Clinical trials: Clinical Trials
Neuromuscular Blockade
Efficacy and Safety of Sugammadex Dosed According to Actual Body Weight (ABW) or Ideal Body Weight (IBW) in Reversal of Neuromuscular Blockade (NMB) in Morbidly Obese Participants (MK-8616-146)
The purpose of this trial is to evaluate the safety and efficacy of Sugammadex when administered according to actual body weight (ABW) as compared to ideal body weight (IBW) for the reversal of both moderate and deep…
- Trial name
- NCT03346070
- Testing
- Sugammadex 2 mg/kg ABW, Sugammadex 2 mg/kg IBW, Sugammadex 4 mg/kg ABW
- Where
- 24 sites in United States, Austria and 3 more
- Volunteers
- 207 people
- Sponsor
- Merck Sharp & Dohme LLC
Pulmonary Disease, Chronic Obstructive, Chronic Bronchitis
Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Patients
The primary objective is to comparatively evaluate the isolated effects of a long-acting beta2-adrenergic (formoterol fumarate 12µg b.i.d.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Chronic Bronchitis, Pulmonary Emphysema
- Trial name
- NCT00680056
- Testing
- Formoterol plus Tiotropium
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Federal University of São Paulo
Skin and Soft Tissue (SST) Infection
INSPIRE Trial for Skin and Soft Tissue Infections
The INSPIRE Skin and Soft Tissue Infection trial is a cluster-randomized controlled trial of HCA Healthcare hospitals comparing routine empiric antibiotic stewardship practices with real-time, precision medicine computerized…
- Trial name
- NCT05423756
- Testing
- Arm 1: Routine Care, Arm 2: INSPIRE Stewardship Bundle for Skin and Soft Tissue Infection
- Where
- 102 sites in United States
- Volunteers
- 118,562 people
- Sponsor
- Harvard Pilgrim Health Care
Dementia
Intervention Study to Improve Life and Care for People With Dementia and Their Caregivers in Primary Care
Caring for people with dementia and treating them is a major challenge for the health care system in Germany. Among the challenges for population-based health care research are (a) identification and early recognition, (b)…
- Trial name
- DelpHi (NCT01401582)
- Testing
- Implementation of Dementia Care Manager
- Where
- Germany
- Volunteers
- 634 people
- Sponsor
- German Center for Neurodegenerative Diseases (DZNE)
Information Seeking Behavior
Dissemination of Findings Fast Using Online-videos Trial
The investigators will conduct a two-arm, randomized controlled trial of the effect of emotional content in online videos on the extent to which the video is disseminated (forwarded).
- Trial name
- DIFFUSION (NCT02109159)
- Testing
- A short online video with emotional content, A short online video with less emotional content
- Where
- United Kingdom
- Volunteers
- 8,353 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Opioid-Use Disorder
Biased Opioid Agonists for Treatment of Opioid Withdrawal in OUD
Background: People with opioid-use disorder (OUD) might benefit from having more treatment drugs to choose from. A new drug, TRV734, could be used like methadone to treat OUD. It might not have as many side effects.
- Trial name
- NCT04316559
- Testing
- TRV734, Oxycodone
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Gingival Retraction Techniques
Comparison of Two Gingival Displacement Procedures
Purpose: To compare the quality of impressions made with a cordless gingival displacement procedure versus impressions made with a corded technique.
- Trial name
- NCT02716727
- Testing
- Aquasil Ultra Cordless, Dentsply, Ultrapak, Ultradent cord
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Healthy Postmenopausal Females
Bioequivalence of Nomegestrol Acetate (NOMAC) and Estradiol (E2) in Commercial Versus Phase 3 Pivotal Clinical Batches of NOMAC-E2 Tablets (P06328)
For the contraceptive application a film-coated tablet has been developed which combines nomegestrol acetate (NOMAC) with estradiol (E2).
- Trial name
- NCT01345786
- Testing
- Commercial NOMAC-E2, Phase 3 NOMAC-E2 "Batch A", Phase 3 NOMAC-E2 "Batch B"
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Malignant Peripheral Nerve Sheath Tumors, Neurofibromatosis 1
SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath Tumors
To determine the clinical benefit rate of selumetinib in combination with sirolimus in patients with unresectable or metastatic neurofibromatosis type 1 (NF1) associated or sporadic MPNST.
- Trial name
- NCT03433183
- Testing
- Selumetinib, Sirolimus
- Where
- 5 sites in United States
- Volunteers
- 21 people
- Sponsor
- Sarcoma Alliance for Research through Collaboration
Crohn's Disease
Effects of Adalimumab on Mucosal Healing in Subjects With Crohn's Disease Involving the Colon
The goal of this study was to test whether adalimumab can induce mucosal healing in subjects with moderate to severe ileocolonic Crohn's Disease.
- Trial name
- NCT00348283
- Testing
- adalimumab
- Where
- 21 sites in United States, Austria and 6 more
- Volunteers
- 135 people
- Sponsor
- Abbott
Sickle Cell Disease
GBT021601-022: A Study of GBT021601 in Participants With Sickle Cell Disease (SCD)
An Open-label Extension Study of GBT021601 in Participants with Sickle Cell Disease
- Trial name
- NCT05632354
- Testing
- Osivelotor
- Where
- 9 sites in United States, Nigeria
- Volunteers
- 47 people
- Sponsor
- Pfizer
Coronary Artery Bypass Grafting
Randomized Endo-Vein Graft Prospective
Coronary artery bypass grafting (CABG) is the most common major surgical procedure in the United States with over 300,000 cases performed each year.
- Trial name
- REGROUP (NCT01850082)
- Testing
- Vein Harvesting Procedures
- Where
- 16 sites in United States
- Volunteers
- 1,150 people
- Sponsor
- VA Office of Research and Development
Perforated Appendicitis
The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis
The objective of this study is to evaluate two standard post-operative pain regimens routinely used after laparoscopic appendectomy for perforated appendicitis.
- Trial name
- NCT02881996
- Testing
- IV tylenol, No IV tylenol, Ketorolac
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Children's Mercy Hospital Kansas City
Transplant; Failure, Kidney
Tacrolimus/Everolimus Versus Tacrolimus/Enteric-Coated Mycophenolate Sodium
A recent therapeutic strategy following renal transplantation includes simultaneous use of reduced calcineurin inhibitor (CNI) dosing and maximized use of a non-nephrotoxic, antiproliferative drug (inosine monophosphate…
- Trial name
- NCT01680861
- Testing
- Tacrolimus, Everolimus, Enteric Coated Mycophenolate Sodium (EC-MPS)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Gaetano Ciancio
Cannabis Use Disorder
Lorcaserin for Cannabis Use Disorder
The primary purpose of this study is to investigate the effect of lorcaserin on reductions in cannabis use and multiple constructs of impulsivity in outpatient treatment-seeking individuals with cannabis use disorder (CUD).
- Trial name
- NCT03637842
- Testing
- Lorcaserin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- New York State Psychiatric Institute
Heart Failure
University of Michigan Advanced Heart Failure Tele-Monitoring and Flexible Diuretic Project
The proposed project is a 2x2 factorial designed study aimed at assessing the impact of 1) a home tele-monitoring system and 2) a flexible diuretic regimen among high risk heart failure patients in the University of Michigan…
- Trial name
- Manifold-HF (NCT02344342)
- Testing
- Telemonitoring, Flexible Diuretic Regimen
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Michigan
Lung Transplant Infection
Inhaled Beclomethasone After Community-Acquired Respiratory Viral Infection in Lung Transplant Recipients
The purpose of this study is to determine if the use of inhaled beclomethasone after a community-acquired respiratory viral infection in a lung transplant recipient decreases the risk of the subsequent development of chronic lung…
- Trial name
- NCT02351180
- Testing
- Inhaled beclomethasone
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Washington University School of Medicine
Colorectal Cancer
Regorafenib Plus 5-Fluorouracil/Leucovorin Beyond Progression in mCRC
This is a single arm open label pilot phase II trial of Regorafenib PO plus 5-FU/LV infusion in 15 mCRC patients who progressed on prior Regorafenib monotherapy as well as 5-FU containing chemotherapy combinations.The study will…
- Trial name
- NCT03099486
- Testing
- Regorafenib, 5-FU, Leucovorin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Fox Chase Cancer Center
Ependymoma
A Trial of Surgery and Fractionated Re-Irradiation for Recurrent Ependymoma
The primary purpose of this study is to investigate whether surgery and re-irradiation will help treat ependymoma that has come back after initial treatment.
- Trial name
- NCT02125786
- Testing
- Irradiation, Surgery, ^1^8F-Fluorodeoxyglucose
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- St. Jude Children's Research Hospital
Patellofemoral Pain Syndrome
Effectiveness Trial for Evaluating IAHA for PFPS
The purpose of this study is to determine the safety and effectiveness of intra-articular hyaluronan (IAHA) injections for the treatment of symptomatic patellofemoral pain syndrome (PFPS) and determine if this treatment can…
- Trial name
- PFPS (NCT01811654)
- Testing
- Intra-Articular Hyaluronic Acid-Euflexxa
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
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