Clinical trials: Closed Head Trauma
Post-Concussion Syndrome, Traumatic Brain Injury
Hyperbaric Oxygen Treatment to Treat Mild Traumatic Brain Injury (mTBI)/Persistent Post-Concussion Syndrome (PPCS)
Objective/Hypothesis: An eight-week course of forty low-pressure Hyperbaric Oxygen Treatment's (HBOT's) can significantly improve symptoms and cognitive function in subjects with the persistent-post concussion syndrome (PPCS) of…
- Trial name
- NCT02089594
- Testing
- Hyperbaric Oxygen, No Hyperbaric Oxygen
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Traumatic Brain Injury, Post-Concussion Syndrome
Cognitive Effects of Hyperbaric Oxygen Therapy (HBOT) After a Traumatic Brain Injury
This is a retrospective, single-center observational study evaluating the cognitive effects of hyperbaric oxygen therapy (HBOT) in adults who sustained a traumatic brain injury (TBI).
- Trial name
- NCT07883668
- Testing
- Hyperbaric Oxygen Therapy - HBOT
- Volunteers
- 1,000 people
- Sponsor
- Assaf-Harofeh Medical Center
Concussion, Mild, Sleep
Impact of Concussion History on Sleep and Physical Performance in Contact Sports Athletes
This study investigates the correlation between a history of concussions and its effects on both sleep patterns and physical performance among athletes engaged in contact sports.
- Conditions
- Concussion, Mild, Sleep, Physical Performance
- Trial name
- NCT06328023
- Testing
- SCOAT 6 to find association
- Where
- Pakistan
- Volunteers
- 115 people
- Sponsor
- Riphah International University
Post Concussion Symptoms
Effects of Anesthesia on Pediatric Surgical Patients With a History of Concussion - Phase I
The purpose of this research study is to determine the number of children who have symptoms of a concussion at the time they are scheduled for orthopedic surgery at Boston Children's Hospital.
- Trial name
- NCT02118220
- Testing
- Concussion Questionnaire
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Boston Children's Hospital
MTBI - Mild Traumatic Brain Injury
Validation of Clinical Outcome Measures Specific to mTBI-Related Oculomotor Disorders
The specific aim of this project is to validate clinical tests to be used as outcome measures in studies of mTBI-related vision problems.
- Trial name
- NCT07282691
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Salus University
Mild Traumatic Brain Injury
Graded Exposure Therapy for Fear Avoidance Behaviour After Concussion
Concussions are very common. Although many people recover well from concussion, some will have persistent symptoms and difficulties with daily activities.
- Trial name
- GET-FAB (NCT05365776)
- Testing
- Graded Exposure Therapy, Prescribed aerobic exercise, Enhanced usual care
- Where
- 7 sites in Canada
- Volunteers
- 220 people
- Sponsor
- University of British Columbia
Cognitive Deficits, Proprioceptive Disorders
Effects of Multiple Concussions in Retired NHL Players
To investigate long term affects of multiple concussions on the cognition, balance, proprioception, and biomarkers in retired National Hockey League players
- Trial name
- NHL (NCT02746523)
- Testing
- Sensory Organization Test, Biomarkers, Conners' Adult ADHD Rating Scale (CAARS)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- New York Institute of Technology
Concussion, Intermediate
Unblinded Data Collection Study of Concussion Using BrainPulse
This is a prospective, non-blinded, matched control study of young athletes (ages 10-28 years old) in collegiate sports. The cohorts are defined in accordance to the athlete's exposure of injury.
- Trial name
- NCT02992795
- Testing
- BrainPulse
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Jan Medical, Inc.
Mild Traumatic Brain Injury
Evaluating a Novel Method of EEG Evoked Response Potential Analysis in Sport Concussion Assessment - Test Stability and Effect of Concussion
Mild traumatic brain injury (mTBI), also known as concussion, occurs commonly in sport. Despite ongoing research, there is no highly sensitive clinical test for cognitive function.
- Trial name
- NCT01535339
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd
Concussion, Mild
Sex and Age Ultrasound Response to Differential Jugular Vein Pressure
Clinical trials have suggested that this device is effective in mitigating changes in brain structure and function in athlete populations.
- Trial name
- NCT03017937
- Testing
- Q-collar
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
MTBI - Mild Traumatic Brain Injury, Concussion, Mild
Controlled DTI Evaluations in High School Football and Female Soccer to Evaluate Efficacy of Jugular Compression Collar
The purpose of the study is to monitor longitudinal changes in brain structure between the preseason and postseason, in a population of football and soccer playing athletes wearing the Device and compared to a similar population…
- Trial name
- NCT04068883
- Testing
- Q collar
- Where
- 2 sites in United States
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Concussion
Trial of Aerobic Treadmill Exercise Treatment for Concussion
A post-concussion syndrome (PCS) diagnosis has historically led to a recommendation of continued mental and physical rest to minimize symptoms.
- Trial name
- NCT02674620
- Testing
- Aerobic Exercise
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Panam Clinic
Transcranial Direct Current Stimulation, Post-Concussion Syndrome
Effects of tDCS for Enhancing Cognitive Function in Individuals With Persistent Post-Concussion Syndrome
Globally, 10 million new traumatic brain injury (TBI) cases are estimated annually, with mild traumatic brain injury (mTBI) accounting for 75-90% of all TBI cases.
- Conditions
- Transcranial Direct Current Stimulation, Post-Concussion Syndrome, Functional Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy
- Trial name
- NCT06376500
- Testing
- tDCS with cognitive training programme
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
Mild Traumatic Brain Injury
Olfactory Function in Patients With Acute Mild Traumatic Brain Injury
In this project the investigators aim to evaluate olfactory and non-olfactory function in patients within the first 24h following a mild traumatic brain injury (acute mTBI) and compare their results to a group of age and sex…
- Trial name
- NCT02977728
- Testing
- Olfactory Evaluation
- Volunteers
- 42 people
- Sponsor
- Hôpital de Viege
Concussion, Mild Traumatic Brain Injury
Impact of a Paced Breathing Exercise Intervention on Autonomic Nervous System Function After Pediatric Concussion (Acute Phase)
The goal of this pilot clinical trial is to assess the feasibility of administering a paced breathing exercise intervention program to children and adolescents in the acute period after concussion.
- Trial name
- Breathe - PED (NCT07572734)
- Testing
- Paced breathing exercises
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Traumatic Brain Injury, Mild Traumatic Brain Injury
Cerebrovascular Reactivity in American Football Players
Investigators will measure cerebrovascular reactivity (CVR) using functional near-infrared spectroscopy (fNIRS) and magnetic resonance imaging (MRI) during the chronic phase after repetitive mild traumatic brain injury (rmTBI) as…
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Post-Concussion Syndrome
- Trial name
- NCT03417492
- Testing
- Sildenafil Citrate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Pennsylvania
Head Injuries, Closed
Study of Neurobehavioral Outcome in Children or Adolescents With Closed Head Injuries
OBJECTIVES: I. Determine the relationship of closed head injury (CHI) severity, focal brain lesions, and the age at injury to the development of working memory, inhibition, and metacognitive skills in children or adolescents with…
- Trial name
- NCT00006128
- Where
- 5 sites in United States, Canada
- Volunteers
- 374 people
- Sponsor
- National Center for Research Resources (NCRR)
Post-Concussion Syndrome
Rehabilitation in Post Concussion Syndrome
This project evaluates and quantifies the effects of an individually tailored exercise program applied to patients with long-lasting symptoms after concussion, minor traumatic brain injury, so-called Post-Concussion Syndrome…
- Trial name
- REPCon (NCT05785000)
- Testing
- Physical exercise programme as an add-on, Control patients receiving usual care
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Concussion, Mild, Vestibular Impairment
Association of History of Concussion With Vestibular Impairment and Cognitive Function in Sports Athletes
This study investigates the potential relationship between prior concussions and their impact on both vestibular function and cognitive abilities in athletes participating in sports.
- Conditions
- Concussion, Mild, Vestibular Impairment, Cognitive Impairment
- Trial name
- NCT06340100
- Testing
- find association between vestibular impairment , cognitive fiunction with concussin
- Where
- Pakistan
- Volunteers
- 115 people
- Sponsor
- Riphah International University
Cerebral Concussion
Concussion in French Amateur Rugby : Survey About the Management and Knowledge of Players
Rugby is a popular contact sport in France the majority of whom are amateur players. Concussion is one of the main risks given its potential severity and frequency (between 2.78 and 10 per 1,000 player hours).
- Trial name
- RUGBY-COM (NCT04760834)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux