Clinical trials: Clinical Study
Clinical Stage II Esophageal Adenocarcinoma AJCC v8, Clinical Stage III Esophageal Adenocarcinoma AJCC v8
Futibatinib With Paclitaxel and Ramucirumab for the Treatment of Locally Advanced or Unresectable Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma
This phase I trial tests the safety, side effects and best dose of futibatinib with paclitaxel and ramucirumab for the treatment of patients with gastric, gastroesophageal junction or esophageal adenocarcinoma that has spread to…
- Conditions
- Clinical Stage II Esophageal Adenocarcinoma AJCC v8, Clinical Stage III Esophageal Adenocarcinoma AJCC v8, Clinical Stage III Gastric Cancer AJCC v8, Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
- Trial name
- NCT07594548
- Testing
- Biospecimen Collection, Computed Tomography, Futibatinib
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Northwestern University
Clinical Stage IV Esophageal Adenocarcinoma AJCC v8, Clinical Stage IV Gastric Cancer AJCC v8
Testing the Addition of Radiotherapy to the Usual Treatment (Chemotherapy) for Patients With Esophageal and Gastric Cancer That Has Spread to a Limited Number of Other Places in the Body
This phase III trial studies how well the addition of radiotherapy to the usual treatment (chemotherapy) works compared to the usual treatment alone in treating patients with esophageal and gastric cancer that has spread to a…
- Conditions
- Clinical Stage IV Esophageal Adenocarcinoma AJCC v8, Clinical Stage IV Gastric Cancer AJCC v8, Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8, Clinical Stage IVA Gastric Cancer AJCC v8
- Trial name
- NCT04248452
- Testing
- Capecitabine, Fluorouracil, Leucovorin
- Where
- 453 sites in United States
- Volunteers
- 314 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Diabete Mellitus, Dyslipidaemia
Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years
Overweight and obesity, as well as periodontitis, are common public health problems with increasing prevalence. Both conditions may be linked through shared mechanisms involving chronic low-grade systemic inflammation.
- Conditions
- Diabete Mellitus, Dyslipidaemia, Chronic Kidney Disease, Psychiatric Disorder
- Trial name
- NCT07880717
- Testing
- Periodontal Examination, Questionnaire interview, Anthropometric measurements
- Where
- Thailand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Resectable Clinical Stage IB to III NSCLC
Prospective Observational Study of Baseline Tumor Genomic Profiling and Circulating Tumor DNA in Neoadjuvant Chemoimmunotherapy for Stage IB-III Non-Small Cell Lung Cancer
The goal of this observational study is to learn whether tests on tumor tissue and blood can predict how well patients with stage IB-III non-small cell lung cancer respond to chemotherapy combined with immunotherapy given before…
- Trial name
- NCT06907160
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Burnout, Clinical Burnout
Comparing ACT, Recuperation, and ACT Plus Vocational Support for Clinical Burnout
This study compares three different online psychological treatments for people with clinical burnout (stress-related exhaustion) who are on sick leave or have major difficulties coping at work or in daily life.
- Conditions
- Burnout, Clinical Burnout, Exhaustion Disorder
- Trial name
- NCT07272421
- Testing
- ACT, Recuperation, Vocational support
- Where
- Sweden
- Volunteers
- 210 people
- Sponsor
- Uppsala University
Clinical Intuition
CLINICAL INTUITION is an Experience-based, Often Unconscious Assessment of a Patient's Resilience and Tolerance. It is INFLUENCED by Clinical Signs, Behavior, Functioning, and Context. While it MAY PREDICT Patient Dropout, it is Difficult to Objectify.
Patient selection for Phase I oncology trials is formally based on protocol-defined inclusion and exclusion criteria. In practice, however, healthcare professionals also take clinical intuition and professional experience into…
- Trial name
- MINC (NCT07877623)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
To Evaluate the Clinical Efficacy and Safety of the New ALSS
Clinical Observation of CABA System in the Treatment of End-stage Liver Disease With Inflammation
End-stage liver disease (ESLD) refers to the late stage of liver disease caused by various chronic liver damage. ESLD is an important cause of global incidence rate and mortality, which has a significant impact on the health care…
- Trial name
- NCT05780190
- Testing
- New artificial liver CABA system (BS330+CA280) +PE
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Qin Ning
Endodontic Diseases, Clinical Communication
Generative AI-Based Immersive Training for Endodontic Risk Disclosure and Informed Consent Among Dental Students
The objective of this prospective, parallel-group, 1:1 randomized controlled trial is to evaluate the effectiveness of a generative artificial intelligence (AI)-based immersive training program, utilizing the Gemini platform, in…
- Conditions
- Endodontic Diseases, Clinical Communication, Informed Consent
- Trial name
- GAI-ENDORDIC (NCT07731867)
- Testing
- Generative AI-Based Immersive Training, Conventional Case-Based Learning
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancers
This phase I trial studies how well tacrolimus, nivolumab, and ipilimumab work in treating kidney transplant recipients with cancer that cannot be removed by surgery (unresectable) or has spread to other places in the body…
- Conditions
- Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8, Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8
- Trial name
- NCT03816332
- Testing
- Ipilimumab, Nivolumab, Prednisone
- Where
- 7 sites in United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Hypercholesterolemia, Familial, Clinical Decision Support
Clinical Decision Support for Familial Hypercholesterolemia
A cluster randomized study in the primary care setting to evaluate a computer-based clinical decision support system to aid in the identification and management of patients with FH.
- Trial name
- CDS-FH (NCT03989167)
- Testing
- Clinical decision support
- Where
- Sweden
- Volunteers
- 472,029 people
- Sponsor
- University Hospital, Linkoeping
Clinical Stage 0 Esophageal Adenocarcinoma AJCC v8, Clinical Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8
Remote Telemonitoring of Patient-Generated Physiologic Health Data and Patient-Reported Outcomes
This study examines at-home monitoring of patient-generated phsyiologic health data and patient-reported outcomes. Patient-generated health data using at-home monitoring devices and smart device applications are used more and…
- Conditions
- Clinical Stage 0 Esophageal Adenocarcinoma AJCC v8, Clinical Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8, Clinical Stage 0 Gastric Cancer AJCC v8, Clinical Stage I Esophageal Adenocarcinoma AJCC v8
- Trial name
- NCT04501913
- Testing
- Patient Monitoring, Questionnaire Administration
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- City of Hope Medical Center
Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Melanoma
Testing the Addition of the Anti-cancer Drug, Tazemetostat, to the Usual Treatment (Dabrafenib and Trametinib) for Metastatic Melanoma That Has Progressed on the Usual Treatment
This phase I/II trial investigates the best dose, possible benefits and/or side effects of tazemetostat in combination with dabrafenib and trametinib in treating patients with melanoma that has a specific mutation in the BRAF…
- Trial name
- NCT04557956
- Testing
- Biopsy Procedure, Computed Tomography, Dabrafenib Mesylate
- Where
- 17 sites in United States
- Volunteers
- 16 people
- Sponsor
- National Cancer Institute (NCI)
Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer
This phase II trial tests the combination of nivolumab and ipilimumab with sirolimus and prednisone for the treatment of skin (cutaneous) cancer that cannot be removed by surgery (unresectable) or that has spread from where it…
- Conditions
- Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8, Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8
- Trial name
- NCT05896839
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- 26 sites in United States
- Volunteers
- 16 people
- Sponsor
- National Cancer Institute (NCI)
Clinical Skills Training, Midwifery Education
VR Goggles-Supported Virtual Reality Model in Midwifery Basic Clinical Skills Training
This randomized controlled trial evaluated the effects of virtual reality (VR)-supported training compared with low-fidelity simulation on learning satisfaction, self-confidence in learning, and perceived stress among…
- Trial name
- NCT07260929
- Testing
- VR Goggle-Assisted Simulation Training, Standard Clinical Skills Training
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Skill Development of Staff, Clinical Practice
Peripheral Venous Access Management by Radiologic Technologists in Radiodiagnostic Procedure
The goal of this interventional study is to evaluate the impact of a structured training program on the ability of Radiologic Technologists (RTs) to safely and effectively perform peripheral venous access (PVA) placement for…
- Conditions
- Skill Development of Staff, Clinical Practice, Patient Satisfaction
- Trial name
- TSRM_01 (NCT07411430)
- Testing
- Structured Peripheral Venous Access Training Program
- Where
- Italy
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Musculoskeletal Discomfort, Ergonomic Risk Perception
Musculoskeletal Discomfort and Ergonomic Factors in Midwifery Students
The aim of this observational study is to assess regional musculoskeletal discomfort, ergonomic risk perception, and protective ergonomic behaviors among undergraduate midwifery students at Mardin Artuklu University, Türkiye.
- Conditions
- Musculoskeletal Discomfort, Ergonomic Risk Perception, Protective Ergonomic Behaviours, Clinical Task Exposure
- Trial name
- NCT07873567
- Where
- Turkey (Türkiye)
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- Mardin Artuklu University
Advanced Head and Neck Squamous Cell Carcinoma, Advanced Hypopharyngeal Squamous Cell Carcinoma
Testing the Addition of M3814 (Peposertib) to Radiation Therapy for Patients With Advanced Head and Neck Cancer Who Cannot Take Cisplatin
This phase I trial investigates the side effects and best dose of peposertib when given together with radiation therapy in treating patients with head and neck cancer that has spread to other places in the body (advanced) who…
- Conditions
- Advanced Head and Neck Squamous Cell Carcinoma, Advanced Hypopharyngeal Squamous Cell Carcinoma, Advanced Laryngeal Squamous Cell Carcinoma, Advanced Oral Cavity Squamous Cell Carcinoma
- Trial name
- NCT04533750
- Testing
- Intensity-Modulated Radiation Therapy, Peposertib
- Where
- 27 sites in United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Schizophrenia, Clinical High Risk for Psychosis (CHR)
Mobile Thinking Intervention: A Inital Test
This study will test the inital efficacy of a brief mobile intervention targeting biased thinking.
- Trial name
- NCT06909422
- Testing
- Mobile Intervention for Biased Thinking
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Pulmonary Embolism (Diagnosis), Pulmonary Embolism Acute
Repeated Examinations for Typing Pulmonary Embolism
PURPOSE The two related purposes of the RE-TyPE study are: 1. To improve understanding of the early clinical course of intermediate-high risk pulmonary embolism and its association with outcome and 2.
- Conditions
- Pulmonary Embolism (Diagnosis), Pulmonary Embolism Acute, Pulmonary Embolism With Acute Cor Pulmonale, Pulmonary Embolism With Right Ventricle Enlargement
- Trial name
- RE-TyPE (NCT07491094)
- Where
- 3 sites in Sweden
- Volunteers
- 400 people
- Sponsor
- Sahlgrenska University Hospital
Mental Health Stigma, Cognitive Flexibility
Integrated Mental Health Nursing Program: Effects on Stigma, Cognitive Flexibility, and Clinical Readiness
This quasi-experimental one-group pretest-posttest study aims to evaluate the effect of an Integrated Mental Health Nursing Educational Program on stigma, cognitive flexibility, and clinical readiness among undergraduate nursing…
- Conditions
- Mental Health Stigma, Cognitive Flexibility, Clinical Readiness, Mental Health Nursing Education
- Trial name
- IMHNEP (NCT07517861)
- Testing
- Integrated Mental Health Nursing Educational Program (IMHNEP)
- Where
- Egypt
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Alexandria University