Clinical trials: Clinical Sepsis
Sepsis
Sepsis Alert Routine Implementation in the Emergency Department
This study evaluates the impact of a structured sepsis alert routine, that has been implemented in the Emergency Department (ED) of Karolinska University Hospital Huddinge, Sweden.
- Trial name
- SARIED (NCT07020598)
- Volunteers
- 3,389 people
- Sponsor
- Region Stockholm
Acinetobacter Infections
Clinical Outcomes and Global Epidemiology -Data Coordinating Center
The primary objective is to assess for independent predictors of in-hospital mortality (up to 28 days) in patients with Acinetobacter bloodstream infection.
- Trial name
- NCT00524563
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Pittsburgh
Meningitis, Meningococcal Disease
Understanding the Immune Response to Two Different Meningitis Vaccines
The bacterium (germ) Neisseria meningitidis causes meningitis and blood poisoning. N meningitidis is classified into different serogroups (types), based on its outer polysaccharide (carbohydrate) capsule.
- Conditions
- Meningitis, Meningococcal Disease, Septicaemia
- Trial name
- NCT01593514
- Testing
- MenACWY-CRM conjugate vaccine (Menveo, Novartis), MenACWY-PS polysaccharide vaccine, ( ACWYVax, GSK) and MenACWY-CRM conjugate vaccine (Menveo, Novartis), 1/5th dose MenACWY-PS polysaccharide vaccine, ( ACWYVax, GSK) and MenACWY-CRM conjugate vaccine (Menveo, Novartis)
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Bacterial Vaginosis, Premature Birth
Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity
The trial intends to evaluate the efficacy of specially designed probiotics to prevent premature birth and related neonatal morbidity associated to intra-uterine infection.
- Conditions
- Bacterial Vaginosis, Premature Birth, Sepsis, Periventricular Leukomalacia
- Trial name
- NCT00303082
- Testing
- Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14
- Where
- 2 sites in Brazil
- Volunteers
- 645 people
- Sponsor
- Oswaldo Cruz Foundation
Chorioamnionitis, Early Onset Neonatal Sepsis
Chorioamnionitis: Observation of at Risk Infants vs Standard Care
This study evaluates the non-inferiority of a protocol of limited evaluation (complete blood count, blood culture) and clinical observation by standardized physical examination versus the algorithm suggested in the CDC's 2010…
- Conditions
- Chorioamnionitis, Early Onset Neonatal Sepsis, Sepsis of the Newborn
- Trial name
- CHORIS-RCT (NCT02886910)
- Testing
- Clinical observation, Standard management
- Where
- Italy
- Sponsor
- IRCCS Burlo Garofolo
Endotoxemia, Systemic Inflammatory Response
PK/PD of EA-230 During Endotoxemia
EA-230 is a newly developed synthetic compound with anti-inflammatory properties. Pre-clinical data indicate that EA-230 may be a valuable treatment for systemic inflammation resulting from a variety of causes such as surgery…
- Trial name
- NCT02629874
- Testing
- EA-230, Endotoxin
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Sepsis at Intensive Care Unit
Clinical Study Evaluating the Efficacy and Safety of Colchicine in Adult Patients With Sepsis
Inflammatory markers are found to be an important contributor in sepsis. We evaluate the effect of colchicine on inflammatory processes and its possible protective effect against oxidative stress and organ dysfunction in adult…
- Trial name
- NCT07074990
- Testing
- conventional sepsis therapy alone, colchicine 500 mcg oral twice daily plus conventional sepsis therapy.
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Tanta University
Sepsis
Performance and Impact of the Sepsis ImmunoScore
The goal of this prospective cohort device study is to assess clinical usage and impact, diagnostic performance, and prognostic performance of the Sepsis ImmunoScore.
- Trial name
- NCT07543497
- Testing
- Sepsis ImmunoScore
- Volunteers
- 5,000 people
- Sponsor
- Prenosis, Inc.
Sepsis
Assessing the Procalcitonin-guidance and Molecular-guided Diagnosis for Therapy of Severe Infections (the MODIFY Trial)
MODIFY is a randomized, open-labeled, and prospective study that will be conducted in multiple Intensive Care Units (ICUs) and departments of Internal Medicine across Greece.
- Trial name
- MODIFY (NCT05909683)
- Testing
- Change of antimicrobials based on BCID2 and Reveal Rapid AST tests. Stop of antimicrobials based on PCT results., Standard of Care
- Where
- 15 sites in Greece
- Volunteers
- 190 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Fatal Outcome
Proadrenomedullin for Early Risk Assessment in the Emergency Department
The study ia aiming to the assessment of Mid-Regional proadrenomedullin (MR-proADM) as a novel biomarker that can provide accurate short-, mid- and long term prognostic information in the triage and multi-dimensional risk…
- Trial name
- ADRISK (NCT02823704)
- Where
- Greece
- Volunteers
- 300 people
- Sponsor
- University of Athens
Sepsis
Clinical Efficacy of Ulinastatin for Treatment of Sepsis With Systemic Inflammatory Response Syndrome
Sepsis is a life-threatening organ dysfunction caused by the maladjusted response of the host to infection. It is a clinical syndrome with high mortality.
- Trial name
- CURE-SepSIRS (NCT05391789)
- Testing
- Ulinastatin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huashan Hospital
Infection Due to Resistant Bacteria, Pneumonia, Ventilator-Associated
Colistin and Rifampicin for MDR-Acinetobacter
Acinetobacter baumannii causes severe infections (pneumonia, bacteremia, organ space) with high lethality in hospitalised critically ill patients.
- Conditions
- Infection Due to Resistant Bacteria, Pneumonia, Ventilator-Associated, Hospital Acquired Pneumonia, Infection of Bloodstream
- Trial name
- CoRAb (NCT01577862)
- Testing
- Colistin, Rifampicin
- Volunteers
- 210 people
- Sponsor
- University of Campania Luigi Vanvitelli
Septic Shock
UK ANDROMEDA-Shock-2 RCT
The purpose of the trial is to test if a strategy of resuscitation guided by capillary refill time and individualised clinical hemodynamic phenotyping can improve important clinical outcomes within 28 days in septic shock…
- Trial name
- NCT06366854
- Testing
- Personalised fluid and haemodynamic resuscitation
- Volunteers
- 25 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Severe Sepsis
De-escalation of Empirical Antimicrobial Therapy Study in Severe Sepsis
Rational: Severe sepsis is one of the leading cause of mortality in intensive care unit patients. Early initiation of an appropriate empirical antimicrobial therapy is associated with improved outcomes.
- Trial name
- NCT01626612
- Testing
- continuation of the empirical antimicrobial therapy, streamlining of the empirical antimicrobial therapy
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Hospital Admission Duration, Postoperative Hematoma Formation
Drain or no Drain After Thyroid Surgery: a Randomized Clinical Trial at Mulago Hospital
Thyroidectomy is one of the most commonly performed operations in general surgery. Available data seem to suggest an association between no-drain usage and a shorter duration of hospital stay.
- Conditions
- Hospital Admission Duration, Postoperative Hematoma Formation, Wound Sepsis
- Trial name
- NCT01729741
- Testing
- drain was inserted after thyroid surgery
- Where
- 2 sites in Uganda
- Volunteers
- 68 people
- Sponsor
- Makerere University
Learning Process in Nursing Graduation, Stress
Effectiveness of Simulation With Nursing Students in the Care of Patients With Sepsis
Simulation is an active teaching strategy capable of reproducing real situations and allowing practical experiences, in which the student is the protagonist of his own knowledge.
- Trial name
- NCT04512183
- Testing
- High-Fidelity Simulation, Low-Fidelity Simulation
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Septic Shock, Stress Response
Effect of Dexmedetomidine vs Esmolol or Placebo on Cerebral Hemodynamics in Septic Shock
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Some researchers proposed that the dysregulated response or organ dysfunction can be lessened by reducing the stress…
- Conditions
- Septic Shock, Stress Response, Cerebral Hemodynamics
- Trial name
- NCT06169475
- Testing
- Dexmedetomidine Hydrochloride, Esmolol Hydrochloride
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Xinchen Wang
Sepsis
Curcumin in Critically Ill Patients With Sepsis
Sepsis is a life-threatening condition that occurs when the body's response to an infection becomes overwhelming and damages its own organs.
- Trial name
- NCT07436130
- Testing
- Curcumin
- Where
- Mexico
- Volunteers
- 56 people
- Sponsor
- Hospital Civil de Guadalajara
Drug Resistance, Carbapenem-Resistant Enterobacteriaceae Infection
Optimizing Antibiotic Dosing Regimens for the Treatment of Infection Caused by Carbapenem Resistant Enterobacteriaceae
The purpose of this study is to evaluate the treatment outcomes in patients with CRE infections.
- Conditions
- Drug Resistance, Carbapenem-Resistant Enterobacteriaceae Infection, Sepsis, Septic Shock
- Trial name
- NCT04516395
- Testing
- Combined antibiotic regimens, Standard antibiotic regimens
- Where
- Thailand
- Volunteers
- 102 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Sepsis, Septic Shock
Micro and Macro Circulation in Sepsis
Purpose: To assess the prognostic role of Handheld Vital Microscopy (HVM) and evaluate levels of endothelial glycocalyx (eGC) breakdown in patients demonstrating Hemodynamic Incoherence (HI), to elucidate a mechanistic link…
- Trial name
- DAISY (NCT05694455)
- Testing
- Starling Stroke Volume (Starling SV)- Passive Leg Raise, Microscan Sublingual Microscopy, Venous Excess Ultrasound Scoring (VExUS)
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority