHF remains complex, especially in high-risk populations.
- Trial name
- NCT07262723
- Testing
- Levosimendan, Standard care
- Where
- 6 sites in Bangladesh
- Volunteers
- 332 people
- Sponsor
- Chittagong Medical College
Clinical Practice, Virtual Reality
The Effect of the Operating Room Environment on Patients Experienced With Virtual Reality Glasses Before Surgery
This study was planned as a randomized controlled experimental study with a pretest-posttest design to examine the effect of the operating room environment experience of preoperative patients using virtual reality glasses on the…
- Conditions
- Clinical Practice, Virtual Reality, Nursing Care, Simulation
- Trial name
- NCT06666465
- Testing
- Operating Room Environment Experienced by Patients Wearing Virtual Reality Glasses Before Surgery The Effect of Surgery Experience on Surgical Fear Level and Care Perceptions
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Nephrolithiasis
Postoperative Analgesia Practices After Percutaneous Nephrolithotomy
This prospective observational study aims to evaluate the effectiveness and safety of different postoperative analgesia methods used in patients undergoing percutaneous nephrolithotomy (PCNL).
- Trial name
- NCT07258901
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Istinye University
Evidence Based Practice
Education Program on Evidence-based Practices on Nurses' Competencies and Clinical Decision-Making Levels
This clinical trial aims to develop an online education program and an educational booklet for nurses on EBP and to compare the evidence-based competencies and clinical decision-making levels of nurses trained with these two…
- Trial name
- RCT (NCT06569407)
- Testing
- Online Educational Intervention, Educational Booklet
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Koç University
Prostate Biopsy
Use of a Virtual Reality Headset During Prostate Biopsy Under Local Anesthesia to Improve the Patient's Experience
This is a post-market clinical investigation evaluating the effect of immersive virtual reality (VR) as an adjunct to standard local anesthesia during transperineal prostate biopsy.
- Trial name
- NCT07701421
- Testing
- Standard Local Anesthesia, Immersive Virtual Reality (VR) Headset
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Diabetes
Achieving Chronic Care equiTy by leVeraging the Telehealth Ecosystem
This study examines the impact of a multi-level intervention aiming to improve telehealth access for low-income patients managing chronic health conditions, such as hypertension and diabetes.
- Trial name
- ACCTiVATE (NCT06598436)
- Testing
- Digital Health Coaching (Patient-Level Intervention), Practice Facilitation (Clinic-Level Intervention)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- University of California, San Francisco
Hidradenitis Suppurativa (HS), Hidradenitis Suppurativa (Acne Inversa)
Efficacy and Safety of Secukinumab in Conjunction With Surgery in Moderate to Severe Hidradenitis Suppurativa
This study aims to retrospectively analyze the efficacy and safety of secukinumab combined with surgery in treating moderate to severe HS in real-world clinical practice, providing clinical practioners with real-world evidence in…
- Conditions
- Hidradenitis Suppurativa (HS), Hidradenitis Suppurativa (Acne Inversa), Secukinumab
- Trial name
- NCT06926192
- Testing
- Surgery combined with secukinumab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College
Prostate Cancer, Risk Assessment
PROstate Cancer Risk Calculator for ACTionable Clinical Decision-making in Nigeria
This study is a pilot trial that builds on findings from the validation of prostate cancer risk calculators in Nigerian men. The goal of the overall study is to improve the early detection of prostate cancer in a high-risk…
- Conditions
- Prostate Cancer, Risk Assessment, Clinical Decision Support Systems, Predictive Value of Tests
- Trial name
- PROACT (NCT07733440)
- Testing
- (a) Training and (b) Supported risk assessment
- Where
- Nigeria
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Ahmadu Bello University
Safety and Effectiveness of Midline Catheters, Vascular Access Devices
Evaluating Midline Catheters in Clinical Practice
The goal of this observational study is to learn about the safety and effectiveness of midline catheters in patients who receive midline catheter placement as part of their routine clinical care.
- Trial name
- NCT07677696
- Testing
- Midline catheter placement
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Shandong Branden Med.Device Co.,Ltd
Perineal Trauma
Ward-Level Implementation and Post-Market Clinical Follow-up Study of ASISU Under Routine Clinical Practice
This is a single-center, prospective, non-randomized post-market clinical follow-up study evaluating the implementation and clinical performance of ASISU during routine vaginal childbirth.
- Trial name
- ASISU-PMCF (NCT07844005)
- Testing
- Perineal protection device
- Where
- Denmark
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- oasicare ApS