Clinical trials: Clinical Trials, open to volunteers
Proximal Junctional Kyphosis
Efficacy of Sub-laminar and/or Interspinous Tethers to Prevent Proximal Junctional Kyphosis After Surgical Correction of Adult Spinal Deformity
PJK (proximal junctional kyphosis) at the upper end of spinal fusions after surgical correction of adult spinal deformity is not uncommon.
- Trial name
- TRANSITION (NCT07618897)
- Testing
- Tether strategy, Reference
- Where
- 6 sites in France
- Volunteers
- 128 people
- Sponsor
- Hospices Civils de Lyon
Septic Shock, Methylene Blue
Efficacy and Safety of Methylene Blue in the Treatment of Severe Septic Shock
The goal of this clinical trial is to investigate whether methylene blue injection can safely and effectively improve the survival rate of patients with severe septic shock, shorten the duration of norepinephrine use, reduce the…
- Conditions
- Septic Shock, Methylene Blue, Sepsis
- Trial name
- NCT06481410
- Testing
- Methylene Blue Intervention Group, Normal Saline Control Group
- Where
- China
- Volunteers
- 488 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Diabete Type 2, Cardiovascular Diseases
COLchicine and Non-enteric Coated Aspirin in the Cardiovascular Outcomes Trial of Patients With Type 2 Diabetes
To evaluate the efficacy and safety of colchicine and non-enteric coated aspirin, combined or alone, to improve cardiovascular outcomes in high-risk patients with type 2 diabetes.
- Trial name
- COLCOT-T2D (NCT05633810)
- Testing
- Aspirin, Colchicine
- Where
- 39 sites in Australia, Canada and 6 more
- Volunteers
- 10,000 people
- Sponsor
- Montreal Heart Institute
Sciatic Leg Pain, Hamstring Muscle Tightness
Acute Effects of Neurodynamics on Strength and Endurance in Athletes
This study explores the acute effects of neurodynamics, an intervention commonly used by physical therapist to improve nerve mobility and decrease pain, on the strength and muscular endurance in the athletic population.
- Conditions
- Sciatic Leg Pain, Hamstring Muscle Tightness, Hamstring Muscle Strain, Hamstring Muscle Strength
- Trial name
- NCT07721220
- Testing
- Sciatic Slider, Sciatic Tensioner, Mechanically loaded neurodynamic sciatic floss
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- High Point University
Extraction Sites After Removal and Bone Replacement Grafting at Extraction Sockets of Dentally Hopeless Single-rooted Teeth
To Compare Post-Extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse.
This study will compare commercially available, commonly used mouth rinses (0.12% chlorhexidine (CHX) vs. Ethylenediaminetetraacetic acid (EDTA)) for immediate post-operative and daily antiseptic use after tooth extraction and…
- Trial name
- NCT07191262
- Testing
- 0.12% CHX and Essential Oil mouthrinse, 2.6% EDTA and 0.2% EDTA mouth rinse
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Gingival Cleft, Orthodontic Space Closure
Gingival Cleft Development at Two Time Points of Canine Retraction
The goal of this split-mouth randomized controlled trial is to assess whether the timing of extraction space closure-early vs. delayed initiation-affects the incidence of gingival cleft development in orthodontic patients.
- Trial name
- NCT07210762
- Testing
- Early space closure, Delayed space closure
- Where
- Pakistan
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Bahria University
Blood Loss Anemia, Extracorporeal Membrane Oxygenation Complication
Red Blood Cell Transfusion in ECMO - A Feasibility Trial
Extracorporeal Membrane Oxygenation (ECMO) is an invasive and resource intense treatment used to support critically ill patients who have suffered severe cardiac arrest, cardiac failure or respiratory failure (including severe…
- Conditions
- Blood Loss Anemia, Extracorporeal Membrane Oxygenation Complication, Disability Physical, Cognitive Ability, General
- Trial name
- ROSETTA (NCT05814094)
- Testing
- Red Blood Cell Transfusion
- Where
- 2 sites in Australia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Phenylketonuria (PKU) and Hyperphenylalaninemia, Brain Diseases, Metabolic, Inborn
Market Research of a Slow Release Protein Substitute for the Dietary Management of PKU
XPhePiccosMR is a prospective, single-arm, open label, observational study that aims to evaluate the acceptability and tolerability of XPhe Piccos, a slow-release, phenylalanine-free protein substitute in the form of tiny…
- Conditions
- Phenylketonuria (PKU) and Hyperphenylalaninemia, Brain Diseases, Metabolic, Inborn, Brain Disorder, Metabolic, Brain Diseases
- Trial name
- XPhePiccosMR (NCT07802366)
- Testing
- Slow release, phenylalanine-free protein substitute tablets
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- metaX Institut fuer Diatetik GmbH
Pre-diabetes
Effects of Milk Powder Intervention on Blood Glucose Control and Fluctuation in Middle-aged and Elderly People With Pre-diabetes
This study aims to conduct a 8-week intervention involving one formula milk powder for middle-aged and elderly individuals with pre-diabetes, assessing its impact on blood glucose control and fluctuations in comparison to…
- Trial name
- NCT06863766
- Testing
- fortified formula milk powder group, regular milk powder group
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Huilian Zhu
Kidney Calculi, Ureteral Calculi
New Laser and Suction Sheath for Kidney Stone Treatment
The goal of this clinical trial is to learn if the combination of super pulsed thulium fiber laser (sTFL) with a flexible negative pressure suction sheath is more effective and safer than sTFL with a conventional sheath in…
- Trial name
- NCT06667466
- Testing
- Super Pulsed Thulium Fiber Laser (sTFL) + Flexible Negative Pressure Ureteral Access Sheath (UAS) Intervention, Super Pulsed Thulium Fiber Laser (sTFL) + Conventional Ureteral Access Sheath (UAS) Intervention
- Volunteers
- 140 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
PSMA Positive Tumors or Tumor Tissues
PSMA-specific CAR-T Cell Therapy
The purpose of this clinical trial is to assess the feasibility, safety and efficacy of PSMA-specific CAR-T cell therapy in patients with PSMA positive tumor.
- Trial name
- NCT04429451
- Testing
- 4SCAR-PSMA T cells
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Anterior Shoulder Dislocation
Apprehension-based Training Compared With Standard Physical Therapy for Military Personnel Following Anterior Shoulder Dislocation - a Randomized Clinical Trial
The goal of this clinical trial is to determine if a new rehabilitation protocol (apprehension-based training), leads to better recovery after shoulder dislocation among military personnel.
- Trial name
- NCT06752551
- Testing
- Apprehension-based training, Standard physical therapy
- Where
- Israel
- Volunteers
- 85 people
- Sponsor
- Alon Rabin
Gastric Insufflation
Determination of the Optimal Inspiratory Pressure to Decrease Incidence of Gastric Insufflation With Adequate Ventilation During Facemask Ventilation in Morbidly Obese Patients
The goal of this randomized clinical trial is to optimize the inspiratory pressure during facemask ventilation (FMV) in morbidly obese patients (BMI ≥40 kg/m²), to ensure adequate ventilation while minimizing the risk of gastric…
- Trial name
- NCT07480031
- Testing
- "Ultrasound-Guided Optimization of Inspiratory Pressure During Facemask Ventilation"
- Where
- Egypt
- Volunteers
- 144 people
- Sponsor
- Benha University
HIV, HIV Infection
Clinical Trial to Evaluate the Efficacy and Safety of Codivir® in Addition to Standard Antiretroviral Treatment for HIV Infection in Antiretroviral-naïve Participants
The study will begin with a two-week lead-in period (W-2 and W-1), when participants randomized to Codivir® will receive Codivir® 2 mL, 1 subcutaneous injection every day.
- Trial name
- Codivir® (NCT06676410)
- Testing
- ICF, Eligibility Assessment, Demographic data
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Code Pharma
Acute Kidney Injury, Cardiac Surgery
Fluid-removal Guided by VeXUS Score With Usual Care in Patients With Acute Kidney Injury After Cardiac Surgery
Acute kidney injury affects more than 30% of patients after cardiac surgery, and is associated with an excess in mortality. There is a clinical continuum between acute kidney injury (transient if <48h, persistent if >48h), the…
- Conditions
- Acute Kidney Injury, Cardiac Surgery, Venous Congestion, Hemodynamic Stability
- Trial name
- VeXUS (NCT06251713)
- Testing
- VeXUS score guided fluid management strategy, Usual care
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Prostate Cancer Surgery, Prostate Cancer Metastatic Disease
Safety and Efficacy of OTL78
This is a trial to assess the accuracy of an imaging agent, PSMA targeted fluorescent dye OTL78 (zopocianine), in combination with Near InfraRed (NIR) fluorescent imaging, to improve the detection of malignant (growing in an…
- Trial name
- NCT07725523
- Testing
- 0.06 mg/kg ZOPOCIANINE given 1-7 days prior to surgery
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Clinton Bahler
Post ERCP Pancreatitis
Comparative Effectiveness Between Indomethacin and Pancreatic Stenting in the Prevention of Post ERCP Pancreatitis
Post ERCP pancreatitis (PEP) occurs in 4 to 5% of patients and is associated with significant morbidities and occasional mortalities.
- Trial name
- NCT03713879
- Testing
- pancreatic stenting, Indomethacin
- Where
- 7 sites in China, Hong Kong and 1 more
- Volunteers
- 1,734 people
- Sponsor
- Chinese University of Hong Kong
Anastomotic Leak
PARLAR-02 Trial：Modified Transanal Drainage Tube Use for Preventing Anastomotic Leakage
Surgical resection remains the primary treatment for rectal cancer, but the postoperative incidence of anastomotic leakage (AL) is relatively high.
- Trial name
- NCT07036588
- Testing
- Modified Transanal Drainage Tube
- Where
- China
- Volunteers
- 968 people
- Sponsor
- Third Military Medical University
Overweight and Obesity
Home-Based Exercise for Adults Living With Overweight and Obesity
The study aims to implement a 12-week home-based exercise programme utilising an online intervention delivery platform. The focus will be on increasing exercise behaviour within the participant's home setting using aerobic…
- Trial name
- WEIGH (NCT05807386)
- Testing
- Home-based exercise programme
- Volunteers
- 30 people
- Sponsor
- Coventry University
T1D, T1DM
Pre-Exercise Whey and Pea Protein in Adolescents With Type 1 Diabetes
The goal of this clinical trial is to learn whether drinking whey protein or pea protein before exercise affects blood sugar levels and appetite in adolescents with type 1 diabetes.
- Trial name
- NCT07836673
- Testing
- low whey protein, moderate whey protein, low Pea protein
- Volunteers
- 30 people
- Sponsor
- University of Jordan
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