Clinical trials: Clinical Sepsis
Interleukin-6
Effectiveness of the Cytokine Hemadsorption on Sepsis
In this prospective study, we aimed to compare the laboratory and clinical results of cytokine hemadsorption as an immunomodulation therapy in ICU patients diagnosed with sepsis or septic shock.
- Trial name
- NCT05057455
- Testing
- cytokine hemadsorption
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Biruni University
Sepsis, Acute Kidney Injury
VExUS Combined With CVP to Predict Clinical Outcomes in Sepsis Participants
Introduction: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host immune response to infection, and it is a common critical condition in the ICU.
- Trial name
- NCT06524622
- Testing
- Point-of-care ultrasound (POCUS)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The Second People's Hospital of Yibin
Septic Shock, Sepsis
Impact of Systematic Point-of-Care Ultrasound Implementation on Clinical Outcomes and Survival in Septic Shock: A Retrospective Single-Center Cohort Study
This study aims to evaluate the clinical impact of the systematic implementation of point-of-care ultrasound (POCUS) in the management of patients with septic shock in the intensive care unit (ICU).
- Trial name
- SHOCK (NCT07565649)
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Septic Shock
Initiation of Hydrocortisone for the Treatment of Septic Shock
The purpose of this study : 1）to determine whether hydrocortisone is effective in the treatment of septic shock and 2) to identify the role of timing of low dose hydrocortisone administration in septic shock patients.
- Trial name
- NCT02580240
- Testing
- Hydrocortisone, saline
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Northern Jiangsu People's Hospital
Bloodstream Infection, Septic Shock
Bloodstream Infection Due to Multidrug-Resistant Organisms - Multicenter Study on Determinants of Clinical Outcomes
Continual surveillance of both community-acquired and nosocomial bloodstream infections for specific target organisms. Analysis of comorbidities, complications, bacterial resistance patterns, bacterial genomics (e. g.
- Trial name
- BLOOMY-COM (NCT03578835)
- Where
- 6 sites in Germany
- Volunteers
- 6,000 people
- Sponsor
- University Hospital Tuebingen
Sepsis
A Clinical Trial of Procalcitonin-guided Antimicrobial Therapy in Sepsis
The aim of the study is to demonstrate if using one procalcitonin (PCT)-guided rule of stop of antimicrobials, the incidence of infections by C.difficile and by Multi-Drug-Resistant (MDR) bacteria during the next six months may…
- Trial name
- PROGRESS (NCT03333304)
- Testing
- Procalcitonin measurement
- Where
- 7 sites in Greece
- Volunteers
- 266 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Ventilator-associated Pneumonia, Sepsis
Diagnostic Value of Pulmonary Ultrasound in the Diagnosis of Ventilator-associated Pneumoniae
This study evaluates the respective values and combined CPIS (Clinical Pulmonary Infection Score), bronchoalveolar lavage (BAL), tracheal aspiration and pulmonary ultrasonography (LUS - Lung Ultrasound) for early diagnosis of…
- Trial name
- PAVM (NCT02536547)
- Testing
- VAP
- Volunteers
- 100 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Sepsis, Acute Myeloid Leukemia
Clinical Factors Associated With the Development of Severe Sepsis in Patients Being Treated for Acute Myeloid Leukemia
Acute leukemia is a life threatening illness that strikes people of all ages. In addition to surviving the direct effects of the disease, the treatment of leukemia generally requires chemotherapy which has its own burden.
- Trial name
- AML (NCT00806325)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Ohio State University
Sepsis
Early Diagnostic of Sepsis and Potential Impact on Antibiotic Management Based on Serial.Pancreatic Stone Protein (PSP) Measured Using the AbioScope.
The main purpose of this study is to compare the early detection of sepsis and the decision, by the Investigator to start or not, or to change, antibiotics in Intensive Care Unit (ICU) patients at high risk of sepsis, based on…
- Trial name
- NCT03474809
- Testing
- Blood sampling
- Where
- 14 sites in France, Italy and 2 more
- Volunteers
- 296 people
- Sponsor
- Abionic SA
Severe Sepsis
S.A.F.E.BT System Extracorporeal Treatment With DIAPACT CRRT
The purpose of this study is to determine if Selective Adsorption System for Removal of Bacterial Toxins (S.A.F.E.BT) therapy is effective in the treatment of severe sepsis.
- Trial name
- SAFEbt (NCT01312675)
- Testing
- S.A.F.E.BT
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- B. Braun Medical Inc.
Sepsis, Septic Shock
Optimized Caloric-proteic Nutrition in Septic and Septic Shock Patients
In this pilot randomized prospective controlled trial the investigators intend to compare the use of a nutritional therapy based on caloric intake determined by indirect calorimetry and high protein intake with nutritional…
- Trial name
- NCT02731144
- Testing
- Peptamen intense, Novasource senior
- Volunteers
- 10 people
- Sponsor
- Hospital Sao Domingos
Sepsis
Clinical Evaluation of e- Ab Sensor - Based Real-time Diagnosis of Serum Procalcitonin Level
The purpose of this study is to develop a real-time diagnostic technique with e- Ab sensor for serum PCT level measurement will offer a test with lower cost, and increase the applicability of serum Procalcitonin (PCT) level in…
- Trial name
- NCT01388114
- Testing
- Electrosensing Antibody Probe System (e- Ab sensing)
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Septic Shock, Sepsis
Fluid Resuscitation in Early Septic Shock
Severe infection in the intensive care unit is common accounting for about 10% of admissions and has a death rate of approximately 40-50%. It is almost always associated with significant reductions in blood pressure.
- Conditions
- Septic Shock, Sepsis, Severe Sepsis
- Trial name
- PRECISE (NCT00819416)
- Testing
- 5% albumin, Normal Saline
- Where
- 6 sites in Canada
- Volunteers
- 47 people
- Sponsor
- Ottawa Hospital Research Institute
Neonatal Sepsis
Serum Presepsin as Early Predictor for Neonatal Early-onset Sepsis
124 neonates aged ≤7 days with suspected EOS were clinically evaluated using SNAP-II and gave blood samples for BC, total leucocytic count (TLC), lymphocytic and neutrophil count, and ELISA estimation of serum levels of PSP…
- Trial name
- NCT05022043
- Testing
- Serum Presepsin
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Tanta University
Sepsis Syndrome
Diagnostic Accuracy in Sepsis
The sepsis syndrome has recently been more stringently defined as "a life-threatening organ dysfunction caused by a dysregulated host response to infection".
- Trial name
- NCT03956043
- Where
- Norway
- Volunteers
- 1,989 people
- Sponsor
- Oslo University Hospital
Sepsis
Clinical Score Usefulness and EHR Integration
The SOFA score is a severity of illness and prognostic score used in the ICU. It has also recently been adopted as part of the definition of sepsis.
- Trial name
- ScoreInt (NCT02755025)
- Testing
- Automated SOFA scoring calculator
- Volunteers
- 215 people
- Sponsor
- Mayo Clinic
Septic Shock
Evaluating Dynamic Arterial Elastance in Septic Shock Patients.
Assess the effectiveness and safety of using dynamic arterial elastance as a tool for weaning vasopressor support in patients with septic shock, compared to a control group
- Trial name
- EaDyn (NCT06118775)
- Testing
- EaDyn Weaning Arm:, PAM Weaning Arm:
- Where
- Colombia
- Volunteers
- 114 people
- Sponsor
- Fundación Santa Fe de Bogota
Sepsis
Personalized Swiss Sepsis Study
This multi-center study is to focus on patients with sepsis in Intensive Care Units (ICUs) in order to better understand the complex host-pathogen interaction and clinical heterogeneity associated with sepsis.
- Trial name
- PSSS_digital (NCT04130789)
- Testing
- compare data patterns by data-driven algorithms to determine sepsis, compare data patterns by data-driven algorithms to predict sepsis-related mortality
- Where
- 16 sites in Switzerland
- Volunteers
- 17,500 people
- Sponsor
- University Hospital, Basel, Switzerland
Sepsis
Emapalumab Treatment For Anticipated Clinical Benefit In Sepsis Driven By The Interferon-Gamma Endotype (The EMBRACE Trial)
EMBRACE is a double-blind, randomized, placebo-controlled, phase IIa study that will be conducted in multiple Intensive Care Units (ICUs) and departments of Internal Medicine across Greece.
- Trial name
- EMBRACE (NCT06694701)
- Testing
- Emapalumab-Izsg
- Where
- 24 sites in Greece
- Volunteers
- 75 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Sepsis
Evidence-based Evaluation and Mechanism of Shenhuang Granules in the Treatment of Sepsis
Sepsis is a life-threatening organ dysfunction caused by the body's dysfunctional response to infection, most patients require treatment in the ICU, and is the leading cause of death worldwide.
- Trial name
- NCT06514339
- Testing
- shenhuang granule
- Where
- China
- Volunteers
- 410 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University