Clinical trials: Closed Head Trauma
Insomnia, Concussion Post Syndrome
Post-Concussion Sleep and Brain-heart Functions
This project is designed as a randomized controlled trial (RCT), with an active control group. Sleep and heart rate will be monitored at home for 1 week before and after the intervention.
- Trial name
- CBT-pI (NCT07636408)
- Testing
- CBT-pI, Sleep Hygiene
- Volunteers
- 70 people
- Sponsor
- University of Ottawa
Mild Traumatic Brain Injury, Concussion Post Syndrome
Treatment for Patients With Chronic Post-Concussion Symptoms
The current project will examine the effect of a brief psychological intervention on post-concussion symptoms, neurocognitive function, cerebral blood flow (CBF), and psychophysiological and salivary cortisol markers of autonomic…
- Trial name
- NCT03759808
- Testing
- Psychological Intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Concussion, Brain
Neurocognitive Dysfunction After Anesthesia in Patients With Recent Concussion
Researchers are trying to determine if the impact of a concussion on the brain is affected by anesthesia and surgery.
- Trial name
- NCT03952208
- Testing
- Neurocognitive Testing
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
TBI
Evaluation of Spot Light: A Concussion Injury Management App for Youth Sports
Sports-related traumatic brain injuries (TBIs), including mTBIs-commonly referred to as concussions-are a serious public health concern.
- Trial name
- SpotLight (NCT02249533)
- Testing
- Spot Light Concussion App
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Lara McKenzie
Concussion, Mild, Diagnoses, Syndromes, and Conditions
Diagnosis of Sport-related Concussion Using Urine Metabolites
Millions of sport related concussions (SRC) occur yearly in the United States, and current diagnosis of concussion is based upon largely subjective clinical evaluations.
- Trial name
- NCT03653195
- Testing
- urine metabolomics
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Sports Injuries, Concussion, Brain
AIM CONTROL and SWECON - Handball The SWEdish CONcussion Study in Elite Handball
Handball is reported to be top 5 in Europe when it comes to sports injuries. There are few studies based on player reported data, and earlier Swedish data is mainly based on data from Insurance ´companies and mostly acute…
- Conditions
- Sports Injuries, Concussion, Brain, Exposure, Psychological
- Trial name
- NCT04109677
- Where
- Sweden
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Adult Growth Hormone Deficiency, Mild Traumatic Brain Injury
Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)
The purpose of this study is to determine whether growth hormone replacement therapy (GHRT) is effective versus placebo in the improvement of Quality of Life in patients with adult growth hormone deficiency (AGHD) and mild…
- Trial name
- GRIT (NCT04867317)
- Testing
- Somatropin
- Where
- 16 sites in United States
- Volunteers
- 172 people
- Sponsor
- VA Office of Research and Development
Brain Concussion
Tele-Rehabilitation to Improve Mild Traumatic Brain Injury Recovery and Reduce Subsequent Injury Risk
The goal of this clinical trial is to examine the feasibility, utility, and efficacy of a smartphone-based assessment battery and remotely administered virtual Neuromuscular/Dual-Task (vNDT) intervention among healthy U.S.
- Trial name
- NCT05594225
- Testing
- Virtual Neuromuscular/Dual-Task Training
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Colorado, Denver
Depression, Mild Traumatic Brain Injury
Combined Neuromodulation and Cognitive Training for Post-mTBI Depression
The primary goal of this clinical trial is to evaluate whether Personalized Augmented Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS) is effective for treating depression in Service Members, Veterans…
- Conditions
- Depression, Mild Traumatic Brain Injury, Concussion, Brain
- Trial name
- NCT05682677
- Testing
- iTBS, Personalized, Augmented Cognitive Training (PACT)
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of California, San Diego
Concussion, Brain
Salivary Biomarkers for Concussion Recovery
The overarching purpose of this proposed research is to determine whether BDNF and/or specific miRNAs can serve as biomarkers for recovery from a concussion during prescribed exercise.
- Trial name
- NCT05379920
- Testing
- High Volume Aerobic Exercise, Low Volume Aerobic Exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Concussion, Intermediate
Magnesium and Riboflavin Treatment for Post-Concussion Headache
This clinical trial will try to determine if the supplements magnesium and riboflavin will reduce the pain and duration of headaches in persons diagnosed with a concussion.
- Trial name
- NCT06260072
- Testing
- magnesium and riboflavin supplement
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Virginia
Persistent Post-concussive Symptoms, Convergence Insufficiency
Persistent Post-Concussion Symptoms With Convergence Insufficiency
Our successful R01 discovered 1) the neural mechanistic difference between typically occurring convergence insufficiency (TYP-CI) and binocularly normal controls and 2) the underlying mechanism of office-based vergence and…
- Conditions
- Persistent Post-concussive Symptoms, Convergence Insufficiency, Mild Traumatic Brain Injury, Concussion, Mild
- Trial name
- PPCS-CI (NCT05262361)
- Testing
- Office-based Vergence and Accommodative Therapy
- Where
- 2 sites in United States
- Volunteers
- 112 people
- Sponsor
- New Jersey Institute of Technology
Insomnia
Gabapentin's Effects on Insomnia in Patients With Recent Concussion
In this open-label, pilot study the investigators will be assessing gabapentin's effects on insomnia and other concussion-related symptoms in patients with a recent concussion experiencing insomnia.
- Trial name
- NCT01421264
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- State University of New York at Buffalo
Concussion
Evaluation of an EEG Based Concussion System
This study will evaluate the accuracy of a new concussion system at detecting concussions. The investigators will be evaluating the degree to which data collected with the device agrees with a physician's determination of a…
- Trial name
- NCT03710109
- Testing
- EEG
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Mild Traumatic Brain Injury
Transcranial Ultrasonography for the Management of Patients With Mild TBI
The investigators hypothesize that patients with mild TBI and normal TCD can be safely discharged home immediately after the ED.
- Trial name
- TRUST (NCT03989999)
- Testing
- Transcranial Doppler (TCD)
- Where
- 12 sites in France
- Volunteers
- 550 people
- Sponsor
- University Hospital, Grenoble
Mild Traumatic Brain Injury
Acute and Mild TBI Injury in Military and Civilian Population Using Advanced MR Imaging
This is a prospective longitudinal study of patients with acute mTBI and comparison with chronic mTBI patients and a cohort without history of TBI or none within 5 years of enrollment.
- Trial name
- NCT05101239
- Testing
- MRI imaging exam
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The Geneva Foundation
Traumatic Brain Injury, Mild Traumatic Brain Injury
Comparison of Two Group Wellness Interventions for Individuals With Neurologic Conditions and Their Support Persons
Approximately 5.3 million people live with a long-term disability resulting from a traumatic brain injury (TBI) and between 5-8% of those older than 60 suffer from Alzheimer's disease or other forms of dementia (ADRD).
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Alzheimer's Disease, Brain Injury Traumatic Moderate
- Trial name
- NCT05048966
- Testing
- Group Wellness Class 1, Group Wellness Class 2
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Kessler Foundation
Cerebral Concussion
Baseline Reference Values for Concussion Assessments in Football
The primary objective is to provide normal concussion assessment references values for use in football. All National Football Associations participating in The International Football Association Board's additional permanent…
- Trial name
- NCT05542628
- Testing
- No intervention included
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Federation Internationale de Football Association
Mild Traumatic Brain Injury; Concussion
CORE (Cognitive Optimization Through Rehabilitation and Education) Study
Mild traumatic brain injury (mTBI) affects millions of individuals worldwide every year. It has long been thought that the vast majority of individuals who sustain a mTBI experience natural recovery with little or no intervention…
- Trial name
- CORE (NCT06859996)
- Testing
- Tools for Rehabilitation and Cognitive Care (On-TRACC), Brain Health psychoeducation
- Where
- 2 sites in United States
- Volunteers
- 354 people
- Sponsor
- University of Washington
Persistent Post-concussive Syndrome, Concussion Post Syndrome
Hyperbaric Oxygen Effects on Persistent Post-concussive Symptoms
Persistent post-concussive symptoms (PPCS) are a source of significant burden among a subset of patients with concussion with prevalence rates previously reported between 11 - 82% based on timing of assessment, diagnostic…
- Trial name
- HOINPCS (NCT05173818)
- Testing
- Hyperbaric oxygen at 1.5 ATA
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Essentia Health