Clinical trials: Clopidogrel
Diabetes, Clopidogrel Resistance
Platelet Reactivity, B-amyloid, MOTS-c and Mortality of Type II Diabetics With CAD
Increased circulating b-amyloid and decreased Mitochondrial-derived peptide (MOTS-c), a peptide improving tissue insulin sensitivity, are reported in diabetes.
- Conditions
- Diabetes, Clopidogrel Resistance, Amyloid, Insulin Resistance
- Trial name
- NCT04027712
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- University of Athens
Acute Myocardial Infarction
Efficacy and Safety of Adding Clopidogrel to Aspirin or Use of Metoprolol in Myocardial Infarction
COMMIT/CCS2 is a large randomised trial of the effects of clopidogrel plus Aspirin versus Aspirin alone in acute heart disease. Patients presenting within 24 hours of the onset of suspected acute MI were potentially eligible…
- Trial name
- NCT00222573
- Testing
- clopidogrel and metoprolol
- Where
- 2 sites in China, United Kingdom
- Volunteers
- 46,000 people
- Sponsor
- University of Oxford
Coronary Stenting
Effect of Proton Pump Inhibitor on Residual Platelet Reactivity After Clopidogrel in Homogenous Genetic Strata
This study aims to prospectively assess whether there is an interaction between genetic status in terms of 2C19 activity and residual platelet reactivity after clopidogrel intake in patients who underwent coronary stenting for…
- Trial name
- GENIOUS (NCT01512953)
- Testing
- Lansoprazole
- Where
- Italy
- Volunteers
- 522 people
- Sponsor
- Università degli Studi di Ferrara
Blood Pressure, Endothelial Function
Effects of Clopidogrel on Blood Pressure
Context: Soluble CD40 ligand (sCD40L) released from activated platelets induces inflammatory transformation of the vascular endothelium and is an independent predictor of cardiovascular events.
- Conditions
- Blood Pressure, Endothelial Function, Platelet Function
- Trial name
- NCT01112137
- Testing
- Clopidogrel
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 46 people
- Sponsor
- University of Cologne
Ischemic Heart Disease
Optimum Platelet Inhibition After Coronary Bypass Surgery
To investigate the effect of different dosages of aspirin on platelet aggregation and to determine the possible mechanisms of aspirin resistance, we intend to compare the effects of low, medium dose aspirin with clopidogrel (an…
- Trial name
- NCT00262275
- Testing
- Aspirin, Clopidogrel
- Where
- United Kingdom
- Sponsor
- Papworth Hospital NHS Foundation Trust
Severe Aortic Stenosis
Aspirin vs Clopidogrel After TAVR
Currently, the optimal antithrombotic therapy after transcatheter aortic valve replacement (TAVR) remains still unknown., The purpose of the study is to compare aspirin versus clopidogrel monoantiplatelet therapy for preventive…
- Trial name
- NCT05493657
- Testing
- Aspirin single antiplatelet therapy, Clopidogrel single antiplatelet therapy
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Yonsei University
Plaque, Atherosclerotic
Comparison of Clopidogrel Versus Ticagrelor Therapy for Atherosclerotic Plaque Inflammation
Objectives: To compare the effects of clopidogrel versus ticagrelor on atherosclerotic plaque inflammation using serial FDG PET/CT imaging of carotid artery and ascending aorta.
- Trial name
- NCT01905566
- Testing
- Clopidogrel, Ticagrelor
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- CHEOL WHAN LEE, M.D., Ph.D
Acute Coronary Syndrome:, Non ST Elevation Myocardial Infarction
Assessment of Coronary Flow Reserve by Doppler Flow Wire in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Differences Between the Loading Dose of Ticagrelor and Clopidogrel
The administration of these drugs is realized according to the European Society of Cardiology guidelines. All patients will be pretreated with aspirin 300 mg orally, heparin iv to maintain an activated clotting time of >250 sec…
- Conditions
- Acute Coronary Syndrome:, Non ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction, Unstable Angina
- Trial name
- NCT02032290
- Testing
- Assessment of Coronary Flow Reserve, Percutaneous coronary intervention, ticagrelor loading
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Azienda Policlinico Umberto I
Acute Coronary Syndrome or B Cerebral Infarction Requiring DAPT(Clopidogrel + Aspirin) for at Least 6 Months
An Observational Study to Evaluate the Incidence of MACCE According to Time Interval of Taking Medication in Patients With Acute Coronary Syndrome or Cerebral Infarction Who Received DAPT for the Secondary Prevention and Esomezol Cap for the Prevention of Gastrointestinal Bleeding
This study is to evaluate the incidence rate of Major Adverse CardioCerebrovascular Events(MACCE) in Patients with Acute Coronary Syndrome or Cerebral Infarction Who Received DAPT for the secondary prevention and Esomezol Cap for…
- Trial name
- NCT05487560
- Testing
- Esomezol Cap
- Where
- South Korea
- Volunteers
- 4,133 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Graft Patency, Coronary Artery Bypass Grafting Surgery
ThrombElastoGraphic Haemostatic Status and Antiplatelet Therapy After Coronary Artery Bypass Graft Surgery
The purpose of this study is to determine whether adding clopidogrel to aspirin after coronary bypass operation (CABG) improves graft patency, in patients that have preoperatively increased platelet activity(hypercoagulable) and…
- Conditions
- Graft Patency, Coronary Artery Bypass Grafting Surgery, Hypercoagulability, Thrombosis
- Trial name
- TEG-CABG (NCT01046942)
- Testing
- Clopidogrel+acetylsalicylic acid, acetylsalicylic acid
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Coronary Syndrome, Bleeding
The Risk of Major Bleeding With Novel Anti-platelets: A Comparison of Ticagrelor With Clopidogrel in a Real World Population of 5000 Patients Treated for Acute Coronary Syndrome
A retrospective real world analysis of bleeding events with ticagrelor compared to clopidogrel in ACS patients.
- Conditions
- Acute Coronary Syndrome, Bleeding, Novel Anti-platelets, Ticagrelor
- Trial name
- ROBOT-ACS (NCT02484924)
- Testing
- Ticagrelor
- Where
- United Kingdom
- Volunteers
- 5,225 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Aortic Valve Disease, Myocardial Infarction
Aspirin Versus Aspirin+Clopidogrel as Antithrombotic Treatment Following TAVI
The purpose of this study is to compare aspirin/acetylsalicylic acid+ clopidogrel with aspirin/acetylsalicylic acid alone as antithrombotic treatment following TAVI for the prevention of major ischemic events (MI, ischemic…
- Conditions
- Aortic Valve Disease, Myocardial Infarction, Stroke, Bleeding
- Trial name
- ARTE (NCT02640794)
- Testing
- Clopidogrel, Aspirin
- Where
- 4 sites in Canada, Chile and 1 more
- Volunteers
- 222 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Kidney Failure, Hemodialysis Fistula Thrombosis
Clopidogrel Prevention of Early Arteriovenous (AV) Fistula Thrombosis
The objective of the study is to determine whether clopidogrel reduces the early failure rate of native AV fistulae. This study was originally registered as NCT00067119 which included two protocols, this one and the GRAFT study)
- Trial name
- FISTULA (NCT03289520)
- Testing
- Clopidogrel
- Where
- 9 sites in United States
- Volunteers
- 877 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Coronary Surgery, Hemorrhage
Impact of Combination of Clopidogrel With Aspirin on Postoperative Bleeding in Coronary Surgical Patients
Aims Aspirin combined with clopidogrel is the treatment of choice for acute coronary syndromes. Although the maintenance of aspirin until surgery does not affect postoperative bleeding after coronary artery bypass graft (CABG)…
- Trial name
- ICARE (NCT01216150)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Ischemic Stroke, Transient Ischemic Attack
Lovaza's Effect on Clopidogrel in a Neuro Population
In patients who have suffered an ischemic stroke or TIA (mini-stroke), as well as in patients who are candidates for neuroendovascular stenting, it is standard of care to treat these patients with antiplatelet therapy, or…
- Trial name
- NCT01526824
- Testing
- omega-3 polyunsaturated fatty acids (Lovaza)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Millard Fillmore Gates Hospital
Aortic Valve Stenosis
Safety Profile Evaluation of TICagrelor Alone Compared to a Combination of Lysine Acetylsalicylate-Clopidogrel in the Context of Transcatheter Aortic Valve Implantation (TAVI)
Transcatheter Aortic Valve Implantation (TAVI) is now the method of choice to treat aortic stenosis in old and frail patients. Antiplatelet therapy must be associated for the procedure and during few weeks after implantation in…
- Trial name
- TICTAVI (NCT02817789)
- Testing
- Ticagrelor alone, Combination lysine acetylsalicylate - clopidogrel
- Where
- 5 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Head Injury Trauma Blunt
Platelet Function Analysis in Head Trauma: ASA/Plavix
The investigators are assessing the platelet function analysis of those who sustained significant head trauma while on aspirin or plavix and to assess if any qualitative difference is obtained if platelets are administered.
- Trial name
- ASA/Plavix (NCT01534117)
- Testing
- Platelets, DDAVP
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Chang, Steve S., M.D.
Stent Thrombosis, Myocardial Infarction, Acute
TADCLOT- a Double Blind Randomized Controlled Trial
Compare the safety and efficacy of a twice-daily Clopidogrel regimen vs. Ticagrelor in reducing major adverse events in patients undergoing primary PCI in a double-blind randomized controlled trial.
- Trial name
- TADCLOT (NCT06318481)
- Testing
- Ticagrelor 90 MG, Clopidogrel
- Where
- Pakistan
- Volunteers
- 2,200 people
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Percutaneous Coronary Intervention
A Phase 2 Safety and Efficacy Study of PRT060128, a Novel Intravenous and Oral P2Y12 Inhibitor, in Non-Urgent PCI
This is a multi-center, randomized, double-blind, triple-dummy, clopidogrel-controlled study of IV and oral PRT060128 compared to clopidogrel in patients undergoing non-urgent (including elective) PCI.
- Trial name
- INNOVATE-PCI (NCT00751231)
- Testing
- clopidogrel, PRT060128
- Where
- 59 sites in United States, Austria and 3 more
- Volunteers
- 652 people
- Sponsor
- Portola Pharmaceuticals
Atherosclerosis
Trial of Clopidogrel After Surgery for Coronary Artery Disease (CASCADE Trial)
The purpose of this study is to determine whether the combination of clopidogrel with aspirin prevents the development of blockages (atherosclerosis) in vein grafts one year after coronary artery bypass surgery (CABG) compared to…
- Trial name
- CASCADE (NCT00228423)
- Testing
- Clopidogrel 75 mg daily, water pill daily
- Where
- Canada
- Volunteers
- 113 people
- Sponsor
- Ottawa Heart Institute Research Corporation