Clinical trials: Clinical Stratification
Atrial Fibrillation
Thromboembolic and Bleeding Risk Stratification in Patients With Non-valvular Atrial Fibrillation
The aim of the present prospective study is to further develop and validate a composite risk score predicting both ischemic and bleeding risk, based on epidemiologic, clinical, biological, and/or morphologic complementary data.
- Trial name
- FASTRHAC (NCT02741349)
- Where
- 4 sites in France
- Volunteers
- 825 people
- Sponsor
- Saint Antoine University Hospital
Major Depressive Disorder
Precision Medicine for the Prediction of Treatment (PROMPT) Response (PROMPT)
Major depressive disorder (MDD) is the most common psychiatric disease worldwide with a huge socio-economic impact. Pharmacotherapy represents the first-line treatment choice; however, only about one third of patients respond to…
- Trial name
- PROMPT (NCT05537558)
- Testing
- Antidepressant
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital Muenster
Leukemia
Efficacy Study of Low-dose Glucocorticoid Prophylaxis for Acute Graft-versus-host Disease(GVHD)
Hematopoietic stem cell transplantation (HSCT) is one of the best, and sometimes the only, option for the treatment of leukemia. However, GVHD rate was still high after haploidentical HSCT.
- Trial name
- NCT01607580
- Testing
- low-dose glucocorticoid Methylprednisolone
- Where
- 2 sites in China
- Volunteers
- 145 people
- Sponsor
- Peking University People's Hospital
Breast Cancer
Implementing Polygenic Risk Scores for Breast Cancer Prevention: a Feasibility Study
This single-arm interventional feasibility study will evaluate whether integrating polygenic risk scores (PRS) into the CanRisk model can improve breast cancer risk prediction and personalized prevention in women at risk of…
- Trial name
- MIG (NCT06922708)
- Testing
- Clinical pathway for breast cancer prevention based on PRS-integrated CanRisk assessment
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Internal Carotid Artery Dolichoarteriopathy, Carotid Artery Tortuosity
Clinical Significance of Internal Carotid Artery Dolichoarteriopathy
This observational study aims to investigate the clinical significance of internal carotid artery dolichoarteriopathy, including tortuosity, kinking, and coiling, and to identify factors associated with cerebral dysfunction and…
- Trial name
- DALISTA (NCT07882875)
- Where
- Russia
- Volunteers
- 560 people
- Sponsor
- Kuban State Medical University
Colo-rectal Cancer
The AIDPRO-CRC Trial
The AIDPRO-CRC trial aims to improve outcomes for patients undergoing surgery for colorectal cancer by using artificial intelligence (AI) to assist surgeons in risk assessment.
- Trial name
- AIDPRO-CRC (NCT06645015)
- Testing
- AI augmented risk-stratification, Expert-based Risk-stratification
- Where
- 8 sites in Denmark
- Volunteers
- 1,200 people
- Sponsor
- Zealand University Hospital
Cancer, Frailty
Association of ICU Admission Time, Age Stratification, and Clinical Frailty Scale With 30-Day Mortality in Geriatric Oncology Patients
Geriatric oncology patients frequently require intensive care admission and are at increased risk of adverse outcomes due to advanced age, frailty, and critical illness.
- Conditions
- Cancer, Frailty, Mortality
- Trial name
- NCT07825090
- Testing
- Observation
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Purpura, Thrombocytopenic, Idiopathic
The Combination of ATRA and Eltrombopag as the Treatment of Steroid-resistant/Relapse ITP Based on MSC-C5b-9
A Prospective, Randomized, Open-Label, Multicenter Clinical Trial study to compare the efficacy and safety of ATRA plus eltrombopag compared to eltrombopag monotherapy in the treatment of steroid-resistant/relapsed immune…
- Trial name
- NCT05438875
- Testing
- all-trans retinoic acid, Eltrombopag
- Where
- 5 sites in China
- Volunteers
- 96 people
- Sponsor
- Peking University People's Hospital
Obese Adults, BMI/Body Composition
Precision Lifestyle Medicine Program for IFHAS Participants
The goal of this clinical trial is to evaluate whether a precision lifestyle medicine intervention can improve cardiometabolic health in Emirati adults aged 25 to 50 years living in Abu Dhabi with obesity (BMI 30-35 kg/m²) who…
- Conditions
- Obese Adults, BMI/Body Composition, Cardiometabolic Risk, Cardiovascular Disease Risk
- Trial name
- NCT07742917
- Testing
- Precision Lifestyle Medicine Program, Standard IFHAS Care
- Where
- United Arab Emirates
- Volunteers
- 150 people
- Sponsor
- Institute for Healthier Living Abu Dhabi
Gastrointestinal Hemorrhage
Artificial Intelligent Clinical Decision Support System Simulation Center Study for Technology Acceptance
The purpose of this research study is to measure the effect on of a large language model interface on the usability, attitudes, and provider trust when using a machine learning algorithm-based clinical decision support system in…
- Trial name
- NCT05816473
- Testing
- LLM
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Yale University
Colorectal Liver Metastases
Integrated Clinical-molecular Risk Stratification to Early Recurrence in Colorectal Liver Metastases
The goal of this observational study is to develop an integrated clinical-molecular risk stratification to identifypatients who are at high risk of recurrence and who would benefit from adjuvant chemotherapy in patients with…
- Trial name
- NCT07391007
- Testing
- gene sequencing, observational study
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University
Sickle Cell Disease, Sickle Cell Anemia
Risk Clinical Stratification of Sickle Cell Disease in Nigeria, Assessment of Efficacy/Safety of Hydroxyurea Treatment
The vast majority of births with sickle cell disease (SCD) occur in Africa and 90% are thought to die before the age of five. Hydroxyurea (HU) is the only drug approved by the FDA for the treatment of sickle cell anemia.
- Trial name
- NCT02149537
- Testing
- hydroxyurea
- Where
- Nigeria
- Volunteers
- 53 people
- Sponsor
- Loyola University